TIAM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIAM2
Entrez Gene ID	26230
Full Name	T cell lymphoma invasion and metastasis 2
Synonyms	STEF,TIAM-2
General protein information	Preferred Names T cell lymphoma invasion and metastasis 2 Names T-lymphoma invasion and metastasis-inducing protein 2 SIF and TIAM1-like exchange factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q25.2-q25.3
Summary	This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:	604709

mRNA and Protein(s)

mRNA	Protein	Name
NM_001010927.2	NP_001010927.1	T-lymphoma invasion and metastasis-inducing protein 2 isoform b
NM_001010927.3	NP_001010927.2	T-lymphoma invasion and metastasis-inducing protein 2 isoform b
NM_012454.3	NP_036586.2	T-lymphoma invasion and metastasis-inducing protein 2 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	TIAM2	NP_036586.2
	LOC701688	XP_002808441.1
Canis lupus familiaris (dog)	TIAM2	XP_541162.4
Bos taurus (cattle)	TIAM2	XP_003586537.2
Mus musculus (house mouse)	Tiam2	NP_036008.2
Rattus norvegicus (Norway rat)	LOC100362710	XP_003748741.1
Gallus gallus (chicken)	TIAM2	NP_001254464.1
Pan troglodytes (chimpanzee)	TIAM2	XP_527545.2
Danio rerio (zebrafish)	tiam2	XP_002665298.2

Gene Ontology
Bibliography

Related articles in PubMed

Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.
Gaitanos TN, Koerner J, Klein R
The Journal of cell biology214(6)735-52(2016 Sep)

Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.
Yen WH, Ke WS, Hung JJ, Chen TM, Chen JS, Sun HS
Cancer medicine5(3)465-77(2016 Mar)

TIAM2 enhances non-small cell lung cancer cell invasion and motility.
Zhao ZY, Han CG, Liu JT, Wang CL, Wang Y, Cheng LY
Asian Pacific journal of cancer prevention : APJCP14(11)6305-9(2013)

Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer.
Chen JS, Su IJ, Leu YW, Young KC, Sun HS
International journal of cancer130(6)1302-13(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tiam2/Rac are key components of EphB2 trans-endocytosis and are important for cell repulsion.
Title: Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.

Results provide evidence that Sp1 positively controls TIAM2S transcription and that Sp1-mediated transcriptional activation is essential for TIAM2S ectopic expression in liver cancer cells.
Title: Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.

Knockdown of TIAM2 could up-regulate the expression of E-cadherin.
Title: TIAM2 enhances non-small cell lung cancer cell invasion and motility.

TIAM2 expression was undetectable in normal human liver but was induced in all HCC cell lines and in 86% (78/91) of HCC biopsies.
Title: Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following TIAM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIAM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02106	NM_001010927.2 Latest version!	Homo sapiens T cell lymphoma invasion and metastasis 2 (TIAM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu06251	NM_012454.3 Latest version!	Homo sapiens TIAM Rac1 associated GEF 2 (TIAM2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$679.50-$951.30 $1359.00
OHu108324	NM_001010927.3 Latest version!	Homo sapiens TIAM Rac1 associated GEF 2 (TIAM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIAM2 ( NM_001010927.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010927.1 Homo sapiens T cell lymphoma invasion and metastasis 2 (TIAM2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02106
Clone ID Related Accession (Same CDS sequence)	NM_001010927.2
Accession Version	NM_001010927.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	T-lymphoma invasion and metastasis-inducing protein 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP199501.1, BC022469.1, AL122086.1 and AL139101.13. On Aug 23, 2005 this sequence version replaced NM_001010927.1. Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.186220.1, SRR1660805.110991.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGGAC CGCGGGAGAA TCAGGATCCT CCTCCGAGGC CTCTGGCCCG CCACCTGTCT 
GATGCAGACC GCCTCCGCAA AGTCATCCAG GAGCTTGTGG ACACAGAGAA GTCCTACGTG 
AAGGATTTGA GCTGCCTCTT TGAATTATAC TTGGAGCCAC TTCAGAATGA GACCTTTCTT 
ACCCAAGATG AGATGGAGTC ACTTTTTGGA AGTTTGCCAG AGATGCTTGA GTTTCAGAAG 
GTGTTTCTGG AGACCCTGGA GGATGGGATT TCAGCATCAT CTGACTTTAA CACCCTAGAA 
ACCCCCTCAC AGTTTAGAAA ATTACTGTTT TCCCTTGGAG GCTCTTTCCT TTATTACGCG 
GACCACTTTA AACTGTACAG TGGATTCTGT GCTAACCATA TCAAAGTACA GAAGGTTCTG 
GAGCGAGCTA AAACTGACAA AGCCTTCAAG GCTTTTCTGG ACGCCCGGAA CCCCACCAAG 
CAGCATTCCT CCACGCTGGA GTCCTACCTC ATCAAGCCGG TTCAGAGAGT GCTCAAGTAC 
CCGCTGCTGC TCAAGGAGCT GGTGTCCCTG ACGGACCAGG AGAGCGAGGA GCACTACCAC 
CTGACGGAAG CACTAAAGGC AATGGAGAAA GTAGCGAGCC ACATCAATGA GATGCAGAAG 
ATCTATGAGG ATTATGGGAC CGTGTTTGAC CAGCTAGTAG CTGAGCAGAG CGGAACAGAG 
AAGGAGGTAA CAGAACTTTC GATGGGAGAG CTTCTGATGC ACTCTACGGT TTCCTGGTTG 
AATCCATTTC TGTCTCTAGG AAAAGCTAGA AAGGACCTTG AGCTCACAGT ATTTGTTTTT 
AAGAGAGCCG TCATACTGGT TTATAAAGAA AACTGCAAAC TGAAAAAGAA ATTGCCCTCG 
AATTCCCGGC CTGCACACAA CTCTACTGAC TTGGACCCAT TTAAATTCCG CTGGTTGATC 
CCCATCTCCG CGCTTCAAGT CAGACTGGGG AATCCAGCAG GGACAGAAAA TAATTCCATA 
TGGGAACTGA TCCATACGAA GTCAGAAATA GAAGGACGGC CAGAAACCAT CTTTCAGTTG 
TGTTGCAGTG ACAGTGAAAG CAAAACCAAC ATTGTTAAGG TGATTCGTTC TATTCTGAGG 
GAGAACTTCA GGCGTCACAT AAAGTGTGAA TTACCACTGG AGAAAACGTG TAAGGATCGC 
CTGGTACCTC TTAAGAACCG AGTTCCTGTT TCGGCCAAAT TAGCTTCATC CAGGTCTTTA 
AAAGTCCTGA AGAATTCCTC CAGCAACGAG TGGACCGGTG AGACTGGCAA GGGAACCTTG 
CTGGACTCTG ACGAGGGCAG CTTGAGCAGC GGCACCCAGA GCAGCGGCTG CCCCACGGCT 
GAGGGCAGGC AGGACTCCAA GAGCACTTCT CCCGGGAAAT ACCCACACCC CGGCTTGGCA 
GATTTTGCCG ACAATCTCAT CAAAGAGAGT GACATCCTGA GCGATGAAGA TGATGACCAC 
CGTCAGACTG TGAAGCAGGG CAGCCCTACT AAAGACATCG AAATTCAGTT CCAGAGACTG 
AGGATTTCCG AGGACCCAGA CGTTCACCCC GAGGCTGAGC AGCAGCCTGG CCCGGAGTCG 
GGTGAGGGTC AGAAAGGAGG AGAGCAGCCC AAACTGGTCC GGGGGCACTT CTGCCCCATT 
AAACGAAAAG CCAACAGCAC CAAGAGGGAC AGAGGAACTT TGCTCAAGGC GCAGATCCGT 
CACCAGTCCC TTGACAGTCA GTCTGAAAAT GCCACCATCG ACCTAAATTC TGTTCTAGAG 
CGAGAATTCA GTGTCCAGAG TTTAACATCT GTTGTCAGTG AGGAGTGTTT TTATGAAACA 
GAGAGCCACG GAAAATCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010927.1
CDS	186..2066
Translation	MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSVQSLTSVVSEECFYETESHGKS

Target ORF information:

RefSeq Version	NM_001010927.2
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell lymphoma invasion and metastasis 2 (TIAM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010927.2

ORF Insert Sequence:

ATGGAAGGAC CGCGGGAGAA TCAGGATCCT CCTCCGAGGC CTCTGGCCCG CCACCTGTCT 
GATGCAGACC GCCTCCGCAA AGTCATCCAG GAGCTTGTGG ACACAGAGAA GTCCTACGTG 
AAGGATTTGA GCTGCCTCTT TGAATTATAC TTGGAGCCAC TTCAGAATGA GACCTTTCTT 
ACCCAAGATG AGATGGAGTC ACTTTTTGGA AGTTTGCCAG AGATGCTTGA GTTTCAGAAG 
GTGTTTCTGG AGACCCTGGA GGATGGGATT TCAGCATCAT CTGACTTTAA CACCCTAGAA 
ACCCCCTCAC AGTTTAGAAA ATTACTGTTT TCCCTTGGAG GCTCTTTCCT TTATTACGCG 
GACCACTTTA AACTGTACAG TGGATTCTGT GCTAACCATA TCAAAGTACA GAAGGTTCTG 
GAGCGAGCTA AAACTGACAA AGCCTTCAAG GCTTTTCTGG ACGCCCGGAA CCCCACCAAG 
CAGCATTCCT CCACGCTGGA GTCCTACCTC ATCAAGCCGG TTCAGAGAGT GCTCAAGTAC 
CCGCTGCTGC TCAAGGAGCT GGTGTCCCTG ACGGACCAGG AGAGCGAGGA GCACTACCAC 
CTGACGGAAG CACTAAAGGC AATGGAGAAA GTAGCGAGCC ACATCAATGA GATGCAGAAG 
ATCTATGAGG ATTATGGGAC CGTGTTTGAC CAGCTAGTAG CTGAGCAGAG CGGAACAGAG 
AAGGAGGTAA CAGAACTTTC GATGGGAGAG CTTCTGATGC ACTCTACGGT TTCCTGGTTG 
AATCCATTTC TGTCTCTAGG AAAAGCTAGA AAGGACCTTG AGCTCACAGT ATTTGTTTTT 
AAGAGAGCCG TCATACTGGT TTATAAAGAA AACTGCAAAC TGAAAAAGAA ATTGCCCTCG 
AATTCCCGGC CTGCACACAA CTCTACTGAC TTGGACCCAT TTAAATTCCG CTGGTTGATC 
CCCATCTCCG CGCTTCAAGT CAGACTGGGG AATCCAGCAG GGACAGAAAA TAATTCCATA 
TGGGAACTGA TCCATACGAA GTCAGAAATA GAAGGACGGC CAGAAACCAT CTTTCAGTTG 
TGTTGCAGTG ACAGTGAAAG CAAAACCAAC ATTGTTAAGG TGATTCGTTC TATTCTGAGG 
GAGAACTTCA GGCGTCACAT AAAGTGTGAA TTACCACTGG AGAAAACGTG TAAGGATCGC 
CTGGTACCTC TTAAGAACCG AGTTCCTGTT TCGGCCAAAT TAGCTTCATC CAGGTCTTTA 
AAAGTCCTGA AGAATTCCTC CAGCAACGAG TGGACCGGTG AGACTGGCAA GGGAACCTTG 
CTGGACTCTG ACGAGGGCAG CTTGAGCAGC GGCACCCAGA GCAGCGGCTG CCCCACGGCT 
GAGGGCAGGC AGGACTCCAA GAGCACTTCT CCCGGGAAAT ACCCACACCC CGGCTTGGCA 
GATTTTGCCG ACAATCTCAT CAAAGAGAGT GACATCCTGA GCGATGAAGA TGATGACCAC 
CGTCAGACTG TGAAGCAGGG CAGCCCTACT AAAGACATCG AAATTCAGTT CCAGAGACTG 
AGGATTTCCG AGGACCCAGA CGTTCACCCC GAGGCTGAGC AGCAGCCTGG CCCGGAGTCG 
GGTGAGGGTC AGAAAGGAGG AGAGCAGCCC AAACTGGTCC GGGGGCACTT CTGCCCCATT 
AAACGAAAAG CCAACAGCAC CAAGAGGGAC AGAGGAACTT TGCTCAAGGC GCAGATCCGT 
CACCAGTCCC TTGACAGTCA GTCTGAAAAT GCCACCATCG ACCTAAATTC TGTTCTAGAG 
CGAGAATTCA GTGTCCAGAG TTTAACATCT GTTGTCAGTG AGGAGTGTTT TTATGAAACA 
GAGAGCCACG GAAAATCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIAM2 ( NM_012454.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036586.2 Homo sapiens TIAM Rac1 associated GEF 2 (TIAM2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06251
Clone ID Related Accession (Same CDS sequence)	NM_012454.3
Accession Version	NM_012454.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5106bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Homo sapiens(human)
Product	T-lymphoma invasion and metastasis-inducing protein 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK123859.1, AL355343.18, AL122086.1 and AL139101.13. On Aug 23, 2005 this sequence version replaced NM_012454.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AB095936.2, BC137275.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGGCAACT CCGACAGTCA GTACACCCTT CAAGGATCTA AAAATCATAG CAATACTATT 
ACTGGTGCTA AGCAAATTCC TTGCTCCCTG AAAATACGTG GCATTCATGC AAAAGAGGAA 
