GBP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GBP1
Entrez Gene ID	2633
Full Name	guanylate binding protein 1
General protein information	Preferred Names guanylate binding protein 1 Names guanylate-binding protein 1 GBP-1 GTP-binding protein 1 guanine nucleotide-binding protein 1 guanylate binding protein 1, interferon-inducible, 67kDa huGBP-1 interferon-induced guanylate-binding protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p22.2
Summary	Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008].
Disorder MIM:	600411

mRNA and Protein(s)

mRNA	Protein	Name
NM_002053.2	NP_002044.2	guanylate-binding protein 1
XM_024446351.1	XP_024302119.1	guanylate-binding protein 1 isoform X1
NM_002053.3	NP_002044.2	guanylate-binding protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gbp1	XP_006233487.1
Gallus gallus (chicken)	GBP7	XP_427251.4
Danio rerio (zebrafish)	LOC100334992	XP_002665322.3
Danio rerio (zebrafish)	LOC100334716	XP_002660908.2
Homo sapiens (human)	GBP1	NP_002044.2
Bos taurus (cattle)	LOC511531	XP_005204419.1
Danio rerio (zebrafish)	si:ch211-209n20.1	XP_002660909.3
Danio rerio (zebrafish)	si:dkey-61p9.3	NP_001038355.1
Danio rerio (zebrafish)	LOC100535674	XP_003200453.2
Canis lupus familiaris (dog)	GBP1	XP_005622016.1
Danio rerio (zebrafish)	gbp1	NP_001002343.1
Pan troglodytes (chimpanzee)	GBP1	XP_001147994.1
Bos taurus (cattle)	LOC512486	NP_001231158.1
Danio rerio (zebrafish)	LOC100149641	XP_001920654.4

Gene Ontology
Bibliography

Related articles in PubMed

T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.
Mustafa DAM, Pedrosa RMSM, Smid M, van der Weiden M, de Weerd V, Nigg AL, Berrevoets C, Zeneyedpour L, Priego N, Valiente M, Luider TM, Debets R, Martens JWM, Foekens JA, Sieuwerts AM, Kros JM
Acta neuropathologica(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, these results provide a new understanding of the antiviral mechanism of human GBP1, which possesses potent anti-Kaposi's sarcoma-associated herpesvirus activity, and suggest the critical role of viral RTA in the evasion of the innate immune response during primary infection by Kaposi's sarcoma-associated herpesvirus.
Title: Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament.

Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution.
Title: The human guanylate-binding proteins hGBP-1 and hGBP-5 cycle between monomers and dimers only.

In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1, TLR3, OAS1, EIF2AK2, HLA-E, IFI6, and STAT1, showed higher expression in the islet core compared with the peri-islet area containing the surrounding immune cells
Title: Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes.

Elevated hGBP-1 RNA in ovarian tumors correlates with shorter recurrence-free survival. hGBP-1 does not confer paclitaxel resistance on MCF-7 and TMX2-28 breast cancer cells.
Title: Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel.

the study not only highlights the importance of hGBP1 tetramer in stimulated GMP formation, but also demonstrates its role in the antiviral activity against hepatitis C virus.
Title: Tetrameric assembly of hGBP1 is crucial for both stimulated GMP formation and antiviral activity.

The following GBP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GBP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19969	NM_002053.3 Latest version!	Homo sapiens guanylate binding protein 1 (GBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OHu33339	XM_024446351.1 Latest version!	Homo sapiens guanylate binding protein 1 (GBP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu19969	NM_002053.2	Homo sapiens guanylate binding protein 1 (GBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GBP1 ( NM_002053.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002044.2 Homo sapiens guanylate binding protein 1 (GBP1), mRNA.

