SYCE2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SYCE2
Entrez Gene ID	256126
Full Name	synaptonemal complex central element protein 2
Synonyms	CESC1
General protein information	Preferred Names synaptonemal complex central element protein 2 Names synaptonemal complex central element protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.13
Summary	The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012].
Disorder MIM:	611487

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105578.1	NP_001099048.1	synaptonemal complex central element protein 2
XM_011527883.2	XP_011526185.1	synaptonemal complex central element protein 2 isoform X3
XM_011527882.2	XP_011526184.1	synaptonemal complex central element protein 2 isoform X1
XM_005259848.4	XP_005259905.1	synaptonemal complex central element protein 2 isoform X2
NM_001105578.2	NP_001099048.1	synaptonemal complex central element protein 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	SYCE2	XP_003643433.1
	LOC100431090	XP_002801138.1
Bos taurus (cattle)	SYCE2	XP_005208737.1
Mus musculus (house mouse)	Syce2	NP_001161718.1
Rattus norvegicus (Norway rat)	Syce2	NP_001178486.1
Homo sapiens (human)	SYCE2	NP_001099048.1
Pan troglodytes (chimpanzee)	SYCE2	XP_001155819.3
Canis lupus familiaris (dog)	SYCE2	XP_005632877.1

Gene Ontology
Bibliography

Related articles in PubMed

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Goldstein JI, Jarskog LF, Hilliard C, Alfirevic A, Duncan L, Fourches D, Huang H, Lek M, Neale BM, Ripke S, Shianna K, Szatkiewicz JP, Tropsha A, van den Oord EJ, Cascorbi I, Dettling M, Gazit E, Goff DC, Holden AL, Kelly DL, Malhotra AK, Nielsen J, Pirmohamed M, Rujescu D, Werge T, Levy DL, Josiassen RC, Kennedy JL, Lieberman JA, Daly MJ, Sullivan PF
Nature communications54757(2014 Sep)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

Seventy-five genetic loci influencing the human red blood cell.
van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, Al-Hussani A, Asselbergs FW, Ciullo M, Danjou F, Dina C, Esko T, Evans DM, Franke L, G?gele M, Hartiala J, Hersch M, Holm H, Hottenga JJ, Kanoni S, Kleber ME, Lagou V, Langenberg C, Lopez LM, Lyytik?inen LP, Melander O, Murgia F, Nolte IM, O'Reilly PF, Padmanabhan S, Parsa A, Pirastu N, Porcu E, Portas L, Prokopenko I, Ried JS, Shin SY, Tang CS, Teumer A, Traglia M, Ulivi S, Westra HJ, Yang J, Zhao JH, Anni F, Abdellaoui A, Attwood A, Balkau B, Bandinelli S, Bastardot F, Benyamin B, Boehm BO, Cookson WO, Das D, de Bakker PI, de Boer RA, de Geus EJ, de Moor MH, Dimitriou M, Domingues FS, D?ring A, Engstr?m G, Eyjolfsson GI, Ferrucci L, Fischer K, Galanello R, Garner SF, Genser B, Gibson QD, Girotto G, Gudbjartsson DF, Harris SE, Hartikainen AL, Hastie CE, Hedblad B, Illig T, Jolley J, K?h?nen M, Kema IP, Kemp JP, Liang L, Lloyd-Jones H, Loos RJ, Meacham S, Medland SE, Meisinger C, Memari Y, Mihailov E, Miller K, Moffatt MF, Nauck M, Novatchkova M, Nutile T, Olafsson I, Onundarson PT, Parracciani D, Penninx BW, Perseu L, Piga A, Pistis G, Pouta A, Puc U, Raitakari O, Ring SM, Robino A, Ruggiero D, Ruokonen A, Saint-Pierre A, Sala C, Salumets A, Sambrook J, Schepers H, Schmidt CO, Sillj? HH, Sladek R, Smit JH, Starr JM, Stephens J, Sulem P, Tanaka T, Thorsteinsdottir U, Tragante V, van Gilst WH, van Pelt LJ, van Veldhuisen DJ, V?lker U, Whitfield JB, Willemsen G, Winkelmann BR, Wirnsberger G, Algra A, Cucca F, d'Adamo AP, Danesh J, Deary IJ, Dominiczak AF, Elliott P, Fortina P, Froguel P, Gasparini P, Greinacher A, Hazen SL, Jarvelin MR, Khaw KT, Lehtim?ki T, Maerz W, Martin NG, Metspalu A, Mitchell BD, Montgomery GW, Moore C, Navis G, Pirastu M, Pramstaller PP, Ramirez-Solis R, Schadt E, Scott J, Shuldiner AR, Smith GD, Smith JG, Snieder H, Sorice R, Spector TD, Stefansson K, Stumvoll M, Tang WH, Toniolo D, T?njes A, Visscher PM, Vollenweider P, Wareham NJ, Wolffenbuttel BH, Boomsma DI, Beckmann JS, Dedoussis GV, Deloukas P, Ferreira MA, Sanna S, Uda M, Hicks AA, Penninger JM, Gieger C, Kooner JS, Ouwehand WH, Soranzo N, Chambers JC
Nature492(7429)369-75(2012 Dec)

Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.
Davies OR, Maman JD, Pellegrini L
Open biology2(7)120099(2012 Jul)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a model of chromosome synapsis driven by growth of SYCE2-TEX12 higher-order structures within the CE of the SC.
Title: Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following SYCE2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SYCE2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18187	NM_001105578.2 Latest version!	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu51539	XM_005259848.4 Latest version!	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu78359	XM_011527882.2 Latest version!	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu78360	XM_011527883.2 Latest version!	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu18187	NM_001105578.1	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SYCE2 ( NM_001105578.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001099048.1 Homo sapiens synaptonemal complex central element protein 2 (SYCE2), mRNA.

Price & Availability↑

CloneID	OHu18187
Clone ID Related Accession (Same CDS sequence)	NM_001105578.1 , NM_001105578.2
Accession Version	NM_001105578.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	synaptonemal complex central element protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB449708.1 and BC035819.2. This sequence is a reference standard in the RefSeqGene project. ##Evidence-Data-START## Transcript exon combination :: AK302373.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGCAGAG CCTAAGACTC AGATGGGGGC CAGACCACTC TAGGGGAAAG 
TCCCCACCAC GTCCCGGCAA CTCACAGCCC CCAGACGTGT TCGTTTCTTC TGTGGCTGAA 
ACTACTTCTC AGGCCACTGC TTCAGAAGTA CAGACCAACA GAGATGGTGA ATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099048.1
CDS	16..672
Translation	MERQGVDVPHVKCKDQEPQPLGESKEHPRWEENCEEEAGGGPASASCQLTVLEGKSGLYFSSLDSSIDILQKRAQELIENINKSRQKDHALMTNFRNSLKTKVSDLTEKLEERIYQIYNDHNKIIQEKLQEFTQKMAKISHLETELKQVCHSVETVYKDLCLQPEQSLRLRWGPDHSRGKSPPRPGNSQPPDVFVSSVAETTSQATASEVQTNRDGEC

Target ORF information:

RefSeq Version	NM_001105578.1
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105578.1

ORF Insert Sequence:

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGCAGAG CCTAAGACTC AGATGGGGGC CAGACCACTC TAGGGGAAAG 
TCCCCACCAC GTCCCGGCAA CTCACAGCCC CCAGACGTGT TCGTTTCTTC TGTGGCTGAA 
ACTACTTCTC AGGCCACTGC TTCAGAAGTA CAGACCAACA GAGATGGTGA ATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYCE2 ( NM_001105578.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001099048.1 Homo sapiens synaptonemal complex central element protein 2 (SYCE2), mRNA.

