FBXO8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXO8
Entrez Gene ID	26269
Full Name	F-box protein 8
Synonyms	DC10,FBS,FBX8
General protein information	Preferred Names F-box protein 8 Names F-box only protein 8 F-box protein Fbx8 F-box/SEC7 protein FBS
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q34.1
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008].
Disorder MIM:	605649

mRNA and Protein(s)

mRNA	Protein	Name
NM_012180.2	NP_036312.2	F-box only protein 8
XM_017008020.1	XP_016863509.1	F-box only protein 8 isoform X1
NM_012180.3	NP_036312.2	F-box only protein 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXO8	NP_036312.2
Rattus norvegicus (Norway rat)	Fbxo8	NP_001012050.1
Canis lupus familiaris (dog)	FBXO8	XP_534554.3
Pan troglodytes (chimpanzee)	FBXO8	XP_517540.3
	FBXO8	XP_001087766.2
Mus musculus (house mouse)	Fbxo8	NP_056606.2
Bos taurus (cattle)	FBXO8	NP_001015667.1
Gallus gallus (chicken)	FBXO8	NP_001006446.1
Danio rerio (zebrafish)	fbxo8	NP_001035397.1
Xenopus tropicalis (tropical clawed frog)	fbxo8	NP_001120293.1

Gene Ontology
Bibliography

Related articles in PubMed

FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma.
Wang FF, Zhang XJ, Yan YR, Zhu XH, Yu J, Ding Y, Hu JL, Zhou WJ, Zeng ZC, Liao WT, Ding YQ, Liang L
Cancer letters38885-95(2017 Mar)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Significance of FBX8 in progression of gastric cancer.
Wu P, Wang F, Wang Y, Men H, Zhu X, He G, Ma W, Xin S, Wu J, Liao W, Ding Y, He M, Liang L
Experimental and molecular pathology98(3)360-6(2015 Jun)

Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma.
Yu Y, Sun L, Ren N, Li Y, Rong L, Zhao G
International journal of clinical and experimental pathology7(11)8071-6(2014)

FBX8 Acts as an Invasion and Metastasis Suppressor and Correlates with Poor Survival in Hepatocellular Carcinoma.
Wang F, Qiao Y, Yu J, Ren X, Wang J, Ding Y, Zhang X, Ma W, Ding Y, Liang L
PloS one8(6)e65495(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FBX8 as a metastasis suppressor that functions through mTOR signaling pathway and has significant prognostic power.
Title: FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma.

FBX8 was markedly down-regulated in gastric cancer tissues. Knocking down FBX8 promoted proliferation and invasion in tumor cell line. Patients with low FBX8 had poor prognosis.
Title: Significance of FBX8 in progression of gastric cancer.

FBX8 down-expression was an independent prognostic indicator for glioma patient's survival.
Title: Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma.

Study demonstrates that down-regulation of FBX8 in hepatocellular carcinoma (HCC) correlates with poor survival of patients. All of the functional experiments confirm FBX8 as a tumor suppressor in the progression of HCC. The preferential down-regulation of FBX8 in HCC patients with invasion and metastasis suggested that FBX8 may be a significant biomarker for HCC progression.
Title: FBX8 Acts as an Invasion and Metastasis Suppressor and Correlates with Poor Survival in Hepatocellular Carcinoma.

FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity
Title: c-Myc stimulates cell invasion by inhibiting FBX8 function.

The following FBXO8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXO8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13135	NM_012180.3 Latest version!	Homo sapiens F-box protein 8 (FBXO8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu95060	XM_017008020.1 Latest version!	Homo sapiens F-box protein 8 (FBXO8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu13135	NM_012180.2	Homo sapiens F-box protein 8 (FBXO8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXO8 ( NM_012180.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036312.2 Homo sapiens F-box protein 8 (FBXO8), mRNA.

