NPAS4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPAS4
Entrez Gene ID	266743
Full Name	neuronal PAS domain protein 4
Synonyms	Le-PAS,NXF,PASD10,bHLHe79
General protein information	Preferred Names neuronal PAS domain protein 4 Names neuronal PAS domain-containing protein 4 HLH-PAS transcription factor NXF PAS domain-containing protein 10 class E basic helix-loop-helix protein 79 neuronal PAS4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].
Disorder MIM:	608554

mRNA and Protein(s)

mRNA	Protein	Name
XM_017017538.1	XP_016873027.1	neuronal PAS domain-containing protein 4 isoform X2
NM_178864.4	NP_849195.2	neuronal PAS domain-containing protein 4 isoform 1
XM_017017537.1	XP_016873026.1	neuronal PAS domain-containing protein 4 isoform X1
NM_178864.3	NP_849195.2	neuronal PAS domain-containing protein 4 isoform 1
NM_001318804.1	NP_001305733.1	neuronal PAS domain-containing protein 4 isoform 2
XM_017017539.1	XP_016873028.1	neuronal PAS domain-containing protein 4 isoform X3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NPAS4	XP_540832.2
Danio rerio (zebrafish)	npas4a	NP_001038786.1
Gallus gallus (chicken)	LOC101750093	XP_004940231.1
Pan troglodytes (chimpanzee)	NPAS4	XP_001171566.1
Danio rerio (zebrafish)	LOC794051	XP_001333944.2
Mus musculus (house mouse)	Npas4	NP_705781.1
Danio rerio (zebrafish)	LOC100534657	XP_003200884.2
Xenopus tropicalis (tropical clawed frog)	npas4	NP_001072906.2
Homo sapiens (human)	NPAS4	NP_849195.2
	NPAS4	XP_001110331.1
Bos taurus (cattle)	NPAS4	XP_002699401.1
Rattus norvegicus (Norway rat)	Npas4	NP_705890.1

Gene Ontology
Bibliography

Related articles in PubMed

The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.
Esser JS, Charlet A, Schmidt M, Heck S, Allen A, Lother A, Epting D, Patterson C, Bode C, Moser M
Cardiovascular research113(2)222-223(2017 Feb)

The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.
Choy FC, Klari? TS, Koblar SA, Lewis MD
International journal of molecular sciences16(12)29011-28(2015 Dec)

A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells.
Klaric TS, Thomas PQ, Dottori M, Leong WK, Koblar SA, Lewis MD
Stem cell research & therapy5(3)64(2014 May)

Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.
Bersten DC, Bruning JB, Peet DJ, Whitelaw ML
PloS one9(1)e85768(2014)

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

Nature genetics43(10)977-83(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NPAS4 is expressed in endothelial cells, regulates VE-cadherin expression and regulates sprouting angiogenesis.
Title: The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.

This review summarizes the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. [review]
Title: The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.

we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain
Title: A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells.

These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation.
Title: Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.

a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 in the mental retardation of Down's syndrome
Title: Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.

The following NPAS4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPAS4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07538	NM_178864.4 Latest version!	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu92130	XM_017017539.1 Latest version!	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu100161	NM_001318804.1 Latest version!	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OHu92128	XM_017017537.1 Latest version!	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00
OHu92129	XM_017017538.1 Latest version!	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu07538	NM_178864.3	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPAS4 ( NM_178864.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_849195.2 Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07538
Clone ID Related Accession (Same CDS sequence)	NM_178864.4 , NM_178864.3
Accession Version	NM_178864.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	neuronal PAS domain-containing protein 4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK096253.1, AB049469.1 and AP001107.5. On Nov 23, 2018 this sequence version replaced NM_178864.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AB049469.1, AK096253.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311034.7/ ENSP00000311196.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTACCGCT CCACCAAGGG CGCCTCCAAG GCGCGCCGGG ACCAGATCAA CGCCGAGATC 
CGGAACCTCA AGGAGCTGCT GCCGCTGGCC GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GCCTCGCCTG CATCTACACT CGCAAGGGCG TCTTCTTCGC TGGTGGCACT 
CCTCTGGCGG GCCCCACGGG GCTTCTCTCA GCTCAAGAGC TTGAGGACAT CGTAGCGGCA 
CTACCCGGCT TTCTGCTTGT GTTCACAGCC GAGGGGAAAT TGCTCTACCT GTCTGAGAGT 
GTGAGCGAGC ATCTGGGCCA CTCCATGGTG GACCTGGTTG CCCAGGGTGA CAGCATCTAC 
GACATCATTG ACCCAGCTGA CCACCTCACT GTGCGCCAGC AACTCACCCT GCCCTCTGCC 
CTGGACACTG ATCGCCTCTT CCGCTGCCGC TTCAACACCT CCAAGTCCCT CAGGCGCCAG 
AGTGCAGGCA ACAAACTCGT GCTTATTCGA GGCCGATTCC ATGCTCACCC ACCTGGAGCC 
TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC CTCTGGAGCC GAGACCCCGC 
CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC TGGCCATGTT CCAGAGCCGC 
CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG TCCTAATCTA CCTGGGCTTT 
GAGCGCAGTG AACTGCTTTG TAAATCATGG TATGGACTGC TGCACCCCGA GGACCTGGCC 
CACGCTTCTG CTCAACACTA CCGCCTGTTG GCTGAGAGTG GAGATATTCA GGCAGAGATG 
GTGGTGAGGC TACAGGCCAA GACTGGAGGC TGGGCATGGA TTTACTGCCT GTTATACTCA 
GAAGGTCCAG AGGGACCCAT TACTGCCAAT AACTACCCAA TCAGTGACAT GGAAGCCTGG 
AGCCTCCGCC AGCAGTTGAA CTCTGAAGAC ACCCAGGCAG CTTATGTCCT GGGCACTCCG 
ACCATGCTGC CCTCATTCCC TGAAAACATT CTTTCCCAGG AAGAGTGCTC CAGCACTAAC 
CCACTCTTCA CCGCAGCACT GGGGGCTCCC AGAAGCACCA GCTTCCCCAG TGCTCCTGAA 
CTGAGTGTTG TCTCTGCATC AGAAGAGCTT CCCCGACCCT CCAAAGAACT GGACTTCAGT 
TACCTGACAT TCCCTTCTGG GCCTGAGCCT TCTCTCCAAG CAGAACTAAG CAAGGATCTT 
GTGTGCACTC CACCTTACAC GCCCCATCAG CCAGGAGGCT GTGCCTTCCT CTTCAGCCTC 
CATGAGCCCT TCCAGACCCA TTTGCCCACC CCATCCAGCA CTCTTCAAGA ACAGCTGACT 
CCAAGCACTG CGACCTTCTC TGATCAGTTG ACGCCCAGCA GTGCAACCTT CCCAGATCCA 
CTAACTAGCC CACTGCAAGG CCAGTTGACT GAAACCTCGG TCAGAAGCTA TGAAGACCAG 
TTGACTCCCT GCACCTCCAC CTTCCCAGAC CAGCTGCTTC CCAGCACAGC CACCTTCCCA 
GAGCCTCTGG GCAGCCCTGC CCATGAACAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CACCTGGACA GCCCCAGCCA AACCTTCCCA GAGCAACTGA GCCCCAACCC TACCAAGACT 
TACTTTGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGCAC GCTCTTGGCC CTAGCCCAGC TCCGGGGCCC CCTCTCTGTG 
GATGTCCCCC TGGTGCCCGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAGAGT 
TTCTTCCACT ACTCTGAAAA GGAGCAGAAT GAGATAGACC GTCTCATCCA GCAGATTAGC 
CAATTGGCTC AGGGCATGGA CAGACCCTTC TCAGCTGAGG CTGGCACTGG CGGACTAGAG 
CCACTTGGAG GACTGGAGCC CCTGGACTCC AACCTGTCCC TGTCAGGGGC AGGCCCCCCT 
GTGCTCAGCC TGGACCTGAA ACCCTGGAAA TGCCAGGAGC TGGACTTCCT GGCTGACCCT 
GATAACATGT TCCTGGAAGA GACGCCCGTG GAAGACATCT TCATGGATCT CTCTACCCCA 
GATCCCAGTG AGGAATGGGG CTCAGGGGAT CCTGAGGCAG AGGGCCCAGG AGGGGCCCCA 
TCGCCTTGCA ACAACCTGTC CCCAGAAGAC CACAGCTTCC TGGAGGACCT GGCCACATAT 
GAAACCGCCT TTGAGACAGG TGTCTCAGCA TTCCCCTATG ATGGGTTTAC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_849195.2
CDS	146..2554
Translation	MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTPDPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDELHQLQSQVQDSFHEDGSGGEPTF