Price & Availability↑

CloneID	OHu19969
Clone ID Related Accession (Same CDS sequence)	NM_002053.2 , NM_002053.3
Accession Version	NM_002053.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	guanylate-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC002666.2, AK291783.1, CB164272.1, BF058809.1 and CD676970.1. On Feb 1, 2008 this sequence version replaced NM_002053.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002666.2, SRR1803611.52693.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCATCAG AGATCCACAT GACAGGCCCA ATGTGCCTCA TTGAGAACAC TAATGGGCGA 
CTGATGGCGA ATCCAGAAGC TCTGAAGATC CTTTCTGCCA TTACACAGCC TATGGTGGTG 
GTGGCAATTG TGGGCCTCTA CCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGA 
AAGAAAAAGG GCTTCTCTCT GGGCTCCACG GTGCAGTCTC ACACTAAAGG AATCTGGATG 
TGGTGTGTGC CCCACCCCAA GAAGCCAGGC CACATCCTAG TTCTGCTGGA CACCGAGGGT 
CTGGGAGATG TAGAGAAGGG TGACAACCAG AATGACTCCT GGATCTTCGC CCTGGCCGTC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATAGGAACCA TCAACCAGCA GGCTATGGAC 
CAACTGTACT ATGTGACAGA GCTGACACAT AGAATCCGAT CAAAATCCTC ACCTGATGAG 
AATGAGAATG AGGTTGAGGA TTCAGCTGAC TTTGTGAGCT TCTTCCCAGA CTTTGTGTGG 
ACACTGAGAG ATTTCTCCCT GGACTTGGAA GCAGATGGAC AACCCCTCAC ACCAGATGAG 
TACCTGACAT ACTCCCTGAA GCTGAAGAAA GGTACCAGTC AAAAAGATGA AACTTTTAAC 
CTGCCCAGAC TCTGTATCCG GAAATTCTTC CCAAAGAAAA AATGCTTTGT CTTTGATCGG 
CCCGTTCACC GCAGGAAGCT TGCCCAGCTC GAGAAACTAC AAGATGAAGA GCTGGACCCC 
GAATTTGTGC AACAAGTAGC AGACTTCTGT TCCTACATCT TTAGTAATTC CAAAACTAAA 
ACTCTTTCAG GAGGCATCCA GGTCAACGGG CCTCGTCTAG AGAGCCTGGT GCTGACCTAC 
GTCAATGCCA TCAGCAGTGG GGATCTGCCG TGCATGGAGA ACGCAGTCCT GGCCTTGGCC 
CAGATAGAGA ACTCAGCTGC AGTGCAAAAG GCTATTGCCC ACTATGAACA GCAGATGGGC 
CAGAAGGTGC AGCTGCCCAC AGAAACCCTC CAGGAGCTGC TGGACCTGCA CAGGGACAGT 
GAGAGAGAGG CCATTGAAGT CTTCATCAGG AGTTCCTTCA AAGATGTGGA CCATCTATTT 
CAAAAGGAGT TAGCGGCCCA GCTAGAAAAA AAGCGGGATG ACTTTTGTAA ACAGAATCAG 
GAAGCATCAT CAGATCGTTG CTCAGCTTTA CTTCAGGTCA TTTTCAGTCC TCTAGAAGAA 
GAAGTGAAGG CGGGAATTTA TTCGAAACCA GGGGGCTATC GTCTCTTTGT TCAGAAGCTA 
CAAGACCTGA AGAAAAAGTA CTATGAGGAA CCGAGGAAGG GGATACAGGC TGAAGAGATT 
CTGCAGACAT ACTTGAAATC CAAGGAGTCT ATGACTGATG CAATTCTCCA GACAGACCAG 
ACTCTCACAG AAAAAGAAAA GGAGATTGAA GTGGAACGTG TGAAAGCTGA GTCTGCACAG 
GCTTCAGCAA AAATGTTGCA GGAAATGCAA AGAAAGAATG AGCAGATGAT GGAACAGAAG 
GAGAGGAGTT ATCAGGAACA CTTGAAACAA CTGACTGAGA AGATGGAGAA CGACAGGGTC 
CAGTTGCTGA AAGAGCAAGA GAGGACCCTC GCTCTTAAAC TTCAGGAACA GGAGCAACTA 
CTAAAAGAGG GATTTCAAAA AGAAAGCAGA ATAATGAAAA ATGAGATACA GGATCTCCAG 
ACGAAAATGA GACGACGAAA GGCATGTACC ATAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002044.2
CDS	221..1999
Translation	MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS

Target ORF information:

RefSeq Version	NM_002053.2
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate binding protein 1 (GBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002053.2

ORF Insert Sequence:

ATGGCATCAG AGATCCACAT GACAGGCCCA ATGTGCCTCA TTGAGAACAC TAATGGGCGA 
CTGATGGCGA ATCCAGAAGC TCTGAAGATC CTTTCTGCCA TTACACAGCC TATGGTGGTG 
GTGGCAATTG TGGGCCTCTA CCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGA 
AAGAAAAAGG GCTTCTCTCT GGGCTCCACG GTGCAGTCTC ACACTAAAGG AATCTGGATG 
TGGTGTGTGC CCCACCCCAA GAAGCCAGGC CACATCCTAG TTCTGCTGGA CACCGAGGGT 
CTGGGAGATG TAGAGAAGGG TGACAACCAG AATGACTCCT GGATCTTCGC CCTGGCCGTC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATAGGAACCA TCAACCAGCA GGCTATGGAC 
CAACTGTACT ATGTGACAGA GCTGACACAT AGAATCCGAT CAAAATCCTC ACCTGATGAG 
AATGAGAATG AGGTTGAGGA TTCAGCTGAC TTTGTGAGCT TCTTCCCAGA CTTTGTGTGG 
ACACTGAGAG ATTTCTCCCT GGACTTGGAA GCAGATGGAC AACCCCTCAC ACCAGATGAG 
TACCTGACAT ACTCCCTGAA GCTGAAGAAA GGTACCAGTC AAAAAGATGA AACTTTTAAC 
CTGCCCAGAC TCTGTATCCG GAAATTCTTC CCAAAGAAAA AATGCTTTGT CTTTGATCGG 
CCCGTTCACC GCAGGAAGCT TGCCCAGCTC GAGAAACTAC AAGATGAAGA GCTGGACCCC 
GAATTTGTGC AACAAGTAGC AGACTTCTGT TCCTACATCT TTAGTAATTC CAAAACTAAA 
ACTCTTTCAG GAGGCATCCA GGTCAACGGG CCTCGTCTAG AGAGCCTGGT GCTGACCTAC 
GTCAATGCCA TCAGCAGTGG GGATCTGCCG TGCATGGAGA ACGCAGTCCT GGCCTTGGCC 
CAGATAGAGA ACTCAGCTGC AGTGCAAAAG GCTATTGCCC ACTATGAACA GCAGATGGGC 
CAGAAGGTGC AGCTGCCCAC AGAAACCCTC CAGGAGCTGC TGGACCTGCA CAGGGACAGT 
GAGAGAGAGG CCATTGAAGT CTTCATCAGG AGTTCCTTCA AAGATGTGGA CCATCTATTT 
CAAAAGGAGT TAGCGGCCCA GCTAGAAAAA AAGCGGGATG ACTTTTGTAA ACAGAATCAG 
GAAGCATCAT CAGATCGTTG CTCAGCTTTA CTTCAGGTCA TTTTCAGTCC TCTAGAAGAA 
GAAGTGAAGG CGGGAATTTA TTCGAAACCA GGGGGCTATC GTCTCTTTGT TCAGAAGCTA 
CAAGACCTGA AGAAAAAGTA CTATGAGGAA CCGAGGAAGG GGATACAGGC TGAAGAGATT 
CTGCAGACAT ACTTGAAATC CAAGGAGTCT ATGACTGATG CAATTCTCCA GACAGACCAG 
ACTCTCACAG AAAAAGAAAA GGAGATTGAA GTGGAACGTG TGAAAGCTGA GTCTGCACAG 
GCTTCAGCAA AAATGTTGCA GGAAATGCAA AGAAAGAATG AGCAGATGAT GGAACAGAAG 
GAGAGGAGTT ATCAGGAACA CTTGAAACAA CTGACTGAGA AGATGGAGAA CGACAGGGTC 
CAGTTGCTGA AAGAGCAAGA GAGGACCCTC GCTCTTAAAC TTCAGGAACA GGAGCAACTA 
CTAAAAGAGG GATTTCAAAA AGAAAGCAGA ATAATGAAAA ATGAGATACA GGATCTCCAG 
ACGAAAATGA GACGACGAAA GGCATGTACC ATAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GBP1 ( NM_002053.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002044.2 Homo sapiens guanylate binding protein 1 (GBP1), mRNA.

