SLC17A8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC17A8
Entrez Gene ID	246213
Full Name	solute carrier family 17 member 8
Synonyms	DFNA25,VGLUT3
General protein information	Preferred Names solute carrier family 17 member 8 Names vesicular glutamate transporter 3 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 solute carrier family 17 (vesicular glutamate transporter), member 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q23.1
Summary	This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Disorder MIM:	607557
Disorder Html:	Deafness, autosomal dominant 25, 605583 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145288.1	NP_001138760.1	vesicular glutamate transporter 3 isoform 2
NM_001145288.2	NP_001138760.1	vesicular glutamate transporter 3 isoform 2
NM_139319.2	NP_647480.1	vesicular glutamate transporter 3 isoform 1
NM_139319.3	NP_647480.1	vesicular glutamate transporter 3 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC17A8	XP_509298.2
Gallus gallus (chicken)	SLC17A8	XP_425451.3
Homo sapiens (human)	SLC17A8	NP_647480.1
Xenopus tropicalis (tropical clawed frog)	slc17a8	XP_002936892.1
Canis lupus familiaris (dog)	SLC17A8	XP_539740.3
Mus musculus (house mouse)	Slc17a8	NP_892004.1
Rattus norvegicus (Norway rat)	Slc17a8	NP_714947.1
	SLC17A8	XP_001089949.1
Bos taurus (cattle)	SLC17A8	NP_001179607.1
Danio rerio (zebrafish)	slc17a8	NP_001076304.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing.
Ryu N, Lee S, Park HJ, Lee B, Kwon TJ, Bok J, Park CI, Lee KY, Baek JI, Kim UK
Gene627233-238(2017 Sep)

Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles.
Ramet L, Zimmermann J, Bersot T, Poirel O, De Gois S, Silm K, Sakae DY, Mansouri-Guilani N, Bourque MJ, Trudeau LE, Pietrancosta N, Daumas S, Bernard V, Rosenmund C, El Mestikawy S
The Journal of neuroscience : the official journal of the Society for Neuroscience37(15)4181-4199(2017 Apr)

Screening of the SLC17A8 gene as a causative factor for autosomal dominant non-syndromic hearing loss in Koreans.
Ryu N, Sagong B, Park HJ, Kim MA, Lee KY, Choi JY, Kim UK
BMC medical genetics176(2016 Jan)

The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
Sakae DY, Marti F, Lecca S, Vorspan F, Mart?n-Garc?a E, Morel LJ, Henrion A, Guti?rrez-Cuesta J, Besnard A, Heck N, Herzog E, Bolte S, Prado VF, Prado MA, Bellivier F, Eap CB, Crettol S, Vanhoutte P, Caboche J, Gratton A, Moquin L, Giros B, Maldonado R, Daumas S, Mameli M, Jamain S, El Mestikawy S
Molecular psychiatry20(11)1448-59(2015 Nov)

Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.
Divito CB, Steece-Collier K, Case DT, Williams SP, Stancati JA, Zhi L, Rubio ME, Sortwell CE, Collier TJ, Sulzer D, Edwards RH, Zhang H, Seal RP
The Journal of neuroscience : the official journal of the Society for Neuroscience35(45)14983-99(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Novel pathogenic splicing mutation in SLC17A8 gene identified in a family with hearing loss.
Title: Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing.

A point mutation in VGLUT3 dramatically reduces its expression in synaptic terminals without altering its function.
Title: Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles.

The results from our study suggest that the p.M206Nfs*4 mutation in the SLC17A8 gene is likely a pathogenic mutation that causes autosomal dominant non-syndromic hearing loss.
Title: Screening of the SLC17A8 gene as a causative factor for autosomal dominant non-syndromic hearing loss in Koreans.

The results of this study identify VGLUT3 as an unexpected regulator of drug abuse.
Title: The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.

The absence of VGLUT3 in transgenic mice leads to an up-regulation of the midbrain dopamine system and ameliorates motor dysfunction in a model of Parkinson's disease.
Title: Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.