Target ORF information:

RefSeq Version	NM_178864.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178864.4

ORF Insert Sequence:

ATGTACCGCT CCACCAAGGG CGCCTCCAAG GCGCGCCGGG ACCAGATCAA CGCCGAGATC 
CGGAACCTCA AGGAGCTGCT GCCGCTGGCC GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GCCTCGCCTG CATCTACACT CGCAAGGGCG TCTTCTTCGC TGGTGGCACT 
CCTCTGGCGG GCCCCACGGG GCTTCTCTCA GCTCAAGAGC TTGAGGACAT CGTAGCGGCA 
CTACCCGGCT TTCTGCTTGT GTTCACAGCC GAGGGGAAAT TGCTCTACCT GTCTGAGAGT 
GTGAGCGAGC ATCTGGGCCA CTCCATGGTG GACCTGGTTG CCCAGGGTGA CAGCATCTAC 
GACATCATTG ACCCAGCTGA CCACCTCACT GTGCGCCAGC AACTCACCCT GCCCTCTGCC 
CTGGACACTG ATCGCCTCTT CCGCTGCCGC TTCAACACCT CCAAGTCCCT CAGGCGCCAG 
AGTGCAGGCA ACAAACTCGT GCTTATTCGA GGCCGATTCC ATGCTCACCC ACCTGGAGCC 
TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC CTCTGGAGCC GAGACCCCGC 
CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC TGGCCATGTT CCAGAGCCGC 
CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG TCCTAATCTA CCTGGGCTTT 
GAGCGCAGTG AACTGCTTTG TAAATCATGG TATGGACTGC TGCACCCCGA GGACCTGGCC 
CACGCTTCTG CTCAACACTA CCGCCTGTTG GCTGAGAGTG GAGATATTCA GGCAGAGATG 
GTGGTGAGGC TACAGGCCAA GACTGGAGGC TGGGCATGGA TTTACTGCCT GTTATACTCA 
GAAGGTCCAG AGGGACCCAT TACTGCCAAT AACTACCCAA TCAGTGACAT GGAAGCCTGG 
AGCCTCCGCC AGCAGTTGAA CTCTGAAGAC ACCCAGGCAG CTTATGTCCT GGGCACTCCG 
ACCATGCTGC CCTCATTCCC TGAAAACATT CTTTCCCAGG AAGAGTGCTC CAGCACTAAC 
CCACTCTTCA CCGCAGCACT GGGGGCTCCC AGAAGCACCA GCTTCCCCAG TGCTCCTGAA 
CTGAGTGTTG TCTCTGCATC AGAAGAGCTT CCCCGACCCT CCAAAGAACT GGACTTCAGT 
TACCTGACAT TCCCTTCTGG GCCTGAGCCT TCTCTCCAAG CAGAACTAAG CAAGGATCTT 
GTGTGCACTC CACCTTACAC GCCCCATCAG CCAGGAGGCT GTGCCTTCCT CTTCAGCCTC 
CATGAGCCCT TCCAGACCCA TTTGCCCACC CCATCCAGCA CTCTTCAAGA ACAGCTGACT 
CCAAGCACTG CGACCTTCTC TGATCAGTTG ACGCCCAGCA GTGCAACCTT CCCAGATCCA 
CTAACTAGCC CACTGCAAGG CCAGTTGACT GAAACCTCGG TCAGAAGCTA TGAAGACCAG 
TTGACTCCCT GCACCTCCAC CTTCCCAGAC CAGCTGCTTC CCAGCACAGC CACCTTCCCA 
GAGCCTCTGG GCAGCCCTGC CCATGAACAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CACCTGGACA GCCCCAGCCA AACCTTCCCA GAGCAACTGA GCCCCAACCC TACCAAGACT 
TACTTTGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGCAC GCTCTTGGCC CTAGCCCAGC TCCGGGGCCC CCTCTCTGTG 
GATGTCCCCC TGGTGCCCGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAGAGT 
TTCTTCCACT ACTCTGAAAA GGAGCAGAAT GAGATAGACC GTCTCATCCA GCAGATTAGC 
CAATTGGCTC AGGGCATGGA CAGACCCTTC TCAGCTGAGG CTGGCACTGG CGGACTAGAG 
CCACTTGGAG GACTGGAGCC CCTGGACTCC AACCTGTCCC TGTCAGGGGC AGGCCCCCCT 
GTGCTCAGCC TGGACCTGAA ACCCTGGAAA TGCCAGGAGC TGGACTTCCT GGCTGACCCT 
GATAACATGT TCCTGGAAGA GACGCCCGTG GAAGACATCT TCATGGATCT CTCTACCCCA 
GATCCCAGTG AGGAATGGGG CTCAGGGGAT CCTGAGGCAG AGGGCCCAGG AGGGGCCCCA 
TCGCCTTGCA ACAACCTGTC CCCAGAAGAC CACAGCTTCC TGGAGGACCT GGCCACATAT 
GAAACCGCCT TTGAGACAGG TGTCTCAGCA TTCCCCTATG ATGGGTTTAC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPAS4 ( NM_178864.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_849195.2 Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07538
Clone ID Related Accession (Same CDS sequence)	NM_178864.4 , NM_178864.3
Accession Version	NM_178864.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	neuronal PAS domain-containing protein 4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK096253.1 and AB049469.1. On Jul 11, 2008 this sequence version replaced NM_178864.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK096253.1, SRR1803616.63288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACCGCT CCACCAAGGG CGCCTCCAAG GCGCGCCGGG ACCAGATCAA CGCCGAGATC 
CGGAACCTCA AGGAGCTGCT GCCGCTGGCC GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GCCTCGCCTG CATCTACACT CGCAAGGGCG TCTTCTTCGC TGGTGGCACT 
CCTCTGGCGG GCCCCACGGG GCTTCTCTCA GCTCAAGAGC TTGAGGACAT CGTAGCGGCA 
CTACCCGGCT TTCTGCTTGT GTTCACAGCC GAGGGGAAAT TGCTCTACCT GTCTGAGAGT 
GTGAGCGAGC ATCTGGGCCA CTCCATGGTG GACCTGGTTG CCCAGGGTGA CAGCATCTAC 
GACATCATTG ACCCAGCTGA CCACCTCACT GTGCGCCAGC AACTCACCCT GCCCTCTGCC 
CTGGACACTG ATCGCCTCTT CCGCTGCCGC TTCAACACCT CCAAGTCCCT CAGGCGCCAG 
AGTGCAGGCA ACAAACTCGT GCTTATTCGA GGCCGATTCC ATGCTCACCC ACCTGGAGCC 
TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC CTCTGGAGCC GAGACCCCGC 
CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC TGGCCATGTT CCAGAGCCGC 
CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG TCCTAATCTA CCTGGGCTTT 
GAGCGCAGTG AACTGCTTTG TAAATCATGG TATGGACTGC TGCACCCCGA GGACCTGGCC 
CACGCTTCTG CTCAACACTA CCGCCTGTTG GCTGAGAGTG GAGATATTCA GGCAGAGATG 
GTGGTGAGGC TACAGGCCAA GACTGGAGGC TGGGCATGGA TTTACTGCCT GTTATACTCA 
GAAGGTCCAG AGGGACCCAT TACTGCCAAT AACTACCCAA TCAGTGACAT GGAAGCCTGG 
AGCCTCCGCC AGCAGTTGAA CTCTGAAGAC ACCCAGGCAG CTTATGTCCT GGGCACTCCG 
ACCATGCTGC CCTCATTCCC TGAAAACATT CTTTCCCAGG AAGAGTGCTC CAGCACTAAC 
CCACTCTTCA CCGCAGCACT GGGGGCTCCC AGAAGCACCA GCTTCCCCAG TGCTCCTGAA 
CTGAGTGTTG TCTCTGCATC AGAAGAGCTT CCCCGACCCT CCAAAGAACT GGACTTCAGT 
TACCTGACAT TCCCTTCTGG GCCTGAGCCT TCTCTCCAAG CAGAACTAAG CAAGGATCTT 
GTGTGCACTC CACCTTACAC GCCCCATCAG CCAGGAGGCT GTGCCTTCCT CTTCAGCCTC 
CATGAGCCCT TCCAGACCCA TTTGCCCACC CCATCCAGCA CTCTTCAAGA ACAGCTGACT 
CCAAGCACTG CGACCTTCTC TGATCAGTTG ACGCCCAGCA GTGCAACCTT CCCAGATCCA 
CTAACTAGCC CACTGCAAGG CCAGTTGACT GAAACCTCGG TCAGAAGCTA TGAAGACCAG 
TTGACTCCCT GCACCTCCAC CTTCCCAGAC CAGCTGCTTC CCAGCACAGC CACCTTCCCA 
GAGCCTCTGG GCAGCCCTGC CCATGAACAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CACCTGGACA GCCCCAGCCA AACCTTCCCA GAGCAACTGA GCCCCAACCC TACCAAGACT 
TACTTTGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGCAC GCTCTTGGCC CTAGCCCAGC TCCGGGGCCC CCTCTCTGTG 
GATGTCCCCC TGGTGCCCGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAGAGT 
TTCTTCCACT ACTCTGAAAA GGAGCAGAAT GAGATAGACC GTCTCATCCA GCAGATTAGC 
CAATTGGCTC AGGGCATGGA CAGACCCTTC TCAGCTGAGG CTGGCACTGG CGGACTAGAG 
CCACTTGGAG GACTGGAGCC CCTGGACTCC AACCTGTCCC TGTCAGGGGC AGGCCCCCCT 
GTGCTCAGCC TGGACCTGAA ACCCTGGAAA TGCCAGGAGC TGGACTTCCT GGCTGACCCT 
GATAACATGT TCCTGGAAGA GACGCCCGTG GAAGACATCT TCATGGATCT CTCTACCCCA 
GATCCCAGTG AGGAATGGGG CTCAGGGGAT CCTGAGGCAG AGGGCCCAGG AGGGGCCCCA 
TCGCCTTGCA ACAACCTGTC CCCAGAAGAC CACAGCTTCC TGGAGGACCT GGCCACATAT 
GAAACCGCCT TTGAGACAGG TGTCTCAGCA TTCCCCTATG ATGGGTTTAC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_849195.2
CDS	177..2585
Translation	MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTPDPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDELHQLQSQVQDSFHEDGSGGEPTF