Price & Availability↑

CloneID	OHu13135
Clone ID Related Accession (Same CDS sequence)	NM_012180.2 , NM_012180.3
Accession Version	NM_012180.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	F-box only protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014903.1 and AF115514.1. On Jun 18, 2004 this sequence version replaced NM_012180.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014903.1, AK123740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMN03267753 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTCAAG GGTTGTGGAG AGTGGTCAGA AACCAGCAGC TGCAACAAGA AGGCTACAGT 
GAGCAAGGCT ACCTCACCAG AGAGCAGAGC AGGAGAATGG CTGCGAGCAA CATTTCTAAC 
ACCAATCATC GTAAACAAGT CCAAGGAGGC ATTGACATAT ATCATCTTTT GAAGGCAAGG 
AAATCGAAAG AACAGGAAGG ATTCATTAAT TTGGAAATGT TGCCTCCTGA GCTAAGCTTT 
ACCATCTTGT CCTACCTGAA TGCAACTGAC CTTTGCTTGG CTTCATGTGT TTGGCAGGAC 
CTTGCGAATG ATGAACTTCT CTGGCAAGGG TTGTGCAAAT CCACTTGGGG TCACTGTTCC 
ATATACAATA AGAACCCACC TTTAGGATTT TCTTTTAGAA AATTGTATAT GCAGCTGGAT 
GAAGGCAGCC TCACCTTTAA TGCCAACCCA GATGAGGGAG TGAACTACTT TATGTCCAAG 
GGTATCCTGG ATGATTCGCC AAAGGAAATA GCAAAGTTTA TCTTCTGTAC AAGAACACTA 
AATTGGAAAA AACTGAGAAT CTATCTTGAT GAAAGGAGAG ATGTCTTGGA TGACCTTGTA 
ACATTGCATA ATTTTAGAAA TCAGTTCTTG CCAAATGCAC TGAGAGAATT TTTTCGTCAT 
ATCCATGCCC CTGAAGAGCG TGGAGAGTAT CTTGAAACTC TTATAACAAA GTTCTCACAT 
AGATTCTGTG CTTGCAACCC TGATTTAATG CGAGAACTTG GCCTTAGTCC TGATGCTGTC 
TATGTACTGT GCTACTCTTT GATTCTACTT TCCATTGACC TCACTAGCCC TCATGTGAAG 
AATAAAATGT CAAAAAGGGA ATTTATTCGA AATACCCGTC GCGCTGCTCA AAATATTAGT 
GAAGATTTTG TAGGGCATCT TTATGACAAT ATCTACCTTA TTGGCCATGT GGCTGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036312.2
CDS	851..1810
Translation	MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHRKQVQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA

Target ORF information:

RefSeq Version	NM_012180.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 8 (FBXO8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012180.2

ORF Insert Sequence:

ATGGGTCAAG GGTTGTGGAG AGTGGTCAGA AACCAGCAGC TGCAACAAGA AGGCTACAGT 
GAGCAAGGCT ACCTCACCAG AGAGCAGAGC AGGAGAATGG CTGCGAGCAA CATTTCTAAC 
ACCAATCATC GTAAACAAGT CCAAGGAGGC ATTGACATAT ATCATCTTTT GAAGGCAAGG 
AAATCGAAAG AACAGGAAGG ATTCATTAAT TTGGAAATGT TGCCTCCTGA GCTAAGCTTT 
ACCATCTTGT CCTACCTGAA TGCAACTGAC CTTTGCTTGG CTTCATGTGT TTGGCAGGAC 
CTTGCGAATG ATGAACTTCT CTGGCAAGGG TTGTGCAAAT CCACTTGGGG TCACTGTTCC 
ATATACAATA AGAACCCACC TTTAGGATTT TCTTTTAGAA AATTGTATAT GCAGCTGGAT 
GAAGGCAGCC TCACCTTTAA TGCCAACCCA GATGAGGGAG TGAACTACTT TATGTCCAAG 
GGTATCCTGG ATGATTCGCC AAAGGAAATA GCAAAGTTTA TCTTCTGTAC AAGAACACTA 
AATTGGAAAA AACTGAGAAT CTATCTTGAT GAAAGGAGAG ATGTCTTGGA TGACCTTGTA 
ACATTGCATA ATTTTAGAAA TCAGTTCTTG CCAAATGCAC TGAGAGAATT TTTTCGTCAT 
ATCCATGCCC CTGAAGAGCG TGGAGAGTAT CTTGAAACTC TTATAACAAA GTTCTCACAT 
AGATTCTGTG CTTGCAACCC TGATTTAATG CGAGAACTTG GCCTTAGTCC TGATGCTGTC 
TATGTACTGT GCTACTCTTT GATTCTACTT TCCATTGACC TCACTAGCCC TCATGTGAAG 
AATAAAATGT CAAAAAGGGA ATTTATTCGA AATACCCGTC GCGCTGCTCA AAATATTAGT 
GAAGATTTTG TAGGGCATCT TTATGACAAT ATCTACCTTA TTGGCCATGT GGCTGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO8 ( NM_012180.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036312.2 Homo sapiens F-box protein 8 (FBXO8), mRNA.

