NIPSNAP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NIPSNAP2
Entrez Gene ID	2631
Full Name	nipsnap homolog 2
Synonyms	GBAS
General protein information	Preferred Names nipsnap homolog 2 Names protein NipSnap homolog 2 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like 2 glioblastoma amplified sequence
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p11.2
Summary	This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. The encoded protein is localized to mitochondria and plays a role in oxidative phosphorylation. A pseudogene of this gene is located on the long arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].
Disorder MIM:	603004

mRNA and Protein(s)

mRNA	Protein	Name
NM_001483.2	NP_001474.1	protein NipSnap homolog 2 isoform 1
NM_001483.3	NP_001474.1	protein NipSnap homolog 2 isoform 1
NM_001202469.2	NP_001189398.1	protein NipSnap homolog 2 isoform 2
NM_001202469.1	NP_001189398.1	protein NipSnap homolog 2 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	GBAS	NP_001474.1
	GBAS	XP_002808399.1
Canis lupus familiaris (dog)	GBAS	XP_536828.1
Gallus gallus (chicken)	GBAS	NP_001025884.1
Drosophila melanogaster (fruit fly)	Nipsnap	NP_727931.1
Xenopus tropicalis (tropical clawed frog)	gbas	NP_001039092.1
Bos taurus (cattle)	GBAS	NP_001070479.1
Rattus norvegicus (Norway rat)	Gbas	NP_001017486.1
Pan troglodytes (chimpanzee)	GBAS	XP_001158461.1
Mus musculus (house mouse)	Gbas	NP_032121.3
Danio rerio (zebrafish)	gbas	NP_571109.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003200	XP_312904.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012981	XP_003436417.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production.
Yamamoto S, Ogasawara N, Yamamoto K, Uemura C, Takaya Y, Shiraishi T, Sato T, Hashimoto S, Tsutsumi H, Takano K, Himi T, Yokota SI
Biochemical and biophysical research communications483(3)911-916(2017 02)

NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.
Yamamoto S, Okamoto T, Ogasawara N, Hashimoto S, Shiraishi T, Sato T, Yamamoto K, Tsutsumi H, Takano K, Himi T, Itoh H, Yokota SI
Biochemical and biophysical research communications483(3)917-922(2017 02)

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.
Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, Chuprun JK, Jog NR, Houser SR, Koch WJ, Elrod JW, Madesh M
Molecular cell60(1)47-62(2015 Oct)

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR
Autophagy10(10)1749-60(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified mitochondrial proteins 4-nitrophenylphosphatase domain and non-neuronal synaptosomal associated protein 25-like protein homolog (NIP-SNAP)-1 and -2 as clarithromycin-binding proteins. Production of proinflammatory cytokines induced by lipopolysaccharides and Pam3-CSK4 in epithelial cell lines BEAS-2B and T24 were suppressed by knockdown of NIP-SNAP-1 or -2
Title: Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production.

NIP-SNAP-1 and -2 localized in the mitochondrial inner membrane space, whereas HSP60 localized in the matrix. Expression levels of NIP-SNAP-1 and -2 in cells were decreased by knockdown of HSP60, but not HSP10. The findings indicate that HSP60 promotes folding and maintains the stability of NIP-SNAP-1 and -2.
Title: NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.

GBAS mutations could not explain phenotype of patients with combined oxidative phosphorylation system deficiencies.
Title: Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.