AAGTCATTGC ATGGATGGGG TCACGGAAGC AACGGAGCAG GTTACAAGTC CAGGTCCCTG 
GCCCGAAGCT GCCTTTCTCA CTTTAAGAGT AACCAGCCTT ACGCATCGAG ACTCGGTGGC 
CCCACATGCA AGGTCTCCAG AGGTGTTGCC TACTCCACGC ACAGGACAAA TGCCCCAGGG 
AAGGATTTCC AGGGCATCAG TGCTGCTTTC TCAACTGAGA ATGGCTTCCA CTCTGTTGGC 
CACGAGCTGG CAGATAACCA CATCACCTCC AGAGACTGCA ACGGACACCT TCTCAACTGC 
TACGGGAGGA ATGAGAGCAT TGCCTCCACC CCACCGGGCG AAGACCGCAA GAGCCCCCGA 
GTGCTCATCA AAACGCTGGG GAAGCTGGAT GGGTGTTTAA GGGTCGAGTT CCACAATGGT 
GGCAACCCCA GCAAAGTGCC TGCAGAGGAC TGCAGTGAGC CGGTGCAGCT GCTGAGGTAC 
TCACCTACCT TAGCATCGGA AACCTCCCCT GTGCCTGAAG CCAGGAGGGG GTCCAGCGCC 
GATTCCCTGC CCAGCCATCG CCCCTCTCCC ACGGACTCTC GCCTGCGGTC CAGCAAAGGC 
AGCTCCCTGA GTTCTGAGTC ATCCTGGTAC GACTCCCCTT GGGGCAATGC TGGAGAGCTG 
AGCGAGGCTG AGGGCTCCTT CCTGGCCCCC GGCATGCCTG ACCCCAGTCT CCATGCCAGC 
TTCCCACCTG GCGATGCCAA AAAGCCTTTC AACCAAAGCT CTTCCCTCTC CTCCCTCCGG 
GAACTGTACA AAGATGCCAA CCTGGGGAGC CTCTCCCCCT CAGGTATCCG CCTTTCTGAT 
GAATACATGG GCACGCATGC CAGCCTGAGC AACCGTGTCT CTTTTGCTTC CGACATTGAT 
GTGCCCTCCA GAGTGGCACA CGGGGACCCC ATCCAGTACA GTTCCTTCAC TCTCCCCTGT 
CGGAAGCCCA AAGCCTTTGT TGAGGATACT GCGAAGAAGG ACTCCCTCAA AGCCAGGATG 
CGACGGATCA GTGACTGGAC GGGAAGCCTC TCAAGGAAGA AAAGGAAACT CCAGGAGCCG 
AGGTCCAAGG AGGGCAGTGA CTACTTTGAC AGTCGCTCTG ATGGACTGAA TACAGATGTG 
CAGGGATCCT CCCAGGCATC TGCTTTTCTG TGGTCAGGGG GCTCTACTCA GATCCTGTCT 
CAGAGAAGTG AATCCACACA TGCGATTGGC AGCGATCCCC TCCGGCAGAA CATTTATGAG 
AATTTCATGC GAGAGTTGGA AATGAGCAGG ACCAACACTG AGAACATAGA AACATCTACA 
GAAACCGCCG AGTCCAGCAG CGAGTCACTC AGCTCTCTGG AACAGCTGGA TCTGCTCTTT 
GAGAAGGAAC AGGGGGTGGT CCGGAAGGCC GGGTGGCTCT TCTTCAAGCC CCTGGTCACT 
GTGCAGAAGG AAAGGAAGCT TGAGCTGGTG GCACGAAGGA AATGGAAACA GTACTGGGTA 
ACGCTGAAAG GATGCACGCT GCTGTTTTAT GAGACCTATG GGAAGAATTC CATGGATCAG 
AGCAGTGCCC CTCGGTGTGC TCTGTTTGCA GAAGACAGCA TAGTGCAGTC TGTTCCAGAG 
CATCCCAAGA AAGAAAATGT GTTCTGCCTC AGCAACTCCT TTGGAGATGT CTACCTTTTC 
CAGGCCACCA GCCAGACAGA TCTAGAAAAC TGGGTCACTG CTGTACACTC TGCTTGTGCA 
TCCCTTTTTG CAAAGAAGCA TGGGAAAGAG GACACGCTGC GGCTGCTGAA GAACCAGACC 
AAAAACCTGC TTCAGAAGAT AGACATGGAC AGCAAGATGA AGAAGATGGC AGAGCTGCAG 
CTGTCCGTGG TGAGCGACCC AAAGAACAGG AAAGCCATAG AGAACCAGAT CCAGCAATGG 
GAGCAGAATC TTGAGAAATT TCACATGGAT CTGTTCAGGA TGCGCTGCTA TCTGGCCAGC 
CTACAAGGTG GGGAGTTACC GAACCCAAAG AGTCTCCTTG CAGCCGCCAG CCGCCCCTCC 
AAGCTGGCCC TCGGCAGGCT GGGCATCTTG TCTGTTTCCT CTTTCCATGC TCTGGTATGT 
TCTAGAGATG ACTCTGCTCT CCGGAAAAGG ACACTGTCAC TGACCCAGCG AGGGAGAAAC 
AAGAAGGGAA TATTTTCTTC GTTAAAAGGG CTGGACACAC TGGCCAGAAA AGGCAAGGAG 
AAGAGACCTT CTATAACTCA GGTCGATGAA CTTCTGCATA TATATGGTTC AACAGTAGAC 
GGTGTTCCCC GAGACAATGC ATGGGAAATC CAGACTTATG TCCACTTTCA GGACAATCAC 
GGAGTTACTG TAGGGATCAA GCCAGAGCAC AGAGTAGAAG ATATTTTGAC TTTGGCATGC 
AAGATGAGGC AGTTGGAACC CAGCCATTAT GGCCTACAGC TTCGAAAATT AGTAGATGAC 
AATGTTGAGT ATTGCATCCC TGCACCATAT GAATATATGC AACAACAGGT TTATGATGAA 
ATAGAAGTCT TTCCACTAAA TGTTTATGAC GTGCAGCTCA CGAAGACTGG GAGTGTGTGT 
GACTTTGGGT TTGCAGTTAC AGCGCAGGTG GATGAGCGTC AGCATCTCAG CCGGATATTT 
ATAAGCGACG TTCTTCCCGA TGGCCTGGCG TATGGGGAAG GGCTGAGAAA GGGCAATGAG 
ATCATGACCT TAAATGGGGA AGCTGTGTCT GATCTTGACC TTAAGCAGAT GGAGGCCCTG 
TTTTCTGAGA AGAGCGTCGG ACTCACTCTG ATTGCCCGGC CTCCGGACAC AAAAGCAACC 
CTGTGTACAT CCTGGTCAGA CAGTGACCTG TTCTCCAGGG ACCAGAAGAG TCTGCTGCCC 
