ALOX12B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALOX12B
Entrez Gene ID	242
Full Name	arachidonate 12-lipoxygenase, 12R type
Synonyms	12R-LOX,ARCI2
General protein information	Preferred Names arachidonate 12-lipoxygenase, 12R type Names arachidonate 12-lipoxygenase, 12R-type 12R-lipoxygenase epidermis-type lipoxygenase 12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Sep 2015].
Disorder MIM:	603741
Disorder Html:	Ichthyosis, congenital, autosomal recessive 2, 242100 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001139.3	NP_001130.1	arachidonate 12-lipoxygenase, 12R-type
NM_001139.2	NP_001130.1	arachidonate 12-lipoxygenase, 12R-type

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Alox12b	NP_033789.1
Homo sapiens (human)	ALOX12B	NP_001130.1
Pan troglodytes (chimpanzee)	ALOX12B	XP_511864.2
Bos taurus (cattle)	ALOX12B	NP_001178967.1
Canis lupus familiaris (dog)	ALOX12B	XP_546604.2
Rattus norvegicus (Norway rat)	Alox12b	NP_001034466.1

Gene Ontology
Bibliography

Related articles in PubMed

Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates.
Bastaki F, Mohamed M, Nair P, Saif F, Mustafa EM, Bizzari S, Al-Ali MT, Hamzeh AR
International journal of dermatology56(5)514-523(2017 May)

A novel deletion mutation in the ALOX12B gene in a Kurdish family with autosomal recessive congenital ichthyosis.
Lolas IB, Sommerlund M, Okkels H, Ramsing M, Petersen MB
Journal of the European Academy of Dermatology and Venereology : JEADV30(11)e144-e145(2016 Nov)

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.
Mu?oz-Garcia A, Thomas CP, Keeney DS, Zheng Y, Brash AR
Biochimica et biophysica acta1841(3)401-8(2014 Mar)

The role of lipoxygenases in epidermis.
Krieg P, F?rstenberger G
Biochimica et biophysica acta1841(3)390-400(2014 Mar)

Non-syndromic autosomal recessive congenital ichthyosis in the Israeli population.
Israeli S, Goldberg I, Fuchs-Telem D, Bergman R, Indelman M, Bitterman-Deutsch O, Harel A, Mashiach Y, Sarig O, Sprecher E
Clinical and experimental dermatology38(8)911-6(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The rare homozygous ALOX12B mutation found in Patient 5 causes a change in a conserved residue; Leu315 into a proline in the catalytic domain of 12R-LOX.
Title: Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates.

report adds information on the clinical picture of autosomal recessive congenital ichthyosis caused by ALOX12B mutations
Title: A novel deletion mutation in the ALOX12B gene in a Kurdish family with autosomal recessive congenital ichthyosis.

This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3. [review]
Title: The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.

Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis. [review]
Title: The role of lipoxygenases in epidermis.

We found that the contribution of the ALOX12B gene to the pathogenesis of Autosomal Recessive Congenital Ichthyosis to be as important as that of TGM1 in families of Arab Muslim origin
Title: Non-syndromic autosomal recessive congenital ichthyosis in the Israeli population.

The following ALOX12B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALOX12B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17816	NM_001139.3 Latest version!	Homo sapiens arachidonate 12-lipoxygenase, 12R type (ALOX12B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu17816	NM_001139.2	Homo sapiens arachidonate 12-lipoxygenase, 12R type (ALOX12B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALOX12B ( NM_001139.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001130.1 Homo sapiens arachidonate 12-lipoxygenase, 12R type (ALOX12B), mRNA.

