HEYL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HEYL
Entrez Gene ID	26508
Full Name	hes related family bHLH transcription factor with YRPW motif-like
Synonyms	HESR3,HEY3,HRT3,bHLHb33
General protein information	Preferred Names hes related family bHLH transcription factor with YRPW motif-like Names hairy/enhancer-of-split related with YRPW motif-like protein HEY-like protein HRT-3 class B basic helix-loop-helix protein 33 hHRT3 hHeyL hairy-related transcription factor 3 hairy/enhancer-of-split related with YRPW motif 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.2
Summary	This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	609034

mRNA and Protein(s)

mRNA	Protein	Name
XM_005270745.2	XP_005270802.1	hairy/enhancer-of-split related with YRPW motif-like protein isoform X1
NM_014571.3	NP_055386.1	hairy/enhancer-of-split related with YRPW motif-like protein
NM_014571.4	NP_055386.2	hairy/enhancer-of-split related with YRPW motif-like protein
XM_005270745.3	XP_005270802.1	hairy/enhancer-of-split related with YRPW motif-like protein isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HEYL	XP_001171234.1
	LOC716117	XP_001113370.1
Canis lupus familiaris (dog)	HEYL	XP_849702.1
Gallus gallus (chicken)	HEYL	XP_001234406.2
Danio rerio (zebrafish)	heyl	NP_859425.1
Homo sapiens (human)	HEYL	NP_055386.1
Bos taurus (cattle)	HEYL	NP_001019736.2
Mus musculus (house mouse)	Heyl	NP_038933.2
Rattus norvegicus (Norway rat)	Heyl	NP_001101447.1

Gene Ontology
Bibliography

Related articles in PubMed

Polymorphisms in Epithelial-Mesenchymal Transition-Related Genes and the Prognosis of Surgically Treated Non-small Cell Lung Cancer.
Seok Y, Kang HG, Lee SY, Jeong JY, Choi JE, Jung DK, Jin CC, Hong MJ, Do SK, Lee WK, Park JY, Shin KM, Yoo SS, Lee J, Cho S, Cha SI, Kim CH, Jheon S, Lee EB, Park JY
Annals of surgical oncology24(11)3386-3395(2017 Oct)

LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL.
Hirano K, Namihira M
Stem cells (Dayton, Ohio)34(7)1872-82(2016 07)

The Notch pathway inhibits TGF? signaling in breast cancer through HEYL-mediated crosstalk.
Han L, Diehl A, Nguyen NK, Korangath P, Teo W, Cho S, Kominsky S, Huso DL, Feigenbaum L, Rein A, Argani P, Landberg G, Gessler M, Sukumar S
Cancer research74(22)6509-18(2014 Nov)