Price & Availability↑

CloneID	OHu18187
Clone ID Related Accession (Same CDS sequence)	NM_001105578.1 , NM_001105578.2
Accession Version	NM_001105578.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	synaptonemal complex central element protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092069.2, DB449708.1, BC035819.2 and AD000092.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001105578.1. ##Evidence-Data-START## Transcript exon combination :: AK302373.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000293695.8/ ENSP00000293695.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGCAGAG CCTAAGACTC AGATGGGGGC CAGACCACTC TAGGGGAAAG 
TCCCCACCAC GTCCCGGCAA CTCACAGCCC CCAGACGTGT TCGTTTCTTC TGTGGCTGAA 
ACTACTTCTC AGGCCACTGC TTCAGAAGTA CAGACCAACA GAGATGGTGA ATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099048.1
CDS	37..693
Translation	MERQGVDVPHVKCKDQEPQPLGESKEHPRWEENCEEEAGGGPASASCQLTVLEGKSGLYFSSLDSSIDILQKRAQELIENINKSRQKDHALMTNFRNSLKTKVSDLTEKLEERIYQIYNDHNKIIQEKLQEFTQKMAKISHLETELKQVCHSVETVYKDLCLQPEQSLRLRWGPDHSRGKSPPRPGNSQPPDVFVSSVAETTSQATASEVQTNRDGEC

Target ORF information:

RefSeq Version	NM_001105578.2
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105578.2

ORF Insert Sequence:

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGCAGAG CCTAAGACTC AGATGGGGGC CAGACCACTC TAGGGGAAAG 
TCCCCACCAC GTCCCGGCAA CTCACAGCCC CCAGACGTGT TCGTTTCTTC TGTGGCTGAA 
ACTACTTCTC AGGCCACTGC TTCAGAAGTA CAGACCAACA GAGATGGTGA ATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYCE2 ( XM_005259848.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259905.1 Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu51539
Clone ID Related Accession (Same CDS sequence)	XM_005259848.4
Accession Version	XM_005259848.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	synaptonemal complex central element protein 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259848.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGCAGAG CCTAAGACTC AGATGGGGGC CAGACCACTC TAGGGGAAAG 
TCCCCACCAC GTCCCGGCAA CTCACAGCCC CCAGACGTGT TCGTTTCTTC TGTGGCTGAA 
ACTACTTCTC AGGTGGTTAC CAGTAAACCG GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259905.1
CDS	88..723
Translation	MERQGVDVPHVKCKDQEPQPLGESKEHPRWEENCEEEAGGGPASASCQLTVLEGKSGLYFSSLDSSIDILQKRAQELIENINKSRQKDHALMTNFRNSLKTKVSDLTEKLEERIYQIYNDHNKIIQEKLQEFTQKMAKISHLETELKQVCHSVETVYKDLCLQPEQSLRLRWGPDHSRGKSPPRPGNSQPPDVFVSSVAETTSQVVTSKPA

Target ORF information:

RefSeq Version	XM_005259848.4
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259848.4

ORF Insert Sequence:

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGCAGAG CCTAAGACTC AGATGGGGGC CAGACCACTC TAGGGGAAAG 
TCCCCACCAC GTCCCGGCAA CTCACAGCCC CCAGACGTGT TCGTTTCTTC TGTGGCTGAA 
ACTACTTCTC AGGTGGTTAC CAGTAAACCG GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYCE2 ( XM_011527882.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526184.1 Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu78359
Clone ID Related Accession (Same CDS sequence)	XM_011527882.2
Accession Version	XM_011527882.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	synaptonemal complex central element protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527882.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGAGCCT AAGACTCAGA TGGGGGCCAG ACCACTCTAG GGGAAAGTCC 
CCACCACGTC CCGGCAACTC ACAGCCCCCA GACGTGTTCG TTTCTTCTGT GGCTGAAACT 
ACTTCTCAGG CCACTGCTTC AGAAGTACAG ACCAACAGAG ATGGTGAATG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526184.1
CDS	418..1071
Translation	MERQGVDVPHVKCKDQEPQPLGESKEHPRWEENCEEEAGGGPASASCQLTVLEGKSGLYFSSLDSSIDILQKRAQELIENINKSRQKDHALMTNFRNSLKTKVSDLTEKLEERIYQIYNDHNKIIQEKLQEFTQKMAKISHLETELKQVCHSVETVYKDLCLQPESLRLRWGPDHSRGKSPPRPGNSQPPDVFVSSVAETTSQATASEVQTNRDGEC