The following SLC17A8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC17A8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12506	NM_001145288.2 Latest version!	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu22464	NM_139319.3 Latest version!	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$249.50-$349.30 $499.00
View Old Accession Versions >>
OHu12506	NM_001145288.1	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu22464	NM_139319.2	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$249.50-$349.30 $499.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC17A8 ( NM_001145288.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138760.1 Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12506
Clone ID Related Accession (Same CDS sequence)	NM_001145288.1 , NM_001145288.2
Accession Version	NM_001145288.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1620bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-10
Organism	Homo sapiens(human)
Product	vesicular glutamate transporter 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK128319.1, BC143396.1, AJ459241.1 and AC126308.6. Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC143396.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2144335 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTGTGGGTC TCTTGTCAGC AGTCCCACAC ATGGTTATGA CAATCGTTGT ACCTATTGGA 
GGACAATTGG CTGATTATTT AAGAAGCAGA CAAATTTTAA CCACAACTGC TGTCAGAAAA 
ATCATGAACT GTGGAGGTTT TGGCATGGAG GCAACCTTAC TCCTGGTGGT TGGCTTTTCG 
CATACCAAAG GGGTGGCTAT CTCCTTTCTG GTACTTGCTG TAGGATTTAG TGGCTTCGCT 
ATTTCAGGTT TTAATGTCAA CCACCTGGAC ATTGCCCCAC GCTATGCCAG CATTCTCATG 
GGGATCTCAA ACGGAGTGGG AACCCTCTCT GGAATGGTCT GTCCCCTCAT TGTCGGTGCA 
ATGACCAGGC ACAAGACCCG TGAAGAATGG CAGAATGTGT TCCTCATAGC TGCCCTGGTG 
CATTACAGTG GTGTGATCTT CTATGGGGTC TTTGCTTCTG GGGAGAAACA GGAGTGGGCT 
GACCCAGAGA ATCTCTCTGA GGAGAAATGT GGAATCATTG ACCAGGACGA ATTAGCTGAG 
GAGATAGAAC TCAACCATGA GAGTTTTGCG AGTCCCAAAA AGAAGATGTC TTATGGAGCC 
ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG GAATGGAAAG GACAGAGAGG AGCGACCCTT 
GATGAGGAAG AGCTGACATC CTACCAGAAT GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138760.1
CDS	314..1933
Translation	MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHESFASPKKKMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS

Target ORF information:

RefSeq Version	NM_001145288.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145288.1

ORF Insert Sequence:

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTGTGGGTC TCTTGTCAGC AGTCCCACAC ATGGTTATGA CAATCGTTGT ACCTATTGGA 
GGACAATTGG CTGATTATTT AAGAAGCAGA CAAATTTTAA CCACAACTGC TGTCAGAAAA 
ATCATGAACT GTGGAGGTTT TGGCATGGAG GCAACCTTAC TCCTGGTGGT TGGCTTTTCG 
CATACCAAAG GGGTGGCTAT CTCCTTTCTG GTACTTGCTG TAGGATTTAG TGGCTTCGCT 
ATTTCAGGTT TTAATGTCAA CCACCTGGAC ATTGCCCCAC GCTATGCCAG CATTCTCATG 
GGGATCTCAA ACGGAGTGGG AACCCTCTCT GGAATGGTCT GTCCCCTCAT TGTCGGTGCA 
ATGACCAGGC ACAAGACCCG TGAAGAATGG CAGAATGTGT TCCTCATAGC TGCCCTGGTG 
CATTACAGTG GTGTGATCTT CTATGGGGTC TTTGCTTCTG GGGAGAAACA GGAGTGGGCT 
GACCCAGAGA ATCTCTCTGA GGAGAAATGT GGAATCATTG ACCAGGACGA ATTAGCTGAG 
GAGATAGAAC TCAACCATGA GAGTTTTGCG AGTCCCAAAA AGAAGATGTC TTATGGAGCC 
ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG GAATGGAAAG GACAGAGAGG AGCGACCCTT 
GATGAGGAAG AGCTGACATC CTACCAGAAT GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC17A8 ( NM_001145288.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138760.1 Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12506
Clone ID Related Accession (Same CDS sequence)	NM_001145288.1 , NM_001145288.2
Accession Version	NM_001145288.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1620bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	vesicular glutamate transporter 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026110.42, AK128319.1, BC143396.1, AJ459241.1 and AC126308.6. On Jun 1, 2019 this sequence version replaced NM_001145288.1. Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC143396.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2144335 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTGTGGGTC TCTTGTCAGC AGTCCCACAC ATGGTTATGA CAATCGTTGT ACCTATTGGA 
GGACAATTGG CTGATTATTT AAGAAGCAGA CAAATTTTAA CCACAACTGC TGTCAGAAAA 
ATCATGAACT GTGGAGGTTT TGGCATGGAG GCAACCTTAC TCCTGGTGGT TGGCTTTTCG 
CATACCAAAG GGGTGGCTAT CTCCTTTCTG GTACTTGCTG TAGGATTTAG TGGCTTCGCT 
ATTTCAGGTT TTAATGTCAA CCACCTGGAC ATTGCCCCAC GCTATGCCAG CATTCTCATG 
GGGATCTCAA ACGGAGTGGG AACCCTCTCT GGAATGGTCT GTCCCCTCAT TGTCGGTGCA 
ATGACCAGGC ACAAGACCCG TGAAGAATGG CAGAATGTGT TCCTCATAGC TGCCCTGGTG 
CATTACAGTG GTGTGATCTT CTATGGGGTC TTTGCTTCTG GGGAGAAACA GGAGTGGGCT 
GACCCAGAGA ATCTCTCTGA GGAGAAATGT GGAATCATTG ACCAGGACGA ATTAGCTGAG 
GAGATAGAAC TCAACCATGA GAGTTTTGCG AGTCCCAAAA AGAAGATGTC TTATGGAGCC 
ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG GAATGGAAAG GACAGAGAGG AGCGACCCTT 
GATGAGGAAG AGCTGACATC CTACCAGAAT GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138760.1
CDS	319..1938
Translation	MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHESFASPKKKMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS

Target ORF information:

RefSeq Version	NM_001145288.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145288.2

ORF Insert Sequence:

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTGTGGGTC TCTTGTCAGC AGTCCCACAC ATGGTTATGA CAATCGTTGT ACCTATTGGA 
GGACAATTGG CTGATTATTT AAGAAGCAGA CAAATTTTAA CCACAACTGC TGTCAGAAAA 
ATCATGAACT GTGGAGGTTT TGGCATGGAG GCAACCTTAC TCCTGGTGGT TGGCTTTTCG 
CATACCAAAG GGGTGGCTAT CTCCTTTCTG GTACTTGCTG TAGGATTTAG TGGCTTCGCT 
ATTTCAGGTT TTAATGTCAA CCACCTGGAC ATTGCCCCAC GCTATGCCAG CATTCTCATG 
GGGATCTCAA ACGGAGTGGG AACCCTCTCT GGAATGGTCT GTCCCCTCAT TGTCGGTGCA 
ATGACCAGGC ACAAGACCCG TGAAGAATGG CAGAATGTGT TCCTCATAGC TGCCCTGGTG 
CATTACAGTG GTGTGATCTT CTATGGGGTC TTTGCTTCTG GGGAGAAACA GGAGTGGGCT 
GACCCAGAGA ATCTCTCTGA GGAGAAATGT GGAATCATTG ACCAGGACGA ATTAGCTGAG 
GAGATAGAAC TCAACCATGA GAGTTTTGCG AGTCCCAAAA AGAAGATGTC TTATGGAGCC 
ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG GAATGGAAAG GACAGAGAGG AGCGACCCTT 
GATGAGGAAG AGCTGACATC CTACCAGAAT GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC17A8 ( NM_139319.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_647480.1 Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22464
Clone ID Related Accession (Same CDS sequence)	NM_139319.2 , NM_139319.3
Accession Version	NM_139319.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	vesicular glutamate transporter 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK128319.1, AC126308.6 and AJ459241.1. This sequence is a reference standard in the RefSeqGene project. On Feb 19, 2009 this sequence version replaced NM_139319.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128319.1, SRR1660803.167526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267766, SAMN03465418 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTAAATTTA GTACCCCATG GAAAAGATTT TTCACATCTT TGCCGGTTTA TGCAATCATT 
GTGGCAAATT TTTGCAGAAG CTGGACCTTT TATTTGCTCC TCATAAGTCA GCCTGCTTAT 
TTTGAAGAGG TCTTTGGATT TGCAATAAGT AAGGTGGGTC TCTTGTCAGC AGTCCCACAC 
ATGGTTATGA CAATCGTTGT ACCTATTGGA GGACAATTGG CTGATTATTT AAGAAGCAGA 
CAAATTTTAA CCACAACTGC TGTCAGAAAA ATCATGAACT GTGGAGGTTT TGGCATGGAG 
GCAACCTTAC TCCTGGTGGT TGGCTTTTCG CATACCAAAG GGGTGGCTAT CTCCTTTCTG 
GTACTTGCTG TAGGATTTAG TGGCTTCGCT ATTTCAGGTT TTAATGTCAA CCACCTGGAC 
ATTGCCCCAC GCTATGCCAG CATTCTCATG GGGATCTCAA ACGGAGTGGG AACCCTCTCT 
GGAATGGTCT GTCCCCTCAT TGTCGGTGCA ATGACCAGGC ACAAGACCCG TGAAGAATGG 
CAGAATGTGT TCCTCATAGC TGCCCTGGTG CATTACAGTG GTGTGATCTT CTATGGGGTC 
TTTGCTTCTG GGGAGAAACA GGAGTGGGCT GACCCAGAGA ATCTCTCTGA GGAGAAATGT 
GGAATCATTG ACCAGGACGA ATTAGCTGAG GAGATAGAAC TCAACCATGA GAGTTTTGCG 
AGTCCCAAAA AGAAGATGTC TTATGGAGCC ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG 
GAATGGAAAG GACAGAGAGG AGCGACCCTT GATGAGGAAG AGCTGACATC CTACCAGAAT 
GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647480.1
CDS	314..2083
Translation	MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHESFASPKKKMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS

Target ORF information:

RefSeq Version	NM_139319.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139319.2

ORF Insert Sequence:

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTAAATTTA GTACCCCATG GAAAAGATTT TTCACATCTT TGCCGGTTTA TGCAATCATT 
GTGGCAAATT TTTGCAGAAG CTGGACCTTT TATTTGCTCC TCATAAGTCA GCCTGCTTAT 
TTTGAAGAGG TCTTTGGATT TGCAATAAGT AAGGTGGGTC TCTTGTCAGC AGTCCCACAC 
ATGGTTATGA CAATCGTTGT ACCTATTGGA GGACAATTGG CTGATTATTT AAGAAGCAGA 
CAAATTTTAA CCACAACTGC TGTCAGAAAA ATCATGAACT GTGGAGGTTT TGGCATGGAG 
GCAACCTTAC TCCTGGTGGT TGGCTTTTCG CATACCAAAG GGGTGGCTAT CTCCTTTCTG 
GTACTTGCTG TAGGATTTAG TGGCTTCGCT ATTTCAGGTT TTAATGTCAA CCACCTGGAC 
ATTGCCCCAC GCTATGCCAG CATTCTCATG GGGATCTCAA ACGGAGTGGG AACCCTCTCT 
GGAATGGTCT GTCCCCTCAT TGTCGGTGCA ATGACCAGGC ACAAGACCCG TGAAGAATGG 
CAGAATGTGT TCCTCATAGC TGCCCTGGTG CATTACAGTG GTGTGATCTT CTATGGGGTC 
TTTGCTTCTG GGGAGAAACA GGAGTGGGCT GACCCAGAGA ATCTCTCTGA GGAGAAATGT 
GGAATCATTG ACCAGGACGA ATTAGCTGAG GAGATAGAAC TCAACCATGA GAGTTTTGCG 
AGTCCCAAAA AGAAGATGTC TTATGGAGCC ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG 
GAATGGAAAG GACAGAGAGG AGCGACCCTT GATGAGGAAG AGCTGACATC CTACCAGAAT 
GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC17A8 ( NM_139319.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_647480.1 Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 1, mRNA.

