REXO2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	REXO2
Entrez Gene ID	25996
Full Name	RNA exonuclease 2
Synonyms	CGI-114,REX2,RFN,SFN
General protein information	Preferred Names RNA exonuclease 2 Names oligoribonuclease, mitochondrial REX2, RNA exonuclease 2 homolog RNA exonuclease 2 homolog small fragment nuclease
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.2
Summary	This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011].
Disorder MIM:	607149

mRNA and Protein(s)

mRNA	Protein	Name
NM_015523.4	NP_056338.2	oligoribonuclease, mitochondrial precursor
NM_015523.3	NP_056338.2	oligoribonuclease, mitochondrial precursor

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os02g0465500	NP_001046810.1
Pan troglodytes (chimpanzee)	REXO2	XP_508768.1
Canis lupus familiaris (dog)	REXO2	XP_005619809.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004759	XP_318057.3
Saccharomyces cerevisiae (baker's yeast)	REX2	NP_013160.1
Eremothecium gossypii	AGOS_ACR217C	NP_983619.1
Arabidopsis thaliana (thale cress)	AT2G26970	NP_850090.1
	REXO2	XP_001087552.1
Mus musculus (house mouse)	Rexo2	NP_077195.2
Kluyveromyces lactis	KLLA0F08998g	XP_455489.1
Homo sapiens (human)	REXO2	NP_056338.2
Gallus gallus (chicken)	REXO2	NP_001265049.1
Drosophila melanogaster (fruit fly)	CG10214	NP_651184.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012804	XP_307582.4
Caenorhabditis elegans (roundworm)	CELE_C08B6.8	NP_001256185.1
Xenopus tropicalis (tropical clawed frog)	rexo2	XP_004916097.1
Bos taurus (cattle)	REXO2	NP_001075204.1
Rattus norvegicus (Norway rat)	Rexo2	NP_001008327.1
Danio rerio (zebrafish)	smfn	NP_957038.1
Schizosaccharomyces pombe (fission yeast)	rex2	NP_596699.2
Magnaporthe oryzae (rice blast fungus)	MGG_04496	XP_003710959.1

Gene Ontology
Bibliography

Related articles in PubMed

14-3-3? confers cisplatin resistance in esophageal squamous cell carcinoma cells via regulating DNA repair molecules.
Lai KK, Chan KT, Choi MY, Wang HK, Fung EY, Lam HY, Tan W, Tung LN, Tong DK, Sun RW, Lee NP, Law S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(2)2127-36(2016 Feb)

14-3-3 Binding and Sumoylation Concur to the Down-Modulation of ?-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.
Mancini M, Leo E, Takemaru K, Campi V, Castagnetti F, Soverini S, De Benedittis C, Rosti G, Cavo M, Santucci MA, Martinelli G
PloS one10(7)e0131074(2015)

The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.
Vogel S, Herzinger T
Photodermatology, photoimmunology & photomedicine29(6)300-10(2013 Dec)

REXO2 is an oligoribonuclease active in human mitochondria.
Bruni F, Gramegna P, Oliveira JM, Lightowlers RN, Chrzanowska-Lightowlers ZM
PloS one8(5)e64670(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results demonstrate that 14-3-3sigma induces cisplatin resistance in esophageal squamous cell carcinoma cells
Title: 14-3-3? confers cisplatin resistance in esophageal squamous cell carcinoma cells via regulating DNA repair molecules.

CBY1 downregulation in CML arises from reduced protein stability upon binding to 14-3-3sigma adapter protein. The ubiquitin proteasome system UPS participates in reducing stability of CBY1 bound with 14-3-3sigma through enhanced SUMOylation.
Title: 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of ?-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.

Loss of 14-3-3sigma sensitizes cells to UVB. After a transient cell cycle arrest, 14-3-3sigma-deficient cells die by undergoing mitotic catastrophe.
Title: The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.

REXO2 is an oligoribonuclease active in human mitochondria and present both in cytosolic and mitochondrial fractions.
Title: REXO2 is an oligoribonuclease active in human mitochondria.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following REXO2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the REXO2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09086	NM_015523.4 Latest version!	Homo sapiens RNA exonuclease 2 (REXO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09086	NM_015523.3	Homo sapiens RNA exonuclease 2 (REXO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

REXO2 ( NM_015523.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056338.2 Homo sapiens RNA exonuclease 2 (REXO2), mRNA.