Target ORF information:

RefSeq Version	NM_178864.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178864.3

ORF Insert Sequence:

ATGTACCGCT CCACCAAGGG CGCCTCCAAG GCGCGCCGGG ACCAGATCAA CGCCGAGATC 
CGGAACCTCA AGGAGCTGCT GCCGCTGGCC GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GCCTCGCCTG CATCTACACT CGCAAGGGCG TCTTCTTCGC TGGTGGCACT 
CCTCTGGCGG GCCCCACGGG GCTTCTCTCA GCTCAAGAGC TTGAGGACAT CGTAGCGGCA 
CTACCCGGCT TTCTGCTTGT GTTCACAGCC GAGGGGAAAT TGCTCTACCT GTCTGAGAGT 
GTGAGCGAGC ATCTGGGCCA CTCCATGGTG GACCTGGTTG CCCAGGGTGA CAGCATCTAC 
GACATCATTG ACCCAGCTGA CCACCTCACT GTGCGCCAGC AACTCACCCT GCCCTCTGCC 
CTGGACACTG ATCGCCTCTT CCGCTGCCGC TTCAACACCT CCAAGTCCCT CAGGCGCCAG 
AGTGCAGGCA ACAAACTCGT GCTTATTCGA GGCCGATTCC ATGCTCACCC ACCTGGAGCC 
TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC CTCTGGAGCC GAGACCCCGC 
CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC TGGCCATGTT CCAGAGCCGC 
CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG TCCTAATCTA CCTGGGCTTT 
GAGCGCAGTG AACTGCTTTG TAAATCATGG TATGGACTGC TGCACCCCGA GGACCTGGCC 
CACGCTTCTG CTCAACACTA CCGCCTGTTG GCTGAGAGTG GAGATATTCA GGCAGAGATG 
GTGGTGAGGC TACAGGCCAA GACTGGAGGC TGGGCATGGA TTTACTGCCT GTTATACTCA 
GAAGGTCCAG AGGGACCCAT TACTGCCAAT AACTACCCAA TCAGTGACAT GGAAGCCTGG 
AGCCTCCGCC AGCAGTTGAA CTCTGAAGAC ACCCAGGCAG CTTATGTCCT GGGCACTCCG 
ACCATGCTGC CCTCATTCCC TGAAAACATT CTTTCCCAGG AAGAGTGCTC CAGCACTAAC 
CCACTCTTCA CCGCAGCACT GGGGGCTCCC AGAAGCACCA GCTTCCCCAG TGCTCCTGAA 
CTGAGTGTTG TCTCTGCATC AGAAGAGCTT CCCCGACCCT CCAAAGAACT GGACTTCAGT 
TACCTGACAT TCCCTTCTGG GCCTGAGCCT TCTCTCCAAG CAGAACTAAG CAAGGATCTT 
GTGTGCACTC CACCTTACAC GCCCCATCAG CCAGGAGGCT GTGCCTTCCT CTTCAGCCTC 
CATGAGCCCT TCCAGACCCA TTTGCCCACC CCATCCAGCA CTCTTCAAGA ACAGCTGACT 
CCAAGCACTG CGACCTTCTC TGATCAGTTG ACGCCCAGCA GTGCAACCTT CCCAGATCCA 
CTAACTAGCC CACTGCAAGG CCAGTTGACT GAAACCTCGG TCAGAAGCTA TGAAGACCAG 
TTGACTCCCT GCACCTCCAC CTTCCCAGAC CAGCTGCTTC CCAGCACAGC CACCTTCCCA 
GAGCCTCTGG GCAGCCCTGC CCATGAACAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CACCTGGACA GCCCCAGCCA AACCTTCCCA GAGCAACTGA GCCCCAACCC TACCAAGACT 
TACTTTGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGCAC GCTCTTGGCC CTAGCCCAGC TCCGGGGCCC CCTCTCTGTG 
GATGTCCCCC TGGTGCCCGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAGAGT 
TTCTTCCACT ACTCTGAAAA GGAGCAGAAT GAGATAGACC GTCTCATCCA GCAGATTAGC 
CAATTGGCTC AGGGCATGGA CAGACCCTTC TCAGCTGAGG CTGGCACTGG CGGACTAGAG 
CCACTTGGAG GACTGGAGCC CCTGGACTCC AACCTGTCCC TGTCAGGGGC AGGCCCCCCT 
GTGCTCAGCC TGGACCTGAA ACCCTGGAAA TGCCAGGAGC TGGACTTCCT GGCTGACCCT 
GATAACATGT TCCTGGAAGA GACGCCCGTG GAAGACATCT TCATGGATCT CTCTACCCCA 
GATCCCAGTG AGGAATGGGG CTCAGGGGAT CCTGAGGCAG AGGGCCCAGG AGGGGCCCCA 
TCGCCTTGCA ACAACCTGTC CCCAGAAGAC CACAGCTTCC TGGAGGACCT GGCCACATAT 
GAAACCGCCT TTGAGACAGG TGTCTCAGCA TTCCCCTATG ATGGGTTTAC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPAS4 ( XM_017017539.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873028.1 Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X3, mRNA.

