IBTK cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IBTK
Entrez Gene ID	25998
Full Name	inhibitor of Bruton tyrosine kinase
Synonyms	BTBD26,BTKI
General protein information	Preferred Names inhibitor of Bruton tyrosine kinase Names inhibitor of Bruton tyrosine kinase BTK-binding protein Bruton agammaglobulinemia tyrosine kinase inhibitor inhibitor of Bruton's tyrosine kinase-alpha inhibitor of Bruton's tyrosine kinase-beta inhibitor of Bruton's tyrosine kinase-gamma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q14.1
Summary	Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Disorder MIM:	606457

mRNA and Protein(s)

mRNA	Protein	Name
XM_006715454.2	XP_006715517.1	inhibitor of Bruton tyrosine kinase isoform X2
NM_001300906.2	NP_001287835.1	inhibitor of Bruton tyrosine kinase isoform 2
XM_006715454.3	XP_006715517.1	inhibitor of Bruton tyrosine kinase isoform X2
NM_015525.4	NP_056340.2	inhibitor of Bruton tyrosine kinase isoform 1
NM_015525.3	NP_056340.2	inhibitor of Bruton tyrosine kinase isoform 1
XM_006715453.2	XP_006715516.1	inhibitor of Bruton tyrosine kinase isoform X1
XM_006715453.3	XP_006715516.1	inhibitor of Bruton tyrosine kinase isoform X1
NM_001300906.1	NP_001287835.1	inhibitor of Bruton tyrosine kinase isoform 2

Pathways from BioSystems

Homologies

	IBTK	XP_002803869.1
Bos taurus (cattle)	IBTK	NP_001192969.1
Drosophila melanogaster (fruit fly)	CG8060	NP_611117.2
Pan troglodytes (chimpanzee)	IBTK	XP_001148806.1
Xenopus tropicalis (tropical clawed frog)	ibtk	XP_002938503.2
Canis lupus familiaris (dog)	IBTK	XP_539018.2
Mus musculus (house mouse)	Ibtk	NP_001074751.1
Rattus norvegicus (Norway rat)	Ibtk	XP_006243569.1
Gallus gallus (chicken)	IBTK	XP_004940475.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009939	XP_319065.4
Homo sapiens (human)	IBTK	NP_056340.2
Danio rerio (zebrafish)	ibtk	XP_005157916.1

Gene Ontology
Bibliography

Related articles in PubMed

The expression of inhibitor of bruton's tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis.
Albano F, Chiurazzi F, Mimmi S, Vecchio E, Pastore A, Cimmino C, Frieri C, Iaccino E, Pisano A, Golino G, Fiume G, Mallardo M, Scala G, Quinto I
Cell death & disease9(1)13(2018 Jan)

Function of inhibitor of Bruton's tyrosine kinase isoform ? (IBTK?) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.
Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC
The Journal of biological chemistry292(34)14050-14065(2017 08)

IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells.
Fiume G, Scialdone A, Rizzo F, De Filippo MR, Laudanna C, Albano F, Golino G, Vecchio E, Pontoriero M, Mimmi S, Ceglia S, Pisano A, Iaccino E, Palmieri C, Paduano S, Viglietto G, Weisz A, Scala G, Quinto I
International journal of molecular sciences17(11)(2016 Nov)

CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation.
Pisano A, Ceglia S, Palmieri C, Vecchio E, Fiume G, de Laurentiis A, Mimmi S, Falcone C, Iaccino E, Scialdone A, Pontoriero M, Masci FF, Valea R, Krishnan S, Gaspari M, Cuda G, Scala G, Quinto I
The Journal of biological chemistry290(22)13958-71(2015 May)

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTK?.
Baird TD, Palam LR, Fusakio ME, Willy JA, Davis CM, McClintick JN, Anthony TG, Wek RC
Molecular biology of the cell25(10)1686-97(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that IBTKalpha is (a) localized in hepatocytes in endoplasmic reticulum (ER), (b) associates with specific proteins (LC3b, SEC16A, SEC31A), and (c) plays role in autophagy. Progression of nonalcoholic fatty liver disease is associated with changes in liver: (a) up-regulation of expression of IBTKalpha, (b) unfolded protein response, (c) ER stress, and (d) inhibition of autophagy.
Title: Function of inhibitor of Bruton's tyrosine kinase isoform ? (IBTK?) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.

The results indicate that IBTKa differently modulates gene expression and RNA splicing in HeLa and K562 cells, demonstrating a novel biological role of this protein.
Title: IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells.

