PARS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PARS2
Entrez Gene ID	25973
Full Name	prolyl-tRNA synthetase 2, mitochondrial
Synonyms	MT-PRORS,proRS
General protein information	Preferred Names prolyl-tRNA synthetase 2, mitochondrial Names probable proline--tRNA ligase, mitochondrial proline tRNA ligase 2, mitochondrial (putative) prolyl-tRNA synthetase 2, mitochondrial (putative)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p32.3
Summary	This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015].
Disorder MIM:	612036

mRNA and Protein(s)

mRNA	Protein	Name
NM_152268.3	NP_689481.2	probable proline--tRNA ligase, mitochondrial precursor
NM_152268.4	NP_689481.2	probable proline--tRNA ligase, mitochondrial precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Pars2	NP_001014086.1
Saccharomyces cerevisiae (baker's yeast)	AIM10	NP_011010.1
Kluyveromyces lactis	KLLA0E19801g	XP_454847.1
Xenopus tropicalis (tropical clawed frog)	pars2	NP_001120088.1
Homo sapiens (human)	PARS2	NP_689481.2
Canis lupus familiaris (dog)	PARS2	XP_005620314.1
Gallus gallus (chicken)	PARS2	NP_001264545.1
Danio rerio (zebrafish)	pars2	NP_991118.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003589	XP_313346.3
Eremothecium gossypii	AGOS_ACR233W	NP_983635.1
Pan troglodytes (chimpanzee)	PARS2	XP_513427.3
	PARS2	XP_001114166.1
Schizosaccharomyces pombe (fission yeast)	SPBC24C6.03	NP_595957.1
Magnaporthe oryzae (rice blast fungus)	MGG_06345	XP_003717237.1
Bos taurus (cattle)	PARS2	XP_002686423.1
Mus musculus (house mouse)	Pars2	NP_001077356.1
Drosophila melanogaster (fruit fly)	Aats-pro	NP_647737.1
Caenorhabditis elegans (roundworm)	pars-2	NP_001040689.1
Neurospora crassa	NCU09892	XP_958617.2

Gene Ontology
Bibliography

Related articles in PubMed

PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder.
Mizuguchi T, Nakashima M, Kato M, Yamada K, Okanishi T, Ekhilevitch N, Mandel H, Eran A, Toyono M, Sawaishi Y, Motoi H, Shiina M, Ogata K, Miyatake S, Miyake N, Saitsu H, Matsumoto N
Journal of human genetics62(5)525-529(2017 Apr)

Chronic Rhinosinusitis Patients Show Accumulation of Genetic Variants in PARS2.
Henmyr V, Lind-Halld?n C, Halld?n C, S?ll T, Carlberg D, Bachert C, Cardell LO
PloS one11(6)e0158202(2016)

Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.
Sofou K, Kollberg G, Holmstr?m M, D?vila M, Darin N, Gustafsson CM, Holme E, Oldfors A, Tulinius M, Asin-Cayuela J
Molecular genetics & genomic medicine3(1)59-68(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The individuals with PARS2 and NARS2 mutations demonstrate similar neurological features as those previously reported, with diversity in clinical presentation such as hearing loss and seizure type.
Title: PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder.

The PARS2 gene produced a significant association signal in a recent replication study of all known CRS-associations and is now the first human gene to be re-sequenced within CRS research. PARS2 showed an accumulation of low-frequency variants in CRS patients compared to background populations.
Title: Chronic Rhinosinusitis Patients Show Accumulation of Genetic Variants in PARS2.

unusual 2.0 A structure showing that ATP directly locks onto and orients two parts of halofuginone (HF) onto human ProRS, so that one part of HF mimics bound proline and the other mimics the 3' end of bound tRNA.
Title: ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following PARS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PARS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09326	NM_152268.4 Latest version!	Homo sapiens prolyl-tRNA synthetase 2, mitochondrial (PARS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu09326	NM_152268.3	Homo sapiens prolyl-tRNA synthetase 2, mitochondrial (PARS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PARS2 ( NM_152268.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689481.2 Homo sapiens prolyl-tRNA synthetase 2, mitochondrial (PARS2), mRNA.

