TIMM13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIMM13
Entrez Gene ID	26517
Full Name	translocase of inner mitochondrial membrane 13
Synonyms	TIM13,TIM13B,TIMM13A,TIMM13B,ppv1
General protein information	Preferred Names translocase of inner mitochondrial membrane 13 Names mitochondrial import inner membrane translocase subunit Tim13 mitochondrial import inner membrane translocase subunit Tim13B translocase of inner mitochondrial membrane 13 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013].
Disorder MIM:	607383

mRNA and Protein(s)

mRNA	Protein	Name
NM_012458.4	NP_036590.1	mitochondrial import inner membrane translocase subunit Tim13
NM_012458.3	NP_036590.1	mitochondrial import inner membrane translocase subunit Tim13

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TIMM13	XP_001151542.1
Bos taurus (cattle)	TIMM13	NP_001073746.1
Danio rerio (zebrafish)	timm13	NP_001002465.1
Drosophila melanogaster (fruit fly)	CG34132	NP_001036344.1
Mus musculus (house mouse)	Timm13	NP_038923.1
Rattus norvegicus (Norway rat)	Timm13	NP_665724.1
Gallus gallus (chicken)	TIMM13	XP_003642882.1
Xenopus tropicalis (tropical clawed frog)	timm13	NP_001039237.1
Homo sapiens (human)	TIMM13	NP_036590.1
	TIMM13	XP_001098008.1
Drosophila melanogaster (fruit fly)	Tim13	NP_648505.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002277	XP_307903.2

Gene Ontology
Bibliography

Related articles in PubMed

Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A, Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, Duru N, He F, Chen M, Finkel T, Weinstein LS, Li JJ
Developmental cell29(2)217-32(2014 Apr)

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space.
Gentle IE, Perry AJ, Alcock FH, Liki? VA, Dolezal P, Ng ET, Purcell AW, McConnville M, Naderer T, Chanez AL, Charri?re F, Aschinger C, Schneider A, Tokatlidis K, Lithgow T
Molecular biology and evolution24(5)1149-60(2007 May)

Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.
Webb CT, Gorman MA, Lazarou M, Ryan MT, Gulbis JM
Molecular cell21(1)123-33(2006 Jan)

The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.
Roesch K, Hynds PJ, Varga R, Tranebjaerg L, Koehler CM
Human molecular genetics13(18)2101-11(2004 Sep)

The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins.
Curran SP, Leuenberger D, Schmidt E, Koehler CM
The Journal of cell biology158(6)1017-27(2002 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TIMM13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIMM13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09684	NM_012458.4 Latest version!	Homo sapiens translocase of inner mitochondrial membrane 13 (TIMM13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09684	NM_012458.3	Homo sapiens translocase of inner mitochondrial membrane 13 (TIMM13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIMM13 ( NM_012458.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036590.1 Homo sapiens translocase of inner mitochondrial membrane 13 (TIMM13), mRNA.

Price & Availability↑

CloneID	OHu09684
Clone ID Related Accession (Same CDS sequence)	NM_012458.4 , NM_012458.3
Accession Version	NM_012458.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit Tim13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY098076.1, AK024764.1 and AC011522.8. On Nov 22, 2018 this sequence version replaced NM_012458.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.773314.1, SRR3476690.880947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000215570.8/ ENSP00000215570.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGGCG GCTTCGGCTC CGATTTCGGG GGCTCCGGCA GCGGGAAGCT GGACCCAGGG 
CTCATAATGG AGCAGGTGAA AGTGCAGATC GCCGTGGCCA ACGCGCAGGA GCTGCTGCAG 
AGGATGACGG ACAAGTGTTT CCGGAAGTGT ATAGGGAAAC CTGGGGGCTC CCTGGACAAC 
TCCGAGCAGA AGTGCATCGC CATGTGCATG GACCGCTACA TGGACGCCTG GAACACCGTG 
TCTCGCGCCT ACAACTCGCG GCTGCAGCGG GAACGAGCCA ACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036590.1
CDS	54..341
Translation	MEGGFGSDFGGSGSGKLDPGLIMEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM

Target ORF information:

RefSeq Version	NM_012458.4
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 13 (TIMM13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012458.4

ORF Insert Sequence:

ATGGAGGGCG GCTTCGGCTC CGATTTCGGG GGCTCCGGCA GCGGGAAGCT GGACCCAGGG 
CTCATAATGG AGCAGGTGAA AGTGCAGATC GCCGTGGCCA ACGCGCAGGA GCTGCTGCAG 
AGGATGACGG ACAAGTGTTT CCGGAAGTGT ATAGGGAAAC CTGGGGGCTC CCTGGACAAC 
TCCGAGCAGA AGTGCATCGC CATGTGCATG GACCGCTACA TGGACGCCTG GAACACCGTG 
TCTCGCGCCT ACAACTCGCG GCTGCAGCGG GAACGAGCCA ACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMM13 ( NM_012458.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036590.1 Homo sapiens translocase of inner mitochondrial membrane 13 (TIMM13), mRNA.

Price & Availability↑

CloneID	OHu09684
Clone ID Related Accession (Same CDS sequence)	NM_012458.4 , NM_012458.3
Accession Version	NM_012458.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit Tim13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA947460.1, HY098076.1, AK024764.1 and AC011522.8. On Jul 31, 2013 this sequence version replaced NM_012458.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK024764.1, SRR1163655.543266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGCG GCTTCGGCTC CGATTTCGGG GGCTCCGGCA GCGGGAAGCT GGACCCAGGG 
CTCATAATGG AGCAGGTGAA AGTGCAGATC GCCGTGGCCA ACGCGCAGGA GCTGCTGCAG 
AGGATGACGG ACAAGTGTTT CCGGAAGTGT ATAGGGAAAC CTGGGGGCTC CCTGGACAAC 
TCCGAGCAGA AGTGCATCGC CATGTGCATG GACCGCTACA TGGACGCCTG GAACACCGTG 
TCTCGCGCCT ACAACTCGCG GCTGCAGCGG GAACGAGCCA ACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036590.1
CDS	384..671
Translation	MEGGFGSDFGGSGSGKLDPGLIMEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM

Target ORF information:

RefSeq Version	NM_012458.3
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 13 (TIMM13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012458.3

ORF Insert Sequence:

ATGGAGGGCG GCTTCGGCTC CGATTTCGGG GGCTCCGGCA GCGGGAAGCT GGACCCAGGG 
CTCATAATGG AGCAGGTGAA AGTGCAGATC GCCGTGGCCA ACGCGCAGGA GCTGCTGCAG 
AGGATGACGG ACAAGTGTTT CCGGAAGTGT ATAGGGAAAC CTGGGGGCTC CCTGGACAAC 
TCCGAGCAGA AGTGCATCGC CATGTGCATG GACCGCTACA TGGACGCCTG GAACACCGTG 
TCTCGCGCCT ACAACTCGCG GCTGCAGCGG GAACGAGCCA ACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
Developmental cell29(2)217-32(2014 Apr)
Wang Z,Fan M,Candas D,Zhang TQ,Qin L,Eldridge A,Wachsmann-Hogiu S,Ahmed KM,Chromy BA,Nantajit D,Duru N,He F,Chen M,Finkel T,Weinstein LS,Li JJ

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space.
Molecular biology and evolution24(5)1149-60(2007 May)
Gentle IE,Perry AJ,Alcock FH,Liki? VA,Dolezal P,Ng ET,Purcell AW,McConnville M,Naderer T,Chanez AL,Charri?re F,Aschinger C,Schneider A,Tokatlidis K,Lithgow T

Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.
Molecular cell21(1)123-33(2006 Jan)
Webb CT,Gorman MA,Lazarou M,Ryan MT,Gulbis JM

The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.
Human molecular genetics13(18)2101-11(2004 Sep)
Roesch K,Hynds PJ,Varga R,Tranebjaerg L,Koehler CM

The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins.
The Journal of cell biology158(6)1017-27(2002 Sep)
Curran SP,Leuenberger D,Schmidt E,Koehler CM

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TIMM13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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