CHCHD10 and GBAS are involved in oxidative phosphorylation.
Title: Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following NIPSNAP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NIPSNAP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15783	NM_001483.3 Latest version!	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu15870	NM_001202469.2 Latest version!	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu15783	NM_001483.2	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu15870	NM_001202469.1	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NIPSNAP2 ( NM_001483.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001474.1 Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15783
Clone ID Related Accession (Same CDS sequence)	NM_001483.2 , NM_001483.3
Accession Version	NM_001483.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Homo sapiens(human)
Product	protein NipSnap homolog 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX166452.1, BC030821.1 and BU753659.1. On Feb 3, 2011 this sequence version replaced NM_001483.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660803.157351.1, SRR1660803.59152.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTTCACAAT 
GTTAAACCGG AATGCCTAGA AGCATACAAC AAAATTTGTC AAGAGGTGTT GCCAAAGATT 
CACGAAGATA AACACTACCC TTGTACTTTG GTGGGGACTT GGAACACGTG GTATGGCGAG 
CAGGACCAAG CTGTCCACCT CTGGAGGTAT GAAGGAGGCT ATCCAGCCCT CACAGAAGTC 
ATGAATAAAC TCAGAGAAAA TAAGGAATTT TTGGAATTTC GTAAGGCAAG AAGTGACATG 
CTTCTCTCCA GGAAGAATCA GCTCCTGTTG GAGTTCAGTT TCTGGAATGA GCCTGTGCCA 
AGATCCGGAC CTAATATATA TGAACTCAGG TCTTACCAAC TCCGACCAGG AACCATGATT 
GAATGGGGCA ATTACTGGGC TCGTGCAATC CGCTTCAGAC AGGATGGTAA CGAAGCCGTC 
GGAGGATTCT TCTCTCAGAT TGGGCAGCTG TACATGGTGC ACCATCTTTG GGCTTACAGG 
GATCTTCAGA CCAGGGAAGA CATACGGAAT GCAGCATGGC ACAAACATGG CTGGGAGGAA 
TTGGTATATT ACACAGTTCC ACTTATTCAG GAAATGGAAT CCAGAATCAT GATCCCACTG 
AAGACCTCGC CCCTCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001474.1
CDS	34..894
Translation	MAARVLRARGAAWAGGLLQRAAPCSLLPRLRTWTSSSNRSREDSWLKSLFVRKVDPRKDAHSNLLAKKETSNLYKLQFHNVKPECLEAYNKICQEVLPKIHEDKHYPCTLVGTWNTWYGEQDQAVHLWRYEGGYPALTEVMNKLRENKEFLEFRKARSDMLLSRKNQLLLEFSFWNEPVPRSGPNIYELRSYQLRPGTMIEWGNYWARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ

Target ORF information:

RefSeq Version	NM_001483.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001483.2

ORF Insert Sequence:

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTTCACAAT 
GTTAAACCGG AATGCCTAGA AGCATACAAC AAAATTTGTC AAGAGGTGTT GCCAAAGATT 
CACGAAGATA AACACTACCC TTGTACTTTG GTGGGGACTT GGAACACGTG GTATGGCGAG 
CAGGACCAAG CTGTCCACCT CTGGAGGTAT GAAGGAGGCT ATCCAGCCCT CACAGAAGTC 
ATGAATAAAC TCAGAGAAAA TAAGGAATTT TTGGAATTTC GTAAGGCAAG AAGTGACATG 
CTTCTCTCCA GGAAGAATCA GCTCCTGTTG GAGTTCAGTT TCTGGAATGA GCCTGTGCCA 
AGATCCGGAC CTAATATATA TGAACTCAGG TCTTACCAAC TCCGACCAGG AACCATGATT 
GAATGGGGCA ATTACTGGGC TCGTGCAATC CGCTTCAGAC AGGATGGTAA CGAAGCCGTC 
GGAGGATTCT TCTCTCAGAT TGGGCAGCTG TACATGGTGC ACCATCTTTG GGCTTACAGG 
GATCTTCAGA CCAGGGAAGA CATACGGAAT GCAGCATGGC ACAAACATGG CTGGGAGGAA 
TTGGTATATT ACACAGTTCC ACTTATTCAG GAAATGGAAT CCAGAATCAT GATCCCACTG 
AAGACCTCGC CCCTCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NIPSNAP2 ( NM_001483.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001474.1 Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15783
Clone ID Related Accession (Same CDS sequence)	NM_001483.2 , NM_001483.3
Accession Version	NM_001483.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	protein NipSnap homolog 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX166452.1, BC030821.1 and BU753659.1. On Nov 22, 2018 this sequence version replaced NM_001483.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.62888.1, SRR3476690.323305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000322090.8/ ENSP00000313050.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTTCACAAT 
GTTAAACCGG AATGCCTAGA AGCATACAAC AAAATTTGTC AAGAGGTGTT GCCAAAGATT 
CACGAAGATA AACACTACCC TTGTACTTTG GTGGGGACTT GGAACACGTG GTATGGCGAG 
CAGGACCAAG CTGTCCACCT CTGGAGGTAT GAAGGAGGCT ATCCAGCCCT CACAGAAGTC 
ATGAATAAAC TCAGAGAAAA TAAGGAATTT TTGGAATTTC GTAAGGCAAG AAGTGACATG 
CTTCTCTCCA GGAAGAATCA GCTCCTGTTG GAGTTCAGTT TCTGGAATGA GCCTGTGCCA 
AGATCCGGAC CTAATATATA TGAACTCAGG TCTTACCAAC TCCGACCAGG AACCATGATT 
GAATGGGGCA ATTACTGGGC TCGTGCAATC CGCTTCAGAC AGGATGGTAA CGAAGCCGTC 
GGAGGATTCT TCTCTCAGAT TGGGCAGCTG TACATGGTGC ACCATCTTTG GGCTTACAGG 
GATCTTCAGA CCAGGGAAGA CATACGGAAT GCAGCATGGC ACAAACATGG CTGGGAGGAA 
TTGGTATATT ACACAGTTCC ACTTATTCAG GAAATGGAAT CCAGAATCAT GATCCCACTG 
AAGACCTCGC CCCTCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001474.1
CDS	26..886
Translation	MAARVLRARGAAWAGGLLQRAAPCSLLPRLRTWTSSSNRSREDSWLKSLFVRKVDPRKDAHSNLLAKKETSNLYKLQFHNVKPECLEAYNKICQEVLPKIHEDKHYPCTLVGTWNTWYGEQDQAVHLWRYEGGYPALTEVMNKLRENKEFLEFRKARSDMLLSRKNQLLLEFSFWNEPVPRSGPNIYELRSYQLRPGTMIEWGNYWARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ

Target ORF information:

RefSeq Version	NM_001483.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001483.3

ORF Insert Sequence:

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTTCACAAT 
GTTAAACCGG AATGCCTAGA AGCATACAAC AAAATTTGTC AAGAGGTGTT GCCAAAGATT 
CACGAAGATA AACACTACCC TTGTACTTTG GTGGGGACTT GGAACACGTG GTATGGCGAG 
CAGGACCAAG CTGTCCACCT CTGGAGGTAT GAAGGAGGCT ATCCAGCCCT CACAGAAGTC 
ATGAATAAAC TCAGAGAAAA TAAGGAATTT TTGGAATTTC GTAAGGCAAG AAGTGACATG 
CTTCTCTCCA GGAAGAATCA GCTCCTGTTG GAGTTCAGTT TCTGGAATGA GCCTGTGCCA 
AGATCCGGAC CTAATATATA TGAACTCAGG TCTTACCAAC TCCGACCAGG AACCATGATT 
GAATGGGGCA ATTACTGGGC TCGTGCAATC CGCTTCAGAC AGGATGGTAA CGAAGCCGTC 
GGAGGATTCT TCTCTCAGAT TGGGCAGCTG TACATGGTGC ACCATCTTTG GGCTTACAGG 
GATCTTCAGA CCAGGGAAGA CATACGGAAT GCAGCATGGC ACAAACATGG CTGGGAGGAA 
TTGGTATATT ACACAGTTCC ACTTATTCAG GAAATGGAAT CCAGAATCAT GATCCCACTG 
AAGACCTCGC CCCTCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NIPSNAP2 ( NM_001202469.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001189398.1 Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15870
Clone ID Related Accession (Same CDS sequence)	NM_001202469.2 , NM_001202469.1
Accession Version	NM_001202469.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	protein NipSnap homolog 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX166452.1, AK097049.1, BC030821.1 and BU753659.1. On Jun 1, 2019 this sequence version replaced NM_001202469.1. Transcript Variant: This variant (2) lacks two exons in the coding region, which result in a frameshift and then resumption of the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.83810.1, SRR1660809.175836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTCAAGAGG 
TGTTGCCAAA GATTCACGAA GATAAACACT ACCCTTGTAC TTTGGTGGGG ACTTGGAACA 
CGTGGTATGG CGAGCAGGAC CAAGCTGGAA TTTTTGGAAT TTCGTAAGGC AAGAAGTGAC 
ATGCTTCTCT CCAGGAAGAA TCAGCTCCTG TTGGAGTTCA GTTTCTGGAA TGAGCCTGTG 
CCAAGATCCG GACCTAATAT ATATGAACTC AGGTCTTACC AACTCCGACC AGGAACCATG 
ATTGAATGGG GCAATTACTG GGCTCGTGCA ATCCGCTTCA GACAGGATGG TAACGAAGCC 
GTCGGAGGAT TCTTCTCTCA GATTGGGCAG CTGTACATGG TGCACCATCT TTGGGCTTAC 
AGGGATCTTC AGACCAGGGA AGACATACGG AATGCAGCAT GGCACAAACA TGGCTGGGAG 
GAATTGGTAT ATTACACAGT TCCACTTATT CAGGAAATGG AATCCAGAAT CATGATCCCA 
CTGAAGACCT CGCCCCTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001189398.1
CDS	26..769
Translation	MAARVLRARGAAWAGGLLQRAAPCSLLPRLRTWTSSSNRSREDSWLKSLFVRKVDPRKDAHSNLLAKKETSNLYKLQFKRCCQRFTKINTTLVLWWGLGTRGMASRTKLEFLEFRKARSDMLLSRKNQLLLEFSFWNEPVPRSGPNIYELRSYQLRPGTMIEWGNYWARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ

Target ORF information:

RefSeq Version	NM_001202469.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001202469.2

ORF Insert Sequence:

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTCAAGAGG 
TGTTGCCAAA GATTCACGAA GATAAACACT ACCCTTGTAC TTTGGTGGGG ACTTGGAACA 
CGTGGTATGG CGAGCAGGAC CAAGCTGGAA TTTTTGGAAT TTCGTAAGGC AAGAAGTGAC 
ATGCTTCTCT CCAGGAAGAA TCAGCTCCTG TTGGAGTTCA GTTTCTGGAA TGAGCCTGTG 
CCAAGATCCG GACCTAATAT ATATGAACTC AGGTCTTACC AACTCCGACC AGGAACCATG 
ATTGAATGGG GCAATTACTG GGCTCGTGCA ATCCGCTTCA GACAGGATGG TAACGAAGCC 
GTCGGAGGAT TCTTCTCTCA GATTGGGCAG CTGTACATGG TGCACCATCT TTGGGCTTAC 
AGGGATCTTC AGACCAGGGA AGACATACGG AATGCAGCAT GGCACAAACA TGGCTGGGAG 
GAATTGGTAT ATTACACAGT TCCACTTATT CAGGAAATGG AATCCAGAAT CATGATCCCA 
CTGAAGACCT CGCCCCTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NIPSNAP2 ( NM_001202469.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001189398.1 Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15870
Clone ID Related Accession (Same CDS sequence)	NM_001202469.2 , NM_001202469.1
Accession Version	NM_001202469.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	protein NipSnap homolog 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX166452.1, AK097049.1, BC030821.1 and BU753659.1. Transcript Variant: This variant (2) lacks two exons in the coding region, which result in a frameshift and then resumption of the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.83810.1, SRR1660809.175836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTCAAGAGG 
TGTTGCCAAA GATTCACGAA GATAAACACT ACCCTTGTAC TTTGGTGGGG ACTTGGAACA 
CGTGGTATGG CGAGCAGGAC CAAGCTGGAA TTTTTGGAAT TTCGTAAGGC AAGAAGTGAC 
ATGCTTCTCT CCAGGAAGAA TCAGCTCCTG TTGGAGTTCA GTTTCTGGAA TGAGCCTGTG 
CCAAGATCCG GACCTAATAT ATATGAACTC AGGTCTTACC AACTCCGACC AGGAACCATG 
ATTGAATGGG GCAATTACTG GGCTCGTGCA ATCCGCTTCA GACAGGATGG TAACGAAGCC 
GTCGGAGGAT TCTTCTCTCA GATTGGGCAG CTGTACATGG TGCACCATCT TTGGGCTTAC 
AGGGATCTTC AGACCAGGGA AGACATACGG AATGCAGCAT GGCACAAACA TGGCTGGGAG 
GAATTGGTAT ATTACACAGT TCCACTTATT CAGGAAATGG AATCCAGAAT CATGATCCCA 
CTGAAGACCT CGCCCCTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001189398.1
CDS	34..777
Translation	MAARVLRARGAAWAGGLLQRAAPCSLLPRLRTWTSSSNRSREDSWLKSLFVRKVDPRKDAHSNLLAKKETSNLYKLQFKRCCQRFTKINTTLVLWWGLGTRGMASRTKLEFLEFRKARSDMLLSRKNQLLLEFSFWNEPVPRSGPNIYELRSYQLRPGTMIEWGNYWARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ

Target ORF information:

RefSeq Version	NM_001202469.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nipsnap homolog 2 (NIPSNAP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001202469.1

ORF Insert Sequence:

ATGGCGGCGC GAGTGCTGCG CGCCCGCGGA GCGGCCTGGG CCGGCGGCCT CCTGCAGCGG 
GCGGCCCCCT GCAGCCTCCT GCCCAGGCTC CGGACATGGA CATCTTCCAG CAACAGATCT 
CGAGAAGACA GCTGGCTAAA ATCCTTATTT GTCCGGAAAG TTGATCCAAG AAAAGATGCC 
CACTCCAATC TCCTAGCCAA AAAGGAAACA AGCAATCTAT ACAAATTACA GTTCAAGAGG 
TGTTGCCAAA GATTCACGAA GATAAACACT ACCCTTGTAC TTTGGTGGGG ACTTGGAACA 
CGTGGTATGG CGAGCAGGAC CAAGCTGGAA TTTTTGGAAT TTCGTAAGGC AAGAAGTGAC 
ATGCTTCTCT CCAGGAAGAA TCAGCTCCTG TTGGAGTTCA GTTTCTGGAA TGAGCCTGTG 
CCAAGATCCG GACCTAATAT ATATGAACTC AGGTCTTACC AACTCCGACC AGGAACCATG 
ATTGAATGGG GCAATTACTG GGCTCGTGCA ATCCGCTTCA GACAGGATGG TAACGAAGCC 
GTCGGAGGAT TCTTCTCTCA GATTGGGCAG CTGTACATGG TGCACCATCT TTGGGCTTAC 
AGGGATCTTC AGACCAGGGA AGACATACGG AATGCAGCAT GGCACAAACA TGGCTGGGAG 
GAATTGGTAT ATTACACAGT TCCACTTATT CAGGAAATGG AATCCAGAAT CATGATCCCA 
CTGAAGACCT CGCCCCTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production.
Biochemical and biophysical research communications483(3)911-916(2017 02)
Yamamoto S,Ogasawara N,Yamamoto K,Uemura C,Takaya Y,Shiraishi T,Sato T,Hashimoto S,Tsutsumi H,Takano K,Himi T,Yokota SI

NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.
Biochemical and biophysical research communications483(3)917-922(2017 02)
Yamamoto S,Okamoto T,Ogasawara N,Hashimoto S,Shiraishi T,Sato T,Yamamoto K,Tsutsumi H,Takano K,Himi T,Itoh H,Yokota SI

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.
Molecular cell60(1)47-62(2015 Oct)
Shanmughapriya S,Rajan S,Hoffman NE,Higgins AM,Tomar D,Nemani N,Hines KJ,Smith DJ,Eguchi A,Vallem S,Shaikh F,Cheung M,Leonard NJ,Stolakis RS,Wolfers MP,Ibetti J,Chuprun JK,Jog NR,Houser SR,Koch WJ,Elrod JW,Madesh M

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
Autophagy10(10)1749-60(2014 Oct)
Dunlop EA,Seifan S,Claessens T,Behrends C,Kamps MA,Rozycka E,Kemp AJ,Nookala RK,Blenis J,Coull BJ,Murray JT,van Steensel MA,Wilkinson S,Tee AR

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NIPSNAP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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