GALNT8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GALNT8
Entrez Gene ID	26290
Full Name	polypeptide N-acetylgalactosaminyltransferase 8
Synonyms	GALNAC-T8
General protein information	Preferred Names polypeptide N-acetylgalactosaminyltransferase 8 Names probable polypeptide N-acetylgalactosaminyltransferase 8 GalNAc transferase 8 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 8 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8) polypeptide GalNAc transferase 8 pp-GaNTase 8 protein-UDP acetylgalactosaminyltransferase 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.32
Summary	This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008].
Disorder MIM:	606250

mRNA and Protein(s)

mRNA	Protein	Name
NM_017417.1	NP_059113.1	probable polypeptide N-acetylgalactosaminyltransferase 8
NM_017417.2	NP_059113.1	probable polypeptide N-acetylgalactosaminyltransferase 8

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GALNT8	XP_002687944.1
Danio rerio (zebrafish)	galnt8b	XP_003198271.2
Homo sapiens (human)	GALNT8	NP_059113.1
Canis lupus familiaris (dog)	GALNT8	XP_543861.3
Danio rerio (zebrafish)	galnt8	XP_003198272.1
Danio rerio (zebrafish)	LOC568500	XP_696923.6
Danio rerio (zebrafish)	LOC568645	XP_697079.2
Pan troglodytes (chimpanzee)	GALNT8	XP_003313486.1
Danio rerio (zebrafish)	galnt8a	XP_696970.2

Gene Ontology
Bibliography

Related articles in PubMed

Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings.
Hussain MR, Nasir J, Al-Aama JY
Journal of cellular biochemistry115(2)313-27(2014 Feb)

Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C.
Nakano R, Maekawa T, Abe H, Hayashida Y, Ochi H, Tsunoda T, Kumada H, Kamatani N, Nakamura Y, Chayama K
The Journal of general virology94(Pt 1)81-9(2013 Jan)

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanch? H, Schreiber S, Nebel A
Mutation research694(1-2)13-9(2010 Dec)

Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2.
Iwasaki H, Zhang Y, Tachibana K, Gotoh M, Kikuchi N, Kwon YD, Togayachi A, Kudo T, Kubota T, Narimatsu H
The Journal of biological chemistry278(8)5613-21(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we integrated different computational tools to perform the in silico analysis of clinically significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3, GALNT8, GALNT12, and GALNT13 genes.
Title: Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings.

GALNT8 variants were associated with treatment outcome independently of HCV genotype.
Title: Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C.

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

This enzyme initiates O-glycan synthesis in IgA1 the hinge region.
Title: Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2.

The following GALNT8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GALNT8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09924	NM_017417.2 Latest version!	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 8 (GALNT8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu09924	NM_017417.1	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 8 (GALNT8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GALNT8 ( NM_017417.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_059113.1 Homo sapiens polypeptide N-acetylgalactosaminyltransferase 8 (GALNT8), mRNA.

Price & Availability↑

CloneID	OHu09924
Clone ID Related Accession (Same CDS sequence)	NM_017417.1 , NM_017417.2
Accession Version	NM_017417.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1914bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	probable polypeptide N-acetylgalactosaminyltransferase 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ271385.1. ##Evidence-Data-START## Transcript exon combination :: AJ271385.1, BC140888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END##