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CloneID	OHu22464
Clone ID Related Accession (Same CDS sequence)	NM_139319.2 , NM_139319.3
Accession Version	NM_139319.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	vesicular glutamate transporter 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026110.42, AK128319.1, AC126308.6 and AJ459241.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_139319.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128319.1, AJ459241.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267766, SAMN03465418 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323346.10/ ENSP00000316909.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTAAATTTA GTACCCCATG GAAAAGATTT TTCACATCTT TGCCGGTTTA TGCAATCATT 
GTGGCAAATT TTTGCAGAAG CTGGACCTTT TATTTGCTCC TCATAAGTCA GCCTGCTTAT 
TTTGAAGAGG TCTTTGGATT TGCAATAAGT AAGGTGGGTC TCTTGTCAGC AGTCCCACAC 
ATGGTTATGA CAATCGTTGT ACCTATTGGA GGACAATTGG CTGATTATTT AAGAAGCAGA 
CAAATTTTAA CCACAACTGC TGTCAGAAAA ATCATGAACT GTGGAGGTTT TGGCATGGAG 
GCAACCTTAC TCCTGGTGGT TGGCTTTTCG CATACCAAAG GGGTGGCTAT CTCCTTTCTG 
GTACTTGCTG TAGGATTTAG TGGCTTCGCT ATTTCAGGTT TTAATGTCAA CCACCTGGAC 
ATTGCCCCAC GCTATGCCAG CATTCTCATG GGGATCTCAA ACGGAGTGGG AACCCTCTCT 
GGAATGGTCT GTCCCCTCAT TGTCGGTGCA ATGACCAGGC ACAAGACCCG TGAAGAATGG 
CAGAATGTGT TCCTCATAGC TGCCCTGGTG CATTACAGTG GTGTGATCTT CTATGGGGTC 
TTTGCTTCTG GGGAGAAACA GGAGTGGGCT GACCCAGAGA ATCTCTCTGA GGAGAAATGT 
GGAATCATTG ACCAGGACGA ATTAGCTGAG GAGATAGAAC TCAACCATGA GAGTTTTGCG 
AGTCCCAAAA AGAAGATGTC TTATGGAGCC ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG 
GAATGGAAAG GACAGAGAGG AGCGACCCTT GATGAGGAAG AGCTGACATC CTACCAGAAT 
GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647480.1
CDS	319..2088
Translation	MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHESFASPKKKMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS

Target ORF information:

RefSeq Version	NM_139319.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 17 member 8 (SLC17A8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139319.3

ORF Insert Sequence:

ATGCCTTTTA AAGCATTTGA TACCTTCAAA GAAAAAATTC TGAAACCTGG GAAGGAAGGA 
GTGAAGAACG CCGTGGGAGA TTCTTTGGGA ATTTTACAAA GAAAAATCGA TGGGACAACT 
GAGGAAGAAG ATAACATTGA GCTGAATGAA GAAGGAAGGC CGGTGCAGAC GTCCAGGCCA 
AGCCCCCCAC TCTGCGACTG CCACTGCTGC GGCCTCCCCA AGCGTTACAT CATTGCTATC 
ATGAGTGGGC TGGGATTCTG CATTTCCTTT GGGATCCGGT GCAATCTTGG AGTTGCCATT 
GTGGAAATGG TCAACAATAG CACCGTATAT GTTGATGGAA AACCGGAAAT TCAGACAGCA 
CAGTTTAACT GGGATCCAGA AACAGTGGGC CTTATCCATG GATCTTTTTT CTGGGGCTAT 
ATTATGACAC AAATTCCAGG TGGTTTCATT TCAAACAAGT TTGCTGCTAA CAGGGTCTTT 
GGAGCTGCCA TCTTCTTAAC ATCGACTCTG AACATGTTTA TTCCCTCTGC AGCCAGAGTG 
CATTACGGAT GCGTCATGTG TGTCAGAATT CTGCAAGGTT TAGTGGAGGG TGTGACCTAC 
CCAGCCTGCC ATGGGATGTG GAGTAAGTGG GCACCACCTT TGGAGAGAAG CCGACTGGCC 
ACAACCTCTT TTTGTGGTTC CTATGCAGGG GCAGTGGTTG CCATGCCCCT GGCTGGGGTG 
TTGGTGCAGT ACATTGGATG GTCCTCTGTC TTTTATATTT ATGGCATGTT TGGGATTATT 
TGGTACATGT TTTGGCTGTT GCAGGCCTAT GAGTGCCCAG CAGCTCATCC AACAATATCC 
AATGAGGAGA AGACCTATAT AGAGACAAGC ATAGGAGAGG GGGCCAACGT GGTTAGTCTA 
AGTAAATTTA GTACCCCATG GAAAAGATTT TTCACATCTT TGCCGGTTTA TGCAATCATT 
GTGGCAAATT TTTGCAGAAG CTGGACCTTT TATTTGCTCC TCATAAGTCA GCCTGCTTAT 
TTTGAAGAGG TCTTTGGATT TGCAATAAGT AAGGTGGGTC TCTTGTCAGC AGTCCCACAC 
ATGGTTATGA CAATCGTTGT ACCTATTGGA GGACAATTGG CTGATTATTT AAGAAGCAGA 
CAAATTTTAA CCACAACTGC TGTCAGAAAA ATCATGAACT GTGGAGGTTT TGGCATGGAG 
GCAACCTTAC TCCTGGTGGT TGGCTTTTCG CATACCAAAG GGGTGGCTAT CTCCTTTCTG 
GTACTTGCTG TAGGATTTAG TGGCTTCGCT ATTTCAGGTT TTAATGTCAA CCACCTGGAC 
ATTGCCCCAC GCTATGCCAG CATTCTCATG GGGATCTCAA ACGGAGTGGG AACCCTCTCT 
GGAATGGTCT GTCCCCTCAT TGTCGGTGCA ATGACCAGGC ACAAGACCCG TGAAGAATGG 
CAGAATGTGT TCCTCATAGC TGCCCTGGTG CATTACAGTG GTGTGATCTT CTATGGGGTC 
TTTGCTTCTG GGGAGAAACA GGAGTGGGCT GACCCAGAGA ATCTCTCTGA GGAGAAATGT 
GGAATCATTG ACCAGGACGA ATTAGCTGAG GAGATAGAAC TCAACCATGA GAGTTTTGCG 
AGTCCCAAAA AGAAGATGTC TTATGGAGCC ACCTCCCAGA ATTGTGAAGT CCAGAAGAAG 
GAATGGAAAG GACAGAGAGG AGCGACCCTT GATGAGGAAG AGCTGACATC CTACCAGAAT 
GAAGAGAGAA ACTTCTCAAC TATATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing.
Gene627233-238(2017 Sep)
Ryu N,Lee S,Park HJ,Lee B,Kwon TJ,Bok J,Park CI,Lee KY,Baek JI,Kim UK

Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(15)4181-4199(2017 Apr)
Ramet L,Zimmermann J,Bersot T,Poirel O,De Gois S,Silm K,Sakae DY,Mansouri-Guilani N,Bourque MJ,Trudeau LE,Pietrancosta N,Daumas S,Bernard V,Rosenmund C,El Mestikawy S

Screening of the SLC17A8 gene as a causative factor for autosomal dominant non-syndromic hearing loss in Koreans.
BMC medical genetics176(2016 Jan)
Ryu N,Sagong B,Park HJ,Kim MA,Lee KY,Choi JY,Kim UK

The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
Molecular psychiatry20(11)1448-59(2015 Nov)
Sakae DY,Marti F,Lecca S,Vorspan F,Mart?n-Garc?a E,Morel LJ,Henrion A,Guti?rrez-Cuesta J,Besnard A,Heck N,Herzog E,Bolte S,Prado VF,Prado MA,Bellivier F,Eap CB,Crettol S,Vanhoutte P,Caboche J,Gratton A,Moquin L,Giros B,Maldonado R,Daumas S,Mameli M,Jamain S,El Mestikawy S

Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(45)14983-99(2015 Nov)
Divito CB,Steece-Collier K,Case DT,Williams SP,Stancati JA,Zhi L,Rubio ME,Sortwell CE,Collier TJ,Sulzer D,Edwards RH,Zhang H,Seal RP

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SLC17A8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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