Price & Availability↑

CloneID	OHu09326
Clone ID Related Accession (Same CDS sequence)	NM_152268.3 , NM_152268.4
Accession Version	NM_152268.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	probable proline--tRNA ligase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB004072.1 and BC011758.2. This sequence is a reference standard in the RefSeqGene project. On May 20, 2010 this sequence version replaced NM_152268.2. ##Evidence-Data-START## Transcript exon combination :: BC011758.2, SRR1803615.230915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGGGC TGCTGACAAG ATGCAGAGCA TTGCCCGCCC TGGCCACCTG CAGCCGCCAG 
CTCTCTGGGT ATGTTCCTTG CAGGTTTCAC CACTGTGCCC CAAGAAGAGG GCGGCGCCTG 
CTGCTGTCTC GTGTGTTCCA GCCACAGAAC CTTCGGGAAG ACCGGGTGCT CTCCCTGCAG 
GACAAATCTG ATGACCTGAC CTGTAAGAGC CAGCGGCTGA TGCTGCAGGT GGGCCTGATC 
TACCCAGCAA GCCCCGGCTG TTACCACCTC CTGCCATATA CCGTCCGTGC CATGGAGAAG 
CTCGTGCGAG TGATAGACCA GGAGATGCAG GCCATCGGGG GCCAGAAAGT CAACATGCCC 
AGCCTCAGCC CGGCAGAGCT CTGGCAAGCC ACCAACCGGT GGGACTTGAT GGGCAAAGAG 
CTGCTAAGAC TTAGAGACAG GCATGGCAAG GAATACTGCT TAGGACCAAC TCACGAGGAA 
GCCATTACGG CCTTAATTGC CTCCCAGAAG AAACTGTCCT ACAAGCAGCT TCCCTTCCTG 
CTGTACCAAG TGACAAGGAA GTTTCGGGAT GAGCCCAGGC CCCGCTTTGG TCTTCTCCGT 
GGCCGAGAGT TTTACATGAA GGATATGTAC ACCTTTGACT CCTCCCCAGA GGCTGCCCAG 
CAGACCTACA GCCTGGTGTG TGATGCCTAC TGCAGCCTGT TCAACAAGCT AGGGCTGCCA 
TTTGTCAAGG TCCAGGCCGA TGTGGGCACC ATCGGGGGCA CAGTGTCTCA TGAGTTCCAG 
CTCCCAGTGG ATATTGGAGA GGACCGGCTT GCCATCTGTC CCCGCTGCAG CTTCTCAGCC 
AACATGGAGA CACTAGACTT GTCACAAATG AACTGCCCTG CTTGCCAGGG CCCATTGACT 
AAAACCAAAG GCATTGAGGT GGGGCACACA TTTTACCTGG GTACCAAGTA CTCATCCATT 
TTCAATGCCC AGTTTACCAA TGTCTGTGGC AAACCAACCC TGGCTGAAAT GGGGTGCTAT 
GGCTTGGGTG TGACACGGAT CTTGGCTGCT GCCATTGAAG TCCTCTCTAC AGAAGACTGT 
GTCCGCTGGC CCAGCCTACT GGCCCCTTAC CAAGCCTGCC TCATCCCCCC TAAGAAGGGC 
AGTAAGGAGC AGGCGGCCTC CGAGCTCATA GGGCAGCTGT ACGACCACAT CACAGAGGCA 
GTGCCTCAGC TTCACGGGGA GGTGCTCCTG GACGACAGGA CCCATCTGAC CATCGGAAAC 
AGACTGAAAG ATGCCAACAA GTTTGGCTAC CCCTTTGTGA TAATCGCTGG CAAGAGGGCC 
CTGGAGGACC CTGCACATTT TGAGGTTTGG TGTCAGAACA CTGGTGAGGT GGCCTTCCTC 
ACCAAAGATG GAGTCATGGA TTTACTGACC CCAGTGCAGA CTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689481.2
CDS	123..1550
Translation	MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQNLREDRVLSLQDKSDDLTCKSQRLMLQVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMPSLSPAELWQATNRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQKKLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSLVCDAYCSLFNKLGLPFVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLTKTKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPSLLAPYQACLIPPKKGSKEQAASELIGQLYDHITEAVPQLHGEVLLDDRTHLTIGNRLKDANKFGYPFVIIAGKRALEDPAHFEVWCQNTGEVAFLTKDGVMDLLTPVQTV