ATGATGTTTT GGAGGAAACT CCCCAAAGCC CTCTTCATTG GGCTGACTCT GGCCATTGCT 
GTCAATCTCC TTCTGGTATT TTCTAGCAAG GGGACTTTAC AAAACCTGTT TACGGGTGGT 
CTCCACAGGG AGCTTCCTTT ACATCTGAAT AAACGCTACG GGGCAGTGAT AAAGAGACTC 
TCCCACTTGG AGGTGGAATT GCAGGATCTG AAAGAAAGTA TGAAATTAGC TCTGAGGCAA 
CAAGAAAATG TGAACAGCAC ACTGAAGAGG GCGAAAGATG AAGTACGCCC TCTTCTAAAG 
GCAATGGAAA CCAAGGTGAA TGAGACAAAG AAGCACAAAA CCCAAATGAA ACTCTTCCCA 
CACTCACAGC TTTTCAGGCA ATGGGGCGAG GATCTTTCTG AGGCCCAGCA GAAGGCGGCC 
CAGGACCTCT TCCGGAAGTT TGGTTACAAC GCGTACCTCA GCAACCAGCT GCCTCTCAAT 
CGCACCATCC CCGACACGCG AGACTACAGA TGTCTTCGGA AGACATATCC TTCCCAACTC 
CCATCCCTCA GTGTCATTCT CATATTCGTG AATGAAGCTC TGTCCATTAT ACAACGGGCC 
ATCACCAGTA TCATCAACCG GACGCCCTCT CGATTGTTGA AGGAAATCAT CTTGGTGGAT 
GATTTCAGCT CAAATGGAGA ACTAAAGGTA CACTTGGATG AGAAGATTAA GCTTTACAAC 
CAGAAGTATC CAGGACTACT GAAAATAATA CGGCATCCTG AAAGGAAAGG TCTTGCTCAA 
GCCCGCAACA CTGGCTGGGA AGCTGCCACA GCAGACGTGG TCGCCATCTT GGATGCTCAC 
ATTGAAGTCA ATGTTGGGTG GGCAGAGCCA ATCTTGGCTC GGATTCAGGA GGACCGCACT 
GTGATTGTGT CTCCTGTGTT TGACAACATT CGTTTTGACA CCTTCAAACT GGATAAGTAT 
GAACTGGCAG TTGATGGGTT TAACTGGGAA CTCTGGTGCC GCTACGATGC ACTGCCACAA 
GCCTGGATTG ATCTGCATGA TGTCACTGCC CCAGTGAAGA GTCCTTCAAT CATGGGCATC 
CTGGCTGCTA ACAGGCACTT CCTGGGAGAG ATCGGGTCTC TGGATGGTGG AATGCTCATC 
TATGGAGGAG AGAACGTGGA GCTTAGCCTG AGGGTGTGGC AGTGTGGAGG GAAGGTCGAG 
ATTTTGCCCT GTTCCCGGAT TGCCCACCTA GAGAGACACC ACAAGCCCTA CGCCTTGGAT 
CTCACCGCTG CCTTGAAGCG CAATGCTCTG CGAGTGGCCG AAATCTGGAT GGATGAGCAC 
AAACACATGG TCTACTTGGC CTGGAACATA CCTCTCCAGA ACTCTGGAAT AGATTTTGGA 
GACGTTTCTT CCAGAATGGC ACTCCGGGAA AAACTGAAAT GTAAAACTTT TGACTGGTAC 
CTGAAAAATG TTTATCCACT CTTGAAGCCA CTCCACACCA TCGTGGGCTA TGGAAGAATG 
AAAAACCTAT TGGATGAAAA TGTCTGCTTG GATCAGGGAC CCGTTCCAGG CAACACCCCC 
ATCATGTATT ACTGCCATGA ATTCAGCTCA CAGAATGTCT ACTATCACCT AACTGGGGAG 
CTCTATGTGG GACAACTGAT TGCAGAGGCC AGTGCTAGTG ATCGCTGCCT GACAGACCCT 
GGCAAGGCGG AGAAGCCCAC CTTAGAACCA TGCTCCAAGG CAGCTAAGAA TAGACTGCAT 
ATATATTGGG ATTTTAAACC GGGAGGAGCT GTCATAAACA GAGATACCAA GCGGTGTCTG 
GAGATGAAGA AGGATCTTTT GGGTAGCCAC GTGCTTGTGC TCCAGACCTG TAGCACGCAA 
GTGTGGGAAA TCCAGCACAC TGTCAGAGAC TGGGGTCAGA CCAACAGCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059113.1
CDS	93..2006
Translation	MMFWRKLPKALFIGLTLAIAVNLLLVFSSKGTLQNLFTGGLHRELPLHLNKRYGAVIKRLSHLEVELQDLKESMKLALRQQENVNSTLKRAKDEVRPLLKAMETKVNETKKHKTQMKLFPHSQLFRQWGEDLSEAQQKAAQDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALSIIQRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVDGFNWELWCRYDALPQAWIDLHDVTAPVKSPSIMGILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYALDLTAALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYPLLKPLHTIVGYGRMKNLLDENVCLDQGPVPGNTPIMYYCHEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCLEMKKDLLGSHVLVLQTCSTQVWEIQHTVRDWGQTNSQ