CRL3(IBTK) is a novel ubiquitin ligase with regulatory roles in cellular pathways, such as the Pdcd4-dependent translation of mRNAs
Title: CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation.

Depletion of IBTKalpha by short hairpin RNA reduced viability of cultured cells coincident with increased caspase 3/7 cleavage, suggesting that IBTKalpha is a key regulator in determining cell fate during the UPR.
Title: Selective mRNA translation during eIF2 phosphorylation induces expression of IBTK?.

A novel pathway of Btk regulation via protein kinase C phosphorylation of IBtkgamma.
Title: Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtk?.

The following IBTK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IBTK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13031	NM_015525.4 Latest version!	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
OHu40771	NM_001300906.2 Latest version!	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
OHu40769	XM_006715453.3 Latest version!	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
OHu40770	XM_006715454.3 Latest version!	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
View Old Accession Versions >>
OHu40770	XM_006715454.2	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
OHu13031	NM_015525.3	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
OHu40769	XM_006715453.2	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
OHu40771	NM_001300906.1	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IBTK ( NM_015525.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056340.2 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13031
Clone ID Related Accession (Same CDS sequence)	NM_015525.4 , NM_015525.3
Accession Version	NM_015525.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ005633.1 and BM670666.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_015525.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.113301.1, SRR1660807.230863.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306270.12/ ENSP00000305721.7 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGCT CTACCCATGG TACCCCAGGA CCAGAAGGCA ACCATATTTC AGATTTACCA 
CTTCTAGACA GTCCCAATCC CTGGCTATCT TCTTCAGTGA CTGCTCCATC CATGGTAGCC 
CCAGTCACTT TTGCATCTAT TGTAGAAGAA GAACTACAAC AAGAAGCAGC TCTTATTAGA 
AGTCGAGAAA AACCGTTGGC TCTGATTCAG ATTGAGGAGC ATGCCATACA AGATTTATTG 
GTTTTCTATG AGGCATTTGG CAACCCTGAA GAGTTTGTCA TTGTTGAAAG GACACCGCAG 
GGACCACTGG CAGTACCTAT GTGGAATAAG CATGGATGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056340.2
CDS	541..4602
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	NM_015525.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015525.4

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGCT CTACCCATGG TACCCCAGGA CCAGAAGGCA ACCATATTTC AGATTTACCA 
CTTCTAGACA GTCCCAATCC CTGGCTATCT TCTTCAGTGA CTGCTCCATC CATGGTAGCC 
CCAGTCACTT TTGCATCTAT TGTAGAAGAA GAACTACAAC AAGAAGCAGC TCTTATTAGA 
AGTCGAGAAA AACCGTTGGC TCTGATTCAG ATTGAGGAGC ATGCCATACA AGATTTATTG 
GTTTTCTATG AGGCATTTGG CAACCCTGAA GAGTTTGTCA TTGTTGAAAG GACACCGCAG 
GGACCACTGG CAGTACCTAT GTGGAATAAG CATGGATGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IBTK ( NM_015525.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056340.2 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 1, mRNA.

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CloneID	OHu13031
Clone ID Related Accession (Same CDS sequence)	NM_015525.4 , NM_015525.3
Accession Version	NM_015525.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ005633.1 and BM670666.1. This sequence is a reference standard in the RefSeqGene project. On Jul 16, 2014 this sequence version replaced NM_015525.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ005633.1, SRR1803613.113301.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGCT CTACCCATGG TACCCCAGGA CCAGAAGGCA ACCATATTTC AGATTTACCA 
CTTCTAGACA GTCCCAATCC CTGGCTATCT TCTTCAGTGA CTGCTCCATC CATGGTAGCC 
CCAGTCACTT TTGCATCTAT TGTAGAAGAA GAACTACAAC AAGAAGCAGC TCTTATTAGA 
AGTCGAGAAA AACCGTTGGC TCTGATTCAG ATTGAGGAGC ATGCCATACA AGATTTATTG 
GTTTTCTATG AGGCATTTGG CAACCCTGAA GAGTTTGTCA TTGTTGAAAG GACACCGCAG 
GGACCACTGG CAGTACCTAT GTGGAATAAG CATGGATGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056340.2
CDS	551..4612
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	NM_015525.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015525.3