Target ORF information:

RefSeq Version	NM_152268.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl-tRNA synthetase 2, mitochondrial (PARS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152268.3

ORF Insert Sequence:

ATGGAAGGGC TGCTGACAAG ATGCAGAGCA TTGCCCGCCC TGGCCACCTG CAGCCGCCAG 
CTCTCTGGGT ATGTTCCTTG CAGGTTTCAC CACTGTGCCC CAAGAAGAGG GCGGCGCCTG 
CTGCTGTCTC GTGTGTTCCA GCCACAGAAC CTTCGGGAAG ACCGGGTGCT CTCCCTGCAG 
GACAAATCTG ATGACCTGAC CTGTAAGAGC CAGCGGCTGA TGCTGCAGGT GGGCCTGATC 
TACCCAGCAA GCCCCGGCTG TTACCACCTC CTGCCATATA CCGTCCGTGC CATGGAGAAG 
CTCGTGCGAG TGATAGACCA GGAGATGCAG GCCATCGGGG GCCAGAAAGT CAACATGCCC 
AGCCTCAGCC CGGCAGAGCT CTGGCAAGCC ACCAACCGGT GGGACTTGAT GGGCAAAGAG 
CTGCTAAGAC TTAGAGACAG GCATGGCAAG GAATACTGCT TAGGACCAAC TCACGAGGAA 
GCCATTACGG CCTTAATTGC CTCCCAGAAG AAACTGTCCT ACAAGCAGCT TCCCTTCCTG 
CTGTACCAAG TGACAAGGAA GTTTCGGGAT GAGCCCAGGC CCCGCTTTGG TCTTCTCCGT 
GGCCGAGAGT TTTACATGAA GGATATGTAC ACCTTTGACT CCTCCCCAGA GGCTGCCCAG 
CAGACCTACA GCCTGGTGTG TGATGCCTAC TGCAGCCTGT TCAACAAGCT AGGGCTGCCA 
TTTGTCAAGG TCCAGGCCGA TGTGGGCACC ATCGGGGGCA CAGTGTCTCA TGAGTTCCAG 
CTCCCAGTGG ATATTGGAGA GGACCGGCTT GCCATCTGTC CCCGCTGCAG CTTCTCAGCC 
AACATGGAGA CACTAGACTT GTCACAAATG AACTGCCCTG CTTGCCAGGG CCCATTGACT 
AAAACCAAAG GCATTGAGGT GGGGCACACA TTTTACCTGG GTACCAAGTA CTCATCCATT 
TTCAATGCCC AGTTTACCAA TGTCTGTGGC AAACCAACCC TGGCTGAAAT GGGGTGCTAT 
GGCTTGGGTG TGACACGGAT CTTGGCTGCT GCCATTGAAG TCCTCTCTAC AGAAGACTGT 
GTCCGCTGGC CCAGCCTACT GGCCCCTTAC CAAGCCTGCC TCATCCCCCC TAAGAAGGGC 
AGTAAGGAGC AGGCGGCCTC CGAGCTCATA GGGCAGCTGT ACGACCACAT CACAGAGGCA 
GTGCCTCAGC TTCACGGGGA GGTGCTCCTG GACGACAGGA CCCATCTGAC CATCGGAAAC 
AGACTGAAAG ATGCCAACAA GTTTGGCTAC CCCTTTGTGA TAATCGCTGG CAAGAGGGCC 
CTGGAGGACC CTGCACATTT TGAGGTTTGG TGTCAGAACA CTGGTGAGGT GGCCTTCCTC 
ACCAAAGATG GAGTCATGGA TTTACTGACC CCAGTGCAGA CTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PARS2 ( NM_152268.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689481.2 Homo sapiens prolyl-tRNA synthetase 2, mitochondrial (PARS2), mRNA.

