DEFB112 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB112
Entrez Gene ID	245915
Full Name	defensin beta 112
Synonyms	DEFB-12
General protein information	Preferred Names defensin beta 112 Names beta-defensin 112 beta-defensin 12 defensin, beta 12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p12.3
Summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001369057.1	NP_001355986.1	beta-defensin 112 precursor
NM_001037498.1	NP_001032587.1	beta-defensin 112
NM_001369057.2	NP_001355986.1	beta-defensin 112 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFB112	NP_001032587.1
Pan troglodytes (chimpanzee)	DEFB112	NP_001123233.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.
Scannell Bryan M, Argos M, Pierce B, Tong L, Rakibuz-Zaman M, Ahmed A, Rahman M, Islam T, Yunus M, Parvez F, Roy S, Jasmine F, Baron JA, Kibriya MG, Ahsan H
PloS one9(8)e105062(2014)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The encoded protein is thought to display antimicrobial activity.
Title: Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

The following DEFB112 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB112 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30094	NM_001037498.1 Latest version!	Homo sapiens defensin beta 112 (DEFB112), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu108701	NM_001369057.2 Latest version!	Homo sapiens defensin beta 112 (DEFB112), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu108701	NM_001369057.1	Homo sapiens defensin beta 112 (DEFB112), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB112 ( NM_001037498.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032587.1 Homo sapiens defensin beta 112 (DEFB112), mRNA.

Price & Availability↑

CloneID	OHu30094
Clone ID Related Accession (Same CDS sequence)	NM_001037498.1
Accession Version	NM_001037498.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	beta-defensin 112
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ012016.1. ##Evidence-Data-START## Transcript exon combination :: DQ012016.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16033865 ##RefSeq-Attributes-END##

ATGAAATTAT TGACAACCAT ATGTAGACTG AAACTTGAAA AAATGTACTC AAAGACAAAT 
ACATCTTCCA CAATATTTGA AAAGGCCCGA CATGGGACAG AGAAAATCAG CACAGCCAGA 
AGTGAAGGGC ACCATATCAC CTTTAGTAGG TGGAAGTCAT GTACAGCGAT TGGAGGTCGA 
TGTAAAAATC AATGTGATGA TAGTGAATTT AGGATTTCAT ACTGTGCAAG ACCTACAACT 
CATTGCTGCG TGACAGAATG TGACCCTACG GACCCAAATA ATTGGATCCC AAAGGACTCA 
GTAGGGACTC AAGAATGGTA CCCTAAAGAC TCACGTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032587.1
CDS	1..342
Translation	MKLLTTICRLKLEKMYSKTNTSSTIFEKARHGTEKISTARSEGHHITFSRWKSCTAIGGRCKNQCDDSEFRISYCARPTTHCCVTECDPTDPNNWIPKDSVGTQEWYPKDSRH

Target ORF information:

RefSeq Version	NM_001037498.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 112 (DEFB112), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037498.1

ORF Insert Sequence:

ATGAAATTAT TGACAACCAT ATGTAGACTG AAACTTGAAA AAATGTACTC AAAGACAAAT 
ACATCTTCCA CAATATTTGA AAAGGCCCGA CATGGGACAG AGAAAATCAG CACAGCCAGA 
AGTGAAGGGC ACCATATCAC CTTTAGTAGG TGGAAGTCAT GTACAGCGAT TGGAGGTCGA 
TGTAAAAATC AATGTGATGA TAGTGAATTT AGGATTTCAT ACTGTGCAAG ACCTACAACT 
CATTGCTGCG TGACAGAATG TGACCCTACG GACCCAAATA ATTGGATCCC AAAGGACTCA 
GTAGGGACTC AAGAATGGTA CCCTAAAGAC TCACGTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB112 ( NM_001369057.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001355986.1 Homo sapiens defensin beta 112 (DEFB112), mRNA.