CCTCCTAACC AGTCCCAACT GCTGGAGGAA TTCCTGGATA ACTTTAAAAA GAATACAGCC 
AATGATTTCA GCAACGTCCC TGATATCACA ACAGGTCTGA AAAGGAGTCA GACAGATGGC 
ACTCTGGATC AGGTTTCCCA CAGGGAGAAA ATGGAGCAGA CATTCAGGAG TGCTGAGCAG 
ATCACTGCAC TGTGCAGGAG TTTTAACGAC AGTCAGGCCA ACGGCATGGA AGGACCGCGG 
GAGAATCAGG ATCCTCCTCC GAGGCCTCTG GCCCGCCACC TGTCTGATGC AGACCGCCTC 
CGCAAAGTCA TCCAGGAGCT TGTGGACACA GAGAAGTCCT ACGTGAAGGA TTTGAGCTGC 
CTCTTTGAAT TATACTTGGA GCCACTTCAG AATGAGACCT TTCTTACCCA AGATGAGATG 
GAGTCACTTT TTGGAAGTTT GCCAGAGATG CTTGAGTTTC AGAAGGTGTT TCTGGAGACC 
CTGGAGGATG GGATTTCAGC ATCATCTGAC TTTAACACCC TAGAAACCCC CTCACAGTTT 
AGAAAATTAC TGTTTTCCCT TGGAGGCTCT TTCCTTTATT ACGCGGACCA CTTTAAACTG 
TACAGTGGAT TCTGTGCTAA CCATATCAAA GTACAGAAGG TTCTGGAGCG AGCTAAAACT 
GACAAAGCCT TCAAGGCTTT TCTGGACGCC CGGAACCCCA CCAAGCAGCA TTCCTCCACG 
CTGGAGTCCT ACCTCATCAA GCCGGTTCAG AGAGTGCTCA AGTACCCGCT GCTGCTCAAG 
GAGCTGGTGT CCCTGACGGA CCAGGAGAGC GAGGAGCACT ACCACCTGAC GGAAGCACTA 
AAGGCAATGG AGAAAGTAGC GAGCCACATC AATGAGATGC AGAAGATCTA TGAGGATTAT 
GGGACCGTGT TTGACCAGCT AGTAGCTGAG CAGAGCGGAA CAGAGAAGGA GGTAACAGAA 
CTTTCGATGG GAGAGCTTCT GATGCACTCT ACGGTTTCCT GGTTGAATCC ATTTCTGTCT 
CTAGGAAAAG CTAGAAAGGA CCTTGAGCTC ACAGTATTTG TTTTTAAGAG AGCCGTCATA 
CTGGTTTATA AAGAAAACTG CAAACTGAAA AAGAAATTGC CCTCGAATTC CCGGCCTGCA 
CACAACTCTA CTGACTTGGA CCCATTTAAA TTCCGCTGGT TGATCCCCAT CTCCGCGCTT 
CAAGTCAGAC TGGGGAATCC AGCAGGGACA GAAAATAATT CCATATGGGA ACTGATCCAT 
ACGAAGTCAG AAATAGAAGG ACGGCCAGAA ACCATCTTTC AGTTGTGTTG CAGTGACAGT 
GAAAGCAAAA CCAACATTGT TAAGGTGATT CGTTCTATTC TGAGGGAGAA CTTCAGGCGT 
CACATAAAGT GTGAATTACC ACTGGAGAAA ACGTGTAAGG ATCGCCTGGT ACCTCTTAAG 
AACCGAGTTC CTGTTTCGGC CAAATTAGCT TCATCCAGGT CTTTAAAAGT CCTGAAGAAT 
TCCTCCAGCA ACGAGTGGAC CGGTGAGACT GGCAAGGGAA CCTTGCTGGA CTCTGACGAG 
GGCAGCTTGA GCAGCGGCAC CCAGAGCAGC GGCTGCCCCA CGGCTGAGGG CAGGCAGGAC 
TCCAAGAGCA CTTCTCCCGG GAAATACCCA CACCCCGGCT TGGCAGATTT TGCCGACAAT 
CTCATCAAAG AGAGTGACAT CCTGAGCGAT GAAGATGATG ACCACCGTCA GACTGTGAAG 
CAGGGCAGCC CTACTAAAGA CATCGAAATT CAGTTCCAGA GACTGAGGAT TTCCGAGGAC 
CCAGACGTTC ACCCCGAGGC TGAGCAGCAG CCTGGCCCGG AGTCGGGTGA GGGTCAGAAA 
GGAGGAGAGC AGCCCAAACT GGTCCGGGGG CACTTCTGCC CCATTAAACG AAAAGCCAAC 
AGCACCAAGA GGGACAGAGG AACTTTGCTC AAGGCGCAGA TCCGTCACCA GTCCCTTGAC 
AGTCAGTCTG AAAATGCCAC CATCGACCTA AATTCTGTTC TAGAGCGAGA ATTCAGTGTC 
CAGAGTTTAA CATCTGTTGT CAGTGAGGAG TGTTTTTATG AAACAGAGAG CCACGGAAAA 
TCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036586.2
CDS	209..5314
Translation	MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSLARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVGHELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNGGNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKGSSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLRELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPCRKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDVQGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETSTETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWVTLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPSKLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKEKRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLACKMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVCDFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSVQSLTSVVSEECFYETESHGKS

Target ORF information:

RefSeq Version	NM_012454.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TIAM Rac1 associated GEF 2 (TIAM2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012454.3

ORF Insert Sequence:

ATGGGCAACT CCGACAGTCA GTACACCCTT CAAGGATCTA AAAATCATAG CAATACTATT 
ACTGGTGCTA AGCAAATTCC TTGCTCCCTG AAAATACGTG GCATTCATGC AAAAGAGGAA 
AAGTCATTGC ATGGATGGGG TCACGGAAGC AACGGAGCAG GTTACAAGTC CAGGTCCCTG 
GCCCGAAGCT GCCTTTCTCA CTTTAAGAGT AACCAGCCTT ACGCATCGAG ACTCGGTGGC 
CCCACATGCA AGGTCTCCAG AGGTGTTGCC TACTCCACGC ACAGGACAAA TGCCCCAGGG 
AAGGATTTCC AGGGCATCAG TGCTGCTTTC TCAACTGAGA ATGGCTTCCA CTCTGTTGGC 
CACGAGCTGG CAGATAACCA CATCACCTCC AGAGACTGCA ACGGACACCT TCTCAACTGC 
TACGGGAGGA ATGAGAGCAT TGCCTCCACC CCACCGGGCG AAGACCGCAA GAGCCCCCGA 
GTGCTCATCA AAACGCTGGG GAAGCTGGAT GGGTGTTTAA GGGTCGAGTT CCACAATGGT 
GGCAACCCCA GCAAAGTGCC TGCAGAGGAC TGCAGTGAGC CGGTGCAGCT GCTGAGGTAC 
TCACCTACCT TAGCATCGGA AACCTCCCCT GTGCCTGAAG CCAGGAGGGG GTCCAGCGCC 
GATTCCCTGC CCAGCCATCG CCCCTCTCCC ACGGACTCTC GCCTGCGGTC CAGCAAAGGC 
AGCTCCCTGA GTTCTGAGTC ATCCTGGTAC GACTCCCCTT GGGGCAATGC TGGAGAGCTG 
AGCGAGGCTG AGGGCTCCTT CCTGGCCCCC GGCATGCCTG ACCCCAGTCT CCATGCCAGC 
TTCCCACCTG GCGATGCCAA AAAGCCTTTC AACCAAAGCT CTTCCCTCTC CTCCCTCCGG 
GAACTGTACA AAGATGCCAA CCTGGGGAGC CTCTCCCCCT CAGGTATCCG CCTTTCTGAT 
GAATACATGG GCACGCATGC CAGCCTGAGC AACCGTGTCT CTTTTGCTTC CGACATTGAT 
GTGCCCTCCA GAGTGGCACA CGGGGACCCC ATCCAGTACA GTTCCTTCAC TCTCCCCTGT 
CGGAAGCCCA AAGCCTTTGT TGAGGATACT GCGAAGAAGG ACTCCCTCAA AGCCAGGATG 
CGACGGATCA GTGACTGGAC GGGAAGCCTC TCAAGGAAGA AAAGGAAACT CCAGGAGCCG 
AGGTCCAAGG AGGGCAGTGA CTACTTTGAC AGTCGCTCTG ATGGACTGAA TACAGATGTG 
CAGGGATCCT CCCAGGCATC TGCTTTTCTG TGGTCAGGGG GCTCTACTCA GATCCTGTCT 
CAGAGAAGTG AATCCACACA TGCGATTGGC AGCGATCCCC TCCGGCAGAA CATTTATGAG 
AATTTCATGC GAGAGTTGGA AATGAGCAGG ACCAACACTG AGAACATAGA AACATCTACA 
GAAACCGCCG AGTCCAGCAG CGAGTCACTC AGCTCTCTGG AACAGCTGGA TCTGCTCTTT 
GAGAAGGAAC AGGGGGTGGT CCGGAAGGCC GGGTGGCTCT TCTTCAAGCC CCTGGTCACT 
GTGCAGAAGG AAAGGAAGCT TGAGCTGGTG GCACGAAGGA AATGGAAACA GTACTGGGTA 
ACGCTGAAAG GATGCACGCT GCTGTTTTAT GAGACCTATG GGAAGAATTC CATGGATCAG 
AGCAGTGCCC CTCGGTGTGC TCTGTTTGCA GAAGACAGCA TAGTGCAGTC TGTTCCAGAG 
CATCCCAAGA AAGAAAATGT GTTCTGCCTC AGCAACTCCT TTGGAGATGT CTACCTTTTC 
CAGGCCACCA GCCAGACAGA TCTAGAAAAC TGGGTCACTG CTGTACACTC TGCTTGTGCA 
TCCCTTTTTG CAAAGAAGCA TGGGAAAGAG GACACGCTGC GGCTGCTGAA GAACCAGACC 
AAAAACCTGC TTCAGAAGAT AGACATGGAC AGCAAGATGA AGAAGATGGC AGAGCTGCAG 
CTGTCCGTGG TGAGCGACCC AAAGAACAGG AAAGCCATAG AGAACCAGAT CCAGCAATGG 
GAGCAGAATC TTGAGAAATT TCACATGGAT CTGTTCAGGA TGCGCTGCTA TCTGGCCAGC 
CTACAAGGTG GGGAGTTACC GAACCCAAAG AGTCTCCTTG CAGCCGCCAG CCGCCCCTCC 
AAGCTGGCCC TCGGCAGGCT GGGCATCTTG TCTGTTTCCT CTTTCCATGC TCTGGTATGT 
TCTAGAGATG ACTCTGCTCT CCGGAAAAGG ACACTGTCAC TGACCCAGCG AGGGAGAAAC 
AAGAAGGGAA TATTTTCTTC GTTAAAAGGG CTGGACACAC TGGCCAGAAA AGGCAAGGAG 
AAGAGACCTT CTATAACTCA GGTCGATGAA CTTCTGCATA TATATGGTTC AACAGTAGAC 
GGTGTTCCCC GAGACAATGC ATGGGAAATC CAGACTTATG TCCACTTTCA GGACAATCAC 
GGAGTTACTG TAGGGATCAA GCCAGAGCAC AGAGTAGAAG ATATTTTGAC TTTGGCATGC 