Target ORF information:

RefSeq Version	XM_011527882.2
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527882.2

ORF Insert Sequence:

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGAGCCT AAGACTCAGA TGGGGGCCAG ACCACTCTAG GGGAAAGTCC 
CCACCACGTC CCGGCAACTC ACAGCCCCCA GACGTGTTCG TTTCTTCTGT GGCTGAAACT 
ACTTCTCAGG CCACTGCTTC AGAAGTACAG ACCAACAGAG ATGGTGAATG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYCE2 ( XM_011527883.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526185.1 Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X3, mRNA.

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CloneID	OHu78360
Clone ID Related Accession (Same CDS sequence)	XM_011527883.2
Accession Version	XM_011527883.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	synaptonemal complex central element protein 2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527883.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGAGCCT AAGACTCAGA TGGGGGCCAG ACCACTCTAG GGGAAAGTCC 
CCACCACGTC CCGGCAACTC ACAGCCCCCA GACGTGTTCG TTTCTTCTGT GGCTGAAACT 
ACTTCTCAGG TGGTTACCAG TAAACCGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526185.1
CDS	418..1050
Translation	MERQGVDVPHVKCKDQEPQPLGESKEHPRWEENCEEEAGGGPASASCQLTVLEGKSGLYFSSLDSSIDILQKRAQELIENINKSRQKDHALMTNFRNSLKTKVSDLTEKLEERIYQIYNDHNKIIQEKLQEFTQKMAKISHLETELKQVCHSVETVYKDLCLQPESLRLRWGPDHSRGKSPPRPGNSQPPDVFVSSVAETTSQVVTSKPA

Target ORF information:

RefSeq Version	XM_011527883.2
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptonemal complex central element protein 2 (SYCE2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527883.2

ORF Insert Sequence:

ATGGAGCGAC AGGGAGTGGA CGTGCCCCAT GTGAAATGCA AAGACCAGGA ACCGCAGCCC 
TTGGGGGAGA GCAAGGAGCA TCCGCGGTGG GAAGAGAACT GCGAGGAGGA AGCTGGTGGA 
GGGCCAGCTA GTGCCAGTTG CCAGCTGACG GTCCTGGAAG GGAAGTCGGG ACTCTACTTC 
TCCTCTCTGG ACTCAAGCAT TGACATCCTG CAGAAGAGAG CCCAGGAGCT GATCGAAAAC 
ATCAACAAGA GCCGGCAAAA GGACCATGCA CTCATGACCA ACTTCAGGAA CAGCCTGAAG 
ACCAAGGTTT CGGATCTGAC AGAGAAATTA GAGGAGAGGA TCTATCAGAT TTATAATGAC 
CACAACAAGA TCATCCAGGA AAAGCTCCAA GAGTTCACCC AGAAAATGGC AAAGATCAGC 
CATTTGGAGA CAGAGCTCAA ACAAGTCTGC CACAGCGTGG AGACTGTGTA CAAAGACCTG 
TGTCTCCAGC CTGAGAGCCT AAGACTCAGA TGGGGGCCAG ACCACTCTAG GGGAAAGTCC 
CCACCACGTC CCGGCAACTC ACAGCCCCCA GACGTGTTCG TTTCTTCTGT GGCTGAAACT 
ACTTCTCAGG TGGTTACCAG TAAACCGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nature communications54757(2014 Sep)
Goldstein JI,Jarskog LF,Hilliard C,Alfirevic A,Duncan L,Fourches D,Huang H,Lek M,Neale BM,Ripke S,Shianna K,Szatkiewicz JP,Tropsha A,van den Oord EJ,Cascorbi I,Dettling M,Gazit E,Goff DC,Holden AL,Kelly DL,Malhotra AK,Nielsen J,Pirmohamed M,Rujescu D,Werge T,Levy DL,Josiassen RC,Kennedy JL,Lieberman JA,Daly MJ,Sullivan PF

