TMEM158 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM158
Entrez Gene ID	25907
Full Name	transmembrane protein 158 (gene/pseudogene)
Synonyms	BBP,RIS1,p40BBP
General protein information	Preferred Names transmembrane protein 158 (gene/pseudogene) Names transmembrane protein 158 40 kDa BINP-binding protein BINP receptor Ras induced senescence 1 brain injury-derived neurotrophic peptide (BINP) binding protein brain specific binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.31
Summary	Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_015444.2	NP_056259.2	transmembrane protein 158 precursor
NM_015444.3	NP_056259.2	transmembrane protein 158 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TMEM158	XP_001235310.2
Pan troglodytes (chimpanzee)	TMEM158	XP_516408.3
Danio rerio (zebrafish)	LOC100148963	XP_005173504.1
Bos taurus (cattle)	TMEM158	NP_001075095.1
Rattus norvegicus (Norway rat)	Tmem158	NP_476560.1
Mus musculus (house mouse)	Tmem158	NP_001002267.2
Homo sapiens (human)	TMEM158	NP_056259.2

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.
Zhang ZD, Frankish A, Hunt T, Harrow J, Gerstein M
Genome biology11(3)R26(2010)

RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis.
Iglesias D, Fern?ndez-Peralta AM, Nejda N, Daimiel L, Azcoita MM, Oliart S, Gonz?lez-Aguilera JJ
Cancer genetics and cytogenetics167(2)138-44(2006 Jun)

Target genes of the WNT/beta-catenin pathway in Wilms tumors.
Zirn B, Samans B, Wittmann S, Pietsch T, Leuschner I, Graf N, Gessler M
Genes, chromosomes & cancer45(6)565-74(2006 Jun)

Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas.
Silva J, Silva JM, Barradas M, Garc?a JM, Dom?nguez G, Garc?a V, Pe?a C, Gallego I, Espinosa R, Serrano M, Bonilla F
Mutation research594(1-2)78-85(2006 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RIS1 exhibits frameshift mutations in high-frequency microsatellite instability tumors, and its alteration is correlated with mutations in two target genes BAX and TGFBR2, linking it to the mutator pathway in colorectal carcinogenesis.
Title: RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis.

Suggested role of Ris-1 as tumor suppressor gene is not evident, at least in breast cancer.
Title: Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas.

The following TMEM158 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM158 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30068	NM_015444.3 Latest version!	Homo sapiens transmembrane protein 158 (gene/pseudogene) (TMEM158), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
View Old Accession Versions >>
OHu30068	NM_015444.2	Homo sapiens transmembrane protein 158 (gene/pseudogene) (TMEM158), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM158 ( NM_015444.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_056259.2 Homo sapiens transmembrane protein 158 (gene/pseudogene) (TMEM158), mRNA.

Price & Availability↑

CloneID	OHu30068
Clone ID Related Accession (Same CDS sequence)	NM_015444.2 , NM_015444.3
Accession Version	NM_015444.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	transmembrane protein 158 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX459891.2, AF438313.1, BX401325.2, BQ000094.1 and BU627971.1. On Oct 27, 2006 this sequence version replaced NM_015444.1. ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 20210993 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCCC TGCTCGCCGC GCTCCTGGCC GCCGCCTGCC CGCTGCCGCC CGTCCGCGGC 
GGGGCCGCGG ACGCGCCCGG CCTCCTCGGG GTGCCCTCCA ATGCTTCAGT CAACGCGTCC 
TCCGCGGACG AGCCCATCGC CCCGCGGCTG CTGGCCTCGG CGGCCCCCGG GCCCCCCGAG 
CGCCCGGGCC CGGAGGAGGC GGCGGCGGCG GCGGCGCCGT GCAACATCAG CGTGCAGCGG 
CAGATGCTGA GCTCGCTGCT CGTGCGCTGG GGCCGCCCGC GGGGCTTCCA GTGCGACCTA 
CTGCTCTTCT CCACCAACGC GCACGGCCGC GCTTTCTTCG CCGCCGCCTT CCACCGCGTC 
GGGCCGCCGC TGCTCATCGA GCACCTGGGG CTGGCGGCGG GCGGCGCGCA GCAGGACCTG 
CGCCTCTGCG TGGGCTGCGG CTGGGTGCGC GGTCGCCGCA CCGGCCGCCT CCGGCCCGCC 
GCCGCCCCCA GCGCCGCCGC CGCCACCGCC GGGGCGCCCA CCGCGCTGCC AGCCTACCCC 
GCGGCCGAGC CGCCCGGGCC GCTGTGGCTG CAGGGCGAGC CGCTGCATTT CTGCTGCCTA 
GACTTCAGCC TGGAGGAGCT GCAGGGCGAG CCGGGCTGGC GGCTGAACCG TAAGCCCATT 
GAGTCCACGC TGGTGGCCTG CTTCATGACC CTGGTCATCG TGGTGTGGAG CGTGGCCGCC 
CTCATCTGGC CGGTGCCCAT CATCGCCGGC TTCCTGCCCA ACGGCATGGA ACAGCGCCGG 
ACCACCGCCA GCACCACCGC AGCCACCCCC GCCGCAGTGC CCGCAGGGAC CACCGCAGCC 
GCCGCCGCCG CCGCCGCTGC CGCCGCCGCC GCGGCCGTCA CTTCGGGGGT GGCGACCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056259.2
CDS	296..1198
Translation	MLPLLAALLAAACPLPPVRGGAADAPGLLGVPSNASVNASSADEPIAPRLLASAAPGPPERPGPEEAAAAAAPCNISVQRQMLSSLLVRWGRPRGFQCDLLLFSTNAHGRAFFAAAFHRVGPPLLIEHLGLAAGGAQQDLRLCVGCGWVRGRRTGRLRPAAAPSAAAATAGAPTALPAYPAAEPPGPLWLQGEPLHFCCLDFSLEELQGEPGWRLNRKPIESTLVACFMTLVIVVWSVAALIWPVPIIAGFLPNGMEQRRTTASTTAATPAAVPAGTTAAAAAAAAAAAAAAVTSGVATK

Target ORF information:

RefSeq Version	NM_015444.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 158 (gene/pseudogene) (TMEM158), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015444.2

ORF Insert Sequence:

ATGCTGCCCC TGCTCGCCGC GCTCCTGGCC GCCGCCTGCC CGCTGCCGCC CGTCCGCGGC 
GGGGCCGCGG ACGCGCCCGG CCTCCTCGGG GTGCCCTCCA ATGCTTCAGT CAACGCGTCC 
TCCGCGGACG AGCCCATCGC CCCGCGGCTG CTGGCCTCGG CGGCCCCCGG GCCCCCCGAG 
CGCCCGGGCC CGGAGGAGGC GGCGGCGGCG GCGGCGCCGT GCAACATCAG CGTGCAGCGG 
CAGATGCTGA GCTCGCTGCT CGTGCGCTGG GGCCGCCCGC GGGGCTTCCA GTGCGACCTA 
CTGCTCTTCT CCACCAACGC GCACGGCCGC GCTTTCTTCG CCGCCGCCTT CCACCGCGTC 
GGGCCGCCGC TGCTCATCGA GCACCTGGGG CTGGCGGCGG GCGGCGCGCA GCAGGACCTG 
CGCCTCTGCG TGGGCTGCGG CTGGGTGCGC GGTCGCCGCA CCGGCCGCCT CCGGCCCGCC 
GCCGCCCCCA GCGCCGCCGC CGCCACCGCC GGGGCGCCCA CCGCGCTGCC AGCCTACCCC 
GCGGCCGAGC CGCCCGGGCC GCTGTGGCTG CAGGGCGAGC CGCTGCATTT CTGCTGCCTA 
GACTTCAGCC TGGAGGAGCT GCAGGGCGAG CCGGGCTGGC GGCTGAACCG TAAGCCCATT 
GAGTCCACGC TGGTGGCCTG CTTCATGACC CTGGTCATCG TGGTGTGGAG CGTGGCCGCC 
CTCATCTGGC CGGTGCCCAT CATCGCCGGC TTCCTGCCCA ACGGCATGGA ACAGCGCCGG 
ACCACCGCCA GCACCACCGC AGCCACCCCC GCCGCAGTGC CCGCAGGGAC CACCGCAGCC 
GCCGCCGCCG CCGCCGCTGC CGCCGCCGCC GCGGCCGTCA CTTCGGGGGT GGCGACCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM158 ( NM_015444.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056259.2 Homo sapiens transmembrane protein 158 (gene/pseudogene) (TMEM158), mRNA.

Price & Availability↑

CloneID	OHu30068
Clone ID Related Accession (Same CDS sequence)	NM_015444.2 , NM_015444.3
Accession Version	NM_015444.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	transmembrane protein 158 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX459891.2, AF438313.1, BX401325.2, BQ000094.1 and BU627971.1. On May 17, 2019 this sequence version replaced NM_015444.2. ##Evidence-Data-START## Transcript is intronless :: AF438313.1, DRR138528.771567.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000503771.2/ ENSP00000422431.1 polymorphic pseudogene :: PMID: 20210993 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCCC TGCTCGCCGC GCTCCTGGCC GCCGCCTGCC CGCTGCCGCC CGTCCGCGGC 
GGGGCCGCGG ACGCGCCCGG CCTCCTCGGG GTGCCCTCCA ATGCTTCAGT CAACGCGTCC 
TCCGCGGACG AGCCCATCGC CCCGCGGCTG CTGGCCTCGG CGGCCCCCGG GCCCCCCGAG 
CGCCCGGGCC CGGAGGAGGC GGCGGCGGCG GCGGCGCCGT GCAACATCAG CGTGCAGCGG 
CAGATGCTGA GCTCGCTGCT CGTGCGCTGG GGCCGCCCGC GGGGCTTCCA GTGCGACCTA 
CTGCTCTTCT CCACCAACGC GCACGGCCGC GCTTTCTTCG CCGCCGCCTT CCACCGCGTC 
GGGCCGCCGC TGCTCATCGA GCACCTGGGG CTGGCGGCGG GCGGCGCGCA GCAGGACCTG 
CGCCTCTGCG TGGGCTGCGG CTGGGTGCGC GGTCGCCGCA CCGGCCGCCT CCGGCCCGCC 
GCCGCCCCCA GCGCCGCCGC CGCCACCGCC GGGGCGCCCA CCGCGCTGCC AGCCTACCCC 
GCGGCCGAGC CGCCCGGGCC GCTGTGGCTG CAGGGCGAGC CGCTGCATTT CTGCTGCCTA 
GACTTCAGCC TGGAGGAGCT GCAGGGCGAG CCGGGCTGGC GGCTGAACCG TAAGCCCATT 
GAGTCCACGC TGGTGGCCTG CTTCATGACC CTGGTCATCG TGGTGTGGAG CGTGGCCGCC 
CTCATCTGGC CGGTGCCCAT CATCGCCGGC TTCCTGCCCA ACGGCATGGA ACAGCGCCGG 
ACCACCGCCA GCACCACCGC AGCCACCCCC GCCGCAGTGC CCGCAGGGAC CACCGCAGCC 
GCCGCCGCCG CCGCCGCTGC CGCCGCCGCC GCGGCCGTCA CTTCGGGGGT GGCGACCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056259.2
CDS	261..1163
Translation	MLPLLAALLAAACPLPPVRGGAADAPGLLGVPSNASVNASSADEPIAPRLLASAAPGPPERPGPEEAAAAAAPCNISVQRQMLSSLLVRWGRPRGFQCDLLLFSTNAHGRAFFAAAFHRVGPPLLIEHLGLAAGGAQQDLRLCVGCGWVRGRRTGRLRPAAAPSAAAATAGAPTALPAYPAAEPPGPLWLQGEPLHFCCLDFSLEELQGEPGWRLNRKPIESTLVACFMTLVIVVWSVAALIWPVPIIAGFLPNGMEQRRTTASTTAATPAAVPAGTTAAAAAAAAAAAAAAVTSGVATK

Target ORF information:

RefSeq Version	NM_015444.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 158 (gene/pseudogene) (TMEM158), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015444.3

ORF Insert Sequence:

ATGCTGCCCC TGCTCGCCGC GCTCCTGGCC GCCGCCTGCC CGCTGCCGCC CGTCCGCGGC 
GGGGCCGCGG ACGCGCCCGG CCTCCTCGGG GTGCCCTCCA ATGCTTCAGT CAACGCGTCC 
TCCGCGGACG AGCCCATCGC CCCGCGGCTG CTGGCCTCGG CGGCCCCCGG GCCCCCCGAG 
CGCCCGGGCC CGGAGGAGGC GGCGGCGGCG GCGGCGCCGT GCAACATCAG CGTGCAGCGG 
CAGATGCTGA GCTCGCTGCT CGTGCGCTGG GGCCGCCCGC GGGGCTTCCA GTGCGACCTA 
CTGCTCTTCT CCACCAACGC GCACGGCCGC GCTTTCTTCG CCGCCGCCTT CCACCGCGTC 
GGGCCGCCGC TGCTCATCGA GCACCTGGGG CTGGCGGCGG GCGGCGCGCA GCAGGACCTG 
CGCCTCTGCG TGGGCTGCGG CTGGGTGCGC GGTCGCCGCA CCGGCCGCCT CCGGCCCGCC 
GCCGCCCCCA GCGCCGCCGC CGCCACCGCC GGGGCGCCCA CCGCGCTGCC AGCCTACCCC 
GCGGCCGAGC CGCCCGGGCC GCTGTGGCTG CAGGGCGAGC CGCTGCATTT CTGCTGCCTA 
GACTTCAGCC TGGAGGAGCT GCAGGGCGAG CCGGGCTGGC GGCTGAACCG TAAGCCCATT 
GAGTCCACGC TGGTGGCCTG CTTCATGACC CTGGTCATCG TGGTGTGGAG CGTGGCCGCC 
CTCATCTGGC CGGTGCCCAT CATCGCCGGC TTCCTGCCCA ACGGCATGGA ACAGCGCCGG 
ACCACCGCCA GCACCACCGC AGCCACCCCC GCCGCAGTGC CCGCAGGGAC CACCGCAGCC 
GCCGCCGCCG CCGCCGCTGC CGCCGCCGCC GCGGCCGTCA CTTCGGGGGT GGCGACCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.
Genome biology11(3)R26(2010)
Zhang ZD,Frankish A,Hunt T,Harrow J,Gerstein M

RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis.
Cancer genetics and cytogenetics167(2)138-44(2006 Jun)
Iglesias D,Fern?ndez-Peralta AM,Nejda N,Daimiel L,Azcoita MM,Oliart S,Gonz?lez-Aguilera JJ

Target genes of the WNT/beta-catenin pathway in Wilms tumors.
Genes, chromosomes & cancer45(6)565-74(2006 Jun)
Zirn B,Samans B,Wittmann S,Pietsch T,Leuschner I,Graf N,Gessler M

Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas.
Mutation research594(1-2)78-85(2006 Feb)
Silva J,Silva JM,Barradas M,Garc?a JM,Dom?nguez G,Garc?a V,Pe?a C,Gallego I,Espinosa R,Serrano M,Bonilla F

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TMEM158 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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