Price & Availability↑

CloneID	OHu09086
Clone ID Related Accession (Same CDS sequence)	NM_015523.4 , NM_015523.3
Accession Version	NM_015523.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-17
Organism	Homo sapiens(human)
Product	oligoribonuclease, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC143701.1 and AI249345.1. On Nov 23, 2018 this sequence version replaced NM_015523.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL110239.1, SRR5189667.111640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000265881.10/ ENSP00000265881.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTAGGCG GCTCCCTGGG CTCCAGGCTG TTGCGGGGTG TAGGTGGGAG TCACGGACGG 
TTCGGGGCCC GAGGTGTCCG CGAAGGTGGC GCAGCCATGG CGGCAGGGGA GAGCATGGCT 
CAGCGGATGG TCTGGGTGGA CCTGGAGATG ACAGGATTGG ACATTGAGAA GGACCAGATT 
ATTGAGATGG CCTGTCTGAT AACTGACTCT GATCTCAACA TTTTGGCTGA AGGTCCTAAC 
CTGATTATAA AACAACCAGA TGAGTTGCTG GACAGCATGT CAGATTGGTG TAAGGAGCAT 
CACGGGAAGT CTGGCCTTAC CAAGGCAGTG AAGGAGAGTA CAATTACATT GCAGCAGGCA 
GAGTATGAAT TTCTGTCCTT TGTACGACAG CAGACTCCTC CAGGGCTCTG TCCACTTGCA 
GGAAATTCAG TTCATGAAGA TAAGAAGTTT CTTGACAAAT ACATGCCCCA GTTCATGAAA 
CATCTTCATT ATAGAATAAT TGATGTGAGC ACTGTTAAAG AACTGTGCAG ACGCTGGTAT 
CCAGAAGAAT ATGAATTTGC ACCAAAGAAG GCTGCTTCTC ATAGGGCACT TGATGACATT 
AGTGAAAGCA TCAAAGAGCT TCAGTTTTAC CGAAATAACA TCTTCAAGAA AAAAATAGAT 
GAAAAGAAGA GGAAAATTAT AGAAAATGGG GAAAATGAGA AGACCGTGAG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056338.2
CDS	63..776
Translation	MLGGSLGSRLLRGVGGSHGRFGARGVREGGAAMAAGESMAQRMVWVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQAEYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWYPEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENGENEKTVS

Target ORF information:

RefSeq Version	NM_015523.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA exonuclease 2 (REXO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015523.4

ORF Insert Sequence:

ATGCTAGGCG GCTCCCTGGG CTCCAGGCTG TTGCGGGGTG TAGGTGGGAG TCACGGACGG 
TTCGGGGCCC GAGGTGTCCG CGAAGGTGGC GCAGCCATGG CGGCAGGGGA GAGCATGGCT 
CAGCGGATGG TCTGGGTGGA CCTGGAGATG ACAGGATTGG ACATTGAGAA GGACCAGATT 
ATTGAGATGG CCTGTCTGAT AACTGACTCT GATCTCAACA TTTTGGCTGA AGGTCCTAAC 
CTGATTATAA AACAACCAGA TGAGTTGCTG GACAGCATGT CAGATTGGTG TAAGGAGCAT 
CACGGGAAGT CTGGCCTTAC CAAGGCAGTG AAGGAGAGTA CAATTACATT GCAGCAGGCA 
GAGTATGAAT TTCTGTCCTT TGTACGACAG CAGACTCCTC CAGGGCTCTG TCCACTTGCA 
GGAAATTCAG TTCATGAAGA TAAGAAGTTT CTTGACAAAT ACATGCCCCA GTTCATGAAA 
CATCTTCATT ATAGAATAAT TGATGTGAGC ACTGTTAAAG AACTGTGCAG ACGCTGGTAT 
CCAGAAGAAT ATGAATTTGC ACCAAAGAAG GCTGCTTCTC ATAGGGCACT TGATGACATT 
AGTGAAAGCA TCAAAGAGCT TCAGTTTTAC CGAAATAACA TCTTCAAGAA AAAAATAGAT 
GAAAAGAAGA GGAAAATTAT AGAAAATGGG GAAAATGAGA AGACCGTGAG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REXO2 ( NM_015523.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056338.2 Homo sapiens RNA exonuclease 2 (REXO2), mRNA.