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CloneID	OHu92130
Clone ID Related Accession (Same CDS sequence)	XM_017017539.1
Accession Version	XM_017017539.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuronal PAS domain-containing protein 4 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACCGCT CCACCAAGGG CGCCTCCAAG GCGCGCCGGG ACCAGATCAA CGCCGAGATC 
CGGAACCTCA AGGAGCTGCT GCCGCTGGCC GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GCCTCGCCTG CATCTACACT CGCAAGGGCG TCTTCTTCGC TGGTGGCACT 
CCTCTGGCGG GCCCCACGGG GCTTCTCTCA GCTCAAGAGC TTGAGGACAT CGTAGCGGCA 
CTACCCGGCT TTCTGCTTGT GTTCACAGCC GAGGGGAAAT TGCTCTACCT GTCTGAGAGT 
GTGAGCGAGC ATCTGGGCCA CTCCATGGTG GACCTGGTTG CCCAGGGTGA CAGCATCTAC 
GACATCATTG ACCCAGCTGA CCACCTCACT GTGCGCCAGC AACTCACCCT GCCCTCTGCC 
CTGGACACTG ATCGCCTCTT CCGCTGCCGC TTCAACACCT CCAAGTCCCT CAGGCGCCAG 
AGTGCAGGCA ACAAACTCGT GCTTATTCGA GGCCGATTCC ATGCTCACCC ACCTGGAGCC 
TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC CTCTGGAGCC GAGACCCCGC 
CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC TGGCCATGTT CCAGAGCCGC 
CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873028.1
CDS	177..881
Translation	MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESG

Target ORF information:

RefSeq Version	XM_017017539.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017017539.1

ORF Insert Sequence:

ATGTACCGCT CCACCAAGGG CGCCTCCAAG GCGCGCCGGG ACCAGATCAA CGCCGAGATC 
CGGAACCTCA AGGAGCTGCT GCCGCTGGCC GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GCCTCGCCTG CATCTACACT CGCAAGGGCG TCTTCTTCGC TGGTGGCACT 
CCTCTGGCGG GCCCCACGGG GCTTCTCTCA GCTCAAGAGC TTGAGGACAT CGTAGCGGCA 
CTACCCGGCT TTCTGCTTGT GTTCACAGCC GAGGGGAAAT TGCTCTACCT GTCTGAGAGT 
GTGAGCGAGC ATCTGGGCCA CTCCATGGTG GACCTGGTTG CCCAGGGTGA CAGCATCTAC 
GACATCATTG ACCCAGCTGA CCACCTCACT GTGCGCCAGC AACTCACCCT GCCCTCTGCC 
CTGGACACTG ATCGCCTCTT CCGCTGCCGC TTCAACACCT CCAAGTCCCT CAGGCGCCAG 
AGTGCAGGCA ACAAACTCGT GCTTATTCGA GGCCGATTCC ATGCTCACCC ACCTGGAGCC 
TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC CTCTGGAGCC GAGACCCCGC 
CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC TGGCCATGTT CCAGAGCCGC 
CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPAS4 ( NM_001318804.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305733.1 Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 2, mRNA.