Seventy-five genetic loci influencing the human red blood cell.
van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, Al-Hussani A, Asselbergs FW, Ciullo M, Danjou F, Dina C, Esko T, Evans DM, Franke L, G?gele M, Hartiala J, Hersch M, Holm H, Hottenga JJ, Kanoni S, Kleber ME, Lagou V, Langenberg C, Lopez LM, Lyytik?inen LP, Melander O, Murgia F, Nolte IM, O'Reilly PF, Padmanabhan S, Parsa A, Pirastu N, Porcu E, Portas L, Prokopenko I, Ried JS, Shin SY, Tang CS, Teumer A, Traglia M, Ulivi S, Westra HJ, Yang J, Zhao JH, Anni F, Abdellaoui A, Attwood A, Balkau B, Bandinelli S, Bastardot F, Benyamin B, Boehm BO, Cookson WO, Das D, de Bakker PI, de Boer RA, de Geus EJ, de Moor MH, Dimitriou M, Domingues FS, D?ring A, Engstr?m G, Eyjolfsson GI, Ferrucci L, Fischer K, Galanello R, Garner SF, Genser B, Gibson QD, Girotto G, Gudbjartsson DF, Harris SE, Hartikainen AL, Hastie CE, Hedblad B, Illig T, Jolley J, K?h?nen M, Kema IP, Kemp JP, Liang L, Lloyd-Jones H, Loos RJ, Meacham S, Medland SE, Meisinger C, Memari Y, Mihailov E, Miller K, Moffatt MF, Nauck M, Novatchkova M, Nutile T, Olafsson I, Onundarson PT, Parracciani D, Penninx BW, Perseu L, Piga A, Pistis G, Pouta A, Puc U, Raitakari O, Ring SM, Robino A, Ruggiero D, Ruokonen A, Saint-Pierre A, Sala C, Salumets A, Sambrook J, Schepers H, Schmidt CO, Sillj? HH, Sladek R, Smit JH, Starr JM, Stephens J, Sulem P, Tanaka T, Thorsteinsdottir U, Tragante V, van Gilst WH, van Pelt LJ, van Veldhuisen DJ, V?lker U, Whitfield JB, Willemsen G, Winkelmann BR, Wirnsberger G, Algra A, Cucca F, d'Adamo AP, Danesh J, Deary IJ, Dominiczak AF, Elliott P, Fortina P, Froguel P, Gasparini P, Greinacher A, Hazen SL, Jarvelin MR, Khaw KT, Lehtim?ki T, Maerz W, Martin NG, Metspalu A, Mitchell BD, Montgomery GW, Moore C, Navis G, Pirastu M, Pramstaller PP, Ramirez-Solis R, Schadt E, Scott J, Shuldiner AR, Smith GD, Smith JG, Snieder H, Sorice R, Spector TD, Stefansson K, Stumvoll M, Tang WH, Toniolo D, T?njes A, Visscher PM, Vollenweider P, Wareham NJ, Wolffenbuttel BH, Boomsma DI, Beckmann JS, Dedoussis GV, Deloukas P, Ferreira MA, Sanna S, Uda M, Hicks AA, Penninger JM, Gieger C, Kooner JS, Ouwehand WH, Soranzo N, Chambers JC
Nature492(7429)369-75(2012 Dec)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LSD1 directly associates with the promoter of the HEYL gene.
Title: LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL.

repression of TGFbeta signaling by Notch acting through HEYL may promote initiation of breast cancer
Title: The Notch pathway inhibits TGF? signaling in breast cancer through HEYL-mediated crosstalk.

Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.
Title: Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.

In this study, we analyzed the effects of HESR1, -2, and -3 on DAT1 expression in human neuroblastoma SH-SY5Y cells
Title: Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.

The following HEYL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEYL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06538	NM_014571.3 Latest version!	Homo sapiens hes related family bHLH transcription factor with YRPW motif-like (HEYL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu33344	XM_005270745.3 Latest version!	Homo sapiens hes related family bHLH transcription factor with YRPW motif like (HEYL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu107321	NM_014571.4 Latest version!	Homo sapiens hes related family bHLH transcription factor with YRPW motif like (HEYL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu33344	XM_005270745.2	Homo sapiens hes related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HEYL ( NM_014571.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055386.1 Homo sapiens hes related family bHLH transcription factor with YRPW motif-like (HEYL), mRNA.