Price & Availability↑

CloneID	OHu19969
Clone ID Related Accession (Same CDS sequence)	NM_002053.2 , NM_002053.3
Accession Version	NM_002053.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	guanylate-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK291783.1, CB164272.1, BF058809.1 and CD676970.1. On Nov 22, 2018 this sequence version replaced NM_002053.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.325369.1, SRR1803612.197542.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370473.5/ ENSP00000359504.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCATCAG AGATCCACAT GACAGGCCCA ATGTGCCTCA TTGAGAACAC TAATGGGCGA 
CTGATGGCGA ATCCAGAAGC TCTGAAGATC CTTTCTGCCA TTACACAGCC TATGGTGGTG 
GTGGCAATTG TGGGCCTCTA CCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGA 
AAGAAAAAGG GCTTCTCTCT GGGCTCCACG GTGCAGTCTC ACACTAAAGG AATCTGGATG 
TGGTGTGTGC CCCACCCCAA GAAGCCAGGC CACATCCTAG TTCTGCTGGA CACCGAGGGT 
CTGGGAGATG TAGAGAAGGG TGACAACCAG AATGACTCCT GGATCTTCGC CCTGGCCGTC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATAGGAACCA TCAACCAGCA GGCTATGGAC 
CAACTGTACT ATGTGACAGA GCTGACACAT AGAATCCGAT CAAAATCCTC ACCTGATGAG 
AATGAGAATG AGGTTGAGGA TTCAGCTGAC TTTGTGAGCT TCTTCCCAGA CTTTGTGTGG 
ACACTGAGAG ATTTCTCCCT GGACTTGGAA GCAGATGGAC AACCCCTCAC ACCAGATGAG 
TACCTGACAT ACTCCCTGAA GCTGAAGAAA GGTACCAGTC AAAAAGATGA AACTTTTAAC 
CTGCCCAGAC TCTGTATCCG GAAATTCTTC CCAAAGAAAA AATGCTTTGT CTTTGATCGG 
CCCGTTCACC GCAGGAAGCT TGCCCAGCTC GAGAAACTAC AAGATGAAGA GCTGGACCCC 
GAATTTGTGC AACAAGTAGC AGACTTCTGT TCCTACATCT TTAGTAATTC CAAAACTAAA 
ACTCTTTCAG GAGGCATCCA GGTCAACGGG CCTCGTCTAG AGAGCCTGGT GCTGACCTAC 
GTCAATGCCA TCAGCAGTGG GGATCTGCCG TGCATGGAGA ACGCAGTCCT GGCCTTGGCC 
CAGATAGAGA ACTCAGCTGC AGTGCAAAAG GCTATTGCCC ACTATGAACA GCAGATGGGC 
CAGAAGGTGC AGCTGCCCAC AGAAACCCTC CAGGAGCTGC TGGACCTGCA CAGGGACAGT 
GAGAGAGAGG CCATTGAAGT CTTCATCAGG AGTTCCTTCA AAGATGTGGA CCATCTATTT 
CAAAAGGAGT TAGCGGCCCA GCTAGAAAAA AAGCGGGATG ACTTTTGTAA ACAGAATCAG 
GAAGCATCAT CAGATCGTTG CTCAGCTTTA CTTCAGGTCA TTTTCAGTCC TCTAGAAGAA 
GAAGTGAAGG CGGGAATTTA TTCGAAACCA GGGGGCTATC GTCTCTTTGT TCAGAAGCTA 
CAAGACCTGA AGAAAAAGTA CTATGAGGAA CCGAGGAAGG GGATACAGGC TGAAGAGATT 
CTGCAGACAT ACTTGAAATC CAAGGAGTCT ATGACTGATG CAATTCTCCA GACAGACCAG 
ACTCTCACAG AAAAAGAAAA GGAGATTGAA GTGGAACGTG TGAAAGCTGA GTCTGCACAG 
GCTTCAGCAA AAATGTTGCA GGAAATGCAA AGAAAGAATG AGCAGATGAT GGAACAGAAG 
GAGAGGAGTT ATCAGGAACA CTTGAAACAA CTGACTGAGA AGATGGAGAA CGACAGGGTC 
CAGTTGCTGA AAGAGCAAGA GAGGACCCTC GCTCTTAAAC TTCAGGAACA GGAGCAACTA 
CTAAAAGAGG GATTTCAAAA AGAAAGCAGA ATAATGAAAA ATGAGATACA GGATCTCCAG 
ACGAAAATGA GACGACGAAA GGCATGTACC ATAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002044.2
CDS	69..1847
Translation	MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS

Target ORF information:

RefSeq Version	NM_002053.3
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate binding protein 1 (GBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002053.3

ORF Insert Sequence:

ATGGCATCAG AGATCCACAT GACAGGCCCA ATGTGCCTCA TTGAGAACAC TAATGGGCGA 
CTGATGGCGA ATCCAGAAGC TCTGAAGATC CTTTCTGCCA TTACACAGCC TATGGTGGTG 
GTGGCAATTG TGGGCCTCTA CCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGA 
AAGAAAAAGG GCTTCTCTCT GGGCTCCACG GTGCAGTCTC ACACTAAAGG AATCTGGATG 
TGGTGTGTGC CCCACCCCAA GAAGCCAGGC CACATCCTAG TTCTGCTGGA CACCGAGGGT 
CTGGGAGATG TAGAGAAGGG TGACAACCAG AATGACTCCT GGATCTTCGC CCTGGCCGTC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATAGGAACCA TCAACCAGCA GGCTATGGAC 
CAACTGTACT ATGTGACAGA GCTGACACAT AGAATCCGAT CAAAATCCTC ACCTGATGAG 
AATGAGAATG AGGTTGAGGA TTCAGCTGAC TTTGTGAGCT TCTTCCCAGA CTTTGTGTGG 
ACACTGAGAG ATTTCTCCCT GGACTTGGAA GCAGATGGAC AACCCCTCAC ACCAGATGAG 
TACCTGACAT ACTCCCTGAA GCTGAAGAAA GGTACCAGTC AAAAAGATGA AACTTTTAAC 
CTGCCCAGAC TCTGTATCCG GAAATTCTTC CCAAAGAAAA AATGCTTTGT CTTTGATCGG 
CCCGTTCACC GCAGGAAGCT TGCCCAGCTC GAGAAACTAC AAGATGAAGA GCTGGACCCC 
GAATTTGTGC AACAAGTAGC AGACTTCTGT TCCTACATCT TTAGTAATTC CAAAACTAAA 
ACTCTTTCAG GAGGCATCCA GGTCAACGGG CCTCGTCTAG AGAGCCTGGT GCTGACCTAC 
GTCAATGCCA TCAGCAGTGG GGATCTGCCG TGCATGGAGA ACGCAGTCCT GGCCTTGGCC 
CAGATAGAGA ACTCAGCTGC AGTGCAAAAG GCTATTGCCC ACTATGAACA GCAGATGGGC 
CAGAAGGTGC AGCTGCCCAC AGAAACCCTC CAGGAGCTGC TGGACCTGCA CAGGGACAGT 
GAGAGAGAGG CCATTGAAGT CTTCATCAGG AGTTCCTTCA AAGATGTGGA CCATCTATTT 
CAAAAGGAGT TAGCGGCCCA GCTAGAAAAA AAGCGGGATG ACTTTTGTAA ACAGAATCAG 
GAAGCATCAT CAGATCGTTG CTCAGCTTTA CTTCAGGTCA TTTTCAGTCC TCTAGAAGAA 
GAAGTGAAGG CGGGAATTTA TTCGAAACCA GGGGGCTATC GTCTCTTTGT TCAGAAGCTA 
CAAGACCTGA AGAAAAAGTA CTATGAGGAA CCGAGGAAGG GGATACAGGC TGAAGAGATT 
CTGCAGACAT ACTTGAAATC CAAGGAGTCT ATGACTGATG CAATTCTCCA GACAGACCAG 
ACTCTCACAG AAAAAGAAAA GGAGATTGAA GTGGAACGTG TGAAAGCTGA GTCTGCACAG 
GCTTCAGCAA AAATGTTGCA GGAAATGCAA AGAAAGAATG AGCAGATGAT GGAACAGAAG 
GAGAGGAGTT ATCAGGAACA CTTGAAACAA CTGACTGAGA AGATGGAGAA CGACAGGGTC 
CAGTTGCTGA AAGAGCAAGA GAGGACCCTC GCTCTTAAAC TTCAGGAACA GGAGCAACTA 
CTAAAAGAGG GATTTCAAAA AGAAAGCAGA ATAATGAAAA ATGAGATACA GGATCTCCAG 