Target ORF information:

RefSeq Version	NM_017417.1
Organism	Homo sapiens(human)
Definition	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 8 (GALNT8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017417.1

ORF Insert Sequence:

ATGATGTTTT GGAGGAAACT CCCCAAAGCC CTCTTCATTG GGCTGACTCT GGCCATTGCT 
GTCAATCTCC TTCTGGTATT TTCTAGCAAG GGGACTTTAC AAAACCTGTT TACGGGTGGT 
CTCCACAGGG AGCTTCCTTT ACATCTGAAT AAACGCTACG GGGCAGTGAT AAAGAGACTC 
TCCCACTTGG AGGTGGAATT GCAGGATCTG AAAGAAAGTA TGAAATTAGC TCTGAGGCAA 
CAAGAAAATG TGAACAGCAC ACTGAAGAGG GCGAAAGATG AAGTACGCCC TCTTCTAAAG 
GCAATGGAAA CCAAGGTGAA TGAGACAAAG AAGCACAAAA CCCAAATGAA ACTCTTCCCA 
CACTCACAGC TTTTCAGGCA ATGGGGCGAG GATCTTTCTG AGGCCCAGCA GAAGGCGGCC 
CAGGACCTCT TCCGGAAGTT TGGTTACAAC GCGTACCTCA GCAACCAGCT GCCTCTCAAT 
CGCACCATCC CCGACACGCG AGACTACAGA TGTCTTCGGA AGACATATCC TTCCCAACTC 
CCATCCCTCA GTGTCATTCT CATATTCGTG AATGAAGCTC TGTCCATTAT ACAACGGGCC 
ATCACCAGTA TCATCAACCG GACGCCCTCT CGATTGTTGA AGGAAATCAT CTTGGTGGAT 
GATTTCAGCT CAAATGGAGA ACTAAAGGTA CACTTGGATG AGAAGATTAA GCTTTACAAC 
CAGAAGTATC CAGGACTACT GAAAATAATA CGGCATCCTG AAAGGAAAGG TCTTGCTCAA 
GCCCGCAACA CTGGCTGGGA AGCTGCCACA GCAGACGTGG TCGCCATCTT GGATGCTCAC 
ATTGAAGTCA ATGTTGGGTG GGCAGAGCCA ATCTTGGCTC GGATTCAGGA GGACCGCACT 
GTGATTGTGT CTCCTGTGTT TGACAACATT CGTTTTGACA CCTTCAAACT GGATAAGTAT 
GAACTGGCAG TTGATGGGTT TAACTGGGAA CTCTGGTGCC GCTACGATGC ACTGCCACAA 
GCCTGGATTG ATCTGCATGA TGTCACTGCC CCAGTGAAGA GTCCTTCAAT CATGGGCATC 
CTGGCTGCTA ACAGGCACTT CCTGGGAGAG ATCGGGTCTC TGGATGGTGG AATGCTCATC 
TATGGAGGAG AGAACGTGGA GCTTAGCCTG AGGGTGTGGC AGTGTGGAGG GAAGGTCGAG 
ATTTTGCCCT GTTCCCGGAT TGCCCACCTA GAGAGACACC ACAAGCCCTA CGCCTTGGAT 
CTCACCGCTG CCTTGAAGCG CAATGCTCTG CGAGTGGCCG AAATCTGGAT GGATGAGCAC 
AAACACATGG TCTACTTGGC CTGGAACATA CCTCTCCAGA ACTCTGGAAT AGATTTTGGA 
GACGTTTCTT CCAGAATGGC ACTCCGGGAA AAACTGAAAT GTAAAACTTT TGACTGGTAC 
CTGAAAAATG TTTATCCACT CTTGAAGCCA CTCCACACCA TCGTGGGCTA TGGAAGAATG 
AAAAACCTAT TGGATGAAAA TGTCTGCTTG GATCAGGGAC CCGTTCCAGG CAACACCCCC 
ATCATGTATT ACTGCCATGA ATTCAGCTCA CAGAATGTCT ACTATCACCT AACTGGGGAG 
CTCTATGTGG GACAACTGAT TGCAGAGGCC AGTGCTAGTG ATCGCTGCCT GACAGACCCT 
GGCAAGGCGG AGAAGCCCAC CTTAGAACCA TGCTCCAAGG CAGCTAAGAA TAGACTGCAT 
ATATATTGGG ATTTTAAACC GGGAGGAGCT GTCATAAACA GAGATACCAA GCGGTGTCTG 
GAGATGAAGA AGGATCTTTT GGGTAGCCAC GTGCTTGTGC TCCAGACCTG TAGCACGCAA 
GTGTGGGAAA TCCAGCACAC TGTCAGAGAC TGGGGTCAGA CCAACAGCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALNT8 ( NM_017417.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_059113.1 Homo sapiens polypeptide N-acetylgalactosaminyltransferase 8 (GALNT8), mRNA.

