TAS2R31 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R31
Entrez Gene ID	259290
Full Name	taste 2 receptor member 31
Synonyms	T2R31,T2R44,T2R53,TAS2R44
General protein information	Preferred Names taste 2 receptor member 31 Names taste receptor type 2 member 31 taste receptor type 2 member 44 taste receptor type 2 member 53 taste receptor, type 2, member 31
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009].
Disorder MIM:	612669

mRNA and Protein(s)

mRNA	Protein	Name
NM_176885.2	NP_795366.2	taste receptor type 2 member 31

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAS2R31	XP_001151214.2
Mus musculus (house mouse)	Tas2r136	NP_851793.1
Homo sapiens (human)	TAS2R31	NP_795366.2
	LOC693892	XP_001082348.1
Rattus norvegicus (Norway rat)	Tas2r136	NP_001160150.1

Gene Ontology
Bibliography

Related articles in PubMed

Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults.
Bobowski N, Reed DR, Mennella JA
Scientific reports639135(2016 Dec)

Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.
Hayes JE, Feeney EL, Nolden AA, McGeary JE
Chemical senses40(6)437-43(2015 Jul)

Do polymorphisms in chemosensory genes matter for human ingestive behavior?
Hayes JE, Feeney EL, Allen AL
Food quality and preference30(2)202-216(2013 Dec)

Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in
Allen AL, McGeary JE, Hayes JE
Chemosensory perception6(3)(2013 Sep)

Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31.
Allen AL, McGeary JE, Knopik VS, Hayes JE
Chemical senses38(5)379-89(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genotypes for the Val240Ile (rs10772423) SNP in TAS2R31 remains significant at a Bonferroni corrected alpha of 0.025.
Title: Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.

Haplotype analyses revealed that most associations were spurious, arising from LD with variants in TAS2R31.
Title: Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners.

hT2R43 gene allele makes people more sensitive to the bitterness of an artificial sweetener, saccharin; in addition, a closely related gene's (hT2R44's) allele also makes people more sensitive to the bitterness of saccharin.
Title: Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.

hTAS2R43 and hTAS2R44 function as cognate bitter taste receptors and do not contribute to the sweet taste of saccharin and acesulfame K.
Title: Bitter taste receptors for saccharin and acesulfame K.

Activation by denatonium and 6-nitrosaccharin.
Title: Identification of ligands for two human bitter T2R receptors.

The following TAS2R31 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R31 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30073	NM_176885.2 Latest version!	Homo sapiens taste 2 receptor member 31 (TAS2R31), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R31 ( NM_176885.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_795366.2 Homo sapiens taste 2 receptor member 31 (TAS2R31), mRNA.

Price & Availability↑

CloneID	OHu30073
Clone ID Related Accession (Same CDS sequence)	NM_176885.2
Accession Version	NM_176885.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 31
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018630.40. On Oct 17, 2006 this sequence version replaced NM_176885.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC117421.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000390675.2/ ENSP00000375093.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGACAACTT TTATACCCAT CATTTTTTCC AGTGTGGTAG TGGTTCTATT TGTTATTGGA 
AATTTTGCTA ATGGCTTCAT AGCATTGGTA AATTCCATTG AGCGGGTCAA GAGACAAAAG 
ATCTCTTTTG CTGACCAGAT TCTCACTGCT CTGGCGGTCT CCAGAGTTGG TTTGCTCTGG 
GTATTATTAT TAAATTGGTA TTCAACTGTG TTTAATCCAG CTTTTTATAG TGTAGAAGTA 
AGAACTACTG CTTATAATGT CTGGGCAGTA ACCGGCCATT TCAGCAACTG GCTTGCTACT 
AGCCTCAGCA TATTTTATTT GCTCAAGATT GCCAATTTCT CCAACCTTAT TTTTCTTCAC 
TTAAAGAGGA GAGTTAAGAG TGTCATTCTG GTGATGCTGT TGGGGCCTTT ACTATTTTTG 
GCTTGTCAAC TTTTTGTGAT AAACATGAAA GAGATTGTAC GGACAAAAGA ATATGAAGGA 
AACTTGACTT GGAAGATCAA ATTGAGGAGT GCAGTGTACC TTTCAGATGC GACTGTAACC 
ACGCTAGGAA ACTTAGTGCC CTTCACTCTG ACCCTGCTAT GTTTTTTGCT GTTAATCTGT 
TCTCTGTGTA AACATCTCAA GAAGATGCAG CTCCATGGTA AAGGATCTCA AGATCCCAGC 
ACCAAGGTCC ACATAAAAGC TTTGCAAACT GTGATCTTTT TCCTCTTGTT ATGTGCCGTT 
TACTTTCTGT CCATAATGAT ATCAGTTTGG AGTTTTGGGA GTCTGGAAAA CAAACCTGTC 
TTCATGTTCT GCAAAGCTAT TAGATTCAGC TATCCTTCAA TCCACCCATT CATCCTGATT 
TGGGGAAACA AGAAGCTAAA GCAGACTTTT CTTTCAGTTT TGCGGCAAGT GAGGTACTGG 
GTGAAAGGAG AGAAGCCTTC ATCTCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_795366.2
CDS	73..1002
Translation	MTTFIPIIFSSVVVVLFVIGNFANGFIALVNSIERVKRQKISFADQILTALAVSRVGLLWVLLLNWYSTVFNPAFYSVEVRTTAYNVWAVTGHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVILVMLLGPLLFLACQLFVINMKEIVRTKEYEGNLTWKIKLRSAVYLSDATVTTLGNLVPFTLTLLCFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVIFFLLLCAVYFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILIWGNKKLKQTFLSVLRQVRYWVKGEKPSSP