Price & Availability↑

CloneID	OHu09086
Clone ID Related Accession (Same CDS sequence)	NM_015523.4 , NM_015523.3
Accession Version	NM_015523.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	oligoribonuclease, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB471224.1, BC143701.1 and AI249345.1. On Mar 4, 2009 this sequence version replaced NM_015523.2. ##Evidence-Data-START## Transcript exon combination :: AF151872.1, BM452291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTAGGCG GCTCCCTGGG CTCCAGGCTG TTGCGGGGTG TAGGTGGGAG TCACGGACGG 
TTCGGGGCCC GAGGTGTCCG CGAAGGTGGC GCAGCCATGG CGGCAGGGGA GAGCATGGCT 
CAGCGGATGG TCTGGGTGGA CCTGGAGATG ACAGGATTGG ACATTGAGAA GGACCAGATT 
ATTGAGATGG CCTGTCTGAT AACTGACTCT GATCTCAACA TTTTGGCTGA AGGTCCTAAC 
CTGATTATAA AACAACCAGA TGAGTTGCTG GACAGCATGT CAGATTGGTG TAAGGAGCAT 
CACGGGAAGT CTGGCCTTAC CAAGGCAGTG AAGGAGAGTA CAATTACATT GCAGCAGGCA 
GAGTATGAAT TTCTGTCCTT TGTACGACAG CAGACTCCTC CAGGGCTCTG TCCACTTGCA 
GGAAATTCAG TTCATGAAGA TAAGAAGTTT CTTGACAAAT ACATGCCCCA GTTCATGAAA 
CATCTTCATT ATAGAATAAT TGATGTGAGC ACTGTTAAAG AACTGTGCAG ACGCTGGTAT 
CCAGAAGAAT ATGAATTTGC ACCAAAGAAG GCTGCTTCTC ATAGGGCACT TGATGACATT 
AGTGAAAGCA TCAAAGAGCT TCAGTTTTAC CGAAATAACA TCTTCAAGAA AAAAATAGAT 
GAAAAGAAGA GGAAAATTAT AGAAAATGGG GAAAATGAGA AGACCGTGAG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056338.2
CDS	144..857
Translation	MLGGSLGSRLLRGVGGSHGRFGARGVREGGAAMAAGESMAQRMVWVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQAEYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWYPEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENGENEKTVS

Target ORF information:

RefSeq Version	NM_015523.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA exonuclease 2 (REXO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015523.3

ORF Insert Sequence:

ATGCTAGGCG GCTCCCTGGG CTCCAGGCTG TTGCGGGGTG TAGGTGGGAG TCACGGACGG 
TTCGGGGCCC GAGGTGTCCG CGAAGGTGGC GCAGCCATGG CGGCAGGGGA GAGCATGGCT 
CAGCGGATGG TCTGGGTGGA CCTGGAGATG ACAGGATTGG ACATTGAGAA GGACCAGATT 
ATTGAGATGG CCTGTCTGAT AACTGACTCT GATCTCAACA TTTTGGCTGA AGGTCCTAAC 
CTGATTATAA AACAACCAGA TGAGTTGCTG GACAGCATGT CAGATTGGTG TAAGGAGCAT 
CACGGGAAGT CTGGCCTTAC CAAGGCAGTG AAGGAGAGTA CAATTACATT GCAGCAGGCA 
GAGTATGAAT TTCTGTCCTT TGTACGACAG CAGACTCCTC CAGGGCTCTG TCCACTTGCA 
GGAAATTCAG TTCATGAAGA TAAGAAGTTT CTTGACAAAT ACATGCCCCA GTTCATGAAA 
CATCTTCATT ATAGAATAAT TGATGTGAGC ACTGTTAAAG AACTGTGCAG ACGCTGGTAT 
CCAGAAGAAT ATGAATTTGC ACCAAAGAAG GCTGCTTCTC ATAGGGCACT TGATGACATT 
AGTGAAAGCA TCAAAGAGCT TCAGTTTTAC CGAAATAACA TCTTCAAGAA AAAAATAGAT 
GAAAAGAAGA GGAAAATTAT AGAAAATGGG GAAAATGAGA AGACCGTGAG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

14-3-3? confers cisplatin resistance in esophageal squamous cell carcinoma cells via regulating DNA repair molecules.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(2)2127-36(2016 Feb)
Lai KK,Chan KT,Choi MY,Wang HK,Fung EY,Lam HY,Tan W,Tung LN,Tong DK,Sun RW,Lee NP,Law S

14-3-3 Binding and Sumoylation Concur to the Down-Modulation of ?-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.
PloS one10(7)e0131074(2015)
Mancini M,Leo E,Takemaru K,Campi V,Castagnetti F,Soverini S,De Benedittis C,Rosti G,Cavo M,Santucci MA,Martinelli G

The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.
Photodermatology, photoimmunology & photomedicine29(6)300-10(2013 Dec)
Vogel S,Herzinger T

REXO2 is an oligoribonuclease active in human mitochondria.
PloS one8(5)e64670(2013)
Bruni F,Gramegna P,Oliveira JM,Lightowlers RN,Chrzanowska-Lightowlers ZM

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REXO2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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