OPTC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPTC
Entrez Gene ID	26254
Full Name	opticin
Synonyms	OPT
General protein information	Preferred Names opticin Names opticin oculoglycan
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Summary	Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008].
Disorder MIM:	605127

mRNA and Protein(s)

mRNA	Protein	Name
XM_011509406.1	XP_011507708.1	opticin isoform X1
NM_014359.3	NP_055174.1	opticin precursor
NM_014359.4	NP_055174.1	opticin precursor
XM_011509406.2	XP_011507708.1	opticin isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	optc	NP_001003583.2
Pan troglodytes (chimpanzee)	OPTC	XP_001155649.1
Mus musculus (house mouse)	Optc	NP_473417.2
Rattus norvegicus (Norway rat)	Optc	NP_001100646.1
Xenopus tropicalis (tropical clawed frog)	optc	NP_001016499.1
Homo sapiens (human)	OPTC	NP_055174.1
	OPTC	XP_001102193.1
Canis lupus familiaris (dog)	OPTC	NP_001003056.1
Gallus gallus (chicken)	OPTC	NP_989804.1
Bos taurus (cattle)	OPTC	NP_991339.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
Luykx JJ, Bakker SC, Lentjes E, Neeleman M, Strengman E, Mentink L, DeYoung J, de Jong S, Sul JH, Eskin E, van Eijk K, van Setten J, Buizer-Voskamp JE, Cantor RM, Lu A, van Amerongen M, van Dongen EP, Keijzers P, Kappen T, Borgdorff P, Bruins P, Derks EM, Kahn RS, Ophoff RA
Molecular psychiatry19(2)228-34(2014 Feb)

Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.
Le Goff MM, Sutton MJ, Slevin M, Latif A, Humphries MJ, Bishop PN
The Journal of biological chemistry287(33)28027-36(2012 Aug)

Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation.
Ma J, Zhu TP, Moe MC, Ye P, Yao K
Cytokine59(1)100-7(2012 Jul)

Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL
Alcoholism, clinical and experimental research34(5)800-12(2010 May)

An evaluation of OPTC and EPYC as candidate genes for high myopia.
Wang P, Li S, Xiao X, Guo X, Zhang Q
Molecular vision152045-9(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins.
Title: Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.

VEGF and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2.
Title: Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Human variation in alcohol response is influenced by variation in neuronal signaling genes.

Observational study of gene-disease association. (HuGE Navigator)
Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.

Observational study of gene-disease association. (HuGE Navigator)
Title: An evaluation of OPTC and EPYC as candidate genes for high myopia.

The following OPTC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPTC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17905	NM_014359.4 Latest version!	Homo sapiens opticin (OPTC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu17905	XM_011509406.2 Latest version!	Homo sapiens opticin (OPTC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu17905	NM_014359.3	Homo sapiens opticin (OPTC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu17905	XM_011509406.1	Homo sapiens opticin (OPTC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPTC ( NM_014359.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055174.1 Homo sapiens opticin (OPTC), mRNA.

Price & Availability↑

CloneID	OHu17905
Clone ID Related Accession (Same CDS sequence)	XM_011509406.1 , NM_014359.3 , NM_014359.4 , XM_011509406.2
Accession Version	NM_014359.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	opticin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ133790.2 and BF724878.1. This sequence is a reference standard in the RefSeqGene project. On Jan 15, 2005 this sequence version replaced NM_014359.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ133790.2, AF161702.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055174.1
CDS	117..1115
Translation	MRLLAFLSLLALVLQETGTASLPRKERKRREEQMPREGDSFEVLPLRNDVLNPDNYGEVIDLSNYEELTDYGDQLPEVKVTSLAPATSISPAKSTTAPGTPSSNPTMTRPTTAGLLLSSQPNHGLPTCLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYARFNRISRIRAEDFKGLTKLKRIDLSNNLISSIDNDAFRLLHALQDLILPENQLEALPVLPSGIEFLDVRLNRLQSSGIQPAAFRAMEKLQFLYLSDNLLDSIPGPLPLSLRSVHLQNNLIETMQRDVFCDPEEHKHTRRQLEDIRLDGNPINLSLFPSAYFCLPRLPIGRFT

Target ORF information:

RefSeq Version	NM_014359.3
Organism	Homo sapiens(human)
Definition	Homo sapiens opticin (OPTC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014359.3

ORF Insert Sequence:

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPTC ( NM_014359.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055174.1 Homo sapiens opticin (OPTC), mRNA.

Price & Availability↑

CloneID	OHu17905
Clone ID Related Accession (Same CDS sequence)	XM_011509406.1 , NM_014359.3 , NM_014359.4 , XM_011509406.2
Accession Version	NM_014359.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	opticin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ133790.2 and BF724878.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_014359.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ133790.2, AY077681.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367222.7/ ENSP00000356191.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055174.1
CDS	107..1105
Translation	MRLLAFLSLLALVLQETGTASLPRKERKRREEQMPREGDSFEVLPLRNDVLNPDNYGEVIDLSNYEELTDYGDQLPEVKVTSLAPATSISPAKSTTAPGTPSSNPTMTRPTTAGLLLSSQPNHGLPTCLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYARFNRISRIRAEDFKGLTKLKRIDLSNNLISSIDNDAFRLLHALQDLILPENQLEALPVLPSGIEFLDVRLNRLQSSGIQPAAFRAMEKLQFLYLSDNLLDSIPGPLPLSLRSVHLQNNLIETMQRDVFCDPEEHKHTRRQLEDIRLDGNPINLSLFPSAYFCLPRLPIGRFT

Target ORF information:

RefSeq Version	NM_014359.4
Organism	Homo sapiens(human)
Definition	Homo sapiens opticin (OPTC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014359.4