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGCT CTACCCATGG TACCCCAGGA CCAGAAGGCA ACCATATTTC AGATTTACCA 
CTTCTAGACA GTCCCAATCC CTGGCTATCT TCTTCAGTGA CTGCTCCATC CATGGTAGCC 
CCAGTCACTT TTGCATCTAT TGTAGAAGAA GAACTACAAC AAGAAGCAGC TCTTATTAGA 
AGTCGAGAAA AACCGTTGGC TCTGATTCAG ATTGAGGAGC ATGCCATACA AGATTTATTG 
GTTTTCTATG AGGCATTTGG CAACCCTGAA GAGTTTGTCA TTGTTGAAAG GACACCGCAG 
GGACCACTGG CAGTACCTAT GTGGAATAAG CATGGATGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IBTK ( NM_001300906.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287835.1 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu40771
Clone ID Related Accession (Same CDS sequence)	NM_001300906.2 , NM_001300906.1
Accession Version	NM_001300906.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ005633.1, BC143745.1, AK123460.1 and BM670666.1. On May 31, 2019 this sequence version replaced NM_001300906.1. Transcript Variant: This variant (2) uses an alternate in-frame splice acceptor site in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.54357.1, SRR7346977.2865497.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGCTCTACC CATGGTACCC CAGGACCAGA AGGCAACCAT 
ATTTCAGATT TACCACTTCT AGACAGTCCC AATCCCTGGC TATCTTCTTC AGTGACTGCT 
CCATCCATGG TAGCCCCAGT CACTTTTGCA TCTATTGTAG AAGAAGAACT ACAACAAGAA 
GCAGCTCTTA TTAGAAGTCG AGAAAAACCG TTGGCTCTGA TTCAGATTGA GGAGCATGCC 
ATACAAGATT TATTGGTTTT CTATGAGGCA TTTGGCAACC CTGAAGAGTT TGTCATTGTT 
GAAAGGACAC CGCAGGGACC ACTGGCAGTA CCTATGTGGA ATAAGCATGG ATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287835.1
CDS	541..4557
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	NM_001300906.2
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300906.2

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGCTCTACC CATGGTACCC CAGGACCAGA AGGCAACCAT 
ATTTCAGATT TACCACTTCT AGACAGTCCC AATCCCTGGC TATCTTCTTC AGTGACTGCT 
CCATCCATGG TAGCCCCAGT CACTTTTGCA TCTATTGTAG AAGAAGAACT ACAACAAGAA 
GCAGCTCTTA TTAGAAGTCG AGAAAAACCG TTGGCTCTGA TTCAGATTGA GGAGCATGCC 
ATACAAGATT TATTGGTTTT CTATGAGGCA TTTGGCAACC CTGAAGAGTT TGTCATTGTT 
GAAAGGACAC CGCAGGGACC ACTGGCAGTA CCTATGTGGA ATAAGCATGG ATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IBTK ( NM_001300906.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287835.1 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 2, mRNA.

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CloneID	OHu40771
Clone ID Related Accession (Same CDS sequence)	NM_001300906.2 , NM_001300906.1
Accession Version	NM_001300906.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ005633.1, BC143745.1, AK123460.1 and BM670666.1. On Jul 16, 2014 this sequence version replaced XM_006715455.1. Transcript Variant: This variant (2) uses an alternate in-frame splice acceptor site in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.54357.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGCTCTACC CATGGTACCC CAGGACCAGA AGGCAACCAT 
ATTTCAGATT TACCACTTCT AGACAGTCCC AATCCCTGGC TATCTTCTTC AGTGACTGCT 
CCATCCATGG TAGCCCCAGT CACTTTTGCA TCTATTGTAG AAGAAGAACT ACAACAAGAA 
GCAGCTCTTA TTAGAAGTCG AGAAAAACCG TTGGCTCTGA TTCAGATTGA GGAGCATGCC 
ATACAAGATT TATTGGTTTT CTATGAGGCA TTTGGCAACC CTGAAGAGTT TGTCATTGTT 
GAAAGGACAC CGCAGGGACC ACTGGCAGTA CCTATGTGGA ATAAGCATGG ATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287835.1
CDS	551..4567
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	NM_001300906.1
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300906.1

