NOCT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOCT
Entrez Gene ID	25819
Full Name	nocturnin
Synonyms	CCR4L,CCRN4L,Ccr4c,NOC
General protein information	Preferred Names nocturnin Names nocturnin CCR4 carbon catabolite repression 4-like CCR4 protein homolog CCR4-like (carbon catabolite repression 4, S.cerevisiae) carbon catabolite repression 4-like protein circadian deadenylase NOC
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q31.1
Summary	The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008].
Disorder MIM:	608468

mRNA and Protein(s)

mRNA	Protein	Name
NM_012118.4	NP_036250.2	nocturnin
NM_012118.3	NP_036250.2	nocturnin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CCRN4L	NP_001075923.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009893	XP_319013.3
Xenopus tropicalis (tropical clawed frog)	ccrn4l	NP_001016531.1
Gallus gallus (chicken)	CCRN4L	NP_001009928.1
Canis lupus familiaris (dog)	CCRN4L	XP_005631848.1
Mus musculus (house mouse)	Ccrn4l	NP_033964.1
Drosophila melanogaster (fruit fly)	cu	NP_001097747.1
Homo sapiens (human)	CCRN4L	NP_036250.2
Pan troglodytes (chimpanzee)	CCRN4L	XP_003310517.1
	CCRN4L	XP_002804251.1
Rattus norvegicus (Norway rat)	Ccrn4l	NP_612535.1

Gene Ontology
Bibliography

Related articles in PubMed

Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.
Maragozidis P, Papanastasi E, Scutelnic D, Totomi A, Kokkori I, Zarogiannis SG, Kerenidi T, Gourgoulianis KI, Balatsos NA
Molecular cancer14187(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results highlight the clinical significance of PARN and NOC on the survival in SCC diagnosed patients.
Title: Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.

Three tag SNPs (rs938836, rs17050680, rs3805213) in the CCRN4L are significant correlation with genotype and allele frequency in lung cancer.
Title: Association between CLOCK, PER3 and CCRN4L with non?small cell lung cancer in Brazilian patients.

Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.
Title: Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.

Ccr4d functions as an anti-proliferating protein through the induction of cell cycle arrest via a p21-dependent and p53-independent pathway and suggest that Ccr4d might have an important role in carcinogenesis.
Title: RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

The following NOCT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOCT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28287	NM_012118.4 Latest version!	Homo sapiens nocturnin (NOCT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu28287	NM_012118.3	Homo sapiens nocturnin (NOCT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOCT ( NM_012118.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036250.2 Homo sapiens nocturnin (NOCT), mRNA.