Price & Availability↑

CloneID	OHu09924
Clone ID Related Accession (Same CDS sequence)	NM_017417.1 , NM_017417.2
Accession Version	NM_017417.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1914bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	probable polypeptide N-acetylgalactosaminyltransferase 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005833.1 and AJ271385.1. On May 17, 2019 this sequence version replaced NM_017417.1. ##Evidence-Data-START## Transcript exon combination :: AJ271385.1, BC140888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252318.7/ ENSP00000252318.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATGTTTT GGAGGAAACT CCCCAAAGCC CTCTTCATTG GGCTGACTCT GGCCATTGCT 
GTCAATCTCC TTCTGGTATT TTCTAGCAAG GGGACTTTAC AAAACCTGTT TACGGGTGGT 
CTCCACAGGG AGCTTCCTTT ACATCTGAAT AAACGCTACG GGGCAGTGAT AAAGAGACTC 
TCCCACTTGG AGGTGGAATT GCAGGATCTG AAAGAAAGTA TGAAATTAGC TCTGAGGCAA 
CAAGAAAATG TGAACAGCAC ACTGAAGAGG GCGAAAGATG AAGTACGCCC TCTTCTAAAG 
GCAATGGAAA CCAAGGTGAA TGAGACAAAG AAGCACAAAA CCCAAATGAA ACTCTTCCCA 
CACTCACAGC TTTTCAGGCA ATGGGGCGAG GATCTTTCTG AGGCCCAGCA GAAGGCGGCC 
CAGGACCTCT TCCGGAAGTT TGGTTACAAC GCGTACCTCA GCAACCAGCT GCCTCTCAAT 
CGCACCATCC CCGACACGCG AGACTACAGA TGTCTTCGGA AGACATATCC TTCCCAACTC 
CCATCCCTCA GTGTCATTCT CATATTCGTG AATGAAGCTC TGTCCATTAT ACAACGGGCC 
ATCACCAGTA TCATCAACCG GACGCCCTCT CGATTGTTGA AGGAAATCAT CTTGGTGGAT 
GATTTCAGCT CAAATGGAGA ACTAAAGGTA CACTTGGATG AGAAGATTAA GCTTTACAAC 
CAGAAGTATC CAGGACTACT GAAAATAATA CGGCATCCTG AAAGGAAAGG TCTTGCTCAA 
GCCCGCAACA CTGGCTGGGA AGCTGCCACA GCAGACGTGG TCGCCATCTT GGATGCTCAC 
ATTGAAGTCA ATGTTGGGTG GGCAGAGCCA ATCTTGGCTC GGATTCAGGA GGACCGCACT 
GTGATTGTGT CTCCTGTGTT TGACAACATT CGTTTTGACA CCTTCAAACT GGATAAGTAT 