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGCTCTACC CATGGTACCC CAGGACCAGA AGGCAACCAT 
ATTTCAGATT TACCACTTCT AGACAGTCCC AATCCCTGGC TATCTTCTTC AGTGACTGCT 
CCATCCATGG TAGCCCCAGT CACTTTTGCA TCTATTGTAG AAGAAGAACT ACAACAAGAA 
GCAGCTCTTA TTAGAAGTCG AGAAAAACCG TTGGCTCTGA TTCAGATTGA GGAGCATGCC 
ATACAAGATT TATTGGTTTT CTATGAGGCA TTTGGCAACC CTGAAGAGTT TGTCATTGTT 
GAAAGGACAC CGCAGGGACC ACTGGCAGTA CCTATGTGGA ATAAGCATGG ATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IBTK ( XM_006715453.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006715516.1 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu40769
Clone ID Related Accession (Same CDS sequence)	XM_006715453.2 , XM_006715453.3
Accession Version	XM_006715453.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006715453.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGGA GTTTCGTTCT TGTTGCCCAG GCTGGAGTGC AATGGCTTGA TCTCAGCTCA 
CCGCAACCTC TGCCTCCTGG GTTCAAGCGA TTCTCCTGCC TCCGCCACCC TAGTAGCTGG 
GATTACAGAT GCTCTACCCA TGGTACCCCA GGACCAGAAG GCAACCATAT TTCAGATTTA 
CCACTTCTAG ACAGTCCCAA TCCCTGGCTA TCTTCTTCAG TGACTGCTCC ATCCATGGTA 
GCCCCAGTCA CTTTTGCATC TATTGTAGAA GAAGAACTAC AACAAGAAGC AGCTCTTATT 
AGAAGTCGAG AAAAACCGTT GGCTCTGATT CAGATTGAGG AGCATGCCAT ACAAGATTTA 
TTGGTTTTCT ATGAGGCATT TGGCAACCCT GAAGAGTTTG TCATTGTTGA AAGGACACCG 
CAGGGACCAC TGGCAGTACC TATGTGGAAT AAGCATGGAT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006715516.1
CDS	1091..5275
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSSPQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	XM_006715453.2
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006715453.2

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGGA GTTTCGTTCT TGTTGCCCAG GCTGGAGTGC AATGGCTTGA TCTCAGCTCA 
CCGCAACCTC TGCCTCCTGG GTTCAAGCGA TTCTCCTGCC TCCGCCACCC TAGTAGCTGG 
GATTACAGAT GCTCTACCCA TGGTACCCCA GGACCAGAAG GCAACCATAT TTCAGATTTA 
CCACTTCTAG ACAGTCCCAA TCCCTGGCTA TCTTCTTCAG TGACTGCTCC ATCCATGGTA 
GCCCCAGTCA CTTTTGCATC TATTGTAGAA GAAGAACTAC AACAAGAAGC AGCTCTTATT 
AGAAGTCGAG AAAAACCGTT GGCTCTGATT CAGATTGAGG AGCATGCCAT ACAAGATTTA 
TTGGTTTTCT ATGAGGCATT TGGCAACCCT GAAGAGTTTG TCATTGTTGA AAGGACACCG 
CAGGGACCAC TGGCAGTACC TATGTGGAAT AAGCATGGAT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IBTK ( XM_006715453.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006715516.1 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu40769
Clone ID Related Accession (Same CDS sequence)	XM_006715453.2 , XM_006715453.3
Accession Version	XM_006715453.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006715453.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGGA GTTTCGTTCT TGTTGCCCAG GCTGGAGTGC AATGGCTTGA TCTCAGCTCA 
CCGCAACCTC TGCCTCCTGG GTTCAAGCGA TTCTCCTGCC TCCGCCACCC TAGTAGCTGG 
GATTACAGAT GCTCTACCCA TGGTACCCCA GGACCAGAAG GCAACCATAT TTCAGATTTA 
CCACTTCTAG ACAGTCCCAA TCCCTGGCTA TCTTCTTCAG TGACTGCTCC ATCCATGGTA 
GCCCCAGTCA CTTTTGCATC TATTGTAGAA GAAGAACTAC AACAAGAAGC AGCTCTTATT 
AGAAGTCGAG AAAAACCGTT GGCTCTGATT CAGATTGAGG AGCATGCCAT ACAAGATTTA 
TTGGTTTTCT ATGAGGCATT TGGCAACCCT GAAGAGTTTG TCATTGTTGA AAGGACACCG 
CAGGGACCAC TGGCAGTACC TATGTGGAAT AAGCATGGAT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006715516.1
CDS	544..4728
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSSPQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	XM_006715453.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006715453.3