Price & Availability↑

CloneID	OHu108701
Clone ID Related Accession (Same CDS sequence)	NM_001369057.1 , NM_001369057.2
Accession Version	NM_001369057.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	beta-defensin 112 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138879.10. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved Protein has antimicrobial activity :: PMID: 16033865 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAGATCC TTCTCTTTTT CTGTATTTTG CTTTTCTTTG GAGTCCTTAT TCCACCAGCC 
AGAAGTGAAG GGCACCATAT CACCTTTAGT AGGTGGAAGT CATGTACAGC GATTGGAGGT 
CGATGTAAAA ATCAATGTGA TGATAGTGAA TTTAGGATTT CATACTGTGC AAGACCTACA 
ACTCATTGCT GCGTGACAGA ATGTGACCCT ACGGACCCAA ATAATTGGAT CCCAAAGGAC 
TCAGTAGGGA CTCAAGAATG GTACCCTAAA GACTCACGTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001355986.1
CDS	61..345
Translation	MKILLFFCILLFFGVLIPPARSEGHHITFSRWKSCTAIGGRCKNQCDDSEFRISYCARPTTHCCVTECDPTDPNNWIPKDSVGTQEWYPKDSRH

Target ORF information:

RefSeq Version	NM_001369057.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 112 (DEFB112), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001369057.1

ORF Insert Sequence:

ATGAAGATCC TTCTCTTTTT CTGTATTTTG CTTTTCTTTG GAGTCCTTAT TCCACCAGCC 
AGAAGTGAAG GGCACCATAT CACCTTTAGT AGGTGGAAGT CATGTACAGC GATTGGAGGT 
CGATGTAAAA ATCAATGTGA TGATAGTGAA TTTAGGATTT CATACTGTGC AAGACCTACA 
ACTCATTGCT GCGTGACAGA ATGTGACCCT ACGGACCCAA ATAATTGGAT CCCAAAGGAC 
TCAGTAGGGA CTCAAGAATG GTACCCTAAA GACTCACGTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB112 ( NM_001369057.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001355986.1 Homo sapiens defensin beta 112 (DEFB112), mRNA.

Price & Availability↑

CloneID	OHu108701
Clone ID Related Accession (Same CDS sequence)	NM_001369057.1 , NM_001369057.2
Accession Version	NM_001369057.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	beta-defensin 112 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138879.10. On Aug 27, 2019 this sequence version replaced NM_001369057.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.31757.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved Protein has antimicrobial activity :: PMID: 16033865 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAGATCC TTCTCTTTTT CTGTATTTTG CTTTTCTTTG GAGTCCTTAT TCCACCAGCC 
AGAAGTGAAG GGCACCATAT CACCTTTAGT AGGTGGAAGT CATGTACAGC GATTGGAGGT 
CGATGTAAAA ATCAATGTGA TGATAGTGAA TTTAGGATTT CATACTGTGC AAGACCTACA 
ACTCATTGCT GCGTGACAGA ATGTGACCCT ACGGACCCAA ATAATTGGAT CCCAAAGGAC 
TCAGTAGGGA CTCAAGAATG GTACCCTAAA GACTCACGTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001355986.1
CDS	61..345
Translation	MKILLFFCILLFFGVLIPPARSEGHHITFSRWKSCTAIGGRCKNQCDDSEFRISYCARPTTHCCVTECDPTDPNNWIPKDSVGTQEWYPKDSRH

Target ORF information:

RefSeq Version	NM_001369057.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 112 (DEFB112), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001369057.2

ORF Insert Sequence:

ATGAAGATCC TTCTCTTTTT CTGTATTTTG CTTTTCTTTG GAGTCCTTAT TCCACCAGCC 
AGAAGTGAAG GGCACCATAT CACCTTTAGT AGGTGGAAGT CATGTACAGC GATTGGAGGT 
CGATGTAAAA ATCAATGTGA TGATAGTGAA TTTAGGATTT CATACTGTGC AAGACCTACA 
ACTCATTGCT GCGTGACAGA ATGTGACCCT ACGGACCCAA ATAATTGGAT CCCAAAGGAC 
TCAGTAGGGA CTCAAGAATG GTACCCTAAA GACTCACGTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.
PloS one9(8)e105062(2014)
Scannell Bryan M,Argos M,Pierce B,Tong L,Rakibuz-Zaman M,Ahmed A,Rahman M,Islam T,Yunus M,Parvez F,Roy S,Jasmine F,Baron JA,Kibriya MG,Ahsan H

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)
Schutte BC,Mitros JP,Bartlett JA,Walters JD,Jia HP,Welsh MJ,Casavant TL,McCray PB Jr

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DEFB112 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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