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CloneID	OHu100161
Clone ID Related Accession (Same CDS sequence)	NM_001318804.1
Accession Version	NM_001318804.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	neuronal PAS domain-containing protein 4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK096253.1, BC143630.1 and AK094025.1. On or before Jan 14, 2016 this sequence version replaced XR_949877.1, XM_011544938.1. Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC143630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670, SAMN03267771 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCACCC ACCTGGAGCC TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC 
CTCTGGAGCC GAGACCCCGC CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC 
TGGCCATGTT CCAGAGCCGC CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG 
GCTGAGAGTG GAGATATTCA GGCAGAGATG GTGGTGAGGC TACAGGCCAA GACTGGAGGC 
TGGGCATGGA TTTACTGCCT GTTATACTCA GAAGGTCCAG AGGGACCCAT TACTGCCAAT 
AACTACCCAA TCAGTGACAT GGAAGCCTGG AGCCTCCGCC AGCAGTTGAA CTCTGAAGAC 
ACCCAGGCAG CTTATGTCCT GGGCACTCCG ACCATGCTGC CCTCATTCCC TGAAAACATT 
CTTTCCCAGG AAGAGTGCTC CAGCACTAAC CCACTCTTCA CCGCAGCACT GGGGGCTCCC 
AGAAGCACCA GCTTCCCCAG TGCTCCTGAA CTGAGTGTTG TCTCTGCATC AGAAGAGCTT 
CCCCGACCCT CCAAAGAACT GGACTTCAGT TACCTGACAT TCCCTTCTGG GCCTGAGCCT 
TCTCTCCAAG CAGAACTAAG CAAGGATCTT GTGTGCACTC CACCTTACAC GCCCCATCAG 
CCAGGAGGCT GTGCCTTCCT CTTCAGCCTC CATGAGCCCT TCCAGACCCA TTTGCCCACC 
CCATCCAGCA CTCTTCAAGA ACAGCTGACT CCAAGCACTG CGACCTTCTC TGATCAGTTG 
ACGCCCAGCA GTGCAACCTT CCCAGATCCA CTAACTAGCC CACTGCAAGG CCAGTTGACT 
GAAACCTCGG TCAGAAGCTA TGAAGACCAG TTGACTCCCT GCACCTCCAC CTTCCCAGAC 
CAGCTGCTTC CCAGCACAGC CACCTTCCCA GAGCCTCTGG GCAGCCCTGC CCATGAACAG 
CTGACTCCTC CCAGCACAGC ATTCCAAGCA CACCTGGACA GCCCCAGCCA AACCTTCCCA 
GAGCAACTGA GCCCCAACCC TACCAAGACT TACTTTGCCC AGGAGGGATG CAGTTTTCTC 
TATGAGAAGT TGCCCCCAAG TCCTAGCAGC CCTGGTAATG GGGACTGCAC GCTCTTGGCC 
CTAGCCCAGC TCCGGGGCCC CCTCTCTGTG GATGTCCCCC TGGTGCCCGA AGGCCTGCTC 
ACACCTGAGG CCTCTCCAGT CAAGCAGAGT TTCTTCCACT ACTCTGAAAA GGAGCAGAAT 
GAGATAGACC GTCTCATCCA GCAGATTAGC CAATTGGCTC AGGGCATGGA CAGACCCTTC 
TCAGCTGAGG CTGGCACTGG CGGACTAGAG CCACTTGGAG GACTGGAGCC CCTGGACTCC 
AACCTGTCCC TGTCAGGGGC AGGCCCCCCT GTGCTCAGCC TGGACCTGAA ACCCTGGAAA 
TGCCAGGAGC TGGACTTCCT GGCTGACCCT GATAACATGT TCCTGGAAGA GACGCCCGTG 
GAAGACATCT TCATGGATCT CTCTACCCCA GATCCCAGTG AGGAATGGGG CTCAGGGGAT 
CCTGAGGCAG AGGGCCCAGG AGGGGCCCCA TCGCCTTGCA ACAACCTGTC CCCAGAAGAC 
CACAGCTTCC TGGAGGACCT GGCCACATAT GAAACCGCCT TTGAGACAGG TGTCTCAGCA 
TTCCCCTATG ATGGGTTTAC TGATGAGTTG CATCAACTCC AGAGCCAAGT TCAAGACAGC 
TTCCATGAAG ATGGAAGTGG AGGGGAACCA ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305733.1
CDS	697..2475
Translation	MLTHLEPTGQEIPCSQLSVPLWSRDPAQVLALALALPRSSWPCSRAAMLKTWLYWTSPRVAESGDIQAEMVVRLQAKTGGWAWIYCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTPDPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDELHQLQSQVQDSFHEDGSGGEPTF

Target ORF information:

RefSeq Version	NM_001318804.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318804.1

ORF Insert Sequence:

ATGCTCACCC ACCTGGAGCC TACTGGGCAG GAAATCCCGT GTTCACAGCT TTCTGTGCCC 
CTCTGGAGCC GAGACCCCGC CCAGGTCCTG GCCCTGGCCC TGGCCCTGCC TCGCTCTTCC 
TGGCCATGTT CCAGAGCCGC CATGCTAAAG ACCTGGCTCT ACTGGACATC TCCGAGAGTG 
GCTGAGAGTG GAGATATTCA GGCAGAGATG GTGGTGAGGC TACAGGCCAA GACTGGAGGC 
TGGGCATGGA TTTACTGCCT GTTATACTCA GAAGGTCCAG AGGGACCCAT TACTGCCAAT 
AACTACCCAA TCAGTGACAT GGAAGCCTGG AGCCTCCGCC AGCAGTTGAA CTCTGAAGAC 
ACCCAGGCAG CTTATGTCCT GGGCACTCCG ACCATGCTGC CCTCATTCCC TGAAAACATT 
CTTTCCCAGG AAGAGTGCTC CAGCACTAAC CCACTCTTCA CCGCAGCACT GGGGGCTCCC 
AGAAGCACCA GCTTCCCCAG TGCTCCTGAA CTGAGTGTTG TCTCTGCATC AGAAGAGCTT 
CCCCGACCCT CCAAAGAACT GGACTTCAGT TACCTGACAT TCCCTTCTGG GCCTGAGCCT 
TCTCTCCAAG CAGAACTAAG CAAGGATCTT GTGTGCACTC CACCTTACAC GCCCCATCAG 
CCAGGAGGCT GTGCCTTCCT CTTCAGCCTC CATGAGCCCT TCCAGACCCA TTTGCCCACC 
CCATCCAGCA CTCTTCAAGA ACAGCTGACT CCAAGCACTG CGACCTTCTC TGATCAGTTG 
ACGCCCAGCA GTGCAACCTT CCCAGATCCA CTAACTAGCC CACTGCAAGG CCAGTTGACT 
GAAACCTCGG TCAGAAGCTA TGAAGACCAG TTGACTCCCT GCACCTCCAC CTTCCCAGAC 
CAGCTGCTTC CCAGCACAGC CACCTTCCCA GAGCCTCTGG GCAGCCCTGC CCATGAACAG 
CTGACTCCTC CCAGCACAGC ATTCCAAGCA CACCTGGACA GCCCCAGCCA AACCTTCCCA 
GAGCAACTGA GCCCCAACCC TACCAAGACT TACTTTGCCC AGGAGGGATG CAGTTTTCTC 
TATGAGAAGT TGCCCCCAAG TCCTAGCAGC CCTGGTAATG GGGACTGCAC GCTCTTGGCC 
CTAGCCCAGC TCCGGGGCCC CCTCTCTGTG GATGTCCCCC TGGTGCCCGA AGGCCTGCTC 
ACACCTGAGG CCTCTCCAGT CAAGCAGAGT TTCTTCCACT ACTCTGAAAA GGAGCAGAAT 
GAGATAGACC GTCTCATCCA GCAGATTAGC CAATTGGCTC AGGGCATGGA CAGACCCTTC 
TCAGCTGAGG CTGGCACTGG CGGACTAGAG CCACTTGGAG GACTGGAGCC CCTGGACTCC 
AACCTGTCCC TGTCAGGGGC AGGCCCCCCT GTGCTCAGCC TGGACCTGAA ACCCTGGAAA 
TGCCAGGAGC TGGACTTCCT GGCTGACCCT GATAACATGT TCCTGGAAGA GACGCCCGTG 
GAAGACATCT TCATGGATCT CTCTACCCCA GATCCCAGTG AGGAATGGGG CTCAGGGGAT 
CCTGAGGCAG AGGGCCCAGG AGGGGCCCCA TCGCCTTGCA ACAACCTGTC CCCAGAAGAC 
CACAGCTTCC TGGAGGACCT GGCCACATAT GAAACCGCCT TTGAGACAGG TGTCTCAGCA 
TTCCCCTATG ATGGGTTTAC TGATGAGTTG CATCAACTCC AGAGCCAAGT TCAAGACAGC 
TTCCATGAAG ATGGAAGTGG AGGGGAACCA ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPAS4 ( XM_017017537.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873026.1 Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu92128
Clone ID Related Accession (Same CDS sequence)	XM_017017537.1
Accession Version	XM_017017537.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2640bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuronal PAS domain-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCTGGG GGTCTGTTTT GTGCACCTTG GAACCCATCG GATCCCTCCA ATGGAGCTAT 
ATAAGGCGGC GTGAGGCAGG CGAGGGGGGC AGCGCAGCCG AGCGGAGCCC AGGAGAGCAG 
AGAGCGAGCC TGAGCGAGAG ACGGGGAAGC ACGGAGGAGG AAGCCGCCGG TGCGTCGGGA 
CGGGAGCGCA GGTGCTCGGG CACCCGAGCT GGAGCTCCGC AGCCGCCGGT CATGTACCGC 
TCCACCAAGG GCGCCTCCAA GGCGCGCCGG GACCAGATCA ACGCCGAGAT CCGGAACCTC 
AAGGAGCTGC TGCCGCTGGC CGAAGCGGAC AAGGTCCGGC TGTCCTACCT GCACATCATG 
AGCCTCGCCT GCATCTACAC TCGCAAGGGC GTCTTCTTCG CTGGTGGCAC TCCTCTGGCG 
GGCCCCACGG GGCTTCTCTC AGCTCAAGAG CTTGAGGACA TCGTAGCGGC ACTACCCGGC 
TTTCTGCTTG TGTTCACAGC CGAGGGGAAA TTGCTCTACC TGTCTGAGAG TGTGAGCGAG 
CATCTGGGCC ACTCCATGGT GGACCTGGTT GCCCAGGGTG ACAGCATCTA CGACATCATT 
GACCCAGCTG ACCACCTCAC TGTGCGCCAG CAACTCACCC TGCCCTCTGC CCTGGACACT 
GATCGCCTCT TCCGCTGCCG CTTCAACACC TCCAAGTCCC TCAGGCGCCA GAGTGCAGGC 
AACAAACTCG TGCTTATTCG AGGCCGATTC CATGCTCACC CACCTGGAGC CTACTGGGCA 
GGAAATCCCG TGTTCACAGC TTTCTGTGCC CCTCTGGAGC CGAGACCCCG CCCAGGTCCT 
GGCCCTGGCC CTGGCCCTGC CTCGCTCTTC CTGGCCATGT TCCAGAGCCG CCATGCTAAA 
GACCTGGCTC TACTGGACAT CTCCGAGAGT GTCCTAATCT ACCTGGGCTT TGAGCGCAGT 
GAACTGCTTT GTAAATCATG GTATGGACTG CTGCACCCCG AGGACCTGGC CCACGCTTCT 
GCTCAACACT ACCGCCTGTT GGCTGAGAGT GGAGATATTC AGGCAGAGAT GGTGGTGAGG 
CTACAGGCCA AGACTGGAGG CTGGGCATGG ATTTACTGCC TGTTATACTC AGAAGGTCCA 
GAGGGACCCA TTACTGCCAA TAACTACCCA ATCAGTGACA TGGAAGCCTG GAGCCTCCGC 
CAGCAGTTGA ACTCTGAAGA CACCCAGGCA GCTTATGTCC TGGGCACTCC GACCATGCTG 
CCCTCATTCC CTGAAAACAT TCTTTCCCAG GAAGAGTGCT CCAGCACTAA CCCACTCTTC 
ACCGCAGCAC TGGGGGCTCC CAGAAGCACC AGCTTCCCCA GTGCTCCTGA ACTGAGTGTT 
GTCTCTGCAT CAGAAGAGCT TCCCCGACCC TCCAAAGAAC TGGACTTCAG TTACCTGACA 
TTCCCTTCTG GGCCTGAGCC TTCTCTCCAA GCAGAACTAA GCAAGGATCT TGTGTGCACT 
CCACCTTACA CGCCCCATCA GCCAGGAGGC TGTGCCTTCC TCTTCAGCCT CCATGAGCCC 
TTCCAGACCC ATTTGCCCAC CCCATCCAGC ACTCTTCAAG AACAGCTGAC TCCAAGCACT 
GCGACCTTCT CTGATCAGTT GACGCCCAGC AGTGCAACCT TCCCAGATCC ACTAACTAGC 
CCACTGCAAG GCCAGTTGAC TGAAACCTCG GTCAGAAGCT ATGAAGACCA GTTGACTCCC 
TGCACCTCCA CCTTCCCAGA CCAGCTGCTT CCCAGCACAG CCACCTTCCC AGAGCCTCTG 
GGCAGCCCTG CCCATGAACA GCTGACTCCT CCCAGCACAG CATTCCAAGC ACACCTGGAC 
AGCCCCAGCC AAACCTTCCC AGAGCAACTG AGCCCCAACC CTACCAAGAC TTACTTTGCC 
CAGGAGGGAT GCAGTTTTCT CTATGAGAAG TTGCCCCCAA GTCCTAGCAG CCCTGGTAAT 
GGGGACTGCA CGCTCTTGGC CCTAGCCCAG CTCCGGGGCC CCCTCTCTGT GGATGTCCCC 
CTGGTGCCCG AAGGCCTGCT CACACCTGAG GCCTCTCCAG TCAAGCAGAG TTTCTTCCAC 
TACTCTGAAA AGGAGCAGAA TGAGATAGAC CGTCTCATCC AGCAGATTAG CCAATTGGCT 
CAGGGCATGG ACAGACCCTT CTCAGCTGAG GCTGGCACTG GCGGACTAGA GCCACTTGGA 
GGACTGGAGC CCCTGGACTC CAACCTGTCC CTGTCAGGGG CAGGCCCCCC TGTGCTCAGC 
CTGGACCTGA AACCCTGGAA ATGCCAGGAG CTGGACTTCC TGGCTGACCC TGATAACATG 
TTCCTGGAAG AGACGCCCGT GGAAGACATC TTCATGGATC TCTCTACCCC AGATCCCAGT 
GAGGAATGGG GCTCAGGGGA TCCTGAGGCA GAGGGCCCAG GAGGGGCCCC ATCGCCTTGC 
AACAACCTGT CCCCAGAAGA CCACAGCTTC CTGGAGGACC TGGCCACATA TGAAACCGCC 
TTTGAGACAG GTGTCTCAGC ATTCCCCTAT GATGGGTTTA CTGATGAGTT GCATCAACTC 
CAGAGCCAAG TTCAAGACAG CTTCCATGAA GATGGAAGTG GAGGGGAACC AACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873026.1
CDS	1385..4024
Translation	MTWGSVLCTLEPIGSLQWSYIRRREAGEGGSAAERSPGEQRASLSERRGSTEEEAAGASGRERRCSGTRAGAPQPPVMYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTPDPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDELHQLQSQVQDSFHEDGSGGEPTF

Target ORF information:

RefSeq Version	XM_017017537.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017017537.1

ORF Insert Sequence:

ATGACCTGGG GGTCTGTTTT GTGCACCTTG GAACCCATCG GATCCCTCCA ATGGAGCTAT 
ATAAGGCGGC GTGAGGCAGG CGAGGGGGGC AGCGCAGCCG AGCGGAGCCC AGGAGAGCAG 
AGAGCGAGCC TGAGCGAGAG ACGGGGAAGC ACGGAGGAGG AAGCCGCCGG TGCGTCGGGA 
CGGGAGCGCA GGTGCTCGGG CACCCGAGCT GGAGCTCCGC AGCCGCCGGT CATGTACCGC 
TCCACCAAGG GCGCCTCCAA GGCGCGCCGG GACCAGATCA ACGCCGAGAT CCGGAACCTC 
AAGGAGCTGC TGCCGCTGGC CGAAGCGGAC AAGGTCCGGC TGTCCTACCT GCACATCATG 
AGCCTCGCCT GCATCTACAC TCGCAAGGGC GTCTTCTTCG CTGGTGGCAC TCCTCTGGCG 
GGCCCCACGG GGCTTCTCTC AGCTCAAGAG CTTGAGGACA TCGTAGCGGC ACTACCCGGC 
TTTCTGCTTG TGTTCACAGC CGAGGGGAAA TTGCTCTACC TGTCTGAGAG TGTGAGCGAG 
CATCTGGGCC ACTCCATGGT GGACCTGGTT GCCCAGGGTG ACAGCATCTA CGACATCATT 
GACCCAGCTG ACCACCTCAC TGTGCGCCAG CAACTCACCC TGCCCTCTGC CCTGGACACT 
GATCGCCTCT TCCGCTGCCG CTTCAACACC TCCAAGTCCC TCAGGCGCCA GAGTGCAGGC 
AACAAACTCG TGCTTATTCG AGGCCGATTC CATGCTCACC CACCTGGAGC CTACTGGGCA 
GGAAATCCCG TGTTCACAGC TTTCTGTGCC CCTCTGGAGC CGAGACCCCG CCCAGGTCCT 
GGCCCTGGCC CTGGCCCTGC CTCGCTCTTC CTGGCCATGT TCCAGAGCCG CCATGCTAAA 
GACCTGGCTC TACTGGACAT CTCCGAGAGT GTCCTAATCT ACCTGGGCTT TGAGCGCAGT 
GAACTGCTTT GTAAATCATG GTATGGACTG CTGCACCCCG AGGACCTGGC CCACGCTTCT 
GCTCAACACT ACCGCCTGTT GGCTGAGAGT GGAGATATTC AGGCAGAGAT GGTGGTGAGG 
CTACAGGCCA AGACTGGAGG CTGGGCATGG ATTTACTGCC TGTTATACTC AGAAGGTCCA 
GAGGGACCCA TTACTGCCAA TAACTACCCA ATCAGTGACA TGGAAGCCTG GAGCCTCCGC 
CAGCAGTTGA ACTCTGAAGA CACCCAGGCA GCTTATGTCC TGGGCACTCC GACCATGCTG 
CCCTCATTCC CTGAAAACAT TCTTTCCCAG GAAGAGTGCT CCAGCACTAA CCCACTCTTC 
ACCGCAGCAC TGGGGGCTCC CAGAAGCACC AGCTTCCCCA GTGCTCCTGA ACTGAGTGTT 
GTCTCTGCAT CAGAAGAGCT TCCCCGACCC TCCAAAGAAC TGGACTTCAG TTACCTGACA 
TTCCCTTCTG GGCCTGAGCC TTCTCTCCAA GCAGAACTAA GCAAGGATCT TGTGTGCACT 
CCACCTTACA CGCCCCATCA GCCAGGAGGC TGTGCCTTCC TCTTCAGCCT CCATGAGCCC 
TTCCAGACCC ATTTGCCCAC CCCATCCAGC ACTCTTCAAG AACAGCTGAC TCCAAGCACT 
GCGACCTTCT CTGATCAGTT GACGCCCAGC AGTGCAACCT TCCCAGATCC ACTAACTAGC 
CCACTGCAAG GCCAGTTGAC TGAAACCTCG GTCAGAAGCT ATGAAGACCA GTTGACTCCC 
TGCACCTCCA CCTTCCCAGA CCAGCTGCTT CCCAGCACAG CCACCTTCCC AGAGCCTCTG 
GGCAGCCCTG CCCATGAACA GCTGACTCCT CCCAGCACAG CATTCCAAGC ACACCTGGAC 
AGCCCCAGCC AAACCTTCCC AGAGCAACTG AGCCCCAACC CTACCAAGAC TTACTTTGCC 
CAGGAGGGAT GCAGTTTTCT CTATGAGAAG TTGCCCCCAA GTCCTAGCAG CCCTGGTAAT 
GGGGACTGCA CGCTCTTGGC CCTAGCCCAG CTCCGGGGCC CCCTCTCTGT GGATGTCCCC 
CTGGTGCCCG AAGGCCTGCT CACACCTGAG GCCTCTCCAG TCAAGCAGAG TTTCTTCCAC 
TACTCTGAAA AGGAGCAGAA TGAGATAGAC CGTCTCATCC AGCAGATTAG CCAATTGGCT 
CAGGGCATGG ACAGACCCTT CTCAGCTGAG GCTGGCACTG GCGGACTAGA GCCACTTGGA 
GGACTGGAGC CCCTGGACTC CAACCTGTCC CTGTCAGGGG CAGGCCCCCC TGTGCTCAGC 
CTGGACCTGA AACCCTGGAA ATGCCAGGAG CTGGACTTCC TGGCTGACCC TGATAACATG 
TTCCTGGAAG AGACGCCCGT GGAAGACATC TTCATGGATC TCTCTACCCC AGATCCCAGT 
GAGGAATGGG GCTCAGGGGA TCCTGAGGCA GAGGGCCCAG GAGGGGCCCC ATCGCCTTGC 
AACAACCTGT CCCCAGAAGA CCACAGCTTC CTGGAGGACC TGGCCACATA TGAAACCGCC 
TTTGAGACAG GTGTCTCAGC ATTCCCCTAT GATGGGTTTA CTGATGAGTT GCATCAACTC 
CAGAGCCAAG TTCAAGACAG CTTCCATGAA GATGGAAGTG GAGGGGAACC AACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPAS4 ( XM_017017538.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873027.1 Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X2, mRNA.