Price & Availability↑

CloneID	OHu28287
Clone ID Related Accession (Same CDS sequence)	NM_012118.4 , NM_012118.3
Accession Version	NM_012118.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1296bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nocturnin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY067201.1, BC113494.1 and AC093602.5. On Nov 22, 2018 this sequence version replaced NM_012118.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.329239.1, AF183961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000280614.4/ ENSP00000280614.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTTCATA GTCCGCGGCG GCTCTGCTCG GCCCTGCTGC AGAGGGACGC GCCCGGCCTG 
CGCCGCCTGC CCGCCCCAGG GCTGCGCCGC CCGTTGTCCC CGCCGGCTGC TGTTCCCAGG 
CCCGCATCCC CCCGGCTGCT GGCGGCGGCC TCGGCGGCCT CGGGCGCCGC GAGGTCGTGT 
TCCCGAACAG TGTGTTCCAT GGGAACCGGT ACAAGCAGAC TCTATAGTGC TCTCGCCAAG 
ACACTGAACA GCAGCGCTGC CTCCCAGCAC CCAGAGTATT TGGTGTCACC TGACCCAGAG 
CATCTGGAGC CCATTGATCC TAAAGAGCTT CTTGAGGAAT GCAGGGCCGT CCTGCACACC 
CGACCTCCCC GGTTCCAGAG GGATTTTGTG GATCTGAGGA CAGATTGCCC TAGTACCCAC 
CCACCTATCA GGGTTATGCA ATGGAACATC CTCGCCCAAG CTCTTGGAGA AGGCAAAGAC 
AACTTTGTAC AGTGCCCTGT TGAAGCACTC AAATGGGAAG AAAGGAAATG TCTCATCCTG 
GAAGAAATCC TGGCCTACCA GCCTGATATA TTGTGCCTCC AAGAGGTGGA CCACTATTTT 
GACACCTTCC AGCCACTCCT CAGTAGACTA GGCTATCAAG GCACGTTTTT CCCCAAACCC 
TGGTCACCTT GTCTAGATGT AGAACACAAC AATGGACCAG ATGGTTGTGC CTTATTTTTT 
CTTCAAAACC GATTCAAGCT AGTCAACAGT GCCAATATTA GGCTGACAGC CATGACATTG 
AAAACCAACC AGGTGGCCAT TGCACAGACC CTGGAGTGCA AGGAGTCAGG CCGACAGTTC 
TGCATCGCTG TTACCCATCT AAAAGCACGC ACTGGCTGGG AGCGGTTTCG ATCAGCTCAA 
GGCTGTGACC TCCTTCAGAA CCTGCAAAAC ATCACCCAAG GAGCCAAGAT TCCCCTTATT 
GTGTGTGGGG ACTTCAATGC AGAGCCAACA GAAGAGGTCT ACAAACACTT TGCTTCCTCC 
AGCCTCAACC TGAACAGCGC CTACAAGCTG CTGAGTGCTG ATGGGCAGTC AGAACCCCCA 
TACACTACCT GGAAGATCCG GACCTCAGGG GAGTGCAGGC ACACCCTGGA TTACATCTGG 
TATTCTAAAC ATGCTCTAAA TGTAAGGTCA GCTCTCGATC TGCTCACTGA AGAACAGATT 
GGACCCAACA GGTTACCTTC CTTCAATTAT CCTTCAGACC ACCTGTCTCT AGTGTGTGAC 
TTCAGCTTTA CTGAGGAATC TGATGGACTT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036250.2
CDS	202..1497
Translation	MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS

Target ORF information:

RefSeq Version	NM_012118.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nocturnin (NOCT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012118.4

ORF Insert Sequence:

ATGTTTCATA GTCCGCGGCG GCTCTGCTCG GCCCTGCTGC AGAGGGACGC GCCCGGCCTG 
CGCCGCCTGC CCGCCCCAGG GCTGCGCCGC CCGTTGTCCC CGCCGGCTGC TGTTCCCAGG 
CCCGCATCCC CCCGGCTGCT GGCGGCGGCC TCGGCGGCCT CGGGCGCCGC GAGGTCGTGT 
TCCCGAACAG TGTGTTCCAT GGGAACCGGT ACAAGCAGAC TCTATAGTGC TCTCGCCAAG 
ACACTGAACA GCAGCGCTGC CTCCCAGCAC CCAGAGTATT TGGTGTCACC TGACCCAGAG 
CATCTGGAGC CCATTGATCC TAAAGAGCTT CTTGAGGAAT GCAGGGCCGT CCTGCACACC 
CGACCTCCCC GGTTCCAGAG GGATTTTGTG GATCTGAGGA CAGATTGCCC TAGTACCCAC 
CCACCTATCA GGGTTATGCA ATGGAACATC CTCGCCCAAG CTCTTGGAGA AGGCAAAGAC 
AACTTTGTAC AGTGCCCTGT TGAAGCACTC AAATGGGAAG AAAGGAAATG TCTCATCCTG 
GAAGAAATCC TGGCCTACCA GCCTGATATA TTGTGCCTCC AAGAGGTGGA CCACTATTTT 
GACACCTTCC AGCCACTCCT CAGTAGACTA GGCTATCAAG GCACGTTTTT CCCCAAACCC 
TGGTCACCTT GTCTAGATGT AGAACACAAC AATGGACCAG ATGGTTGTGC CTTATTTTTT 
CTTCAAAACC GATTCAAGCT AGTCAACAGT GCCAATATTA GGCTGACAGC CATGACATTG 
AAAACCAACC AGGTGGCCAT TGCACAGACC CTGGAGTGCA AGGAGTCAGG CCGACAGTTC 
TGCATCGCTG TTACCCATCT AAAAGCACGC ACTGGCTGGG AGCGGTTTCG ATCAGCTCAA 
GGCTGTGACC TCCTTCAGAA CCTGCAAAAC ATCACCCAAG GAGCCAAGAT TCCCCTTATT 
GTGTGTGGGG ACTTCAATGC AGAGCCAACA GAAGAGGTCT ACAAACACTT TGCTTCCTCC 
AGCCTCAACC TGAACAGCGC CTACAAGCTG CTGAGTGCTG ATGGGCAGTC AGAACCCCCA 
TACACTACCT GGAAGATCCG GACCTCAGGG GAGTGCAGGC ACACCCTGGA TTACATCTGG 
TATTCTAAAC ATGCTCTAAA TGTAAGGTCA GCTCTCGATC TGCTCACTGA AGAACAGATT 
GGACCCAACA GGTTACCTTC CTTCAATTAT CCTTCAGACC ACCTGTCTCT AGTGTGTGAC 
TTCAGCTTTA CTGAGGAATC TGATGGACTT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOCT ( NM_012118.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036250.2 Homo sapiens nocturnin (NOCT), mRNA.