Target ORF information:

RefSeq Version	NM_176885.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 31 (TAS2R31), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176885.2

ORF Insert Sequence:

ATGACAACTT TTATACCCAT CATTTTTTCC AGTGTGGTAG TGGTTCTATT TGTTATTGGA 
AATTTTGCTA ATGGCTTCAT AGCATTGGTA AATTCCATTG AGCGGGTCAA GAGACAAAAG 
ATCTCTTTTG CTGACCAGAT TCTCACTGCT CTGGCGGTCT CCAGAGTTGG TTTGCTCTGG 
GTATTATTAT TAAATTGGTA TTCAACTGTG TTTAATCCAG CTTTTTATAG TGTAGAAGTA 
AGAACTACTG CTTATAATGT CTGGGCAGTA ACCGGCCATT TCAGCAACTG GCTTGCTACT 
AGCCTCAGCA TATTTTATTT GCTCAAGATT GCCAATTTCT CCAACCTTAT TTTTCTTCAC 
TTAAAGAGGA GAGTTAAGAG TGTCATTCTG GTGATGCTGT TGGGGCCTTT ACTATTTTTG 
GCTTGTCAAC TTTTTGTGAT AAACATGAAA GAGATTGTAC GGACAAAAGA ATATGAAGGA 
AACTTGACTT GGAAGATCAA ATTGAGGAGT GCAGTGTACC TTTCAGATGC GACTGTAACC 
ACGCTAGGAA ACTTAGTGCC CTTCACTCTG ACCCTGCTAT GTTTTTTGCT GTTAATCTGT 
TCTCTGTGTA AACATCTCAA GAAGATGCAG CTCCATGGTA AAGGATCTCA AGATCCCAGC 
ACCAAGGTCC ACATAAAAGC TTTGCAAACT GTGATCTTTT TCCTCTTGTT ATGTGCCGTT 
TACTTTCTGT CCATAATGAT ATCAGTTTGG AGTTTTGGGA GTCTGGAAAA CAAACCTGTC 
TTCATGTTCT GCAAAGCTAT TAGATTCAGC TATCCTTCAA TCCACCCATT CATCCTGATT 
TGGGGAAACA AGAAGCTAAA GCAGACTTTT CTTTCAGTTT TGCGGCAAGT GAGGTACTGG 
GTGAAAGGAG AGAAGCCTTC ATCTCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults.
Scientific reports639135(2016 Dec)
Bobowski N,Reed DR,Mennella JA

Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.
Chemical senses40(6)437-43(2015 Jul)
Hayes JE,Feeney EL,Nolden AA,McGeary JE

Do polymorphisms in chemosensory genes matter for human ingestive behavior?
Food quality and preference30(2)202-216(2013 Dec)
Hayes JE,Feeney EL,Allen AL

Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in
Chemosensory perception6(3)(2013 Sep)
Allen AL,McGeary JE,Hayes JE

Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31.
Chemical senses38(5)379-89(2013 Jun)
Allen AL,McGeary JE,Knopik VS,Hayes JE

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TAS2R31 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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