AAGATGAGGC AGTTGGAACC CAGCCATTAT GGCCTACAGC TTCGAAAATT AGTAGATGAC 
AATGTTGAGT ATTGCATCCC TGCACCATAT GAATATATGC AACAACAGGT TTATGATGAA 
ATAGAAGTCT TTCCACTAAA TGTTTATGAC GTGCAGCTCA CGAAGACTGG GAGTGTGTGT 
GACTTTGGGT TTGCAGTTAC AGCGCAGGTG GATGAGCGTC AGCATCTCAG CCGGATATTT 
ATAAGCGACG TTCTTCCCGA TGGCCTGGCG TATGGGGAAG GGCTGAGAAA GGGCAATGAG 
ATCATGACCT TAAATGGGGA AGCTGTGTCT GATCTTGACC TTAAGCAGAT GGAGGCCCTG 
TTTTCTGAGA AGAGCGTCGG ACTCACTCTG ATTGCCCGGC CTCCGGACAC AAAAGCAACC 
CTGTGTACAT CCTGGTCAGA CAGTGACCTG TTCTCCAGGG ACCAGAAGAG TCTGCTGCCC 
CCTCCTAACC AGTCCCAACT GCTGGAGGAA TTCCTGGATA ACTTTAAAAA GAATACAGCC 
AATGATTTCA GCAACGTCCC TGATATCACA ACAGGTCTGA AAAGGAGTCA GACAGATGGC 
ACTCTGGATC AGGTTTCCCA CAGGGAGAAA ATGGAGCAGA CATTCAGGAG TGCTGAGCAG 
ATCACTGCAC TGTGCAGGAG TTTTAACGAC AGTCAGGCCA ACGGCATGGA AGGACCGCGG 
GAGAATCAGG ATCCTCCTCC GAGGCCTCTG GCCCGCCACC TGTCTGATGC AGACCGCCTC 
CGCAAAGTCA TCCAGGAGCT TGTGGACACA GAGAAGTCCT ACGTGAAGGA TTTGAGCTGC 
CTCTTTGAAT TATACTTGGA GCCACTTCAG AATGAGACCT TTCTTACCCA AGATGAGATG 
GAGTCACTTT TTGGAAGTTT GCCAGAGATG CTTGAGTTTC AGAAGGTGTT TCTGGAGACC 
CTGGAGGATG GGATTTCAGC ATCATCTGAC TTTAACACCC TAGAAACCCC CTCACAGTTT 
AGAAAATTAC TGTTTTCCCT TGGAGGCTCT TTCCTTTATT ACGCGGACCA CTTTAAACTG 
TACAGTGGAT TCTGTGCTAA CCATATCAAA GTACAGAAGG TTCTGGAGCG AGCTAAAACT 
GACAAAGCCT TCAAGGCTTT TCTGGACGCC CGGAACCCCA CCAAGCAGCA TTCCTCCACG 
CTGGAGTCCT ACCTCATCAA GCCGGTTCAG AGAGTGCTCA AGTACCCGCT GCTGCTCAAG 
GAGCTGGTGT CCCTGACGGA CCAGGAGAGC GAGGAGCACT ACCACCTGAC GGAAGCACTA 
AAGGCAATGG AGAAAGTAGC GAGCCACATC AATGAGATGC AGAAGATCTA TGAGGATTAT 
GGGACCGTGT TTGACCAGCT AGTAGCTGAG CAGAGCGGAA CAGAGAAGGA GGTAACAGAA 
CTTTCGATGG GAGAGCTTCT GATGCACTCT ACGGTTTCCT GGTTGAATCC ATTTCTGTCT 
CTAGGAAAAG CTAGAAAGGA CCTTGAGCTC ACAGTATTTG TTTTTAAGAG AGCCGTCATA 
CTGGTTTATA AAGAAAACTG CAAACTGAAA AAGAAATTGC CCTCGAATTC CCGGCCTGCA 
CACAACTCTA CTGACTTGGA CCCATTTAAA TTCCGCTGGT TGATCCCCAT CTCCGCGCTT 
CAAGTCAGAC TGGGGAATCC AGCAGGGACA GAAAATAATT CCATATGGGA ACTGATCCAT 
ACGAAGTCAG AAATAGAAGG ACGGCCAGAA ACCATCTTTC AGTTGTGTTG CAGTGACAGT 
GAAAGCAAAA CCAACATTGT TAAGGTGATT CGTTCTATTC TGAGGGAGAA CTTCAGGCGT 
CACATAAAGT GTGAATTACC ACTGGAGAAA ACGTGTAAGG ATCGCCTGGT ACCTCTTAAG 
AACCGAGTTC CTGTTTCGGC CAAATTAGCT TCATCCAGGT CTTTAAAAGT CCTGAAGAAT 
TCCTCCAGCA ACGAGTGGAC CGGTGAGACT GGCAAGGGAA CCTTGCTGGA CTCTGACGAG 
GGCAGCTTGA GCAGCGGCAC CCAGAGCAGC GGCTGCCCCA CGGCTGAGGG CAGGCAGGAC 
TCCAAGAGCA CTTCTCCCGG GAAATACCCA CACCCCGGCT TGGCAGATTT TGCCGACAAT 
CTCATCAAAG AGAGTGACAT CCTGAGCGAT GAAGATGATG ACCACCGTCA GACTGTGAAG 
CAGGGCAGCC CTACTAAAGA CATCGAAATT CAGTTCCAGA GACTGAGGAT TTCCGAGGAC 
CCAGACGTTC ACCCCGAGGC TGAGCAGCAG CCTGGCCCGG AGTCGGGTGA GGGTCAGAAA 
GGAGGAGAGC AGCCCAAACT GGTCCGGGGG CACTTCTGCC CCATTAAACG AAAAGCCAAC 
AGCACCAAGA GGGACAGAGG AACTTTGCTC AAGGCGCAGA TCCGTCACCA GTCCCTTGAC 
AGTCAGTCTG AAAATGCCAC CATCGACCTA AATTCTGTTC TAGAGCGAGA ATTCAGTGTC 
CAGAGTTTAA CATCTGTTGT CAGTGAGGAG TGTTTTTATG AAACAGAGAG CCACGGAAAA 
TCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIAM2 ( NM_001010927.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010927.2 Homo sapiens TIAM Rac1 associated GEF 2 (TIAM2), transcript variant 2, mRNA.