Price & Availability↑

CloneID	OHu06538
Clone ID Related Accession (Same CDS sequence)	NM_014571.3
Accession Version	NM_014571.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	hairy/enhancer-of-split related with YRPW motif-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL541019.3, BC006087.1, AL035404.20 and BM682076.1. On Jun 1, 2006 this sequence version replaced NM_014571.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL541019.3, SRR1803613.46681.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCGAC CCAAGGAGCC GAGCGGCTCC GACGGGGAGT CCGACGGACC CATCGACGTG 
GGCCAAGAGG GCCAGCTGAG CCAGATGGCC AGGCCGCTGT CCACCCCCAG CTCTTCGCAG 
ATGCAAGCCA GGAAGAAACG CAGAGGGATC ATAGAGAAAC GGCGTCGAGA CCGCATCAAC 
AGTAGCCTTT CTGAATTGCG ACGCTTGGTC CCCACTGCCT TTGAGAAACA GGGCTCTTCC 
AAGCTGGAGA AAGCCGAGGT CTTGCAGATG ACGGTGGATC ACTTGAAAAT GCTCCATGCC 
ACTGGTGGGA CAGGATTCTT TGATGCCCGA GCCCTGGCAG TTGACTTCCG GAGCATTGGT 
TTTCGGGAGT GCCTCACTGA GGTCATCAGG TACCTGGGGG TCCTTGAAGG GCCCAGCAGC 
CGTGCAGACC CCGTCCGGAT TCGCCTTCTC TCCCACCTCA ACAGCTACGC AGCCGAGATG 
GAGCCTTCGC CCACGCCCAC TGGCCCTTTG GCCTTCCCTG CCTGGCCCTG GTCTTTCTTC 
CATAGCTGTC CAGGGCTGCC AGCCCTGAGC AACCAGCTCG CCATCCTGGG AAGAGTGCCC 
AGCCCTGTCC TCCCCGGTGT CTCCTCTCCT GCTTACCCCA TCCCAGCCCT CCGAACCGCT 
CCCCTTCGCA GAGCCACAGG CATCATCCTG CCAGCCCGGA GGAATGTGCT GCCCAGTCGA 
GGGGCATCTT CCACCCGGAG GGCCCGCCCC CTAGAGAGGC CAGCGACCCC TGTGCCTGTC 
GCCCCCAGCA GCAGGGCTGC CAGGAGCAGC CACATCGCTC CCCTCCTGCA GTCTTCCTCC 
CCAACACCCC CTGGTCCTAC AGGGTCGGCT GCTTACGTGG CTGTTCCCAC CCCCAACTCA 
TCCTCCCCAG GGCCAGCTGG GAGGCCAGCG GGAGCCATGC TCTACCACTC CTGGGTCTCT 
GAAATCACTG AAATCGGGGC TTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055386.1
CDS	52..1038
Translation	MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF

Target ORF information:

RefSeq Version	NM_014571.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hes related family bHLH transcription factor with YRPW motif-like (HEYL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014571.3

ORF Insert Sequence:

