AKR7L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AKR7L
Entrez Gene ID	246181
Full Name	aldo-keto reductase family 7 like (gene/pseudogene)
Synonyms	AFAR3,AFB1-AR 3,AFB1-AR3,AKR7A4
General protein information	Preferred Names aldo-keto reductase family 7 like (gene/pseudogene) Names aflatoxin B1 aldehyde reductase member 4 AFB1 aldehyde reductase 3 aldo-keto reductase family 7 pseudogene aldo-keto reductase family 7-like aldoketoreductase 7-like
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.13\|1p35-p36.1
Summary	This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017].
Disorder MIM:	608478

mRNA and Protein(s)

mRNA	Protein	Name
NM_001348421.1	NP_001335350.1	aflatoxin B1 aldehyde reductase member 4

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mammalian genome : official journal of the International Mammalian Genome Society16(12)942-54(2005 Dec)

Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Praml C, Savelyeva L, Schwab M
Oncogene22(30)4765-73(2003 Jul)

The aldo-keto reductase superfamily homepage.
Hyndman D, Bauman DR, Heredia VV, Penning TM
Chemico-biological interactions143-144621-31(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following AKR7L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AKR7L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu100901	NM_001348421.1 Latest version!	Homo sapiens aldo-keto reductase family 7 like (gene/pseudogene) (AKR7L), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AKR7L ( NM_001348421.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335350.1 Homo sapiens aldo-keto reductase family 7 like (gene/pseudogene) (AKR7L), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu100901
Clone ID Related Accession (Same CDS sequence)	NM_001348421.1
Accession Version	NM_001348421.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	aflatoxin B1 aldehyde reductase member 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ083526.1, AJ278012.1, DN998265.1, AL035413.19 and BC035351.1. On Feb 4, 2017 this sequence version replaced NM_201252.3. Transcript Variant: This variant (1) represents the longest transcript and the functional allele that encodes the full-length protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGGC AGCTGTCGCG GGCCCGGCCA GCCACGGTGC TGGGCGCCAT GGAGATGGGG 
CGCCGCATGG ACGCGCCCAC CAGCGCCGCA GTCACGCGCG CCTTCCTGGA GCGCGGCCAC 
ACCGAGATAG ACACGGCCTT CCTGTACAGC GACGGCCAGT CCGAGACCAT CCTTGGCGGC 
CTGGGGCTCC GAATGGGCAG CAGCGACTGC AGAGTGAAAA TTGCTACCAA GGCCAATCCA 
TGGATTGGGA ACTCCCTGAA GCCTGACAGT GTCCGATCCC AGCTGGAGAC GTCACTGAAG 
CGGCTGCAGT GTCCCCGAGT GGACCTCTTC TATCTACATG CACCTGACCA CAGCGCCCCG 
GTGGAAGAGA CACTGCGTGC CTGCCACCAG CTGCACCAGG AGGGCAAGTT CGTGGAGCTT 
GGCCTCTCCA ACTATGCCGC CTGGGAAGTG GCCGAGATCT GTACCCTCTG CAAGAGCAAC 
GGCTGGATCC TGCCCACTGT GTACCAGGGC ATGTACAGCG CCACCACCCG GCAGGTGGAA 
ACGGAGCTCT TCCCCTGCCT CAGGCACTTT GGACTGAGGT TCTATGCCTA CAACCCTCTG 
GCTGGGGGCC TGCTGACCGG CAAGTACAAG TATGAGGACA AGGACGGGAA ACAGCCCGTG 
GGCCGCTTCT TTGGGACTCA GTGGGCAGAG ATCTACAGGA ATCACTTCTG GAAGGAGCAC 
CACTTCGAGG GCATTGCCCT GGTGGAGAAG GCCCTGCAGG CCGCGTATGG CGCCAGCGCT 
CCCAGCATGA CCTCGGCCGC CCTCCGGTGG ATGTACCACC ACTCACAGCT GCAGGGTGCC 
CACGGGGACG CGGTCATCCT GGGCATGTCC AGCCTGGAGC AGCTGGAGCA GAACTTGGCA 
GCGGCAGAGG AAGGGCCCCT GGAGCCGGCT GTCGTGGACG CCTTTAATCA AGCCTGGCAT 
TTGTTTGCCC ACGAATGTCC CAACTACTTC ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335350.1
CDS	49..1044
Translation	MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLFAHECPNYFI

Target ORF information:

RefSeq Version	NM_001348421.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aldo-keto reductase family 7 like (gene/pseudogene) (AKR7L), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348421.1

ORF Insert Sequence:

ATGTCCCGGC AGCTGTCGCG GGCCCGGCCA GCCACGGTGC TGGGCGCCAT GGAGATGGGG 
CGCCGCATGG ACGCGCCCAC CAGCGCCGCA GTCACGCGCG CCTTCCTGGA GCGCGGCCAC 
ACCGAGATAG ACACGGCCTT CCTGTACAGC GACGGCCAGT CCGAGACCAT CCTTGGCGGC 
CTGGGGCTCC GAATGGGCAG CAGCGACTGC AGAGTGAAAA TTGCTACCAA GGCCAATCCA 
TGGATTGGGA ACTCCCTGAA GCCTGACAGT GTCCGATCCC AGCTGGAGAC GTCACTGAAG 
CGGCTGCAGT GTCCCCGAGT GGACCTCTTC TATCTACATG CACCTGACCA CAGCGCCCCG 
GTGGAAGAGA CACTGCGTGC CTGCCACCAG CTGCACCAGG AGGGCAAGTT CGTGGAGCTT 
GGCCTCTCCA ACTATGCCGC CTGGGAAGTG GCCGAGATCT GTACCCTCTG CAAGAGCAAC 
GGCTGGATCC TGCCCACTGT GTACCAGGGC ATGTACAGCG CCACCACCCG GCAGGTGGAA 
ACGGAGCTCT TCCCCTGCCT CAGGCACTTT GGACTGAGGT TCTATGCCTA CAACCCTCTG 
GCTGGGGGCC TGCTGACCGG CAAGTACAAG TATGAGGACA AGGACGGGAA ACAGCCCGTG 
GGCCGCTTCT TTGGGACTCA GTGGGCAGAG ATCTACAGGA ATCACTTCTG GAAGGAGCAC 
CACTTCGAGG GCATTGCCCT GGTGGAGAAG GCCCTGCAGG CCGCGTATGG CGCCAGCGCT 
CCCAGCATGA CCTCGGCCGC CCTCCGGTGG ATGTACCACC ACTCACAGCT GCAGGGTGCC 
CACGGGGACG CGGTCATCCT GGGCATGTCC AGCCTGGAGC AGCTGGAGCA GAACTTGGCA 
GCGGCAGAGG AAGGGCCCCT GGAGCCGGCT GTCGTGGACG CCTTTAATCA AGCCTGGCAT 
TTGTTTGCCC ACGAATGTCC CAACTACTTC ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome analysis of human gastric cancer.
Mammalian genome : official journal of the International Mammalian Genome Society16(12)942-54(2005 Dec)
Oh JH,Yang JO,Hahn Y,Kim MR,Byun SS,Jeon YJ,Kim JM,Song KS,Noh SM,Kim S,Yoo HS,Kim YS,Kim NS

Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Oncogene22(30)4765-73(2003 Jul)
Praml C,Savelyeva L,Schwab M

The aldo-keto reductase superfamily homepage.
Chemico-biological interactions143-144621-31(2003 Feb)
Hyndman D,Bauman DR,Heredia VV,Penning TM

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

AKR7L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報