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGGATTA TTAAAGTCTG GTAAGACCAA TTCTGTGGAA 
TCTCTTCCAG AACTGTTGAC ATCAGACTCT GAAGGAAGCT ATGCAGGAGT GGGTAGTCCT 
AGAGATTTAC AGTCCCCTGA TTTCACAACA GGATTTCATT CAGATAAGAT TGAGGCGAAA 
GTCAAACCGT ATGTTAATGG TACATCTCCT GTGTATTCTA GGGAAGATTT AAAACCATGG 
GAAAAGTCAC CAATACTTAA AATATCTGCT CCACAGCCTA TTCCCAGTAA CAGAATTGAT 
ACTACCAGCT CTGCCAGTTG GGTTGCTGGT TCTTTCAGTC CTGTCAGCCC TCCTGTTGTG 
GATCTCAGAA CTATCATGGA AATAGAAGAA AGTAGACAAA AATGTGGAGC TACACCAAAG 
TCACATTTAG GCAAAACAGT TTCTCATGGA GTTAAACTTT CTCAGAAGCA ACGAAAAATG 
ATTGCATTGA CTACCAAGGA AAACAATTCA GGAATGAATA GCATGGAAAC AGTTTTATTC 
ACTCCTTCAA AAGCCCCCAA ACCAGTGAAT GCATGGGCAT CTTCTCTGCA TTCAGTTTCA 
TCCAAGTCAT TCCGGGATTT CTTACTAGAA GAAAAAAAGT CTGTTACTAG CCATAGTTCA 
GGCGATCATG TCAAAAAAGT TTCTTTTAAA GGAATTGAAA ATTCTCAGGC ACCAAAAATT 
GTCAGATGGA GTTTCGTTCT TGTTGCCCAG GCTGGAGTGC AATGGCTTGA TCTCAGCTCA 
CCGCAACCTC TGCCTCCTGG GTTCAAGCGA TTCTCCTGCC TCCGCCACCC TAGTAGCTGG 
GATTACAGAT GCTCTACCCA TGGTACCCCA GGACCAGAAG GCAACCATAT TTCAGATTTA 
CCACTTCTAG ACAGTCCCAA TCCCTGGCTA TCTTCTTCAG TGACTGCTCC ATCCATGGTA 
GCCCCAGTCA CTTTTGCATC TATTGTAGAA GAAGAACTAC AACAAGAAGC AGCTCTTATT 
AGAAGTCGAG AAAAACCGTT GGCTCTGATT CAGATTGAGG AGCATGCCAT ACAAGATTTA 
TTGGTTTTCT ATGAGGCATT TGGCAACCCT GAAGAGTTTG TCATTGTTGA AAGGACACCG 
CAGGGACCAC TGGCAGTACC TATGTGGAAT AAGCATGGAT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IBTK ( XM_006715454.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006715517.1 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X2, mRNA.

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CloneID	OHu40770
Clone ID Related Accession (Same CDS sequence)	XM_006715454.2 , XM_006715454.3
Accession Version	XM_006715454.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006715454.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGGAGTTTC GTTCTTGTTG CCCAGGCTGG AGTGCAATGG 
CTTGATCTCA GCTCACCGCA ACCTCTGCCT CCTGGGTTCA AGCGATTCTC CTGCCTCCGC 
CACCCTAGTA GCTGGGATTA CAGATGCTCT ACCCATGGTA CCCCAGGACC AGAAGGCAAC 
CATATTTCAG ATTTACCACT TCTAGACAGT CCCAATCCCT GGCTATCTTC TTCAGTGACT 
GCTCCATCCA TGGTAGCCCC AGTCACTTTT GCATCTATTG TAGAAGAAGA ACTACAACAA 
GAAGCAGCTC TTATTAGAAG TCGAGAAAAA CCGTTGGCTC TGATTCAGAT TGAGGAGCAT 
GCCATACAAG ATTTATTGGT TTTCTATGAG GCATTTGGCA ACCCTGAAGA GTTTGTCATT 
GTTGAAAGGA CACCGCAGGG ACCACTGGCA GTACCTATGT GGAATAAGCA TGGATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006715517.1
CDS	1091..5230
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSSPQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	XM_006715454.2
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006715454.2

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGGAGTTTC GTTCTTGTTG CCCAGGCTGG AGTGCAATGG 
CTTGATCTCA GCTCACCGCA ACCTCTGCCT CCTGGGTTCA AGCGATTCTC CTGCCTCCGC 
CACCCTAGTA GCTGGGATTA CAGATGCTCT ACCCATGGTA CCCCAGGACC AGAAGGCAAC 
CATATTTCAG ATTTACCACT TCTAGACAGT CCCAATCCCT GGCTATCTTC TTCAGTGACT 
GCTCCATCCA TGGTAGCCCC AGTCACTTTT GCATCTATTG TAGAAGAAGA ACTACAACAA 
GAAGCAGCTC TTATTAGAAG TCGAGAAAAA CCGTTGGCTC TGATTCAGAT TGAGGAGCAT 
GCCATACAAG ATTTATTGGT TTTCTATGAG GCATTTGGCA ACCCTGAAGA GTTTGTCATT 
GTTGAAAGGA CACCGCAGGG ACCACTGGCA GTACCTATGT GGAATAAGCA TGGATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IBTK ( XM_006715454.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006715517.1 Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X2, mRNA.

