AMELY cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AMELY
Entrez Gene ID	266
Full Name	amelogenin, Y-linked
Synonyms	AMGL,AMGY
General protein information	Preferred Names amelogenin, Y-linked Names amelogenin, Y isoform amelogenin (Y chromosome)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yp11.2
Summary	This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. [provided by RefSeq, Jul 2008].
Disorder MIM:	410000

mRNA and Protein(s)

mRNA	Protein	Name
XM_017030042.1	XP_016885531.1	amelogenin, Y isoform isoform X1
NM_001364814.1	NP_001351743.1	amelogenin, Y isoform isoform 2 precursor
NM_001143.1	NP_001134.1	amelogenin, Y isoform isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	AMELY	NP_001095929.1
Xenopus tropicalis (tropical clawed frog)	amelx	NP_001107153.1
Homo sapiens (human)	AMELY	NP_001134.1
Mus musculus (house mouse)	Amelx	NP_001075447.1

Gene Ontology
Bibliography

Related articles in PubMed

Y-Chromosome Haplogroups in the Bosnian-Herzegovinian Population Based on 23 Y-STR Loci.
Do?an S, A?i? A, Do?an G, Besic L, Marjanovic D
Human biology88(3)201-209(2016 Jul)

Mutation rate at 17 Y-STR loci in "Father/Son" pairs from moroccan population.
Laouina A, Nadifi S, Boulouiz R, El Arji M, Talbi J, El Houate B, Yahia H, Chbel F
Legal medicine (Tokyo, Japan)15(5)269-71(2013 Sep)

Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.
Repnikova EA, Rosenfeld JA, Bailes A, Weber C, Erdman L, McKinney A, Ramsey S, Hashimoto S, Lamb Thrush D, Astbury C, Reshmi SC, Shaffer LG, Gastier-Foster JM, Pyatt RE
Forensic science international. Genetics7(5)475-81(2013 Sep)

Y chromosome interstitial deletion induced Y-STR allele dropout in AMELY-negative individuals.
Ma Y, Kuang JZ, Zhang J, Wang GM, Wang YJ, Jin WM, Hou YP
International journal of legal medicine126(5)713-24(2012 Sep)

[Types and frequencies of variants in Amelogenin gene in Chinese population].
Chen AP, Chen Y, Wang HP, Chen WH, Chen H, Chen LX, Sun HY
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics24(6)615-9(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

252 confirmed and unrelated father/son pairs from the Moroccan population were examined using 17 Y-STR markers of the AmpFISTR Yfiler kit. A total of 15 single repeat mutations between fathers and sons were observed as mutational events.
Title: Mutation rate at 17 Y-STR loci in "Father/Son" pairs from moroccan population.

demonstrate the presence of copy number variations in regions containing 9 of the 13 CODIS(Combined DNA Index System) short tandem repeat(STR) and AMELX/Y loci
Title: Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.

Results of haplogroup prediction showed that seven AMELY dropouts combined with variant Y-STR deletions can be classified as the J2 subdivision, suggesting that some of these Y chromosomes might descend from a common ancestor.
Title: Y chromosome interstitial deletion induced Y-STR allele dropout in AMELY-negative individuals.

Observational study of genotype prevalence. (HuGE Navigator)
Title: [Types and frequencies of variants in Amelogenin gene in Chinese population].

The combined frequency of the AMELY null allele in Singapore and Malaysia populations is 2.7%, 0.6% in Indian and Malay ethnic groups respectively. It is absent among 541 Chinese screened.
Title: Molecular characterization of a polymorphic 3-Mb deletion at chromosome Yp11.2 containing the AMELY locus in Singapore and Malaysia populations.