ORF Insert Sequence:

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPTC ( XM_011509406.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011507708.1 Homo sapiens opticin (OPTC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu17905
Clone ID Related Accession (Same CDS sequence)	XM_011509406.1 , NM_014359.3 , NM_014359.4 , XM_011509406.2
Accession Version	XM_011509406.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	opticin isoform X1
Comment

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011507708.1
Translation	MRLLAFLSLLALVLQETGTASLPRKERKRREEQMPREGDSFEVLPLRNDVLNPDNYGEVIDLSNYEELTDYGDQLPEVKVTSLAPATSISPAKSTTAPGTPSSNPTMTRPTTAGLLLSSQPNHGLPTCLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYARFNRISRIRAEDFKGLTKLKRIDLSNNLISSIDNDAFRLLHALQDLILPENQLEALPVLPSGIEFLDVRLNRLQSSGIQPAAFRAMEKLQFLYLSDNLLDSIPGPLPLSLRSVHLQNNLIETMQRDVFCDPEEHKHTRRQLEDIRLDGNPINLSLFPSAYFCLPRLPIGRFT

Target ORF information:

RefSeq Version	XM_011509406.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens opticin (OPTC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509406.1

ORF Insert Sequence:

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPTC ( XM_011509406.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011507708.1 Homo sapiens opticin (OPTC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu17905
Clone ID Related Accession (Same CDS sequence)	XM_011509406.1 , NM_014359.3 , NM_014359.4 , XM_011509406.2
Accession Version	XM_011509406.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	opticin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509406.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011507708.1
CDS	516..1514
Translation	MRLLAFLSLLALVLQETGTASLPRKERKRREEQMPREGDSFEVLPLRNDVLNPDNYGEVIDLSNYEELTDYGDQLPEVKVTSLAPATSISPAKSTTAPGTPSSNPTMTRPTTAGLLLSSQPNHGLPTCLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYARFNRISRIRAEDFKGLTKLKRIDLSNNLISSIDNDAFRLLHALQDLILPENQLEALPVLPSGIEFLDVRLNRLQSSGIQPAAFRAMEKLQFLYLSDNLLDSIPGPLPLSLRSVHLQNNLIETMQRDVFCDPEEHKHTRRQLEDIRLDGNPINLSLFPSAYFCLPRLPIGRFT

Target ORF information:

RefSeq Version	XM_011509406.2
Organism	Homo sapiens(human)
Definition	Homo sapiens opticin (OPTC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509406.2

ORF Insert Sequence:

ATGAGGCTCC TGGCTTTCCT GAGTCTGCTG GCCTTGGTGC TGCAGGAGAC AGGGACAGCT 
TCTCTCCCAA GGAAGGAGAG GAAGAGGAGA GAGGAGCAGA TGCCCAGGGA AGGCGATTCC 
TTTGAAGTTC TGCCTCTGCG GAATGATGTC CTGAACCCAG ACAACTATGG TGAAGTCATT 
GACCTGAGCA ACTATGAGGA GCTCACAGAT TATGGGGACC AACTCCCCGA GGTTAAGGTG 
ACTAGCCTCG CTCCTGCAAC CAGCATCAGT CCCGCCAAGA GCACTACGGC TCCAGGGACA 
CCCTCGTCAA ACCCCACGAT GACCAGACCT ACTACAGCAG GGCTGCTACT GAGTTCCCAG 
CCCAACCATG GTCTGCCCAC CTGCCTGGTC TGCGTGTGCC TCGGTTCCTC TGTGTATTGC 
GATGACATTG ACCTAGAGGA CATTCCTCCT CTTCCTCGGA GGACTGCCTA CCTGTATGCA 
CGCTTCAACC GCATCAGCCG TATCAGGGCC GAAGACTTCA AAGGGCTGAC AAAGTTGAAG 
AGGATTGACC TCTCCAACAA CCTCATTTCC TCCATCGATA ATGATGCCTT CCGCCTGCTA 
CATGCCCTCC AGGACCTCAT CCTCCCAGAG AACCAGTTGG AAGCTCTGCC CGTGCTGCCC 
AGTGGCATTG AGTTCCTGGA TGTCCGCCTA AATCGGCTCC AGAGCTCGGG GATACAGCCT 
GCAGCCTTCA GGGCAATGGA GAAGCTGCAG TTCCTTTACC TGTCAGACAA CCTGCTGGAT 
TCTATCCCGG GGCCTTTGCC CCTGAGCCTG CGCTCTGTAC ACCTGCAGAA TAACCTGATA 
GAGACCATGC AGAGAGACGT CTTCTGTGAC CCCGAGGAGC ACAAACACAC CCGCAGGCAG 
CTGGAAGACA TCCGCCTGGA TGGCAACCCC ATCAACCTCA GCCTCTTCCC CAGCGCCTAC 
TTCTGCCTGC CTCGGCTCCC CATCGGCCGC TTCACGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
Molecular psychiatry19(2)228-34(2014 Feb)
Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P,Bruins P,Derks EM,Kahn RS,Ophoff RA

Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.
The Journal of biological chemistry287(33)28027-36(2012 Aug)
Le Goff MM,Sutton MJ,Slevin M,Latif A,Humphries MJ,Bishop PN

Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation.
Cytokine59(1)100-7(2012 Jul)
Ma J,Zhu TP,Moe MC,Ye P,Yao K

Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Alcoholism, clinical and experimental research34(5)800-12(2010 May)
Joslyn G,Ravindranathan A,Brush G,Schuckit M,White RL

An evaluation of OPTC and EPYC as candidate genes for high myopia.
Molecular vision152045-9(2009 Oct)
Wang P,Li S,Xiao X,Guo X,Zhang Q

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OPTC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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