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CloneID	OHu40770
Clone ID Related Accession (Same CDS sequence)	XM_006715454.2 , XM_006715454.3
Accession Version	XM_006715454.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	inhibitor of Bruton tyrosine kinase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006715454.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGGAGTTTC GTTCTTGTTG CCCAGGCTGG AGTGCAATGG 
CTTGATCTCA GCTCACCGCA ACCTCTGCCT CCTGGGTTCA AGCGATTCTC CTGCCTCCGC 
CACCCTAGTA GCTGGGATTA CAGATGCTCT ACCCATGGTA CCCCAGGACC AGAAGGCAAC 
CATATTTCAG ATTTACCACT TCTAGACAGT CCCAATCCCT GGCTATCTTC TTCAGTGACT 
GCTCCATCCA TGGTAGCCCC AGTCACTTTT GCATCTATTG TAGAAGAAGA ACTACAACAA 
GAAGCAGCTC TTATTAGAAG TCGAGAAAAA CCGTTGGCTC TGATTCAGAT TGAGGAGCAT 
GCCATACAAG ATTTATTGGT TTTCTATGAG GCATTTGGCA ACCCTGAAGA GTTTGTCATT 
GTTGAAAGGA CACCGCAGGG ACCACTGGCA GTACCTATGT GGAATAAGCA TGGATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006715517.1
CDS	544..4683
Translation	MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSSPQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Target ORF information:

RefSeq Version	XM_006715454.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006715454.3

ORF Insert Sequence:

ATGAGTTCAC CCATGCCTGA CTGCACATCA AAGTGTCGAT CCCTGAAGCA TGCTTTGGAT 
GTCCTTTCTG TGGTAACAAA GGGGAGCGAA AACCAGATTA AGGCCTTTCT CTCCAGTCAT 
TGTTACAATG CTGCAACTAT CAAGGATGTT TTTGGCAGGA ATGCCCTCCA CCTTGTTTCC 
TCCTGTGGAA AGAAAGGAGT GTTAGATTGG CTTATTCAGA AAGGAGTGGA TCTGTTGGTG 
AAAGACAAAG AGTCTGGATG GACAGCATTG CACAGAAGCA TTTTTTATGG ACATATTGAT 
TGTGTTTGGT CTCTATTGAA GCATGGTGTT AGTCTGTATA TTCAAGATAA AGAAGGCTTG 
TCAGCTTTGG ATCTTGTAAT GAAGGATAGA CCAACTCATG TAGTATTCAA GAATACTGAT 
CCTACAGATG TTTATACTTG GGGCGATAAT ACAAATTTTA CCCTGGGTCA TGGAAGCCAG 
AATAGCAAAC ATCATCCAGA GTTGGTGGAT CTGTTCTCCA GGAGTGGGAT TTATATCAAG 
CAGGTGGTGC TTTGTAAATT TCACTCCGTG TTTCTGTCTC AGAAAGGGCA GGTTTATACC 
TGTGGTCATG GTCCTGGAGG GCGATTAGGA CATGGAGATG AACAGACATG CTTGGTCCCT 
CGGCTTGTGG AAGGACTGAA TGGTCATAAT TGTTCCCAAG TGGCAGCTGC TAAGGATCAT 
ACTGTTGTAT TAACTGAAGA TGGATGTGTT TATACATTTG GTCTAAACAT TTTTCATCAA 
TTAGGAATTA TTCCACCGCC TTCCAGTTGT AATGTACCCA GACAGATACA GGCAAAATAT 
CTGAAAGGAA GGACAATCAT TGGCGTTGCA GCAGGCAGGT TTCATACAGT CCTATGGACT 
AGAGAAGCTG TTTACACTAT GGGACTAAAT GGTGGACAAC TGGGTTGTTT GCTAGATCCC 
AATGGAGAAA AGTGTGTAAC TGCTCCTCGT CAGGTCTCTG CCCTTCACCA TAAAGACATT 
GCTCTGTCTT TGGTTGCTGC AAGTGATGGA GCTACAGTCT GTGTTACCAC AAGGGGAGAT 
ATTTACTTAC TTGCAGACTA TCAGTGCAAG AAGATGGCTT CTAAACAGTT GAACTTGAAA 
AAAGTTCTTG TGTCTGGGGG TCATATGGAA TACAAGGTTG ATCCTGAACA TTTGAAAGAA 
AATGGGGGTC AAAAAATTTG CATTCTTGCA ATGGATGGAG CTGGAAGGGT GTTTTGCTGG 
AGATCAGTCA ACAGTTCTCT GAAGCAGTGT CGATGGGCCT ATCCACGTCA GGTCTTCATT 
TCTGATATTG CTTTAAATAG AAATGAAATT CTATTTGTTA CGCAAGATGG AGAAGGATTT 
AGAGGGAGAT GGTTTGAAGA GAAAAGAAAG AGTTCTGAAA AGAAAGAGAT TTTATCAAAC 
CTTCACAATT CCTCATCAGA TGTGTCTTAT GTCTCTGATA TAAATAGTGT GTATGAAAGA 
ATTCGACTTG AGAAACTTAC CTTTGCACAT AGAGCTGTTA GTGTCAGCAC AGATCCAAGT 
GGATGCAACT TTGCAATCCT GCAGTCAGAT CCTAAAACAA GCCTTTATGA AATTCCAGCT 
GTGTCCTCAT CATCCTTTTT TGAAGAGTTT GGCAAACTGT TGAGGGAAGC AGATGAAATG 
GACAGCATTC ATGATGTGAC ATTTCAAGTT GGCAATAGAC TCTTCCCTGC ACATAAATAT 
ATTTTGGCAG TGCATTCTGA TTTTTTTCAG AAATTGTTTC TTTCAGATGG TAATACTTCA 
GAATTTACAG ATATTTACCA GAAAGATGAA GATTCTGCAG GGTGCCATCT CTTTGTGGTA 
GAGAAGGTTC ATCCTGACAT GTTTGAATAC CTTTTACAAT TTATATACAC AGATACTTGT 
GACTTTTTAA CTCATGGCTT CAAACCAAGA ATACACTTAA ACAAAAACCC AGAAGAATAT 
CAGGGAACTC TGAATTCTCA TTTGAATAAA GTGAATTTCC ATGAAGATGA TAACCAGAAG 
TCTGCATTTG AAGTTTACAA AAGTAATCAA GCTCAAACAG TTAGTGAGAG GCAGAAGAGC 
AAACCTAAAT CTTGTAAAAA AGGAAAAAAT ATTAGGGAAG ATGATCCTGT AAGAATGTTG 
CAAACTGTTG CAAAGAAATT CGACTTCAGT AATTTGAGTA GTAGGTTAGA TGGAGTCAGA 
TTTGAAAATG AAAAAATTAA TGTTATTGCC AAGAACACTG GTAATAAACT GAAGCTAAGT 
CAGAAAAAAT GTTCATTTCT GTGTGACGTG ACCATGAAAT CAGTGGATGG AAAGGAATTT 
CCTTGTCATA AATGTGTTCT TTGTGCTAGA CTTGAATATT TTCATAGTAT GCTGAGTAGC 
TCATGGATTG AGGCTTCCAG TTGTGCAGCT CTGGAAATGC CAATACATTC TGATATATTA 
AAAGTTATTT TGGACTACCT CTATACTGAT GAAGCTGTGG TGATAAAAGA ATCTCAAAAT 
GTAGATTTTA TTTGTAGTGT TCTTGTGGTG GCTGATCAAC TTCTCATAAC CCGGTTGAAA 
GAGATTTGTG AAGTAGCATT AACTGAAAAA CTTACCCTGA AGAATGCTGC TATGCTACTG 
GAATTTGCAG CAATGTATAG TGCAAAACAG TTGAAACTGT CTTGTTTACA GTTTATAGGA 
TTGAATATGG CAGCTTTACT TGAAGCAAGG TCTCTTGATG TTTTAAGCGA TGGTGTTTTG 