GAACTGGCAG TTGATGGGTT TAACTGGGAA CTCTGGTGCC GCTACGATGC ACTGCCACAA 
GCCTGGATTG ATCTGCATGA TGTCACTGCC CCAGTGAAGA GTCCTTCAAT CATGGGCATC 
CTGGCTGCTA ACAGGCACTT CCTGGGAGAG ATCGGGTCTC TGGATGGTGG AATGCTCATC 
TATGGAGGAG AGAACGTGGA GCTTAGCCTG AGGGTGTGGC AGTGTGGAGG GAAGGTCGAG 
ATTTTGCCCT GTTCCCGGAT TGCCCACCTA GAGAGACACC ACAAGCCCTA CGCCTTGGAT 
CTCACCGCTG CCTTGAAGCG CAATGCTCTG CGAGTGGCCG AAATCTGGAT GGATGAGCAC 
AAACACATGG TCTACTTGGC CTGGAACATA CCTCTCCAGA ACTCTGGAAT AGATTTTGGA 
GACGTTTCTT CCAGAATGGC ACTCCGGGAA AAACTGAAAT GTAAAACTTT TGACTGGTAC 
CTGAAAAATG TTTATCCACT CTTGAAGCCA CTCCACACCA TCGTGGGCTA TGGAAGAATG 
AAAAACCTAT TGGATGAAAA TGTCTGCTTG GATCAGGGAC CCGTTCCAGG CAACACCCCC 
ATCATGTATT ACTGCCATGA ATTCAGCTCA CAGAATGTCT ACTATCACCT AACTGGGGAG 
CTCTATGTGG GACAACTGAT TGCAGAGGCC AGTGCTAGTG ATCGCTGCCT GACAGACCCT 
GGCAAGGCGG AGAAGCCCAC CTTAGAACCA TGCTCCAAGG CAGCTAAGAA TAGACTGCAT 
ATATATTGGG ATTTTAAACC GGGAGGAGCT GTCATAAACA GAGATACCAA GCGGTGTCTG 
GAGATGAAGA AGGATCTTTT GGGTAGCCAC GTGCTTGTGC TCCAGACCTG TAGCACGCAA 
GTGTGGGAAA TCCAGCACAC TGTCAGAGAC TGGGGTCAGA CCAACAGCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059113.1
CDS	279..2192
Translation	MMFWRKLPKALFIGLTLAIAVNLLLVFSSKGTLQNLFTGGLHRELPLHLNKRYGAVIKRLSHLEVELQDLKESMKLALRQQENVNSTLKRAKDEVRPLLKAMETKVNETKKHKTQMKLFPHSQLFRQWGEDLSEAQQKAAQDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALSIIQRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVDGFNWELWCRYDALPQAWIDLHDVTAPVKSPSIMGILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYALDLTAALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYPLLKPLHTIVGYGRMKNLLDENVCLDQGPVPGNTPIMYYCHEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCLEMKKDLLGSHVLVLQTCSTQVWEIQHTVRDWGQTNSQ

