GALE cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GALE
Entrez Gene ID	2582
Full Name	UDP-galactose-4-epimerase
Synonyms	SDR1E1
General protein information	Preferred Names UDP-galactose-4-epimerase Names UDP-glucose 4-epimerase UDP galactose-4'-epimerase UDP-GalNAc 4-epimerase UDP-GlcNAc 4-epimerase UDP-N-acetylgalactosamine 4-epimerase UDP-N-acetylglucosamine 4-epimerase galactose-4-epimerase, UDP- galactowaldenase short chain dehydrogenase/reductase family 1E, member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and cognitive disability, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	606953
Disorder Html:	Galactose epimerase deficiency, 230350 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000403.3	NP_000394.2	UDP-glucose 4-epimerase
NM_001008216.1	NP_001008217.1	UDP-glucose 4-epimerase
NM_001008216.2	NP_001008217.1	UDP-glucose 4-epimerase
NM_000403.4	NP_000394.2	UDP-glucose 4-epimerase
NM_001127621.1	NP_001121093.1	UDP-glucose 4-epimerase
NM_001127621.2	NP_001121093.1	UDP-glucose 4-epimerase

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gale	NP_001035389.1
Canis lupus familiaris (dog)	GALE	XP_003638951.1
Rattus norvegicus (Norway rat)	Gale	NP_542961.2
Arabidopsis thaliana (thale cress)	UGE2	NP_194123.1
Oryza sativa (rice)	Os05g0595100	NP_001056512.1
Homo sapiens (human)	GALE	NP_001008217.1
Gallus gallus (chicken)	GALE	XP_004947951.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012261	XP_320278.2
Mus musculus (house mouse)	Gale	NP_848476.1
Drosophila melanogaster (fruit fly)	Gale	NP_001246537.1
Caenorhabditis elegans (roundworm)	gale-1	NP_001021051.1
Schizosaccharomyces pombe (fission yeast)	uge1	NP_596043.1
Pan troglodytes (chimpanzee)	GALE	XP_003307924.2
	GALE	XP_001104253.1
Bos taurus (cattle)	GALE	NP_001193137.1
Arabidopsis thaliana (thale cress)	UGE5	NP_192834.1
Arabidopsis thaliana (thale cress)	RHD1	NP_176625.1
Xenopus tropicalis (tropical clawed frog)	gale	NP_001006762.1

Gene Ontology
Bibliography

Related articles in PubMed

A first case report of UDP-galactose-4'-epimerase deficiency in China: genotype and phenotype.
Tong F, Yang R, Hong F, Qian G, Jiang P, Gao R
Journal of pediatric endocrinology & metabolism : JPEM29(3)379-83(2016 Mar)

UDP-hexose 4-epimerases: a view on structure, mechanism and substrate specificity.
Beerens K, Soetaert W, Desmet T
Carbohydrate research4148-14(2015 Sep)

The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding.
Pey AL, Pad?n-Gonzalez E, Mesa-Torres N, Timson DJ
Archives of biochemistry and biophysics562103-14(2014 Nov)

The critical role of UDP-galactose-4-epimerase in osteoarthritis: modulating proteoglycans synthesis of the articular chondrocytes.
Wen Y, Qin J, Deng Y, Wang H, Magdalou J, Chen L
Biochemical and biophysical research communications452(4)906-11(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutation in UDP-galactose-4'-epimerase gene is associated with UDP-galactose-4'-epimerase deficiency.
Title: A first case report of UDP-galactose-4'-epimerase deficiency in China: genotype and phenotype.

Data show the protein structure of GALE and its substrate binding and specificity. It is mutated in type III galactosemia. [review]
Title: UDP-hexose 4-epimerases: a view on structure, mechanism and substrate specificity.

human UDP-galactose 4'-epimerase stability is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding
Title: The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding.

These data indicated a critical role of GALE in maintaining cartilage homeostasis, and suggested that GALE inhibition might contribute to OA progress.
Title: The critical role of UDP-galactose-4-epimerase in osteoarthritis: modulating proteoglycans synthesis of the articular chondrocytes.