Price & Availability↑

CloneID	OHu09326
Clone ID Related Accession (Same CDS sequence)	NM_152268.3 , NM_152268.4
Accession Version	NM_152268.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	probable proline--tRNA ligase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB004072.1 and BC011758.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_152268.3. ##Evidence-Data-START## Transcript exon combination :: BC011758.2, SRR1803615.230915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000371279.4/ ENSP00000360327.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAAGGGC TGCTGACAAG ATGCAGAGCA TTGCCCGCCC TGGCCACCTG CAGCCGCCAG 
CTCTCTGGGT ATGTTCCTTG CAGGTTTCAC CACTGTGCCC CAAGAAGAGG GCGGCGCCTG 
CTGCTGTCTC GTGTGTTCCA GCCACAGAAC CTTCGGGAAG ACCGGGTGCT CTCCCTGCAG 
GACAAATCTG ATGACCTGAC CTGTAAGAGC CAGCGGCTGA TGCTGCAGGT GGGCCTGATC 
TACCCAGCAA GCCCCGGCTG TTACCACCTC CTGCCATATA CCGTCCGTGC CATGGAGAAG 
CTCGTGCGAG TGATAGACCA GGAGATGCAG GCCATCGGGG GCCAGAAAGT CAACATGCCC 
AGCCTCAGCC CGGCAGAGCT CTGGCAAGCC ACCAACCGGT GGGACTTGAT GGGCAAAGAG 
CTGCTAAGAC TTAGAGACAG GCATGGCAAG GAATACTGCT TAGGACCAAC TCACGAGGAA 
GCCATTACGG CCTTAATTGC CTCCCAGAAG AAACTGTCCT ACAAGCAGCT TCCCTTCCTG 
CTGTACCAAG TGACAAGGAA GTTTCGGGAT GAGCCCAGGC CCCGCTTTGG TCTTCTCCGT 
GGCCGAGAGT TTTACATGAA GGATATGTAC ACCTTTGACT CCTCCCCAGA GGCTGCCCAG 
CAGACCTACA GCCTGGTGTG TGATGCCTAC TGCAGCCTGT TCAACAAGCT AGGGCTGCCA 
TTTGTCAAGG TCCAGGCCGA TGTGGGCACC ATCGGGGGCA CAGTGTCTCA TGAGTTCCAG 
CTCCCAGTGG ATATTGGAGA GGACCGGCTT GCCATCTGTC CCCGCTGCAG CTTCTCAGCC 
AACATGGAGA CACTAGACTT GTCACAAATG AACTGCCCTG CTTGCCAGGG CCCATTGACT 
AAAACCAAAG GCATTGAGGT GGGGCACACA TTTTACCTGG GTACCAAGTA CTCATCCATT 
TTCAATGCCC AGTTTACCAA TGTCTGTGGC AAACCAACCC TGGCTGAAAT GGGGTGCTAT 
GGCTTGGGTG TGACACGGAT CTTGGCTGCT GCCATTGAAG TCCTCTCTAC AGAAGACTGT 
GTCCGCTGGC CCAGCCTACT GGCCCCTTAC CAAGCCTGCC TCATCCCCCC TAAGAAGGGC 
AGTAAGGAGC AGGCGGCCTC CGAGCTCATA GGGCAGCTGT ACGACCACAT CACAGAGGCA 
GTGCCTCAGC TTCACGGGGA GGTGCTCCTG GACGACAGGA CCCATCTGAC CATCGGAAAC 
AGACTGAAAG ATGCCAACAA GTTTGGCTAC CCCTTTGTGA TAATCGCTGG CAAGAGGGCC 
CTGGAGGACC CTGCACATTT TGAGGTTTGG TGTCAGAACA CTGGTGAGGT GGCCTTCCTC 
ACCAAAGATG GAGTCATGGA TTTACTGACC CCAGTGCAGA CTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689481.2
CDS	93..1520
Translation	MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQNLREDRVLSLQDKSDDLTCKSQRLMLQVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMPSLSPAELWQATNRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQKKLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSLVCDAYCSLFNKLGLPFVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLTKTKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPSLLAPYQACLIPPKKGSKEQAASELIGQLYDHITEAVPQLHGEVLLDDRTHLTIGNRLKDANKFGYPFVIIAGKRALEDPAHFEVWCQNTGEVAFLTKDGVMDLLTPVQTV

Target ORF information:

RefSeq Version	NM_152268.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl-tRNA synthetase 2, mitochondrial (PARS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152268.4

ORF Insert Sequence:

ATGGAAGGGC TGCTGACAAG ATGCAGAGCA TTGCCCGCCC TGGCCACCTG CAGCCGCCAG 
CTCTCTGGGT ATGTTCCTTG CAGGTTTCAC CACTGTGCCC CAAGAAGAGG GCGGCGCCTG 
CTGCTGTCTC GTGTGTTCCA GCCACAGAAC CTTCGGGAAG ACCGGGTGCT CTCCCTGCAG 
GACAAATCTG ATGACCTGAC CTGTAAGAGC CAGCGGCTGA TGCTGCAGGT GGGCCTGATC 
TACCCAGCAA GCCCCGGCTG TTACCACCTC CTGCCATATA CCGTCCGTGC CATGGAGAAG 
CTCGTGCGAG TGATAGACCA GGAGATGCAG GCCATCGGGG GCCAGAAAGT CAACATGCCC 
AGCCTCAGCC CGGCAGAGCT CTGGCAAGCC ACCAACCGGT GGGACTTGAT GGGCAAAGAG 
CTGCTAAGAC TTAGAGACAG GCATGGCAAG GAATACTGCT TAGGACCAAC TCACGAGGAA 
GCCATTACGG CCTTAATTGC CTCCCAGAAG AAACTGTCCT ACAAGCAGCT TCCCTTCCTG 
CTGTACCAAG TGACAAGGAA GTTTCGGGAT GAGCCCAGGC CCCGCTTTGG TCTTCTCCGT 
GGCCGAGAGT TTTACATGAA GGATATGTAC ACCTTTGACT CCTCCCCAGA GGCTGCCCAG 
CAGACCTACA GCCTGGTGTG TGATGCCTAC TGCAGCCTGT TCAACAAGCT AGGGCTGCCA 
TTTGTCAAGG TCCAGGCCGA TGTGGGCACC ATCGGGGGCA CAGTGTCTCA TGAGTTCCAG 
CTCCCAGTGG ATATTGGAGA GGACCGGCTT GCCATCTGTC CCCGCTGCAG CTTCTCAGCC 
AACATGGAGA CACTAGACTT GTCACAAATG AACTGCCCTG CTTGCCAGGG CCCATTGACT 
AAAACCAAAG GCATTGAGGT GGGGCACACA TTTTACCTGG GTACCAAGTA CTCATCCATT 
TTCAATGCCC AGTTTACCAA TGTCTGTGGC AAACCAACCC TGGCTGAAAT GGGGTGCTAT 
GGCTTGGGTG TGACACGGAT CTTGGCTGCT GCCATTGAAG TCCTCTCTAC AGAAGACTGT 
GTCCGCTGGC CCAGCCTACT GGCCCCTTAC CAAGCCTGCC TCATCCCCCC TAAGAAGGGC 
AGTAAGGAGC AGGCGGCCTC CGAGCTCATA GGGCAGCTGT ACGACCACAT CACAGAGGCA 
GTGCCTCAGC TTCACGGGGA GGTGCTCCTG GACGACAGGA CCCATCTGAC CATCGGAAAC 
AGACTGAAAG ATGCCAACAA GTTTGGCTAC CCCTTTGTGA TAATCGCTGG CAAGAGGGCC 
CTGGAGGACC CTGCACATTT TGAGGTTTGG TGTCAGAACA CTGGTGAGGT GGCCTTCCTC 
ACCAAAGATG GAGTCATGGA TTTACTGACC CCAGTGCAGA CTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder.
Journal of human genetics62(5)525-529(2017 Apr)
Mizuguchi T,Nakashima M,Kato M,Yamada K,Okanishi T,Ekhilevitch N,Mandel H,Eran A,Toyono M,Sawaishi Y,Motoi H,Shiina M,Ogata K,Miyatake S,Miyake N,Saitsu H,Matsumoto N

Chronic Rhinosinusitis Patients Show Accumulation of Genetic Variants in PARS2.
PloS one11(6)e0158202(2016)
Henmyr V,Lind-Halld?n C,Halld?n C,S?ll T,Carlberg D,Bachert C,Cardell LO

Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.
Molecular genetics & genomic medicine3(1)59-68(2015 Jan)
Sofou K,Kollberg G,Holmstr?m M,D?vila M,Darin N,Gustafsson CM,Holme E,Oldfors A,Tulinius M,Asin-Cayuela J

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PARS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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