The following AMELY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AMELY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25617	NM_001143.1 Latest version!	Homo sapiens amelogenin Y-linked (AMELY), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu56238	NM_001364814.1 Latest version!	Homo sapiens amelogenin Y-linked (AMELY), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu56238	XM_017030042.1 Latest version!	Homo sapiens amelogenin, Y-linked (AMELY), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AMELY ( NM_001143.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001134.1 Homo sapiens amelogenin Y-linked (AMELY), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25617
Clone ID Related Accession (Same CDS sequence)	NM_001143.1
Accession Version	NM_001143.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	amelogenin, Y isoform isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M86933.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86933.1, BC074976.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968832, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGACCT GGATTTTGTT TGCCTGCCTT GTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGGTGCTCAC CCCTTTGAAG 
TGGTACCAGA GCATGATAAG ACCACCATAC TCTTCCTATG GTTACGAGCC CATGGGTGGA 
TGGCTGCACC ACCAAATCAT CCCCGTGGTG TCCCAACAGC ACCCCCTGAC TCACACCCTG 
CAGTCTCATC ACCACATCCC AGTGGTGCCA GCTCAGCAGC CCAGGGTCCG CCAGCAAGCA 
CTGATGCCTG TTCCTGGCCA GCAATCCATG ACTCCAACCC AACACCATCA GCCAAACCTC 
CCTCTGCCTG CCCAGCAGCC CTTCCAGCCC CAGCCTGTTC AGCCACAGCC TCACCAGCCC 
ATGCAGCCCC AGCCACCTGT GCAACCCATG CAGCCCCTGC TGCCACAGCC ACCTCTGCCT 
CCAATGTTCC CCCTGCGGCC CCTGCCCCCC ATACTTCCTG ATCTGCATCT GGAAGCTTGG 
CCAGCAACAG ACAAGACCAA GCAGGAGGAA GTGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001134.1
CDS	69..647
Translation	MGTWILFACLVGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRPPYSSYGYEPMGGWLHHQIIPVVSQQHPLTHTLQSHHHIPVVPAQQPRVRQQALMPVPGQQSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQPMQPQPPVQPMQPLLPQPPLPPMFPLRPLPPILPDLHLEAWPATDKTKQEEVD

Target ORF information:

RefSeq Version	NM_001143.1
Organism	Homo sapiens(human)
Definition	Homo sapiens amelogenin Y-linked (AMELY), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001143.1

ORF Insert Sequence:

ATGGGGACCT GGATTTTGTT TGCCTGCCTT GTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGGTGCTCAC CCCTTTGAAG 
TGGTACCAGA GCATGATAAG ACCACCATAC TCTTCCTATG GTTACGAGCC CATGGGTGGA 
TGGCTGCACC ACCAAATCAT CCCCGTGGTG TCCCAACAGC ACCCCCTGAC TCACACCCTG 
CAGTCTCATC ACCACATCCC AGTGGTGCCA GCTCAGCAGC CCAGGGTCCG CCAGCAAGCA 
CTGATGCCTG TTCCTGGCCA GCAATCCATG ACTCCAACCC AACACCATCA GCCAAACCTC 
CCTCTGCCTG CCCAGCAGCC CTTCCAGCCC CAGCCTGTTC AGCCACAGCC TCACCAGCCC 
ATGCAGCCCC AGCCACCTGT GCAACCCATG CAGCCCCTGC TGCCACAGCC ACCTCTGCCT 
CCAATGTTCC CCCTGCGGCC CCTGCCCCCC ATACTTCCTG ATCTGCATCT GGAAGCTTGG 
CCAGCAACAG ACAAGACCAA GCAGGAGGAA GTGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AMELY ( NM_001364814.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001351743.1 Homo sapiens amelogenin Y-linked (AMELY), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu56238
Clone ID Related Accession (Same CDS sequence)	XM_017030042.1 , NM_001364814.1
Accession Version	NM_001364814.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	amelogenin, Y isoform isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M86933.1 and AY487421.1. On Jul 12, 2018 this sequence version replaced XM_017030042.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2159912, SAMEA2161674 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END##