GALE variants can be arranged into three groups depending on the severity of enzyme impairment.
Title: In silico prediction of the effects of mutations in the human UDP-galactose 4'-epimerase gene: towards a predictive framework for type III galactosemia.

The following GALE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GALE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16255	NM_001008216.2 Latest version!	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu16255	NM_000403.4 Latest version!	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu16255	NM_001127621.2 Latest version!	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu16255	NM_001008216.1	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu16255	NM_000403.3	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu16255	NM_001127621.1	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GALE ( NM_000403.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000394.2 Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16255
Clone ID Related Accession (Same CDS sequence)	NM_000403.3 , NM_001008216.1 , NM_001008216.2 , NM_000403.4 , NM_001127621.1 , NM_001127621.2
Accession Version	NM_000403.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	UDP-glucose 4-epimerase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI835132.1, BQ437612.1, BC056880.1 and BC001273.1. On Dec 3, 2004 this sequence version replaced NM_000403.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.14644.1, L41668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000394.2
CDS	235..1281
Translation	MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

Target ORF information:

RefSeq Version	NM_000403.3
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000403.3

ORF Insert Sequence:

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALE ( NM_001008216.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008217.1 Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16255
Clone ID Related Accession (Same CDS sequence)	NM_000403.3 , NM_001008216.1 , NM_001008216.2 , NM_000403.4 , NM_001127621.1 , NM_001127621.2
Accession Version	NM_001008216.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	UDP-glucose 4-epimerase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL530475.3 and BC050685.2. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050685.2, SRR1803611.44739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008217.1
CDS	170..1216
Translation	MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

Target ORF information:

RefSeq Version	NM_001008216.1
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008216.1

ORF Insert Sequence:

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALE ( NM_001008216.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008217.1 Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16255
Clone ID Related Accession (Same CDS sequence)	NM_000403.3 , NM_001008216.1 , NM_001008216.2 , NM_000403.4 , NM_001127621.1 , NM_001127621.2
Accession Version	NM_001008216.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	UDP-glucose 4-epimerase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL530475.3 and BC050685.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001008216.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.346090.1, SRR5189658.83711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000617979.5/ ENSP00000483375.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008217.1
CDS	120..1166
Translation	MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

Target ORF information:

RefSeq Version	NM_001008216.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008216.2

ORF Insert Sequence:

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALE ( NM_000403.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000394.2 Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1, mRNA.

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CloneID	OHu16255
Clone ID Related Accession (Same CDS sequence)	NM_000403.3 , NM_001008216.1 , NM_001008216.2 , NM_000403.4 , NM_001127621.1 , NM_001127621.2
Accession Version	NM_000403.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	UDP-glucose 4-epimerase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031295.1, BI835132.1, BQ437612.1, BC056880.1 and BC001273.1. On May 31, 2019 this sequence version replaced NM_000403.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L41668.1, SRR5189667.87054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000394.2
CDS	269..1315
Translation	MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

Target ORF information:

RefSeq Version	NM_000403.4
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000403.4

ORF Insert Sequence:

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALE ( NM_001127621.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121093.1 Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 3, mRNA.

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CloneID	OHu16255
Clone ID Related Accession (Same CDS sequence)	NM_000403.3 , NM_001008216.1 , NM_001008216.2 , NM_000403.4 , NM_001127621.1 , NM_001127621.2
Accession Version	NM_001127621.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	UDP-glucose 4-epimerase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA043957.1, AK314397.1 and BC050685.2. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.552234.1, AK314397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121093.1
CDS	211..1257
Translation	MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

Target ORF information:

RefSeq Version	NM_001127621.1
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127621.1

ORF Insert Sequence:

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALE ( NM_001127621.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121093.1 Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16255
Clone ID Related Accession (Same CDS sequence)	NM_000403.3 , NM_001008216.1 , NM_001008216.2 , NM_000403.4 , NM_001127621.1 , NM_001127621.2
Accession Version	NM_001127621.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	UDP-glucose 4-epimerase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA043957.1, AK314397.1 and BC050685.2. On May 31, 2019 this sequence version replaced NM_001127621.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314397.1, SRR1163655.552234.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121093.1
CDS	188..1234
Translation	MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

Target ORF information:

RefSeq Version	NM_001127621.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127621.2

ORF Insert Sequence:

ATGGCAGAGA AGGTGCTGGT AACAGGTGGG GCTGGCTACA TTGGCAGCCA CACGGTGCTG 
GAGCTGCTGG AGGCTGGCTA CTTGCCTGTG GTCATCGATA ACTTCCATAA TGCCTTCCGT 
GGAGGGGGCT CCCTGCCTGA GAGCCTGCGG CGGGTCCAGG AGCTGACAGG CCGCTCTGTG 
GAGTTTGAGG AGATGGACAT TTTGGACCAG GGAGCCCTAC AGCGTCTCTT CAAAAAGTAC 
AGCTTTATGG CGGTCATCCA CTTTGCGGGG CTCAAGGCCG TGGGCGAGTC GGTGCAGAAG 
CCTCTGGATT ATTACAGAGT TAACCTGACC GGGACCATCC AGCTTCTGGA GATCATGAAG 
GCCCACGGGG TGAAGAACCT GGTGTTCAGC AGCTCAGCCA CTGTGTACGG GAACCCCCAG 
TACCTGCCCC TTGATGAGGC CCACCCCACG GGTGGTTGTA CCAACCCTTA CGGCAAGTCC 
AAGTTCTTCA TCGAGGAAAT GATCCGGGAC CTGTGCCAGG CAGACAAGAC TTGGAACGCA 
GTGCTGCTGC GCTATTTCAA CCCCACAGGT GCCCATGCCT CTGGCTGCAT TGGTGAGGAT 
CCCCAGGGCA TACCCAACAA CCTCATGCCT TATGTCTCCC AGGTGGCGAT CGGGCGACGG 
GAGGCCCTGA ATGTCTTTGG CAATGACTAT GACACAGAGG ATGGCACAGG TGTCCGGGAT 
TACATCCATG TCGTGGATCT GGCCAAGGGC CACATTGCAG CCTTAAGGAA GCTGAAAGAA 
CAGTGTGGCT GCCGGATCTA CAACCTGGGC ACGGGCACAG GCTATTCAGT GCTGCAGATG 
GTCCAGGCTA TGGAGAAGGC CTCTGGGAAG AAGATCCCGT ACAAGGTGGT GGCACGGCGG 
GAAGGTGATG TGGCAGCCTG TTACGCCAAC CCCAGCCTGG CCCAAGAGGA GCTGGGGTGG 
ACAGCAGCCT TAGGGCTGGA CAGGATGTGT GAGGATCTCT GGCGCTGGCA GAAGCAGAAT 
CCTTCAGGCT TTGGCACGCA AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A first case report of UDP-galactose-4'-epimerase deficiency in China: genotype and phenotype.
Journal of pediatric endocrinology & metabolism : JPEM29(3)379-83(2016 Mar)
Tong F,Yang R,Hong F,Qian G,Jiang P,Gao R

UDP-hexose 4-epimerases: a view on structure, mechanism and substrate specificity.
Carbohydrate research4148-14(2015 Sep)
Beerens K,Soetaert W,Desmet T

The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding.
Archives of biochemistry and biophysics562103-14(2014 Nov)
Pey AL,Pad?n-Gonzalez E,Mesa-Torres N,Timson DJ

The critical role of UDP-galactose-4-epimerase in osteoarthritis: modulating proteoglycans synthesis of the articular chondrocytes.
Biochemical and biophysical research communications452(4)906-11(2014 Oct)
Wen Y,Qin J,Deng Y,Wang H,Magdalou J,Chen L

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GALE cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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