MYCBP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYCBP
Entrez Gene ID	26292
Full Name	MYC binding protein
Synonyms	AMY-1
General protein information	Preferred Names MYC binding protein Names C-Myc-binding protein associate of myc-1 c-myc binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.3
Summary	The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011].
Disorder MIM:	606535

mRNA and Protein(s)

mRNA	Protein	Name
NM_012333.4	NP_036465.2	C-Myc-binding protein
NM_012333.5	NP_036465.2	C-Myc-binding protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mycbp	NP_062634.2
Danio rerio (zebrafish)	mycbp	NP_001035140.1
Homo sapiens (human)	MYCBP	NP_036465.2
Xenopus tropicalis (tropical clawed frog)	mycbp	NP_001017035.1
	MYCBP	XP_001113156.2
Canis lupus familiaris (dog)	MYCBP	NP_001239206.1
Rattus norvegicus (Norway rat)	Mycbp	NP_001258253.1
Gallus gallus (chicken)	MYCBP	XP_001232874.2
Pan troglodytes (chimpanzee)	MYCBP	XP_003949426.1
Bos taurus (cattle)	MYCBP	NP_001033654.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of c-Myc in pterygium and cultured pterygial cells.
Cui D, Pan Z, Zhang S, Zheng J, Huang Q, Wu K
Clinical & experimental ophthalmology39(8)784-92(2011 Nov)

Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein.
Xiong J, Du Q, Liang Z
Oncogene29(35)4980-8(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

c-Myc expression is reduced in pterygium compared with normal conjunctiva.
Title: Downregulation of c-Myc in pterygium and cultured pterygial cells.

miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities.
Title: Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein.

Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway.
Title: PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

An important role for MBP-1 in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration.
Title: c-myc promoter binding protein regulates the cellular response to an altered glucose concentration.

The following MYCBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYCBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01841	NM_012333.5 Latest version!	Homo sapiens MYC binding protein (MYCBP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01841	NM_012333.4	Homo sapiens MYC binding protein (MYCBP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYCBP ( NM_012333.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036465.2 Homo sapiens MYC binding protein (MYCBP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01841
Clone ID Related Accession (Same CDS sequence)	NM_012333.4 , NM_012333.5
Accession Version	NM_012333.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	C-Myc-binding protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU601195.1, BC008686.1, AL139260.19 and CN478752.1. On Dec 9, 2010 this sequence version replaced NM_012333.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.139194.1, SRR1803616.95332.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:12665801) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCATT ACAAAGCCGC CGACTCGAAG CGTGAGCAGT TCCGGAGGTA CTTGGAGAAG 
TCGGGGGTGC TGGACACGCT GACCAAGGTG TTGGTAGCCT TATATGAAGA ACCAGAGAAA 
CCTAACAGTG CTTTGGATTT TTTAAAGCAT CACTTAGGAG CTGCTACTCC AGAAAATCCA 
GAAATAGAGC TGCTTCGCCT AGAACTGGCC GAAATGAAAG AGAAGTATGA AGCTATTGTA 
GAAGAAAATA AAAAACTGAA AGCAAAGCTT GCTCAGTATG AACCACCTCA GGAGGAGAAG 
CGTGCTGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036465.2
CDS	74..385
Translation	MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKAKLAQYEPPQEEKRAE

Target ORF information:

RefSeq Version	NM_012333.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MYC binding protein (MYCBP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012333.4

ORF Insert Sequence:

ATGGCCCATT ACAAAGCCGC CGACTCGAAG CGTGAGCAGT TCCGGAGGTA CTTGGAGAAG 
TCGGGGGTGC TGGACACGCT GACCAAGGTG TTGGTAGCCT TATATGAAGA ACCAGAGAAA 
CCTAACAGTG CTTTGGATTT TTTAAAGCAT CACTTAGGAG CTGCTACTCC AGAAAATCCA 
GAAATAGAGC TGCTTCGCCT AGAACTGGCC GAAATGAAAG AGAAGTATGA AGCTATTGTA 
GAAGAAAATA AAAAACTGAA AGCAAAGCTT GCTCAGTATG AACCACCTCA GGAGGAGAAG 
CGTGCTGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYCBP ( NM_012333.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036465.2 Homo sapiens MYC binding protein (MYCBP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01841
Clone ID Related Accession (Same CDS sequence)	NM_012333.4 , NM_012333.5
Accession Version	NM_012333.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	C-Myc-binding protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU601195.1, BC008686.1, AL139260.19 and CN478752.1. On Nov 22, 2018 this sequence version replaced NM_012333.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.250899.1, SRR1660809.139194.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:12665801) MANE Ensembl match :: ENST00000397572.5/ ENSP00000380702.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCATT ACAAAGCCGC CGACTCGAAG CGTGAGCAGT TCCGGAGGTA CTTGGAGAAG 
TCGGGGGTGC TGGACACGCT GACCAAGGTG TTGGTAGCCT TATATGAAGA ACCAGAGAAA 
CCTAACAGTG CTTTGGATTT TTTAAAGCAT CACTTAGGAG CTGCTACTCC AGAAAATCCA 
GAAATAGAGC TGCTTCGCCT AGAACTGGCC GAAATGAAAG AGAAGTATGA AGCTATTGTA 
GAAGAAAATA AAAAACTGAA AGCAAAGCTT GCTCAGTATG AACCACCTCA GGAGGAGAAG 
CGTGCTGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036465.2
CDS	44..355
Translation	MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKAKLAQYEPPQEEKRAE

Target ORF information:

RefSeq Version	NM_012333.5
Organism	Homo sapiens(human)
Definition	Homo sapiens MYC binding protein (MYCBP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012333.5

ORF Insert Sequence:

ATGGCCCATT ACAAAGCCGC CGACTCGAAG CGTGAGCAGT TCCGGAGGTA CTTGGAGAAG 
TCGGGGGTGC TGGACACGCT GACCAAGGTG TTGGTAGCCT TATATGAAGA ACCAGAGAAA 
CCTAACAGTG CTTTGGATTT TTTAAAGCAT CACTTAGGAG CTGCTACTCC AGAAAATCCA 
GAAATAGAGC TGCTTCGCCT AGAACTGGCC GAAATGAAAG AGAAGTATGA AGCTATTGTA 
GAAGAAAATA AAAAACTGAA AGCAAAGCTT GCTCAGTATG AACCACCTCA GGAGGAGAAG 
CGTGCTGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of c-Myc in pterygium and cultured pterygial cells.
Clinical & experimental ophthalmology39(8)784-92(2011 Nov)
Cui D,Pan Z,Zhang S,Zheng J,Huang Q,Wu K

Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein.
Oncogene29(35)4980-8(2010 Sep)
Xiong J,Du Q,Liang Z

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MYCBP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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