TCTEX1D2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TCTEX1D2
Entrez Gene ID	255758
Full Name	Tctex1 domain containing 2
Synonyms	SRTD17
General protein information	Preferred Names Tctex1 domain containing 2 Names tctex1 domain-containing protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q29
Summary	Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017].
Disorder MIM:	617353
Disorder Html:	Short-rib thoracic dysplasia 17 with or without polydactyly, 617405 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_152773.5	NP_689986.2	tctex1 domain-containing protein 2 isoform 2
NM_001351628.1	NP_001338557.1	tctex1 domain-containing protein 2 isoform 1
NM_152773.4	NP_689986.2	tctex1 domain-containing protein 2 isoform 2
NM_001351628.2	NP_001338557.1	tctex1 domain-containing protein 2 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TCTEX1D2	XP_516972.1
	LOC711098	XP_001100846.1
Rattus norvegicus (Norway rat)	Tctex1d2	NP_001102524.1
Gallus gallus (chicken)	TCTEX1D2	XP_422724.1
Danio rerio (zebrafish)	tctex1d2	XP_685487.3
Homo sapiens (human)	TCTEX1D2	NP_689986.2
Canis lupus familiaris (dog)	TCTEX1D2	XP_005639654.1
Bos taurus (cattle)	TCTEX1D2	NP_001160027.1
Mus musculus (house mouse)	Tctex1d2	NP_079605.1
Xenopus tropicalis (tropical clawed frog)	tctex1d2	XP_002934090.1

Gene Ontology
Bibliography

Related articles in PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.
Schmidts M, Hou Y, Cort?s CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, Scambler PJ, Ueffing M, Kayserili H, Krakow D, King SM, , Beales PL, Al-Gazali L, Wicking C, Cormier-Daire V, Roepman R, Mitchison HM, Witman GB
Nature communications67074(2015 Jun)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.
Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ
Cell cycle (Georgetown, Tex.)14(7)1116-25(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

integral component of the evolutionarily conserved retrograde intraflagellar transport machinery
Title: TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.

Tctex1d2 is a novel dynein light chain important for trafficking to the cilium and potentially retrograde intraflagellar transport.
Title: Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.

The following TCTEX1D2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCTEX1D2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06921	NM_152773.5 Latest version!	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu103264	NM_001351628.2 Latest version!	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu06921	NM_152773.4	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu103264	NM_001351628.1	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TCTEX1D2 ( NM_152773.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_689986.2 Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06921
Clone ID Related Accession (Same CDS sequence)	NM_152773.5 , NM_152773.4
Accession Version	NM_152773.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	tctex1 domain-containing protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC021177.2, BM548106.1 and BM983853.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_152773.4. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.542246.1, SRR1163657.100823.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000325318.10/ ENSP00000324323.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TGACAGTTTA TTCTGCGTTG TAGCAGCATT TGGCTGTTTC 
TACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689986.2
CDS	89..517
Translation	MATSIGVSFSVGDGVPEAEKNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMASRCFWDADTDNYTHDVFMNDSLFCVVAAFGCFYY

Target ORF information:

RefSeq Version	NM_152773.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152773.5

ORF Insert Sequence:

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TGACAGTTTA TTCTGCGTTG TAGCAGCATT TGGCTGTTTC 
TACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCTEX1D2 ( NM_152773.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689986.2 Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06921
Clone ID Related Accession (Same CDS sequence)	NM_152773.5 , NM_152773.4
Accession Version	NM_152773.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	tctex1 domain-containing protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM548106.1, CK818899.1, BC021177.2 and BM983853.1. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2011 this sequence version replaced NM_152773.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.542246.1, SRR1163658.182581.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TGACAGTTTA TTCTGCGTTG TAGCAGCATT TGGCTGTTTC 
TACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689986.2
CDS	143..571
Translation	MATSIGVSFSVGDGVPEAEKNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMASRCFWDADTDNYTHDVFMNDSLFCVVAAFGCFYY

Target ORF information:

RefSeq Version	NM_152773.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152773.4

ORF Insert Sequence:

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TGACAGTTTA TTCTGCGTTG TAGCAGCATT TGGCTGTTTC 
TACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCTEX1D2 ( NM_001351628.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001338557.1 Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu103264
Clone ID Related Accession (Same CDS sequence)	NM_001351628.1 , NM_001351628.2
Accession Version	NM_001351628.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-29
Organism	Homo sapiens(human)
Product	tctex1 domain-containing protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC069257.28. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: HY357702.1, HY160739.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TTTTATTCTG CGTTGTAGCA GCATTTGGCT GTTTCTACTA 
CTGAATGAAT CTTTGAAAAG CTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001338557.1
CDS	143..589
Translation	MATSIGVSFSVGDGVPEAEKNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMASRCFWDADTDNYTHDVFMNFILRCSSIWLFLLLNESLKSW

Target ORF information:

RefSeq Version	NM_001351628.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001351628.1

ORF Insert Sequence:

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TTTTATTCTG CGTTGTAGCA GCATTTGGCT GTTTCTACTA 
CTGAATGAAT CTTTGAAAAG CTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCTEX1D2 ( NM_001351628.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001338557.1 Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu103264
Clone ID Related Accession (Same CDS sequence)	NM_001351628.1 , NM_001351628.2
Accession Version	NM_001351628.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-31
Organism	Homo sapiens(human)
Product	tctex1 domain-containing protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC069257.28. On Jun 1, 2019 this sequence version replaced NM_001351628.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: HY357702.1, HY160739.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TTTTATTCTG CGTTGTAGCA GCATTTGGCT GTTTCTACTA 
CTGAATGAAT CTTTGAAAAG CTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001338557.1
CDS	89..535
Translation	MATSIGVSFSVGDGVPEAEKNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMASRCFWDADTDNYTHDVFMNFILRCSSIWLFLLLNESLKSW

Target ORF information:

RefSeq Version	NM_001351628.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Tctex1 domain containing 2 (TCTEX1D2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001351628.2

ORF Insert Sequence:

ATGGCCACGT CCATCGGAGT GTCCTTCTCG GTGGGCGACG GGGTGCCTGA GGCTGAGAAG 
AACGCAGGGG AGCCCGAGAA CACCTATATT CTGCGGCCTG TTTTCCAGCA GAGGTTCAGG 
CCCTCTGTGG TTAAAGACTG TATCCATGCT GTGCTCAAGG AGGAACTGGC AAATGCTGAA 
TATTCTCCAG AAGAAATGCC TCAGCTTACA AAACATTTAT CAGAAAACAT TAAAGATAAA 
TTAAAAGAAA TGGGATTTGA CCGATACAAA ATGGTGGTGC AAGTAGTGAT TGGAGAACAA 
AGAGGTGAAG GAGTATTCAT GGCTTCTCGC TGTTTCTGGG ATGCTGACAC TGACAACTAT 
ACTCATGATG TTTTCATGAA TTTTATTCTG CGTTGTAGCA GCATTTGGCT GTTTCTACTA 
CTGAATGAAT CTTTGAAAAG CTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.
Nature communications67074(2015 Jun)
Schmidts M,Hou Y,Cort?s CR,Mans DA,Huber C,Boldt K,Patel M,van Reeuwijk J,Plaza JM,van Beersum SE,Yap ZM,Letteboer SJ,Taylor SP,Herridge W,Johnson CA,Scambler PJ,Ueffing M,Kayserili H,Krakow D,King SM,,Beales PL,Al-Gazali L,Wicking C,Cormier-Daire V,Roepman R,Mitchison HM,Witman GB

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.
Cell cycle (Georgetown, Tex.)14(7)1116-25(2015)
Gholkar AA,Senese S,Lo YC,Capri J,Deardorff WJ,Dharmarajan H,Contreras E,Hodara E,Whitelegge JP,Jackson PK,Torres JZ

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TCTEX1D2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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