Price & Availability↑

CloneID	OHu13135
Clone ID Related Accession (Same CDS sequence)	NM_012180.2 , NM_012180.3
Accession Version	NM_012180.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	F-box only protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097653.2. On Jul 15, 2019 this sequence version replaced NM_012180.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF201932.1, AF115514.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTCAAG GGTTGTGGAG AGTGGTCAGA AACCAGCAGC TGCAACAAGA AGGCTACAGT 
GAGCAAGGCT ACCTCACCAG AGAGCAGAGC AGGAGAATGG CTGCGAGCAA CATTTCTAAC 
ACCAATCATC GTAAACAAGT CCAAGGAGGC ATTGACATAT ATCATCTTTT GAAGGCAAGG 
AAATCGAAAG AACAGGAAGG ATTCATTAAT TTGGAAATGT TGCCTCCTGA GCTAAGCTTT 
ACCATCTTGT CCTACCTGAA TGCAACTGAC CTTTGCTTGG CTTCATGTGT TTGGCAGGAC 
CTTGCGAATG ATGAACTTCT CTGGCAAGGG TTGTGCAAAT CCACTTGGGG TCACTGTTCC 
ATATACAATA AGAACCCACC TTTAGGATTT TCTTTTAGAA AATTGTATAT GCAGCTGGAT 
GAAGGCAGCC TCACCTTTAA TGCCAACCCA GATGAGGGAG TGAACTACTT TATGTCCAAG 
GGTATCCTGG ATGATTCGCC AAAGGAAATA GCAAAGTTTA TCTTCTGTAC AAGAACACTA 
AATTGGAAAA AACTGAGAAT CTATCTTGAT GAAAGGAGAG ATGTCTTGGA TGACCTTGTA 
ACATTGCATA ATTTTAGAAA TCAGTTCTTG CCAAATGCAC TGAGAGAATT TTTTCGTCAT 
ATCCATGCCC CTGAAGAGCG TGGAGAGTAT CTTGAAACTC TTATAACAAA GTTCTCACAT 
AGATTCTGTG CTTGCAACCC TGATTTAATG CGAGAACTTG GCCTTAGTCC TGATGCTGTC 
TATGTACTGT GCTACTCTTT GATTCTACTT TCCATTGACC TCACTAGCCC TCATGTGAAG 
AATAAAATGT CAAAAAGGGA ATTTATTCGA AATACCCGTC GCGCTGCTCA AAATATTAGT 
GAAGATTTTG TAGGGCATCT TTATGACAAT ATCTACCTTA TTGGCCATGT GGCTGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036312.2
CDS	267..1226
Translation	MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHRKQVQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA

Target ORF information:

RefSeq Version	NM_012180.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 8 (FBXO8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012180.3

ORF Insert Sequence:

ATGGGTCAAG GGTTGTGGAG AGTGGTCAGA AACCAGCAGC TGCAACAAGA AGGCTACAGT 
GAGCAAGGCT ACCTCACCAG AGAGCAGAGC AGGAGAATGG CTGCGAGCAA CATTTCTAAC 
ACCAATCATC GTAAACAAGT CCAAGGAGGC ATTGACATAT ATCATCTTTT GAAGGCAAGG 
AAATCGAAAG AACAGGAAGG ATTCATTAAT TTGGAAATGT TGCCTCCTGA GCTAAGCTTT 
ACCATCTTGT CCTACCTGAA TGCAACTGAC CTTTGCTTGG CTTCATGTGT TTGGCAGGAC 
CTTGCGAATG ATGAACTTCT CTGGCAAGGG TTGTGCAAAT CCACTTGGGG TCACTGTTCC 
ATATACAATA AGAACCCACC TTTAGGATTT TCTTTTAGAA AATTGTATAT GCAGCTGGAT 
GAAGGCAGCC TCACCTTTAA TGCCAACCCA GATGAGGGAG TGAACTACTT TATGTCCAAG 
GGTATCCTGG ATGATTCGCC AAAGGAAATA GCAAAGTTTA TCTTCTGTAC AAGAACACTA 
AATTGGAAAA AACTGAGAAT CTATCTTGAT GAAAGGAGAG ATGTCTTGGA TGACCTTGTA 
ACATTGCATA ATTTTAGAAA TCAGTTCTTG CCAAATGCAC TGAGAGAATT TTTTCGTCAT 
ATCCATGCCC CTGAAGAGCG TGGAGAGTAT CTTGAAACTC TTATAACAAA GTTCTCACAT 
AGATTCTGTG CTTGCAACCC TGATTTAATG CGAGAACTTG GCCTTAGTCC TGATGCTGTC 
TATGTACTGT GCTACTCTTT GATTCTACTT TCCATTGACC TCACTAGCCC TCATGTGAAG 
AATAAAATGT CAAAAAGGGA ATTTATTCGA AATACCCGTC GCGCTGCTCA AAATATTAGT 
GAAGATTTTG TAGGGCATCT TTATGACAAT ATCTACCTTA TTGGCCATGT GGCTGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO8 ( XM_017008020.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863509.1 Homo sapiens F-box protein 8 (FBXO8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu95060
Clone ID Related Accession (Same CDS sequence)	XM_017008020.1
Accession Version	XM_017008020.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box only protein 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCCTTC ATGAAGGAGT GAACTACTTT ATGTCCAAGG GTATCCTGGA TGATTCGCCA 
AAGGAAATAG CAAAGTTTAT CTTCTGTACA AGAACACTAA ATTGGAAAAA ACTGAGAATC 
TATCTTGATG AAAGGAGAGA TGTCTTGGAT GACCTTGTAA CATTGCATAA TTTTAGAAAT 
CAGTTCTTGC CAAATGCACT GAGAGAATTT TTTCGTCATA TCCATGCCCC TGAAGAGCGT 
GGAGAGTATC TTGAAACTCT TATAACAAAG TTCTCACATA GATTCTGTGC TTGCAACCCT 
GATTTAATGC GAGAACTTGG CCTTAGTCCT GATGCTGTCT ATGTACTGTG CTACTCTTTG 
ATTCTACTTT CCATTGACCT CACTAGCCCT CATGTGAAGA ATAAAATGTC AAAAAGGGAA 
TTTATTCGAA ATACCCGTCG CGCTGCTCAA AATATTAGTG AAGATTTTGT AGGGCATCTT 
TATGACAATA TCTACCTTAT TGGCCATGTG GCTGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863509.1
CDS	556..1074
Translation	MVLHEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA

Target ORF information:

RefSeq Version	XM_017008020.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 8 (FBXO8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008020.1

ORF Insert Sequence:

ATGGTCCTTC ATGAAGGAGT GAACTACTTT ATGTCCAAGG GTATCCTGGA TGATTCGCCA 
AAGGAAATAG CAAAGTTTAT CTTCTGTACA AGAACACTAA ATTGGAAAAA ACTGAGAATC 
TATCTTGATG AAAGGAGAGA TGTCTTGGAT GACCTTGTAA CATTGCATAA TTTTAGAAAT 
CAGTTCTTGC CAAATGCACT GAGAGAATTT TTTCGTCATA TCCATGCCCC TGAAGAGCGT 
GGAGAGTATC TTGAAACTCT TATAACAAAG TTCTCACATA GATTCTGTGC TTGCAACCCT 
GATTTAATGC GAGAACTTGG CCTTAGTCCT GATGCTGTCT ATGTACTGTG CTACTCTTTG 
ATTCTACTTT CCATTGACCT CACTAGCCCT CATGTGAAGA ATAAAATGTC AAAAAGGGAA 
TTTATTCGAA ATACCCGTCG CGCTGCTCAA AATATTAGTG AAGATTTTGT AGGGCATCTT 
TATGACAATA TCTACCTTAT TGGCCATGTG GCTGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma.
Cancer letters38885-95(2017 Mar)
Wang FF,Zhang XJ,Yan YR,Zhu XH,Yu J,Ding Y,Hu JL,Zhou WJ,Zeng ZC,Liao WT,Ding YQ,Liang L

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Significance of FBX8 in progression of gastric cancer.
Experimental and molecular pathology98(3)360-6(2015 Jun)
Wu P,Wang F,Wang Y,Men H,Zhu X,He G,Ma W,Xin S,Wu J,Liao W,Ding Y,He M,Liang L

Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma.
International journal of clinical and experimental pathology7(11)8071-6(2014)
Yu Y,Sun L,Ren N,Li Y,Rong L,Zhao G

FBX8 Acts as an Invasion and Metastasis Suppressor and Correlates with Poor Survival in Hepatocellular Carcinoma.
PloS one8(6)e65495(2013)
Wang F,Qiao Y,Yu J,Ren X,Wang J,Ding Y,Zhang X,Ma W,Ding Y,Liang L

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FBXO8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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