Target ORF information:

RefSeq Version	NM_017417.2
Organism	Homo sapiens(human)
Definition	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 8 (GALNT8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017417.2

ORF Insert Sequence:

ATGATGTTTT GGAGGAAACT CCCCAAAGCC CTCTTCATTG GGCTGACTCT GGCCATTGCT 
GTCAATCTCC TTCTGGTATT TTCTAGCAAG GGGACTTTAC AAAACCTGTT TACGGGTGGT 
CTCCACAGGG AGCTTCCTTT ACATCTGAAT AAACGCTACG GGGCAGTGAT AAAGAGACTC 
TCCCACTTGG AGGTGGAATT GCAGGATCTG AAAGAAAGTA TGAAATTAGC TCTGAGGCAA 
CAAGAAAATG TGAACAGCAC ACTGAAGAGG GCGAAAGATG AAGTACGCCC TCTTCTAAAG 
GCAATGGAAA CCAAGGTGAA TGAGACAAAG AAGCACAAAA CCCAAATGAA ACTCTTCCCA 
CACTCACAGC TTTTCAGGCA ATGGGGCGAG GATCTTTCTG AGGCCCAGCA GAAGGCGGCC 
CAGGACCTCT TCCGGAAGTT TGGTTACAAC GCGTACCTCA GCAACCAGCT GCCTCTCAAT 
CGCACCATCC CCGACACGCG AGACTACAGA TGTCTTCGGA AGACATATCC TTCCCAACTC 
CCATCCCTCA GTGTCATTCT CATATTCGTG AATGAAGCTC TGTCCATTAT ACAACGGGCC 
ATCACCAGTA TCATCAACCG GACGCCCTCT CGATTGTTGA AGGAAATCAT CTTGGTGGAT 
GATTTCAGCT CAAATGGAGA ACTAAAGGTA CACTTGGATG AGAAGATTAA GCTTTACAAC 
CAGAAGTATC CAGGACTACT GAAAATAATA CGGCATCCTG AAAGGAAAGG TCTTGCTCAA 
GCCCGCAACA CTGGCTGGGA AGCTGCCACA GCAGACGTGG TCGCCATCTT GGATGCTCAC 
ATTGAAGTCA ATGTTGGGTG GGCAGAGCCA ATCTTGGCTC GGATTCAGGA GGACCGCACT 
GTGATTGTGT CTCCTGTGTT TGACAACATT CGTTTTGACA CCTTCAAACT GGATAAGTAT 
GAACTGGCAG TTGATGGGTT TAACTGGGAA CTCTGGTGCC GCTACGATGC ACTGCCACAA 
GCCTGGATTG ATCTGCATGA TGTCACTGCC CCAGTGAAGA GTCCTTCAAT CATGGGCATC 
CTGGCTGCTA ACAGGCACTT CCTGGGAGAG ATCGGGTCTC TGGATGGTGG AATGCTCATC 
TATGGAGGAG AGAACGTGGA GCTTAGCCTG AGGGTGTGGC AGTGTGGAGG GAAGGTCGAG 
ATTTTGCCCT GTTCCCGGAT TGCCCACCTA GAGAGACACC ACAAGCCCTA CGCCTTGGAT 
CTCACCGCTG CCTTGAAGCG CAATGCTCTG CGAGTGGCCG AAATCTGGAT GGATGAGCAC 
AAACACATGG TCTACTTGGC CTGGAACATA CCTCTCCAGA ACTCTGGAAT AGATTTTGGA 
GACGTTTCTT CCAGAATGGC ACTCCGGGAA AAACTGAAAT GTAAAACTTT TGACTGGTAC 
CTGAAAAATG TTTATCCACT CTTGAAGCCA CTCCACACCA TCGTGGGCTA TGGAAGAATG 
AAAAACCTAT TGGATGAAAA TGTCTGCTTG GATCAGGGAC CCGTTCCAGG CAACACCCCC 
ATCATGTATT ACTGCCATGA ATTCAGCTCA CAGAATGTCT ACTATCACCT AACTGGGGAG 
CTCTATGTGG GACAACTGAT TGCAGAGGCC AGTGCTAGTG ATCGCTGCCT GACAGACCCT 
GGCAAGGCGG AGAAGCCCAC CTTAGAACCA TGCTCCAAGG CAGCTAAGAA TAGACTGCAT 
ATATATTGGG ATTTTAAACC GGGAGGAGCT GTCATAAACA GAGATACCAA GCGGTGTCTG 
GAGATGAAGA AGGATCTTTT GGGTAGCCAC GTGCTTGTGC TCCAGACCTG TAGCACGCAA 
GTGTGGGAAA TCCAGCACAC TGTCAGAGAC TGGGGTCAGA CCAACAGCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings.
Journal of cellular biochemistry115(2)313-27(2014 Feb)
Hussain MR,Nasir J,Al-Aama JY

Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C.
The Journal of general virology94(Pt 1)81-9(2013 Jan)
Nakano R,Maekawa T,Abe H,Hayashida Y,Ochi H,Tsunoda T,Kumada H,Kamatani N,Nakamura Y,Chayama K

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Mutation research694(1-2)13-9(2010 Dec)
Flachsbart F,Franke A,Kleindorp R,Caliebe A,Blanch? H,Schreiber S,Nebel A

Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2.
The Journal of biological chemistry278(8)5613-21(2003 Feb)
Iwasaki H,Zhang Y,Tachibana K,Gotoh M,Kikuchi N,Kwon YD,Togayachi A,Kudo T,Kubota T,Narimatsu H

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GALNT8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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