Price & Availability↑

CloneID	OHu28287
Clone ID Related Accession (Same CDS sequence)	NM_012118.4 , NM_012118.3
Accession Version	NM_012118.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1296bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	nocturnin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY067201.1, BC113494.1 and AC093602.5. On Jun 30, 2013 this sequence version replaced NM_012118.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.329239.1, AF183961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTCATA GTCCGCGGCG GCTCTGCTCG GCCCTGCTGC AGAGGGACGC GCCCGGCCTG 
CGCCGCCTGC CCGCCCCAGG GCTGCGCCGC CCGTTGTCCC CGCCGGCTGC TGTTCCCAGG 
CCCGCATCCC CCCGGCTGCT GGCGGCGGCC TCGGCGGCCT CGGGCGCCGC GAGGTCGTGT 
TCCCGAACAG TGTGTTCCAT GGGAACCGGT ACAAGCAGAC TCTATAGTGC TCTCGCCAAG 
ACACTGAACA GCAGCGCTGC CTCCCAGCAC CCAGAGTATT TGGTGTCACC TGACCCAGAG 
CATCTGGAGC CCATTGATCC TAAAGAGCTT CTTGAGGAAT GCAGGGCCGT CCTGCACACC 
CGACCTCCCC GGTTCCAGAG GGATTTTGTG GATCTGAGGA CAGATTGCCC TAGTACCCAC 
CCACCTATCA GGGTTATGCA ATGGAACATC CTCGCCCAAG CTCTTGGAGA AGGCAAAGAC 
AACTTTGTAC AGTGCCCTGT TGAAGCACTC AAATGGGAAG AAAGGAAATG TCTCATCCTG 
GAAGAAATCC TGGCCTACCA GCCTGATATA TTGTGCCTCC AAGAGGTGGA CCACTATTTT 
GACACCTTCC AGCCACTCCT CAGTAGACTA GGCTATCAAG GCACGTTTTT CCCCAAACCC 
TGGTCACCTT GTCTAGATGT AGAACACAAC AATGGACCAG ATGGTTGTGC CTTATTTTTT 
CTTCAAAACC GATTCAAGCT AGTCAACAGT GCCAATATTA GGCTGACAGC CATGACATTG 
AAAACCAACC AGGTGGCCAT TGCACAGACC CTGGAGTGCA AGGAGTCAGG CCGACAGTTC 
TGCATCGCTG TTACCCATCT AAAAGCACGC ACTGGCTGGG AGCGGTTTCG ATCAGCTCAA 
GGCTGTGACC TCCTTCAGAA CCTGCAAAAC ATCACCCAAG GAGCCAAGAT TCCCCTTATT 
GTGTGTGGGG ACTTCAATGC AGAGCCAACA GAAGAGGTCT ACAAACACTT TGCTTCCTCC 
AGCCTCAACC TGAACAGCGC CTACAAGCTG CTGAGTGCTG ATGGGCAGTC AGAACCCCCA 
TACACTACCT GGAAGATCCG GACCTCAGGG GAGTGCAGGC ACACCCTGGA TTACATCTGG 
TATTCTAAAC ATGCTCTAAA TGTAAGGTCA GCTCTCGATC TGCTCACTGA AGAACAGATT 
GGACCCAACA GGTTACCTTC CTTCAATTAT CCTTCAGACC ACCTGTCTCT AGTGTGTGAC 
TTCAGCTTTA CTGAGGAATC TGATGGACTT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036250.2
CDS	224..1519
Translation	MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS

Target ORF information:

RefSeq Version	NM_012118.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nocturnin (NOCT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012118.3

ORF Insert Sequence:

ATGTTTCATA GTCCGCGGCG GCTCTGCTCG GCCCTGCTGC AGAGGGACGC GCCCGGCCTG 
CGCCGCCTGC CCGCCCCAGG GCTGCGCCGC CCGTTGTCCC CGCCGGCTGC TGTTCCCAGG 
CCCGCATCCC CCCGGCTGCT GGCGGCGGCC TCGGCGGCCT CGGGCGCCGC GAGGTCGTGT 
TCCCGAACAG TGTGTTCCAT GGGAACCGGT ACAAGCAGAC TCTATAGTGC TCTCGCCAAG 
ACACTGAACA GCAGCGCTGC CTCCCAGCAC CCAGAGTATT TGGTGTCACC TGACCCAGAG 
CATCTGGAGC CCATTGATCC TAAAGAGCTT CTTGAGGAAT GCAGGGCCGT CCTGCACACC 
CGACCTCCCC GGTTCCAGAG GGATTTTGTG GATCTGAGGA CAGATTGCCC TAGTACCCAC 
CCACCTATCA GGGTTATGCA ATGGAACATC CTCGCCCAAG CTCTTGGAGA AGGCAAAGAC 
AACTTTGTAC AGTGCCCTGT TGAAGCACTC AAATGGGAAG AAAGGAAATG TCTCATCCTG 
GAAGAAATCC TGGCCTACCA GCCTGATATA TTGTGCCTCC AAGAGGTGGA CCACTATTTT 
GACACCTTCC AGCCACTCCT CAGTAGACTA GGCTATCAAG GCACGTTTTT CCCCAAACCC 
TGGTCACCTT GTCTAGATGT AGAACACAAC AATGGACCAG ATGGTTGTGC CTTATTTTTT 
CTTCAAAACC GATTCAAGCT AGTCAACAGT GCCAATATTA GGCTGACAGC CATGACATTG 
AAAACCAACC AGGTGGCCAT TGCACAGACC CTGGAGTGCA AGGAGTCAGG CCGACAGTTC 
TGCATCGCTG TTACCCATCT AAAAGCACGC ACTGGCTGGG AGCGGTTTCG ATCAGCTCAA 
GGCTGTGACC TCCTTCAGAA CCTGCAAAAC ATCACCCAAG GAGCCAAGAT TCCCCTTATT 
GTGTGTGGGG ACTTCAATGC AGAGCCAACA GAAGAGGTCT ACAAACACTT TGCTTCCTCC 
AGCCTCAACC TGAACAGCGC CTACAAGCTG CTGAGTGCTG ATGGGCAGTC AGAACCCCCA 
TACACTACCT GGAAGATCCG GACCTCAGGG GAGTGCAGGC ACACCCTGGA TTACATCTGG 
TATTCTAAAC ATGCTCTAAA TGTAAGGTCA GCTCTCGATC TGCTCACTGA AGAACAGATT 
GGACCCAACA GGTTACCTTC CTTCAATTAT CCTTCAGACC ACCTGTCTCT AGTGTGTGAC 
TTCAGCTTTA CTGAGGAATC TGATGGACTT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.
Molecular cancer14187(2015 Nov)
Maragozidis P,Papanastasi E,Scutelnic D,Totomi A,Kokkori I,Zarogiannis SG,Kerenidi T,Gourgoulianis KI,Balatsos NA

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NOCT cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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