AAGGATCTTT CTGAGTTTTA CCGGAAAATG ATTCCAGCAA TGGATAGAAG AGTCATTACA 
CCATATCAAG ATGGACCAGA TATTAGCTAT TTGGAAGTAG AAGATGGAGA TATCTTCTTG 
AAAGAAGAAA TAAATATGGA ACAAAATCAT TCGGAAACTA TGTTCAAGAA AGCAAAAACA 
AAAGCTAAAA AGAAGCCACG TAAACGTTCA GATAGTTCTG GAGGTTATAA CCTTTCAGAT 
ATTATTCAGA GTCCATCATC TACAGAACTG TTGACATCAG ACTCTGAAGG AAGCTATGCA 
GGAGTGGGTA GTCCTAGAGA TTTACAGTCC CCTGATTTCA CAACAGGATT TCATTCAGAT 
AAGATTGAGG CGAAAGTCAA ACCGTATGTT AATGGTACAT CTCCTGTGTA TTCTAGGGAA 
GATTTAAAAC CATGGGAAAA GTCACCAATA CTTAAAATAT CTGCTCCACA GCCTATTCCC 
AGTAACAGAA TTGATACTAC CAGCTCTGCC AGTTGGGTTG CTGGTTCTTT CAGTCCTGTC 
AGCCCTCCTG TTGTGGATCT CAGAACTATC ATGGAAATAG AAGAAAGTAG ACAAAAATGT 
GGAGCTACAC CAAAGTCACA TTTAGGCAAA ACAGTTTCTC ATGGAGTTAA ACTTTCTCAG 
AAGCAACGAA AAATGATTGC ATTGACTACC AAGGAAAACA ATTCAGGAAT GAATAGCATG 
GAAACAGTTT TATTCACTCC TTCAAAAGCC CCCAAACCAG TGAATGCATG GGCATCTTCT 
CTGCATTCAG TTTCATCCAA GTCATTCCGG GATTTCTTAC TAGAAGAAAA AAAGTCTGTT 
ACTAGCCATA GTTCAGGCGA TCATGTCAAA AAAGTTTCTT TTAAAGGAAT TGAAAATTCT 
CAGGCACCAA AAATTGTCAG ATGGAGTTTC GTTCTTGTTG CCCAGGCTGG AGTGCAATGG 
CTTGATCTCA GCTCACCGCA ACCTCTGCCT CCTGGGTTCA AGCGATTCTC CTGCCTCCGC 
CACCCTAGTA GCTGGGATTA CAGATGCTCT ACCCATGGTA CCCCAGGACC AGAAGGCAAC 
CATATTTCAG ATTTACCACT TCTAGACAGT CCCAATCCCT GGCTATCTTC TTCAGTGACT 
GCTCCATCCA TGGTAGCCCC AGTCACTTTT GCATCTATTG TAGAAGAAGA ACTACAACAA 
GAAGCAGCTC TTATTAGAAG TCGAGAAAAA CCGTTGGCTC TGATTCAGAT TGAGGAGCAT 
GCCATACAAG ATTTATTGGT TTTCTATGAG GCATTTGGCA ACCCTGAAGA GTTTGTCATT 
GTTGAAAGGA CACCGCAGGG ACCACTGGCA GTACCTATGT GGAATAAGCA TGGATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The expression of inhibitor of bruton's tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis.
Cell death & disease9(1)13(2018 Jan)
Albano F,Chiurazzi F,Mimmi S,Vecchio E,Pastore A,Cimmino C,Frieri C,Iaccino E,Pisano A,Golino G,Fiume G,Mallardo M,Scala G,Quinto I

Function of inhibitor of Bruton's tyrosine kinase isoform ? (IBTK?) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.
The Journal of biological chemistry292(34)14050-14065(2017 08)
Willy JA,Young SK,Mosley AL,Gawrieh S,Stevens JL,Masuoka HC,Wek RC

IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells.
International journal of molecular sciences17(11)(2016 Nov)
Fiume G,Scialdone A,Rizzo F,De Filippo MR,Laudanna C,Albano F,Golino G,Vecchio E,Pontoriero M,Mimmi S,Ceglia S,Pisano A,Iaccino E,Palmieri C,Paduano S,Viglietto G,Weisz A,Scala G,Quinto I

CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation.
The Journal of biological chemistry290(22)13958-71(2015 May)
Pisano A,Ceglia S,Palmieri C,Vecchio E,Fiume G,de Laurentiis A,Mimmi S,Falcone C,Iaccino E,Scialdone A,Pontoriero M,Masci FF,Valea R,Krishnan S,Gaspari M,Cuda G,Scala G,Quinto I

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTK?.
Molecular biology of the cell25(10)1686-97(2014 May)
Baird TD,Palam LR,Fusakio ME,Willy JA,Davis CM,McClintick JN,Anthony TG,Wek RC

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IBTK cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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