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

Seventy-five genetic loci influencing the human red blood cell.
Nature492(7429)369-75(2012 Dec)
van der Harst P,Zhang W,Mateo Leach I,Rendon A,Verweij N,Sehmi J,Paul DS,Elling U,Allayee H,Li X,Radhakrishnan A,Tan ST,Voss K,Weichenberger CX,Albers CA,Al-Hussani A,Asselbergs FW,Ciullo M,Danjou F,Dina C,Esko T,Evans DM,Franke L,G?gele M,Hartiala J,Hersch M,Holm H,Hottenga JJ,Kanoni S,Kleber ME,Lagou V,Langenberg C,Lopez LM,Lyytik?inen LP,Melander O,Murgia F,Nolte IM,O'Reilly PF,Padmanabhan S,Parsa A,Pirastu N,Porcu E,Portas L,Prokopenko I,Ried JS,Shin SY,Tang CS,Teumer A,Traglia M,Ulivi S,Westra HJ,Yang J,Zhao JH,Anni F,Abdellaoui A,Attwood A,Balkau B,Bandinelli S,Bastardot F,Benyamin B,Boehm BO,Cookson WO,Das D,de Bakker PI,de Boer RA,de Geus EJ,de Moor MH,Dimitriou M,Domingues FS,D?ring A,Engstr?m G,Eyjolfsson GI,Ferrucci L,Fischer K,Galanello R,Garner SF,Genser B,Gibson QD,Girotto G,Gudbjartsson DF,Harris SE,Hartikainen AL,Hastie CE,Hedblad B,Illig T,Jolley J,K?h?nen M,Kema IP,Kemp JP,Liang L,Lloyd-Jones H,Loos RJ,Meacham S,Medland SE,Meisinger C,Memari Y,Mihailov E,Miller K,Moffatt MF,Nauck M,Novatchkova M,Nutile T,Olafsson I,Onundarson PT,Parracciani D,Penninx BW,Perseu L,Piga A,Pistis G,Pouta A,Puc U,Raitakari O,Ring SM,Robino A,Ruggiero D,Ruokonen A,Saint-Pierre A,Sala C,Salumets A,Sambrook J,Schepers H,Schmidt CO,Sillj? HH,Sladek R,Smit JH,Starr JM,Stephens J,Sulem P,Tanaka T,Thorsteinsdottir U,Tragante V,van Gilst WH,van Pelt LJ,van Veldhuisen DJ,V?lker U,Whitfield JB,Willemsen G,Winkelmann BR,Wirnsberger G,Algra A,Cucca F,d'Adamo AP,Danesh J,Deary IJ,Dominiczak AF,Elliott P,Fortina P,Froguel P,Gasparini P,Greinacher A,Hazen SL,Jarvelin MR,Khaw KT,Lehtim?ki T,Maerz W,Martin NG,Metspalu A,Mitchell BD,Montgomery GW,Moore C,Navis G,Pirastu M,Pramstaller PP,Ramirez-Solis R,Schadt E,Scott J,Shuldiner AR,Smith GD,Smith JG,Snieder H,Sorice R,Spector TD,Stefansson K,Stumvoll M,Tang WH,Toniolo D,T?njes A,Visscher PM,Vollenweider P,Wareham NJ,Wolffenbuttel BH,Boomsma DI,Beckmann JS,Dedoussis GV,Deloukas P,Ferreira MA,Sanna S,Uda M,Hicks AA,Penninger JM,Gieger C,Kooner JS,Ouwehand WH,Soranzo N,Chambers JC

Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.
Open biology2(7)120099(2012 Jul)
Davies OR,Maman JD,Pellegrini L

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

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SYCE2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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