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CloneID	OHu92129
Clone ID Related Accession (Same CDS sequence)	XM_017017538.1
Accession Version	XM_017017538.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1572bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuronal PAS domain-containing protein 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGTGA GGCTACAGGC CAAGACTGGA GGCTGGGCAT GGATTTACTG CCTGTTATAC 
TCAGAAGGTC CAGAGGGACC CATTACTGCC AATAACTACC CAATCAGTGA CATGGAAGCC 
TGGAGCCTCC GCCAGCAGTT GAACTCTGAA GACACCCAGG CAGCTTATGT CCTGGGCACT 
CCGACCATGC TGCCCTCATT CCCTGAAAAC ATTCTTTCCC AGGAAGAGTG CTCCAGCACT 
AACCCACTCT TCACCGCAGC ACTGGGGGCT CCCAGAAGCA CCAGCTTCCC CAGTGCTCCT 
GAACTGAGTG TTGTCTCTGC ATCAGAAGAG CTTCCCCGAC CCTCCAAAGA ACTGGACTTC 
AGTTACCTGA CATTCCCTTC TGGGCCTGAG CCTTCTCTCC AAGCAGAACT AAGCAAGGAT 
CTTGTGTGCA CTCCACCTTA CACGCCCCAT CAGCCAGGAG GCTGTGCCTT CCTCTTCAGC 
CTCCATGAGC CCTTCCAGAC CCATTTGCCC ACCCCATCCA GCACTCTTCA AGAACAGCTG 
ACTCCAAGCA CTGCGACCTT CTCTGATCAG TTGACGCCCA GCAGTGCAAC CTTCCCAGAT 
CCACTAACTA GCCCACTGCA AGGCCAGTTG ACTGAAACCT CGGTCAGAAG CTATGAAGAC 
CAGTTGACTC CCTGCACCTC CACCTTCCCA GACCAGCTGC TTCCCAGCAC AGCCACCTTC 
CCAGAGCCTC TGGGCAGCCC TGCCCATGAA CAGCTGACTC CTCCCAGCAC AGCATTCCAA 
GCACACCTGG ACAGCCCCAG CCAAACCTTC CCAGAGCAAC TGAGCCCCAA CCCTACCAAG 
ACTTACTTTG CCCAGGAGGG ATGCAGTTTT CTCTATGAGA AGTTGCCCCC AAGTCCTAGC 
AGCCCTGGTA ATGGGGACTG CACGCTCTTG GCCCTAGCCC AGCTCCGGGG CCCCCTCTCT 
GTGGATGTCC CCCTGGTGCC CGAAGGCCTG CTCACACCTG AGGCCTCTCC AGTCAAGCAG 
AGTTTCTTCC ACTACTCTGA AAAGGAGCAG AATGAGATAG ACCGTCTCAT CCAGCAGATT 
AGCCAATTGG CTCAGGGCAT GGACAGACCC TTCTCAGCTG AGGCTGGCAC TGGCGGACTA 
GAGCCACTTG GAGGACTGGA GCCCCTGGAC TCCAACCTGT CCCTGTCAGG GGCAGGCCCC 
CCTGTGCTCA GCCTGGACCT GAAACCCTGG AAATGCCAGG AGCTGGACTT CCTGGCTGAC 
CCTGATAACA TGTTCCTGGA AGAGACGCCC GTGGAAGACA TCTTCATGGA TCTCTCTACC 
CCAGATCCCA GTGAGGAATG GGGCTCAGGG GATCCTGAGG CAGAGGGCCC AGGAGGGGCC 
CCATCGCCTT GCAACAACCT GTCCCCAGAA GACCACAGCT TCCTGGAGGA CCTGGCCACA 
TATGAAACCG CCTTTGAGAC AGGTGTCTCA GCATTCCCCT ATGATGGGTT TACTGATGAG 
TTGCATCAAC TCCAGAGCCA AGTTCAAGAC AGCTTCCATG AAGATGGAAG TGGAGGGGAA 
CCAACGTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873027.1
CDS	166..1737
Translation	MVVRLQAKTGGWAWIYCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTPDPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDELHQLQSQVQDSFHEDGSGGEPTF

Target ORF information:

RefSeq Version	XM_017017538.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal PAS domain protein 4 (NPAS4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017017538.1

ORF Insert Sequence:

ATGGTGGTGA GGCTACAGGC CAAGACTGGA GGCTGGGCAT GGATTTACTG CCTGTTATAC 
TCAGAAGGTC CAGAGGGACC CATTACTGCC AATAACTACC CAATCAGTGA CATGGAAGCC 
TGGAGCCTCC GCCAGCAGTT GAACTCTGAA GACACCCAGG CAGCTTATGT CCTGGGCACT 
CCGACCATGC TGCCCTCATT CCCTGAAAAC ATTCTTTCCC AGGAAGAGTG CTCCAGCACT 
AACCCACTCT TCACCGCAGC ACTGGGGGCT CCCAGAAGCA CCAGCTTCCC CAGTGCTCCT 
GAACTGAGTG TTGTCTCTGC ATCAGAAGAG CTTCCCCGAC CCTCCAAAGA ACTGGACTTC 
AGTTACCTGA CATTCCCTTC TGGGCCTGAG CCTTCTCTCC AAGCAGAACT AAGCAAGGAT 
CTTGTGTGCA CTCCACCTTA CACGCCCCAT CAGCCAGGAG GCTGTGCCTT CCTCTTCAGC 
CTCCATGAGC CCTTCCAGAC CCATTTGCCC ACCCCATCCA GCACTCTTCA AGAACAGCTG 
ACTCCAAGCA CTGCGACCTT CTCTGATCAG TTGACGCCCA GCAGTGCAAC CTTCCCAGAT 
CCACTAACTA GCCCACTGCA AGGCCAGTTG ACTGAAACCT CGGTCAGAAG CTATGAAGAC 
CAGTTGACTC CCTGCACCTC CACCTTCCCA GACCAGCTGC TTCCCAGCAC AGCCACCTTC 
CCAGAGCCTC TGGGCAGCCC TGCCCATGAA CAGCTGACTC CTCCCAGCAC AGCATTCCAA 
GCACACCTGG ACAGCCCCAG CCAAACCTTC CCAGAGCAAC TGAGCCCCAA CCCTACCAAG 
ACTTACTTTG CCCAGGAGGG ATGCAGTTTT CTCTATGAGA AGTTGCCCCC AAGTCCTAGC 
AGCCCTGGTA ATGGGGACTG CACGCTCTTG GCCCTAGCCC AGCTCCGGGG CCCCCTCTCT 
GTGGATGTCC CCCTGGTGCC CGAAGGCCTG CTCACACCTG AGGCCTCTCC AGTCAAGCAG 
AGTTTCTTCC ACTACTCTGA AAAGGAGCAG AATGAGATAG ACCGTCTCAT CCAGCAGATT 
AGCCAATTGG CTCAGGGCAT GGACAGACCC TTCTCAGCTG AGGCTGGCAC TGGCGGACTA 
GAGCCACTTG GAGGACTGGA GCCCCTGGAC TCCAACCTGT CCCTGTCAGG GGCAGGCCCC 
CCTGTGCTCA GCCTGGACCT GAAACCCTGG AAATGCCAGG AGCTGGACTT CCTGGCTGAC 
CCTGATAACA TGTTCCTGGA AGAGACGCCC GTGGAAGACA TCTTCATGGA TCTCTCTACC 
CCAGATCCCA GTGAGGAATG GGGCTCAGGG GATCCTGAGG CAGAGGGCCC AGGAGGGGCC 
CCATCGCCTT GCAACAACCT GTCCCCAGAA GACCACAGCT TCCTGGAGGA CCTGGCCACA 
TATGAAACCG CCTTTGAGAC AGGTGTCTCA GCATTCCCCT ATGATGGGTT TACTGATGAG 
TTGCATCAAC TCCAGAGCCA AGTTCAAGAC AGCTTCCATG AAGATGGAAG TGGAGGGGAA 
CCAACGTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.
Cardiovascular research113(2)222-223(2017 Feb)
Esser JS,Charlet A,Schmidt M,Heck S,Allen A,Lother A,Epting D,Patterson C,Bode C,Moser M

The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.
International journal of molecular sciences16(12)29011-28(2015 Dec)
Choy FC,Klari? TS,Koblar SA,Lewis MD

A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells.
Stem cell research & therapy5(3)64(2014 May)
Klaric TS,Thomas PQ,Dottori M,Leong WK,Koblar SA,Lewis MD

Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.
PloS one9(1)e85768(2014)
Bersten DC,Bruning JB,Peet DJ,Whitelaw ML

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Nature genetics43(10)977-83(2011 Sep)

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NPAS4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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