ATGGGGACCT GGATTTTGTT TGCCTGCCTT GTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT 
ATCAATGTTG ACAGGATTGC TTTAGTGCTC ACCCCTTTGA AGTGGTACCA GAGCATGATA 
AGACCACCAT ACTCTTCCTA TGGTTACGAG CCCATGGGTG GATGGCTGCA CCACCAAATC 
ATCCCCGTGG TGTCCCAACA GCACCCCCTG ACTCACACCC TGCAGTCTCA TCACCACATC 
CCAGTGGTGC CAGCTCAGCA GCCCAGGGTC CGCCAGCAAG CACTGATGCC TGTTCCTGGC 
CAGCAATCCA TGACTCCAAC CCAACACCAT CAGCCAAACC TCCCTCTGCC TGCCCAGCAG 
CCCTTCCAGC CCCAGCCTGT TCAGCCACAG CCTCACCAGC CCATGCAGCC CCAGCCACCT 
GTGCAACCCA TGCAGCCCCT GCTGCCACAG CCACCTCTGC CTCCAATGTT CCCCCTGCGG 
CCCCTGCCCC CCATACTTCC TGATCTGCAT CTGGAAGCTT GGCCAGCAAC AGACAAGACC 
AAGCAGGAGG AAGTGGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001351743.1
CDS	69..689
Translation	MGTWILFACLVGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRIALVLTPLKWYQSMIRPPYSSYGYEPMGGWLHHQIIPVVSQQHPLTHTLQSHHHIPVVPAQQPRVRQQALMPVPGQQSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQPMQPQPPVQPMQPLLPQPPLPPMFPLRPLPPILPDLHLEAWPATDKTKQEEVD

Target ORF information:

RefSeq Version	NM_001364814.1
Organism	Homo sapiens(human)
Definition	Homo sapiens amelogenin Y-linked (AMELY), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001364814.1

ORF Insert Sequence:

ATGGGGACCT GGATTTTGTT TGCCTGCCTT GTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT 
ATCAATGTTG ACAGGATTGC TTTAGTGCTC ACCCCTTTGA AGTGGTACCA GAGCATGATA 
AGACCACCAT ACTCTTCCTA TGGTTACGAG CCCATGGGTG GATGGCTGCA CCACCAAATC 
ATCCCCGTGG TGTCCCAACA GCACCCCCTG ACTCACACCC TGCAGTCTCA TCACCACATC 
CCAGTGGTGC CAGCTCAGCA GCCCAGGGTC CGCCAGCAAG CACTGATGCC TGTTCCTGGC 
CAGCAATCCA TGACTCCAAC CCAACACCAT CAGCCAAACC TCCCTCTGCC TGCCCAGCAG 
CCCTTCCAGC CCCAGCCTGT TCAGCCACAG CCTCACCAGC CCATGCAGCC CCAGCCACCT 
GTGCAACCCA TGCAGCCCCT GCTGCCACAG CCACCTCTGC CTCCAATGTT CCCCCTGCGG 
CCCCTGCCCC CCATACTTCC TGATCTGCAT CTGGAAGCTT GGCCAGCAAC AGACAAGACC 
AAGCAGGAGG AAGTGGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AMELY ( XM_017030042.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885531.1 Homo sapiens amelogenin, Y-linked (AMELY), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56238
Clone ID Related Accession (Same CDS sequence)	XM_017030042.1 , NM_001364814.1
Accession Version	XM_017030042.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	amelogenin, Y isoform isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000024.10) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGACCT GGATTTTGTT TGCCTGCCTT GTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT 
ATCAATGTTG ACAGGATTGC TTTAGTGCTC ACCCCTTTGA AGTGGTACCA GAGCATGATA 
AGACCACCAT ACTCTTCCTA TGGTTACGAG CCCATGGGTG GATGGCTGCA CCACCAAATC 
ATCCCCGTGG TGTCCCAACA GCACCCCCTG ACTCACACCC TGCAGTCTCA TCACCACATC 
CCAGTGGTGC CAGCTCAGCA GCCCAGGGTC CGCCAGCAAG CACTGATGCC TGTTCCTGGC 
CAGCAATCCA TGACTCCAAC CCAACACCAT CAGCCAAACC TCCCTCTGCC TGCCCAGCAG 
CCCTTCCAGC CCCAGCCTGT TCAGCCACAG CCTCACCAGC CCATGCAGCC CCAGCCACCT 
GTGCAACCCA TGCAGCCCCT GCTGCCACAG CCACCTCTGC CTCCAATGTT CCCCCTGCGG 
CCCCTGCCCC CCATACTTCC TGATCTGCAT CTGGAAGCTT GGCCAGCAAC AGACAAGACC 
AAGCAGGAGG AAGTGGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885531.1
CDS	98..718
Translation	MGTWILFACLVGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRIALVLTPLKWYQSMIRPPYSSYGYEPMGGWLHHQIIPVVSQQHPLTHTLQSHHHIPVVPAQQPRVRQQALMPVPGQQSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQPMQPQPPVQPMQPLLPQPPLPPMFPLRPLPPILPDLHLEAWPATDKTKQEEVD