ACGAAAATGA GACGACGAAA GGCATGTACC ATAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GBP1 ( XM_024446351.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302119.1 Homo sapiens guanylate binding protein 1 (GBP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu33339
Clone ID Related Accession (Same CDS sequence)	XM_024446351.1
Accession Version	XM_024446351.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	guanylate-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAAGTAC AGAGGAGAGA TCCCATCTAT GTGACAGAGC TGACACATAG AATCCGATCA 
AAATCCTCAC CTGATGAGAA TGAGAATGAG GTTGAGGATT CAGCTGACTT TGTGAGCTTC 
TTCCCAGACT TTGTGTGGAC ACTGAGAGAT TTCTCCCTGG ACTTGGAAGC AGATGGACAA 
CCCCTCACAC CAGATGAGTA CCTGACATAC TCCCTGAAGC TGAAGAAAGG TACCAGTCAA 
AAAGATGAAA CTTTTAACCT GCCCAGACTC TGTATCCGGA AATTCTTCCC AAAGAAAAAA 
TGCTTTGTCT TTGATCGGCC CGTTCACCGC AGGAAGCTTG CCCAGCTCGA GAAACTACAA 
GATGAAGAGC TGGACCCCGA ATTTGTGCAA CAAGTAGCAG ACTTCTGTTC CTACATCTTT 
AGTAATTCCA AAACTAAAAC TCTTTCAGGA GGCATCCAGG TCAACGGGCC TCGTCTAGAG 
AGCCTGGTGC TGACCTACGT CAATGCCATC AGCAGTGGGG ATCTGCCGTG CATGGAGAAC 
GCAGTCCTGG CCTTGGCCCA GATAGAGAAC TCAGCTGCAG TGCAAAAGGC TATTGCCCAC 
TATGAACAGC AGATGGGCCA GAAGGTGCAG CTGCCCACAG AAACCCTCCA GGAGCTGCTG 
GACCTGCACA GGGACAGTGA GAGAGAGGCC ATTGAAGTCT TCATCAGGAG TTCCTTCAAA 
GATGTGGACC ATCTATTTCA AAAGGAGTTA GCGGCCCAGC TAGAAAAAAA GCGGGATGAC 
TTTTGTAAAC AGAATCAGGA AGCATCATCA GATCGTTGCT CAGCTTTACT TCAGGTCATT 
TTCAGTCCTC TAGAAGAAGA AGTGAAGGCG GGAATTTATT CGAAACCAGG GGGCTATCGT 
CTCTTTGTTC AGAAGCTACA AGACCTGAAG AAAAAGTACT ATGAGGAACC GAGGAAGGGG 
ATACAGGCTG AAGAGATTCT GCAGACATAC TTGAAATCCA AGGAGTCTAT GACTGATGCA 
ATTCTCCAGA CAGACCAGAC TCTCACAGAA AAAGAAAAGG AGATTGAAGT GGAACGTGTG 
AAAGCTGAGT CTGCACAGGC TTCAGCAAAA ATGTTGCAGG AAATGCAAAG AAAGAATGAG 
CAGATGATGG AACAGAAGGA GAGGAGTTAT CAGGAACACT TGAAACAACT GACTGAGAAG 
ATGGAGAACG ACAGGGTCCA GTTGCTGAAA GAGCAAGAGA GGACCCTCGC TCTTAAACTT 
CAGGAACAGG AGCAACTACT AAAAGAGGGA TTTCAAAAAG AAAGCAGAAT AATGAAAAAT 
GAGATACAGG ATCTCCAGAC GAAAATGAGA CGACGAAAGG CATGTACCAT AAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302119.1
CDS	388..1764
Translation	MQVQRRDPIYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS

Target ORF information:

RefSeq Version	XM_024446351.1
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate binding protein 1 (GBP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446351.1

ORF Insert Sequence:

ATGCAAGTAC AGAGGAGAGA TCCCATCTAT GTGACAGAGC TGACACATAG AATCCGATCA 
AAATCCTCAC CTGATGAGAA TGAGAATGAG GTTGAGGATT CAGCTGACTT TGTGAGCTTC 
TTCCCAGACT TTGTGTGGAC ACTGAGAGAT TTCTCCCTGG ACTTGGAAGC AGATGGACAA 
CCCCTCACAC CAGATGAGTA CCTGACATAC TCCCTGAAGC TGAAGAAAGG TACCAGTCAA 
AAAGATGAAA CTTTTAACCT GCCCAGACTC TGTATCCGGA AATTCTTCCC AAAGAAAAAA 
TGCTTTGTCT TTGATCGGCC CGTTCACCGC AGGAAGCTTG CCCAGCTCGA GAAACTACAA 
GATGAAGAGC TGGACCCCGA ATTTGTGCAA CAAGTAGCAG ACTTCTGTTC CTACATCTTT 
AGTAATTCCA AAACTAAAAC TCTTTCAGGA GGCATCCAGG TCAACGGGCC TCGTCTAGAG 
AGCCTGGTGC TGACCTACGT CAATGCCATC AGCAGTGGGG ATCTGCCGTG CATGGAGAAC 
GCAGTCCTGG CCTTGGCCCA GATAGAGAAC TCAGCTGCAG TGCAAAAGGC TATTGCCCAC 
TATGAACAGC AGATGGGCCA GAAGGTGCAG CTGCCCACAG AAACCCTCCA GGAGCTGCTG 
GACCTGCACA GGGACAGTGA GAGAGAGGCC ATTGAAGTCT TCATCAGGAG TTCCTTCAAA 
GATGTGGACC ATCTATTTCA AAAGGAGTTA GCGGCCCAGC TAGAAAAAAA GCGGGATGAC 
TTTTGTAAAC AGAATCAGGA AGCATCATCA GATCGTTGCT CAGCTTTACT TCAGGTCATT 
TTCAGTCCTC TAGAAGAAGA AGTGAAGGCG GGAATTTATT CGAAACCAGG GGGCTATCGT 
CTCTTTGTTC AGAAGCTACA AGACCTGAAG AAAAAGTACT ATGAGGAACC GAGGAAGGGG 
ATACAGGCTG AAGAGATTCT GCAGACATAC TTGAAATCCA AGGAGTCTAT GACTGATGCA 
ATTCTCCAGA CAGACCAGAC TCTCACAGAA AAAGAAAAGG AGATTGAAGT GGAACGTGTG 
AAAGCTGAGT CTGCACAGGC TTCAGCAAAA ATGTTGCAGG AAATGCAAAG AAAGAATGAG 
CAGATGATGG AACAGAAGGA GAGGAGTTAT CAGGAACACT TGAAACAACT GACTGAGAAG 
ATGGAGAACG ACAGGGTCCA GTTGCTGAAA GAGCAAGAGA GGACCCTCGC TCTTAAACTT 
CAGGAACAGG AGCAACTACT AAAAGAGGGA TTTCAAAAAG AAAGCAGAAT AATGAAAAAT 
GAGATACAGG ATCTCCAGAC GAAAATGAGA CGACGAAAGG CATGTACCAT AAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.
Acta neuropathologica(2018 Jan)
Mustafa DAM,Pedrosa RMSM,Smid M,van der Weiden M,de Weerd V,Nigg AL,Berrevoets C,Zeneyedpour L,Priego N,Valiente M,Luider TM,Debets R,Martens JWM,Foekens JA,Sieuwerts AM,Kros JM

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GBP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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