DEFB114 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB114
Entrez Gene ID	245928
Full Name	defensin beta 114
Synonyms	DEFB-14,DEFB14
General protein information	Preferred Names defensin beta 114 Names beta-defensin 114 beta-defensin 14 defensin, beta 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p12.3
Summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. The protein encoded by this gene is a beta-defensin with antimicrobial activity against E. coli, S. aureus, and C. albicans. The encoded protein also binds and neutralizes lipopolysaccharide (LPS), a factor involved in inflammatory diseases and male reproductive issues. [provided by RefSeq, Nov 2014].
Disorder MIM:	615243

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037499.2	NP_001032588.1	beta-defensin 114 precursor
NM_001037499.1	NP_001032588.1	beta-defensin 114 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DEFB114	XP_001149183.1
Homo sapiens (human)	DEFB114	NP_001032588.1
	DEFB114	XP_001105500.1

Gene Ontology
Bibliography

Related articles in PubMed

The novel human ?-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss.
Yu H, Dong J, Gu Y, Liu H, Xin A, Shi H, Sun F, Zhang Y, Lin D, Diao H
The Journal of biological chemistry288(17)12270-82(2013 Apr)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Human beta-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss. It also has antimicrobial activity against E. coli, S. aureus, and C. albicans.
Title: The novel human ?-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following DEFB114 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB114 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30461	NM_001037499.2 Latest version!	Homo sapiens defensin beta 114 (DEFB114), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30461	NM_001037499.1	Homo sapiens defensin beta 114 (DEFB114), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB114 ( NM_001037499.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032588.1 Homo sapiens defensin beta 114 (DEFB114), mRNA.

Price & Availability↑

CloneID	OHu30461
Clone ID Related Accession (Same CDS sequence)	NM_001037499.2 , NM_001037499.1
Accession Version	NM_001037499.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	beta-defensin 114 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138879.10. On Mar 15, 2019 this sequence version replaced NM_001037499.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000322066.4/ ENSP00000312702.3 Protein has antimicrobial activity :: PMID: 23482568 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGGATCT TTTACTATCT CCATTTTCTG TGTTATGTGA CCTTCATTCT ACCAGCCACA 
TGTACCTTGG TGAATGCTGA TCGTTGCACC AAACGTTACG GTCGTTGTAA AAGAGACTGT 
CTTGAGAGTG AAAAGCAAAT AGACATATGT TCCTTACCAA GAAAAATTTG CTGCACTGAG 
AAATTGTATG AAGAAGATGA TATGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032588.1
CDS	60..269
Translation	MRIFYYLHFLCYVTFILPATCTLVNADRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF

Target ORF information:

RefSeq Version	NM_001037499.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 114 (DEFB114), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037499.2

ORF Insert Sequence:

ATGAGGATCT TTTACTATCT CCATTTTCTG TGTTATGTGA CCTTCATTCT ACCAGCCACA 
TGTACCTTGG TGAATGCTGA TCGTTGCACC AAACGTTACG GTCGTTGTAA AAGAGACTGT 
CTTGAGAGTG AAAAGCAAAT AGACATATGT TCCTTACCAA GAAAAATTTG CTGCACTGAG 
AAATTGTATG AAGAAGATGA TATGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB114 ( NM_001037499.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032588.1 Homo sapiens defensin beta 114 (DEFB114), mRNA.

Price & Availability↑

CloneID	OHu30461
Clone ID Related Accession (Same CDS sequence)	NM_001037499.2 , NM_001037499.1
Accession Version	NM_001037499.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	beta-defensin 114 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ012018.1. On or before Mar 4, 2006 this sequence version replaced XM_930162.1, XM_941743.1. ##Evidence-Data-START## Transcript exon combination :: DQ012018.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23482568 ##RefSeq-Attributes-END##

ATGAGGATCT TTTACTATCT CCATTTTCTG TGTTATGTGA CCTTCATTCT ACCAGCCACA 
TGTACCTTGG TGAATGCTGA TCGTTGCACC AAACGTTACG GTCGTTGTAA AAGAGACTGT 
CTTGAGAGTG AAAAGCAAAT AGACATATGT TCCTTACCAA GAAAAATTTG CTGCACTGAG 
AAATTGTATG AAGAAGATGA TATGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032588.1
CDS	1..210
Translation	MRIFYYLHFLCYVTFILPATCTLVNADRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF

Target ORF information:

RefSeq Version	NM_001037499.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 114 (DEFB114), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037499.1

ORF Insert Sequence:

ATGAGGATCT TTTACTATCT CCATTTTCTG TGTTATGTGA CCTTCATTCT ACCAGCCACA 
TGTACCTTGG TGAATGCTGA TCGTTGCACC AAACGTTACG GTCGTTGTAA AAGAGACTGT 
CTTGAGAGTG AAAAGCAAAT AGACATATGT TCCTTACCAA GAAAAATTTG CTGCACTGAG 
AAATTGTATG AAGAAGATGA TATGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The novel human ?-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss.
The Journal of biological chemistry288(17)12270-82(2013 Apr)
Yu H,Dong J,Gu Y,Liu H,Xin A,Shi H,Sun F,Zhang Y,Lin D,Diao H

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)
Schutte BC,Mitros JP,Bartlett JA,Walters JD,Jia HP,Welsh MJ,Casavant TL,McCray PB Jr

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DEFB114 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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