Target ORF information:

RefSeq Version	XM_017030042.1
Organism	Homo sapiens(human)
Definition	Homo sapiens amelogenin, Y-linked (AMELY), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030042.1

ORF Insert Sequence:

ATGGGGACCT GGATTTTGTT TGCCTGCCTT GTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT 
ATCAATGTTG ACAGGATTGC TTTAGTGCTC ACCCCTTTGA AGTGGTACCA GAGCATGATA 
AGACCACCAT ACTCTTCCTA TGGTTACGAG CCCATGGGTG GATGGCTGCA CCACCAAATC 
ATCCCCGTGG TGTCCCAACA GCACCCCCTG ACTCACACCC TGCAGTCTCA TCACCACATC 
CCAGTGGTGC CAGCTCAGCA GCCCAGGGTC CGCCAGCAAG CACTGATGCC TGTTCCTGGC 
CAGCAATCCA TGACTCCAAC CCAACACCAT CAGCCAAACC TCCCTCTGCC TGCCCAGCAG 
CCCTTCCAGC CCCAGCCTGT TCAGCCACAG CCTCACCAGC CCATGCAGCC CCAGCCACCT 
GTGCAACCCA TGCAGCCCCT GCTGCCACAG CCACCTCTGC CTCCAATGTT CCCCCTGCGG 
CCCCTGCCCC CCATACTTCC TGATCTGCAT CTGGAAGCTT GGCCAGCAAC AGACAAGACC 
AAGCAGGAGG AAGTGGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Y-Chromosome Haplogroups in the Bosnian-Herzegovinian Population Based on 23 Y-STR Loci.
Human biology88(3)201-209(2016 Jul)
Do?an S,A?i? A,Do?an G,Besic L,Marjanovic D

Mutation rate at 17 Y-STR loci in "Father/Son" pairs from moroccan population.
Legal medicine (Tokyo, Japan)15(5)269-71(2013 Sep)
Laouina A,Nadifi S,Boulouiz R,El Arji M,Talbi J,El Houate B,Yahia H,Chbel F

Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.
Forensic science international. Genetics7(5)475-81(2013 Sep)
Repnikova EA,Rosenfeld JA,Bailes A,Weber C,Erdman L,McKinney A,Ramsey S,Hashimoto S,Lamb Thrush D,Astbury C,Reshmi SC,Shaffer LG,Gastier-Foster JM,Pyatt RE

Y chromosome interstitial deletion induced Y-STR allele dropout in AMELY-negative individuals.
International journal of legal medicine126(5)713-24(2012 Sep)
Ma Y,Kuang JZ,Zhang J,Wang GM,Wang YJ,Jin WM,Hou YP

[Types and frequencies of variants in Amelogenin gene in Chinese population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics24(6)615-9(2007 Dec)
Chen AP,Chen Y,Wang HP,Chen WH,Chen H,Chen LX,Sun HY

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AMELY cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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