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CloneID	OHu108324
Clone ID Related Accession (Same CDS sequence)	NM_001010927.3
Accession Version	NM_001010927.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Homo sapiens(human)
Product	T-lymphoma invasion and metastasis-inducing protein 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355343.18, AL596202.5 and AL139101.13. On Jun 2, 2019 this sequence version replaced NM_001010927.2. Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.97712.1, SRR1803617.128619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGGAC CGCGGGAGAA TCAGGATCCT CCTCCGAGGT CTCTGGCCCG CCACCTGTCT 
GATGCAGACC GCCTCCGCAA AGTCATCCAG GAGCTTGTGG ACACAGAGAA GTCCTACGTG 
AAGGATTTGA GCTGCCTCTT TGAATTATAC TTGGAGCCAC TTCAGAATGA GACCTTTCTT 
ACCCAAGATG AGATGGAGTC ACTTTTTGGA AGTTTGCCAG AGATGCTTGA GTTTCAGAAG 
GTGTTTCTGG AGACCCTGGA GGATGGGATT TCAGCATCAT CTGACTTTAA CACCCTAGAA 
ACCCCCTCAC AGTTTAGAAA ATTACTGTTT TCCCTTGGAG GCTCTTTCCT TTATTACGCG 
GACCACTTTA AACTGTACAG TGGATTCTGT GCTAACCATA TCAAAGTACA GAAGGTTCTG 
GAGCGAGCTA AAACTGACAA AGCCTTCAAG GCTTTTCTGG ACGCCCGGAA CCCCACCAAG 
CAGCATTCCT CCACGCTGGA GTCCTACCTC ATCAAGCCGG TTCAGAGAGT GCTCAAGTAC 
CCGCTGCTGC TCAAGGAGCT GGTGTCCCTG ACGGACCAGG AGAGCGAGGA GCACTACCAC 
CTGACGGAAG CACTAAAGGC AATGGAGAAA GTAGCGAGCC ACATCAATGA GATGCAGAAG 
ATCTATGAGG ATTATGGGAC CGTGTTTGAC CAGCTAGTAG CTGAGCAGAG CGGAACAGAG 
AAGGAGGTAA CAGAACTTTC GATGGGAGAG CTTCTGATGC ACTCTACGGT TTCCTGGTTG 
AATCCATTTC TGTCTCTAGG AAAAGCTAGA AAGGACCTTG AGCTCACAGT ATTTGTTTTT 
AAGAGAGCCG TCATACTGGT TTATAAAGAA AACTGCAAAC TGAAAAAGAA ATTGCCCTCG 
AATTCCCGGC CTGCACACAA CTCTACTGAC TTGGACCCAT TTAAATTCCG CTGGTTGATC 
CCCATCTCCG CGCTTCAAGT CAGACTGGGG AATCCAGCAG GGACAGAAAA TAATTCCATA 
TGGGAACTGA TCCATACGAA GTCAGAAATA GAAGGACGGC CAGAAACCAT CTTTCAGTTG 
TGTTGCAGTG ACAGTGAAAG CAAAACCAAC ATTGTTAAGG TGATTCGTTC TATTCTGAGG 
GAGAACTTCA GGCGTCACAT AAAGTGTGAA TTACCACTGG AGAAAACGTG TAAGGATCGC 
CTGGTACCTC TTAAGAACCG AGTTCCTGTT TCGGCCAAAT TAGCTTCATC CAGGTCTTTA 
AAAGTCCTGA AGAATTCCTC CAGCAACGAG TGGACCGGTG AGACTGGCAA GGGAACCTTG 
CTGGACTCTG ACGAGGGCAG CTTGAGCAGC GGCACCCAGA GCAGCGGCTG CCCCACGGCT 
GAGGGCAGGC AGGACTCCAA GAGCACTTCT CCCGGGAAAT ACCCACACCC CGGCTTGGCA 
GATTTTGCCG ACAATCTCAT CAAAGAGAGT GACATCCTGA GCGATGAAGA TGATGACCAC 
CGTCAGACTG TGAAGCAGGG CAGCCCTACT AAAGACATCG AAATTCAGTT CCAGAGACTG 
AGGATTTCCG AGGACCCAGA CGTTCACCCC GAGGCTGAGC AGCAGCCTGG CCCGGAGTCG 
GGTGAGGGTC AGAAAGGAGG AGAGCAGCCC AAACTGGTCC GGGGGCACTT CTGCCCCATT 
AAACGAAAAG CCAACAGCAC CAAGAGGGAC AGAGGAACTT TGCTCAAGGC GCAGATCCGT 
CACCAGTCCC TTGACAGTCA GTCTGAAAAT GCCACCATCG ACCTAAATTC TGTTCTAGAG 
CGAGAATTCA GTGTCCAGAG TTTAACATCT GTTGTCAGTG AGGAGTGTTT TTATGAAACA 
GAGAGCCACG GAAAATCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010927.2
CDS	183..2063
Translation	MEGPRENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSVQSLTSVVSEECFYETESHGKS

Target ORF information:

RefSeq Version	NM_001010927.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TIAM Rac1 associated GEF 2 (TIAM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010927.3

ORF Insert Sequence:

ATGGAAGGAC CGCGGGAGAA TCAGGATCCT CCTCCGAGGT CTCTGGCCCG CCACCTGTCT 
GATGCAGACC GCCTCCGCAA AGTCATCCAG GAGCTTGTGG ACACAGAGAA GTCCTACGTG 
AAGGATTTGA GCTGCCTCTT TGAATTATAC TTGGAGCCAC TTCAGAATGA GACCTTTCTT 
ACCCAAGATG AGATGGAGTC ACTTTTTGGA AGTTTGCCAG AGATGCTTGA GTTTCAGAAG 
GTGTTTCTGG AGACCCTGGA GGATGGGATT TCAGCATCAT CTGACTTTAA CACCCTAGAA 
ACCCCCTCAC AGTTTAGAAA ATTACTGTTT TCCCTTGGAG GCTCTTTCCT TTATTACGCG 
GACCACTTTA AACTGTACAG TGGATTCTGT GCTAACCATA TCAAAGTACA GAAGGTTCTG 
GAGCGAGCTA AAACTGACAA AGCCTTCAAG GCTTTTCTGG ACGCCCGGAA CCCCACCAAG 
CAGCATTCCT CCACGCTGGA GTCCTACCTC ATCAAGCCGG TTCAGAGAGT GCTCAAGTAC 
CCGCTGCTGC TCAAGGAGCT GGTGTCCCTG ACGGACCAGG AGAGCGAGGA GCACTACCAC 
CTGACGGAAG CACTAAAGGC AATGGAGAAA GTAGCGAGCC ACATCAATGA GATGCAGAAG 
ATCTATGAGG ATTATGGGAC CGTGTTTGAC CAGCTAGTAG CTGAGCAGAG CGGAACAGAG 
AAGGAGGTAA CAGAACTTTC GATGGGAGAG CTTCTGATGC ACTCTACGGT TTCCTGGTTG 
AATCCATTTC TGTCTCTAGG AAAAGCTAGA AAGGACCTTG AGCTCACAGT ATTTGTTTTT 
AAGAGAGCCG TCATACTGGT TTATAAAGAA AACTGCAAAC TGAAAAAGAA ATTGCCCTCG 
AATTCCCGGC CTGCACACAA CTCTACTGAC TTGGACCCAT TTAAATTCCG CTGGTTGATC 
CCCATCTCCG CGCTTCAAGT CAGACTGGGG AATCCAGCAG GGACAGAAAA TAATTCCATA 
TGGGAACTGA TCCATACGAA GTCAGAAATA GAAGGACGGC CAGAAACCAT CTTTCAGTTG 
TGTTGCAGTG ACAGTGAAAG CAAAACCAAC ATTGTTAAGG TGATTCGTTC TATTCTGAGG 
GAGAACTTCA GGCGTCACAT AAAGTGTGAA TTACCACTGG AGAAAACGTG TAAGGATCGC 
CTGGTACCTC TTAAGAACCG AGTTCCTGTT TCGGCCAAAT TAGCTTCATC CAGGTCTTTA 
AAAGTCCTGA AGAATTCCTC CAGCAACGAG TGGACCGGTG AGACTGGCAA GGGAACCTTG 
CTGGACTCTG ACGAGGGCAG CTTGAGCAGC GGCACCCAGA GCAGCGGCTG CCCCACGGCT 
GAGGGCAGGC AGGACTCCAA GAGCACTTCT CCCGGGAAAT ACCCACACCC CGGCTTGGCA 
GATTTTGCCG ACAATCTCAT CAAAGAGAGT GACATCCTGA GCGATGAAGA TGATGACCAC 
CGTCAGACTG TGAAGCAGGG CAGCCCTACT AAAGACATCG AAATTCAGTT CCAGAGACTG 
AGGATTTCCG AGGACCCAGA CGTTCACCCC GAGGCTGAGC AGCAGCCTGG CCCGGAGTCG 
GGTGAGGGTC AGAAAGGAGG AGAGCAGCCC AAACTGGTCC GGGGGCACTT CTGCCCCATT 
AAACGAAAAG CCAACAGCAC CAAGAGGGAC AGAGGAACTT TGCTCAAGGC GCAGATCCGT 
CACCAGTCCC TTGACAGTCA GTCTGAAAAT GCCACCATCG ACCTAAATTC TGTTCTAGAG 
CGAGAATTCA GTGTCCAGAG TTTAACATCT GTTGTCAGTG AGGAGTGTTT TTATGAAACA 
GAGAGCCACG GAAAATCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.
The Journal of cell biology214(6)735-52(2016 Sep)
Gaitanos TN,Koerner J,Klein R

Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.
Cancer medicine5(3)465-77(2016 Mar)
Yen WH,Ke WS,Hung JJ,Chen TM,Chen JS,Sun HS

TIAM2 enhances non-small cell lung cancer cell invasion and motility.
Asian Pacific journal of cancer prevention : APJCP14(11)6305-9(2013)
Zhao ZY,Han CG,Liu JT,Wang CL,Wang Y,Cheng LY

Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer.
International journal of cancer130(6)1302-13(2012 Mar)
Chen JS,Su IJ,Leu YW,Young KC,Sun HS

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TIAM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム