TAS2R46 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R46
Entrez Gene ID	259292
Full Name	taste 2 receptor member 46
Synonyms	T2R46,T2R54
General protein information	Preferred Names taste 2 receptor member 46 Names taste receptor type 2 member 46 taste receptor type 2 member 54 taste receptor, type 2, member 46
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009].
Disorder MIM:	612774

mRNA and Protein(s)

mRNA	Protein	Name
NM_176887.2	NP_795368.2	taste receptor type 2 member 46

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAS2R46	XP_001151344.1
Rattus norvegicus (Norway rat)	Tas2r120	NP_001074406.1
Homo sapiens (human)	TAS2R46	NP_795368.2
Mus musculus (house mouse)	Tas2r120	NP_996906.1
Bos taurus (cattle)	TAS2R46	XP_002687824.1
	TAS2R46	XP_001113714.1
Canis lupus familiaris (dog)	CAFA-T2R43	NP_001138979.1
	LOC100427231	XP_002798554.1

Gene Ontology
Bibliography

Related articles in PubMed

Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers.
Yamaki M, Saito H, Isono K, Goto T, Shirakawa H, Shoji N, Satoh-Kuriwada S, Sasano T, Okada R, Kudoh K, Motoi F, Unno M, Komai M
Journal of nutritional science and vitaminology63(2)148-154(2017)

GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
Ledda M, Kutalik Z, Souza Destito MC, Souza MM, Cirillo CA, Zamboni A, Martin N, Morya E, Sameshima K, Beckmann JS, le Coutre J, Bergmann S, Genick UK
Human molecular genetics23(1)259-67(2014 Jan)

Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.
Lund TC, Kobs AJ, Kramer A, Nyquist M, Kuroki MT, Osborn J, Lidke DS, Low-Nam ST, Blazar BR, Tolar J
PloS one8(3)e58945(2013)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MSC express the bitter taste receptor, TAS2R46, a protein more typically localized to the taste bud. Expression was also confirmed in VSMCs.
Title: Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.

The following TAS2R46 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R46 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30358	NM_176887.2 Latest version!	Homo sapiens taste 2 receptor member 46 (TAS2R46), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R46 ( NM_176887.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_795368.2 Homo sapiens taste 2 receptor member 46 (TAS2R46), mRNA.

Price & Availability↑

CloneID	OHu30358
Clone ID Related Accession (Same CDS sequence)	NM_176887.2
Accession Version	NM_176887.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 46
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018630.40. On Nov 3, 2006 this sequence version replaced NM_176887.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000533467.1/ ENSP00000436450.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATAACTT TTCTGCCCAT CATTTTTTCC ATTCTAATAG TGGTTACATT TGTGATTGGA 
AATTTTGCTA ATGGCTTCAT AGCATTGGTA AATTCCATTG AGTGGTTCAA GAGACAAAAG 
ATCTCTTTTG CTGACCAAAT TCTCACTGCT CTGGCAGTCT CCAGAGTTGG TTTACTCTGG 
GTATTAGTAT TAAATTGGTA TGCAACTGAG TTGAATCCAG CTTTTAACAG TATAGAAGTA 
AGAATTACTG CTTACAATGT CTGGGCAGTA ATCAACCATT TCAGCAACTG GCTTGCTACT 
AGCCTCAGCA TATTTTATTT GCTCAAGATT GCCAATTTCT CCAACCTTAT TTTTCTTCAC 
TTAAAGAGGA GAGTTAAGAG TGTTGTTCTG GTGATACTAT TGGGGCCTTT GCTATTTTTG 
GTTTGTCATC TTTTTGTGAT AAACATGAAT CAGATTATAT GGACAAAAGA ATATGAAGGA 
AACATGACTT GGAAGATCAA ACTGAGGAGT GCAATGTACC TTTCAAATAC AACGGTAACC 
ATCCTAGCAA ACTTAGTTCC CTTCACTCTG ACCCTGATAT CTTTTCTGCT GTTAATCTGT 
TCTCTGTGTA AACATCTCAA AAAGATGCAG CTCCATGGCA AAGGATCTCA AGATCCCAGC 
ATGAAGGTCC ACATAAAAGC TTTGCAAACT GTGACCTCCT TCCTCTTGTT ATGTGCCATT 
TACTTTCTGT CCATAATCAT GTCAGTTTGG AGTTTTGAGA GTCTGGAAAA CAAACCTGTC 
TTCATGTTCT GCGAAGCTAT TGCATTCAGC TATCCTTCAA CCCACCCATT CATCCTGATT 
TGGGGAAACA AGAAGCTAAA GCAGACTTTT CTTTCAGTTT TGTGGCATGT GAGGTACTGG 
GTGAAAGGAG AGAAGCCTTC ATCTTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_795368.2
CDS	1..930
Translation	MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS

Target ORF information:

RefSeq Version	NM_176887.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 46 (TAS2R46), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176887.2

ORF Insert Sequence:

ATGATAACTT TTCTGCCCAT CATTTTTTCC ATTCTAATAG TGGTTACATT TGTGATTGGA 
AATTTTGCTA ATGGCTTCAT AGCATTGGTA AATTCCATTG AGTGGTTCAA GAGACAAAAG 
ATCTCTTTTG CTGACCAAAT TCTCACTGCT CTGGCAGTCT CCAGAGTTGG TTTACTCTGG 
GTATTAGTAT TAAATTGGTA TGCAACTGAG TTGAATCCAG CTTTTAACAG TATAGAAGTA 
AGAATTACTG CTTACAATGT CTGGGCAGTA ATCAACCATT TCAGCAACTG GCTTGCTACT 
AGCCTCAGCA TATTTTATTT GCTCAAGATT GCCAATTTCT CCAACCTTAT TTTTCTTCAC 
TTAAAGAGGA GAGTTAAGAG TGTTGTTCTG GTGATACTAT TGGGGCCTTT GCTATTTTTG 
GTTTGTCATC TTTTTGTGAT AAACATGAAT CAGATTATAT GGACAAAAGA ATATGAAGGA 
AACATGACTT GGAAGATCAA ACTGAGGAGT GCAATGTACC TTTCAAATAC AACGGTAACC 
ATCCTAGCAA ACTTAGTTCC CTTCACTCTG ACCCTGATAT CTTTTCTGCT GTTAATCTGT 
TCTCTGTGTA AACATCTCAA AAAGATGCAG CTCCATGGCA AAGGATCTCA AGATCCCAGC 
ATGAAGGTCC ACATAAAAGC TTTGCAAACT GTGACCTCCT TCCTCTTGTT ATGTGCCATT 
TACTTTCTGT CCATAATCAT GTCAGTTTGG AGTTTTGAGA GTCTGGAAAA CAAACCTGTC 
TTCATGTTCT GCGAAGCTAT TGCATTCAGC TATCCTTCAA CCCACCCATT CATCCTGATT 
TGGGGAAACA AGAAGCTAAA GCAGACTTTT CTTTCAGTTT TGTGGCATGT GAGGTACTGG 
GTGAAAGGAG AGAAGCCTTC ATCTTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers.
Journal of nutritional science and vitaminology63(2)148-154(2017)
Yamaki M,Saito H,Isono K,Goto T,Shirakawa H,Shoji N,Satoh-Kuriwada S,Sasano T,Okada R,Kudoh K,Motoi F,Unno M,Komai M

GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
Human molecular genetics23(1)259-67(2014 Jan)
Ledda M,Kutalik Z,Souza Destito MC,Souza MM,Cirillo CA,Zamboni A,Martin N,Morya E,Sameshima K,Beckmann JS,le Coutre J,Bergmann S,Genick UK

Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.
PloS one8(3)e58945(2013)
Lund TC,Kobs AJ,Kramer A,Nyquist M,Kuroki MT,Osborn J,Lidke DS,Low-Nam ST,Blazar BR,Tolar J

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

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TAS2R46 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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