ATGAAGCGAC CCAAGGAGCC GAGCGGCTCC GACGGGGAGT CCGACGGACC CATCGACGTG 
GGCCAAGAGG GCCAGCTGAG CCAGATGGCC AGGCCGCTGT CCACCCCCAG CTCTTCGCAG 
ATGCAAGCCA GGAAGAAACG CAGAGGGATC ATAGAGAAAC GGCGTCGAGA CCGCATCAAC 
AGTAGCCTTT CTGAATTGCG ACGCTTGGTC CCCACTGCCT TTGAGAAACA GGGCTCTTCC 
AAGCTGGAGA AAGCCGAGGT CTTGCAGATG ACGGTGGATC ACTTGAAAAT GCTCCATGCC 
ACTGGTGGGA CAGGATTCTT TGATGCCCGA GCCCTGGCAG TTGACTTCCG GAGCATTGGT 
TTTCGGGAGT GCCTCACTGA GGTCATCAGG TACCTGGGGG TCCTTGAAGG GCCCAGCAGC 
CGTGCAGACC CCGTCCGGAT TCGCCTTCTC TCCCACCTCA ACAGCTACGC AGCCGAGATG 
GAGCCTTCGC CCACGCCCAC TGGCCCTTTG GCCTTCCCTG CCTGGCCCTG GTCTTTCTTC 
CATAGCTGTC CAGGGCTGCC AGCCCTGAGC AACCAGCTCG CCATCCTGGG AAGAGTGCCC 
AGCCCTGTCC TCCCCGGTGT CTCCTCTCCT GCTTACCCCA TCCCAGCCCT CCGAACCGCT 
CCCCTTCGCA GAGCCACAGG CATCATCCTG CCAGCCCGGA GGAATGTGCT GCCCAGTCGA 
GGGGCATCTT CCACCCGGAG GGCCCGCCCC CTAGAGAGGC CAGCGACCCC TGTGCCTGTC 
GCCCCCAGCA GCAGGGCTGC CAGGAGCAGC CACATCGCTC CCCTCCTGCA GTCTTCCTCC 
CCAACACCCC CTGGTCCTAC AGGGTCGGCT GCTTACGTGG CTGTTCCCAC CCCCAACTCA 
TCCTCCCCAG GGCCAGCTGG GAGGCCAGCG GGAGCCATGC TCTACCACTC CTGGGTCTCT 
GAAATCACTG AAATCGGGGC TTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEYL ( XM_005270745.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270802.1 Homo sapiens hes related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu33344
Clone ID Related Accession (Same CDS sequence)	XM_005270745.2 , XM_005270745.3
Accession Version	XM_005270745.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	hairy/enhancer-of-split related with YRPW motif-like protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005270745.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCAGGC CGCTGTCCAC CCCCAGCTCT TCGCAGATGC AAGCCAGGAA GAAACACAGA 
GGGATCATAG AGAAACGGCG TCGAGACCGC ATCAACAGTA GCCTTTCTGA ATTGCGACGC 
TTGGTCCCCA CTGCCTTTGA GAAACAGGGC TCTTCCAAGC TGGAGAAAGC CGAGGTCTTG 
CAGATGACGG TGGATCACTT GAAAATGCTC CATGCCACTG GTGGGACAGG ATTCTTTGAT 
GCCCGAGCCC TGGCAGTTGA CTTCCGGAGC ATTGGTTTTC GGGAGTGCCT CACTGAGGTC 
ATCAGGTACC TGGGGGTCCT TGAAGGGCCC AGCAGCCGTG CAGACCCCGT CCGGATTCGC 
CTTCTCTCCC ACCTCAACAG CTACGCAGCC GAGATGGAGC CTTCGCCCAC GCCCACTGGC 
CCTTTGGCCT TCCCTGCCTG GCCCTGGTCT TTCTTCCATA GCTGTCCAGG GCTGCCAGCC 
CTGAGCAACC AGCTCGCCAT CCTGGGAAGA GTGCCCAGCC CTGTCCTCCC CGGTGTCTCC 
TCTCCTGCTT ACCCCATCCC AGCCCTCCGA ACCGCTCCCC TTCGCAGAGC CACAGGCATC 
ATCCTGCCAG CCCGGAGGAA TGTGCTGCCC AGTCGAGGGG CATCTTCCAC CCGGAGGGCC 
CGCCCCCTAG AGAGGCCAGC GACCCCTGTG CCTGTCGCCC CCAGCAGCAG GGCTGCCAGG 
AGCAGCCACA TCGCTCCCCT CCTGCAGTCT TCCTCCCCAA CACCCCCTGG TCCTACAGGG 
TCGGCTGCTT ACGTGGCTGT TCCCACCCCC AACTCATCCT CCCCAGGGCC AGCTGGGAGG 
CCAGCGGGAG CCATGCTCTA CCACTCCTGG GTCTCTGAAA TCACTGAAAT CGGGGCTTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270802.1
CDS	190..1092
Translation	MARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF

Target ORF information:

RefSeq Version	XM_005270745.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hes related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270745.2

ORF Insert Sequence:

ATGGCCAGGC CGCTGTCCAC CCCCAGCTCT TCGCAGATGC AAGCCAGGAA GAAACACAGA 
GGGATCATAG AGAAACGGCG TCGAGACCGC ATCAACAGTA GCCTTTCTGA ATTGCGACGC 
TTGGTCCCCA CTGCCTTTGA GAAACAGGGC TCTTCCAAGC TGGAGAAAGC CGAGGTCTTG 
CAGATGACGG TGGATCACTT GAAAATGCTC CATGCCACTG GTGGGACAGG ATTCTTTGAT 
GCCCGAGCCC TGGCAGTTGA CTTCCGGAGC ATTGGTTTTC GGGAGTGCCT CACTGAGGTC 
ATCAGGTACC TGGGGGTCCT TGAAGGGCCC AGCAGCCGTG CAGACCCCGT CCGGATTCGC 
CTTCTCTCCC ACCTCAACAG CTACGCAGCC GAGATGGAGC CTTCGCCCAC GCCCACTGGC 
CCTTTGGCCT TCCCTGCCTG GCCCTGGTCT TTCTTCCATA GCTGTCCAGG GCTGCCAGCC 
CTGAGCAACC AGCTCGCCAT CCTGGGAAGA GTGCCCAGCC CTGTCCTCCC CGGTGTCTCC 
TCTCCTGCTT ACCCCATCCC AGCCCTCCGA ACCGCTCCCC TTCGCAGAGC CACAGGCATC 
ATCCTGCCAG CCCGGAGGAA TGTGCTGCCC AGTCGAGGGG CATCTTCCAC CCGGAGGGCC 
CGCCCCCTAG AGAGGCCAGC GACCCCTGTG CCTGTCGCCC CCAGCAGCAG GGCTGCCAGG 
AGCAGCCACA TCGCTCCCCT CCTGCAGTCT TCCTCCCCAA CACCCCCTGG TCCTACAGGG 
TCGGCTGCTT ACGTGGCTGT TCCCACCCCC AACTCATCCT CCCCAGGGCC AGCTGGGAGG 
CCAGCGGGAG CCATGCTCTA CCACTCCTGG GTCTCTGAAA TCACTGAAAT CGGGGCTTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEYL ( XM_005270745.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270802.1 Homo sapiens hes related family bHLH transcription factor with YRPW motif like (HEYL), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu33344
Clone ID Related Accession (Same CDS sequence)	XM_005270745.2 , XM_005270745.3
Accession Version	XM_005270745.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	hairy/enhancer-of-split related with YRPW motif-like protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005270745.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCAGGC CGCTGTCCAC CCCCAGCTCT TCGCAGATGC AAGCCAGGAA GAAACACAGA 
GGGATCATAG AGAAACGGCG TCGAGACCGC ATCAACAGTA GCCTTTCTGA ATTGCGACGC 
TTGGTCCCCA CTGCCTTTGA GAAACAGGGC TCTTCCAAGC TGGAGAAAGC CGAGGTCTTG 
CAGATGACGG TGGATCACTT GAAAATGCTC CATGCCACTG GTGGGACAGG ATTCTTTGAT 
GCCCGAGCCC TGGCAGTTGA CTTCCGGAGC ATTGGTTTTC GGGAGTGCCT CACTGAGGTC 
ATCAGGTACC TGGGGGTCCT TGAAGGGCCC AGCAGCCGTG CAGACCCCGT CCGGATTCGC 
CTTCTCTCCC ACCTCAACAG CTACGCAGCC GAGATGGAGC CTTCGCCCAC GCCCACTGGC 
CCTTTGGCCT TCCCTGCCTG GCCCTGGTCT TTCTTCCATA GCTGTCCAGG GCTGCCAGCC 
CTGAGCAACC AGCTCGCCAT CCTGGGAAGA GTGCCCAGCC CTGTCCTCCC CGGTGTCTCC 
TCTCCTGCTT ACCCCATCCC AGCCCTCCGA ACCGCTCCCC TTCGCAGAGC CACAGGCATC 
ATCCTGCCAG CCCGGAGGAA TGTGCTGCCC AGTCGAGGGG CATCTTCCAC CCGGAGGGCC 
CGCCCCCTAG AGAGGCCAGC GACCCCTGTG CCTGTCGCCC CCAGCAGCAG GGCTGCCAGG 
AGCAGCCACA TCGCTCCCCT CCTGCAGTCT TCCTCCCCAA CACCCCCTGG TCCTACAGGG 
TCGGCTGCTT ACGTGGCTGT TCCCACCCCC AACTCATCCT CCCCAGGGCC AGCTGGGAGG 
CCAGCGGGAG CCATGCTCTA CCACTCCTGG GTCTCTGAAA TCACTGAAAT CGGGGCTTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270802.1
CDS	64..966
Translation	MARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF

Target ORF information:

RefSeq Version	XM_005270745.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hes related family bHLH transcription factor with YRPW motif like (HEYL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270745.3

ORF Insert Sequence:

ATGGCCAGGC CGCTGTCCAC CCCCAGCTCT TCGCAGATGC AAGCCAGGAA GAAACACAGA 
GGGATCATAG AGAAACGGCG TCGAGACCGC ATCAACAGTA GCCTTTCTGA ATTGCGACGC 
TTGGTCCCCA CTGCCTTTGA GAAACAGGGC TCTTCCAAGC TGGAGAAAGC CGAGGTCTTG 
CAGATGACGG TGGATCACTT GAAAATGCTC CATGCCACTG GTGGGACAGG ATTCTTTGAT 
GCCCGAGCCC TGGCAGTTGA CTTCCGGAGC ATTGGTTTTC GGGAGTGCCT CACTGAGGTC 
ATCAGGTACC TGGGGGTCCT TGAAGGGCCC AGCAGCCGTG CAGACCCCGT CCGGATTCGC 
CTTCTCTCCC ACCTCAACAG CTACGCAGCC GAGATGGAGC CTTCGCCCAC GCCCACTGGC 
CCTTTGGCCT TCCCTGCCTG GCCCTGGTCT TTCTTCCATA GCTGTCCAGG GCTGCCAGCC 
CTGAGCAACC AGCTCGCCAT CCTGGGAAGA GTGCCCAGCC CTGTCCTCCC CGGTGTCTCC 
TCTCCTGCTT ACCCCATCCC AGCCCTCCGA ACCGCTCCCC TTCGCAGAGC CACAGGCATC 
ATCCTGCCAG CCCGGAGGAA TGTGCTGCCC AGTCGAGGGG CATCTTCCAC CCGGAGGGCC 
CGCCCCCTAG AGAGGCCAGC GACCCCTGTG CCTGTCGCCC CCAGCAGCAG GGCTGCCAGG 
AGCAGCCACA TCGCTCCCCT CCTGCAGTCT TCCTCCCCAA CACCCCCTGG TCCTACAGGG 
TCGGCTGCTT ACGTGGCTGT TCCCACCCCC AACTCATCCT CCCCAGGGCC AGCTGGGAGG 
CCAGCGGGAG CCATGCTCTA CCACTCCTGG GTCTCTGAAA TCACTGAAAT CGGGGCTTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEYL ( NM_014571.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055386.2 Homo sapiens hes related family bHLH transcription factor with YRPW motif like (HEYL), mRNA.

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CloneID	OHu107321
Clone ID Related Accession (Same CDS sequence)	NM_014571.4
Accession Version	NM_014571.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	hairy/enhancer-of-split related with YRPW motif-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035404.20. On Nov 23, 2018 this sequence version replaced NM_014571.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.46681.1, SRR1803616.44887.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372852.4/ ENSP00000361943.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCGAC CCAAGGAGCC GAGCGGCTCC GACGGGGAGT CCGACGGACC CATCGACGTG 
GGCCAAGAGG GCCAGCTGAG CCAGATGGCC AGGCCGCTGT CCACCCCCAG CTCTTCGCAG 
ATGCAAGCCA GGAAGAAACA CAGAGGGATC ATAGAGAAAC GGCGTCGAGA CCGCATCAAC 
AGTAGCCTTT CTGAATTGCG ACGCTTGGTC CCCACTGCCT TTGAGAAACA GGGCTCTTCC 
AAGCTGGAGA AAGCCGAGGT CTTGCAGATG ACGGTGGATC ACTTGAAAAT GCTCCATGCC 
ACTGGTGGGA CAGGATTCTT TGATGCCCGA GCCCTGGCAG TTGACTTCCG GAGCATTGGT 
TTTCGGGAGT GCCTCACTGA GGTCATCAGG TACCTGGGGG TCCTTGAAGG GCCCAGCAGC 
CGTGCAGACC CCGTCCGGAT TCGCCTTCTC TCCCACCTCA ACAGCTACGC AGCCGAGATG 
GAGCCTTCGC CCACGCCCAC TGGCCCTTTG GCCTTCCCTG CCTGGCCCTG GTCTTTCTTC 
CATAGCTGTC CAGGGCTGCC AGCCCTGAGC AACCAGCTCG CCATCCTGGG AAGAGTGCCC 
AGCCCTGTCC TCCCCGGTGT CTCCTCTCCT GCTTACCCCA TCCCAGCCCT CCGAACCGCT 
CCCCTTCGCA GAGCCACAGG CATCATCCTG CCAGCCCGGA GGAATGTGCT GCCCAGTCGA 
GGGGCATCTT CCACCCGGAG GGCCCGCCCC CTAGAGAGGC CAGCGACCCC TGTGCCTGTC 
GCCCCCAGCA GCAGGGCTGC CAGGAGCAGC CACATCGCTC CCCTCCTGCA GTCTTCCTCC 
CCAACACCCC CTGGTCCTAC AGGGTCGGCT GCTTACGTGG CTGTTCCCAC CCCCAACTCA 
TCCTCCCCAG GGCCAGCTGG GAGGCCAGCG GGAGCCATGC TCTACCACTC CTGGGTCTCT 
GAAATCACTG AAATCGGGGC TTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055386.2
CDS	19..1005
Translation	MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF

Target ORF information:

RefSeq Version	NM_014571.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hes related family bHLH transcription factor with YRPW motif like (HEYL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014571.4

ORF Insert Sequence:

ATGAAGCGAC CCAAGGAGCC GAGCGGCTCC GACGGGGAGT CCGACGGACC CATCGACGTG 
GGCCAAGAGG GCCAGCTGAG CCAGATGGCC AGGCCGCTGT CCACCCCCAG CTCTTCGCAG 
ATGCAAGCCA GGAAGAAACA CAGAGGGATC ATAGAGAAAC GGCGTCGAGA CCGCATCAAC 
AGTAGCCTTT CTGAATTGCG ACGCTTGGTC CCCACTGCCT TTGAGAAACA GGGCTCTTCC 
AAGCTGGAGA AAGCCGAGGT CTTGCAGATG ACGGTGGATC ACTTGAAAAT GCTCCATGCC 
ACTGGTGGGA CAGGATTCTT TGATGCCCGA GCCCTGGCAG TTGACTTCCG GAGCATTGGT 
TTTCGGGAGT GCCTCACTGA GGTCATCAGG TACCTGGGGG TCCTTGAAGG GCCCAGCAGC 
CGTGCAGACC CCGTCCGGAT TCGCCTTCTC TCCCACCTCA ACAGCTACGC AGCCGAGATG 
GAGCCTTCGC CCACGCCCAC TGGCCCTTTG GCCTTCCCTG CCTGGCCCTG GTCTTTCTTC 
CATAGCTGTC CAGGGCTGCC AGCCCTGAGC AACCAGCTCG CCATCCTGGG AAGAGTGCCC 
AGCCCTGTCC TCCCCGGTGT CTCCTCTCCT GCTTACCCCA TCCCAGCCCT CCGAACCGCT 
CCCCTTCGCA GAGCCACAGG CATCATCCTG CCAGCCCGGA GGAATGTGCT GCCCAGTCGA 
GGGGCATCTT CCACCCGGAG GGCCCGCCCC CTAGAGAGGC CAGCGACCCC TGTGCCTGTC 
GCCCCCAGCA GCAGGGCTGC CAGGAGCAGC CACATCGCTC CCCTCCTGCA GTCTTCCTCC 
CCAACACCCC CTGGTCCTAC AGGGTCGGCT GCTTACGTGG CTGTTCCCAC CCCCAACTCA 
TCCTCCCCAG GGCCAGCTGG GAGGCCAGCG GGAGCCATGC TCTACCACTC CTGGGTCTCT 
GAAATCACTG AAATCGGGGC TTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Polymorphisms in Epithelial-Mesenchymal Transition-Related Genes and the Prognosis of Surgically Treated Non-small Cell Lung Cancer.
Annals of surgical oncology24(11)3386-3395(2017 Oct)
Seok Y,Kang HG,Lee SY,Jeong JY,Choi JE,Jung DK,Jin CC,Hong MJ,Do SK,Lee WK,Park JY,Shin KM,Yoo SS,Lee J,Cho S,Cha SI,Kim CH,Jheon S,Lee EB,Park JY

LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL.
Stem cells (Dayton, Ohio)34(7)1872-82(2016 07)
Hirano K,Namihira M

The Notch pathway inhibits TGF? signaling in breast cancer through HEYL-mediated crosstalk.
Cancer research74(22)6509-18(2014 Nov)
Han L,Diehl A,Nguyen NK,Korangath P,Teo W,Cho S,Kominsky S,Huso DL,Feigenbaum L,Rein A,Argani P,Landberg G,Gessler M,Sukumar S

Seventy-five genetic loci influencing the human red blood cell.
Nature492(7429)369-75(2012 Dec)
van der Harst P,Zhang W,Mateo Leach I,Rendon A,Verweij N,Sehmi J,Paul DS,Elling U,Allayee H,Li X,Radhakrishnan A,Tan ST,Voss K,Weichenberger CX,Albers CA,Al-Hussani A,Asselbergs FW,Ciullo M,Danjou F,Dina C,Esko T,Evans DM,Franke L,G?gele M,Hartiala J,Hersch M,Holm H,Hottenga JJ,Kanoni S,Kleber ME,Lagou V,Langenberg C,Lopez LM,Lyytik?inen LP,Melander O,Murgia F,Nolte IM,O'Reilly PF,Padmanabhan S,Parsa A,Pirastu N,Porcu E,Portas L,Prokopenko I,Ried JS,Shin SY,Tang CS,Teumer A,Traglia M,Ulivi S,Westra HJ,Yang J,Zhao JH,Anni F,Abdellaoui A,Attwood A,Balkau B,Bandinelli S,Bastardot F,Benyamin B,Boehm BO,Cookson WO,Das D,de Bakker PI,de Boer RA,de Geus EJ,de Moor MH,Dimitriou M,Domingues FS,D?ring A,Engstr?m G,Eyjolfsson GI,Ferrucci L,Fischer K,Galanello R,Garner SF,Genser B,Gibson QD,Girotto G,Gudbjartsson DF,Harris SE,Hartikainen AL,Hastie CE,Hedblad B,Illig T,Jolley J,K?h?nen M,Kema IP,Kemp JP,Liang L,Lloyd-Jones H,Loos RJ,Meacham S,Medland SE,Meisinger C,Memari Y,Mihailov E,Miller K,Moffatt MF,Nauck M,Novatchkova M,Nutile T,Olafsson I,Onundarson PT,Parracciani D,Penninx BW,Perseu L,Piga A,Pistis G,Pouta A,Puc U,Raitakari O,Ring SM,Robino A,Ruggiero D,Ruokonen A,Saint-Pierre A,Sala C,Salumets A,Sambrook J,Schepers H,Schmidt CO,Sillj? HH,Sladek R,Smit JH,Starr JM,Stephens J,Sulem P,Tanaka T,Thorsteinsdottir U,Tragante V,van Gilst WH,van Pelt LJ,van Veldhuisen DJ,V?lker U,Whitfield JB,Willemsen G,Winkelmann BR,Wirnsberger G,Algra A,Cucca F,d'Adamo AP,Danesh J,Deary IJ,Dominiczak AF,Elliott P,Fortina P,Froguel P,Gasparini P,Greinacher A,Hazen SL,Jarvelin MR,Khaw KT,Lehtim?ki T,Maerz W,Martin NG,Metspalu A,Mitchell BD,Montgomery GW,Moore C,Navis G,Pirastu M,Pramstaller PP,Ramirez-Solis R,Schadt E,Scott J,Shuldiner AR,Smith GD,Smith JG,Snieder H,Sorice R,Spector TD,Stefansson K,Stumvoll M,Tang WH,Toniolo D,T?njes A,Visscher PM,Vollenweider P,Wareham NJ,Wolffenbuttel BH,Boomsma DI,Beckmann JS,Dedoussis GV,Deloukas P,Ferreira MA,Sanna S,Uda M,Hicks AA,Penninger JM,Gieger C,Kooner JS,Ouwehand WH,Soranzo N,Chambers JC

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

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HEYL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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