TIMM10B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIMM10B
Entrez Gene ID	26515
Full Name	translocase of inner mitochondrial membrane 10B
Synonyms	FXC1,TIM10B,Tim9b
General protein information	Preferred Names translocase of inner mitochondrial membrane 10B Names mitochondrial import inner membrane translocase subunit Tim10 B fracture callus 1 homolog fracture callus protein 1 mitochondrial import inner membrane translocase subunit Tim9 B translocase of inner mitochondrial membrane 10 homolog B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004].
Disorder MIM:	607388

mRNA and Protein(s)

mRNA	Protein	Name
NM_012192.3	NP_036324.1	mitochondrial import inner membrane translocase subunit Tim10 B
NM_012192.4	NP_036324.1	mitochondrial import inner membrane translocase subunit Tim10 B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Timm10b	NP_062375.1
Danio rerio (zebrafish)	timm10b	NP_001017829.1
Pan troglodytes (chimpanzee)	FXC1	XP_001165925.1
Canis lupus familiaris (dog)	FXC1	XP_853681.2
Bos taurus (cattle)	FXC1	NP_001035620.1
Homo sapiens (human)	TIMM10B	NP_036324.1
	FXC1	XP_001109886.2
Rattus norvegicus (Norway rat)	Timm10b	NP_445823.1

Gene Ontology
Bibliography

Related articles in PubMed

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
Vukotic M, Nolte H, K?nig T, Saita S, Ananjew M, Kr?ger M, Tatsuta T, Langer T
Molecular cell67(3)471-483.e7(2017 Aug)

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D
eLife5(2016 08)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.
M?hlenbein N, Hofmann S, Rothbauer U, Bauer MF
The Journal of biological chemistry279(14)13540-6(2004 Apr)

Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.
Rothbauer U, Hofmann S, M?hlenbein N, Paschen SA, Gerbitz KD, Neupert W, Brunner M, Bauer MF
The Journal of biological chemistry276(40)37327-34(2001 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following TIMM10B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIMM10B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31193	NM_012192.4 Latest version!	Homo sapiens translocase of inner mitochondrial membrane 10B (TIMM10B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31193	NM_012192.3	Homo sapiens translocase of inner mitochondrial membrane 10B (TIMM10B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIMM10B ( NM_012192.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036324.1 Homo sapiens translocase of inner mitochondrial membrane 10B (TIMM10B), mRNA.

Price & Availability↑

CloneID	OHu31193
Clone ID Related Accession (Same CDS sequence)	NM_012192.3 , NM_012192.4
Accession Version	NM_012192.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit Tim10 B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA290694.1, BC011014.1, AC084337.7 and AI052126.1. On Jun 20, 2007 this sequence version replaced NM_012192.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.562186.1, SRR1660805.60638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 14726512; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGGC AGCAGCAGCA GCAACAGCAA CTGCGAAACC TGCGTGACTT CCTGTTGGTC 
TACAATCGGA TGACAGAACT CTGCTTCCAG CGCTGTGTGC CCAGCTTGCA CCACCGAGCT 
CTGGACGCTG AGGAGGAGGC CTGTCTGCAC AGCTGTGCTG GGAAGCTGAT CCATTCCAAC 
CACCGCCTCA TGGCCGCTTA CGTGCAGCTC ATGCCTGCCC TGGTACAGCG CCGCATCGCA 
GACTACGAGG CTGCCTCGGC TGTGCCAGGC GTTGCTGCTG AACAGCCTGG GGTCTCTCCA 
TCAGGCAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036324.1
CDS	71..382
Translation	MERQQQQQQQLRNLRDFLLVYNRMTELCFQRCVPSLHHRALDAEEEACLHSCAGKLIHSNHRLMAAYVQLMPALVQRRIADYEAASAVPGVAAEQPGVSPSGS

Target ORF information:

RefSeq Version	NM_012192.3
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 10B (TIMM10B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012192.3

ORF Insert Sequence:

ATGGAGCGGC AGCAGCAGCA GCAACAGCAA CTGCGAAACC TGCGTGACTT CCTGTTGGTC 
TACAATCGGA TGACAGAACT CTGCTTCCAG CGCTGTGTGC CCAGCTTGCA CCACCGAGCT 
CTGGACGCTG AGGAGGAGGC CTGTCTGCAC AGCTGTGCTG GGAAGCTGAT CCATTCCAAC 
CACCGCCTCA TGGCCGCTTA CGTGCAGCTC ATGCCTGCCC TGGTACAGCG CCGCATCGCA 
GACTACGAGG CTGCCTCGGC TGTGCCAGGC GTTGCTGCTG AACAGCCTGG GGTCTCTCCA 
TCAGGCAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMM10B ( NM_012192.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036324.1 Homo sapiens translocase of inner mitochondrial membrane 10B (TIMM10B), mRNA.

Price & Availability↑

CloneID	OHu31193
Clone ID Related Accession (Same CDS sequence)	NM_012192.3 , NM_012192.4
Accession Version	NM_012192.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit Tim10 B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA290694.1, BC011014.1, AC084337.7 and AI052126.1. On Nov 23, 2018 this sequence version replaced NM_012192.3. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.76223.1, SRR1660805.155022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 14726512; reported by MitoCarta MANE Ensembl match :: ENST00000254616.11/ ENSP00000254616.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCGGC AGCAGCAGCA GCAACAGCAA CTGCGAAACC TGCGTGACTT CCTGTTGGTC 
TACAATCGGA TGACAGAACT CTGCTTCCAG CGCTGTGTGC CCAGCTTGCA CCACCGAGCT 
CTGGACGCTG AGGAGGAGGC CTGTCTGCAC AGCTGTGCTG GGAAGCTGAT CCATTCCAAC 
CACCGCCTCA TGGCCGCTTA CGTGCAGCTC ATGCCTGCCC TGGTACAGCG CCGCATCGCA 
GACTACGAGG CTGCCTCGGC TGTGCCAGGC GTTGCTGCTG AACAGCCTGG GGTCTCTCCA 
TCAGGCAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036324.1
CDS	17..328
Translation	MERQQQQQQQLRNLRDFLLVYNRMTELCFQRCVPSLHHRALDAEEEACLHSCAGKLIHSNHRLMAAYVQLMPALVQRRIADYEAASAVPGVAAEQPGVSPSGS

Target ORF information:

RefSeq Version	NM_012192.4
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 10B (TIMM10B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012192.4

ORF Insert Sequence:

ATGGAGCGGC AGCAGCAGCA GCAACAGCAA CTGCGAAACC TGCGTGACTT CCTGTTGGTC 
TACAATCGGA TGACAGAACT CTGCTTCCAG CGCTGTGTGC CCAGCTTGCA CCACCGAGCT 
CTGGACGCTG AGGAGGAGGC CTGTCTGCAC AGCTGTGCTG GGAAGCTGAT CCATTCCAAC 
CACCGCCTCA TGGCCGCTTA CGTGCAGCTC ATGCCTGCCC TGGTACAGCG CCGCATCGCA 
GACTACGAGG CTGCCTCGGC TGTGCCAGGC GTTGCTGCTG AACAGCCTGG GGTCTCTCCA 
TCAGGCAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
Molecular cell67(3)471-483.e7(2017 Aug)
Vukotic M,Nolte H,K?nig T,Saita S,Ananjew M,Kr?ger M,Tatsuta T,Langer T

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
eLife5(2016 08)
Kang Y,Baker MJ,Liem M,Louber J,McKenzie M,Atukorala I,Ang CS,Keerthikumar S,Mathivanan S,Stojanovski D

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.
The Journal of biological chemistry279(14)13540-6(2004 Apr)
M?hlenbein N,Hofmann S,Rothbauer U,Bauer MF

Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.
The Journal of biological chemistry276(40)37327-34(2001 Oct)
Rothbauer U,Hofmann S,M?hlenbein N,Paschen SA,Gerbitz KD,Neupert W,Brunner M,Bauer MF

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TIMM10B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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