Price & Availability↑

CloneID	OHu17816
Clone ID Related Accession (Same CDS sequence)	NM_001139.3 , NM_001139.2
Accession Version	NM_001139.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2106bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	arachidonate 12-lipoxygenase, 12R-type
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC129492.6, BC041058.1 and AF059250.1. This sequence is a reference standard in the RefSeqGene project. On Jul 31, 2018 this sequence version replaced NM_001139.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF059250.1, BC041058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000647874.1/ ENSP00000497784.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT ACAAAGTCAG GGTGGCCACA GGCACCGACC TCTTGTCGGG AACACGGGAC 
TCCATCTCAC TGACCATTGT GGGGACACAA GGAGAGAGCC ATAAGCAGCT GCTGAACCAC 
TTTGGGAGAG ACTTTGCAAC TGGGGCGGTG GGCCAGTACA CCGTGCAGTG CCCTCAGGAC 
CTGGGTGAGC TCATCATCAT CCGCCTGCAC AAAGAGCGGT ACGCCTTCTT CCCCAAGGAC 
CCTTGGTACT GCAACTATGT GCAGATCTGT GCCCCCAACG GCCGTATCTA CCACTTCCCC 
GCCTACCAGT GGATGGATGG CTACGAGACC CTGGCACTCC GGGAGGCCAC AGGAAAGACA 
ACAGCAGATG ACTCGCTCCC CGTCCTCCTG GAGCACAGAA AAGAGGAGAT CAGAGCCAAG 
CAGGACTTCT ACCACTGGCG AGTCTTTCTT CCTGGCCTGC CCAGCTATGT GCACATTCCC 
AGTTACCGCC CTCCGGTGCG GAGGCATCGC AACCCCAACC GGCCTGAGTG GAATGGCTAT 
ATTCCGGGAT TCCCAATTCT CATCAACTTT AAGGCCACCA AGTTCCTGAA CTTAAATCTC 
CGCTACTCCT TCCTCAAGAC GGCCTCCTTC TTCGTCCGCC TGGGGCCCAT GGCACTGGCT 
TTCAAAGTCC GCGGCCTGTT GGACTGCAAA CATTCGTGGA AGAGGCTGAA GGACATTAGG 
AAAATTTTCC CTGGCAAGAA ATCTGTCGTC TCCGAGTACG TGGCCGAGCA CTGGGCAGAG 
GACACCTTCT TTGGGTACCA GTACCTCAAC GGCGTCAACC CCGGCCTGAT CCGCCGCTGC 
ACGCGGATCC CAGACAAGTT CCCCGTCACA GACGACATGG TGGCTCCGTT CCTGGGCGAG 
GGAACGTGCT TGCAAGCGGA GCTGGAGAAG GGGAACATTT ACCTGGCCGA CTACCGCATC 
ATGGAGGGCA TCCCCACCGT GGAGCTCAGC GGCCGGAAGC AGCACCACTG CGCCCCCCTC 
TGCCTGCTGC ACTTTGGACC CGAGGGCAAG ATGATGCCCA TCGCCATCCA GCTCAGCCAG 
ACCCCTGGGC CAGATTGCCC CATCTTCCTG CCCAGTGATT CTGAGTGGGA CTGGCTGCTA 
GCCAAGACGT GGGTACGCTA TGCGGAGTTC TACAGCCACG AGGCCATCGC CCACCTGCTG 
GAGACACACC TCATTGCTGA GGCCTTCTGC CTGGCCTTGC TGAGGAACCT GCCCATGTGC 
CACCCCCTCT ACAAGCTCCT CATCCCCCAT ACCCGATACA CCGTCCAGAT CAACAGCATT 
GGCCGGGCCG TTCTCCTCAA TGAGGGGGGG CTCTCTGCCA AGGGCATGTC CCTGGGCGTG 
GAAGGCTTTG CTGGGGTGAT GGTACGGGCT CTGTCGGAGC TCACCTATGA CAGCCTCTAC 
CTCCCCAATG ACTTTGTGGA GCGTGGGGTC CAGGACCTGC CTGGATATTA CTACCGCGAT 
GACAGCTTGG CGGTGTGGAA TGCACTGGAG AAGTATGTGA CGGAGATCAT CACCTATTAT 
TACCCGAGTG ACGCAGCCGT GGAGGGTGAT CCGGAATTGC AGTCTTGGGT GCAGGAAATA 
TTTAAAGAGT GCCTCCTGGG GCGGGAGAGC TCAGGCTTCC CTAGGTGCTT GCGAACCGTG 
CCTGAGCTGA TCCGATATGT CACTATAGTC ATCTACACCT GCTCTGCCAA GCACGCTGCT 
GTCAACACAG GCCAGATGGA GTTCACCGCC TGGATGCCCA ACTTCCCAGC GTCCATGCGG 
AATCCACCGA TTCAGACTAA GGGGCTGACC ACTCTGGAGA CCTTCATGGA CACGTTGCCG 
GATGTGAAGA CCACGTGCAT CACGCTGCTG GTGCTCTGGA CCCTCAGCCG AGAGCCTGAC 
GACAGGCGGC CCCTGGGACA CTTCCCGGAC ATTCACTTCG TGGAGGAGGC CCCGCGGAGG 
AGCATAGAGG CGTTCCGCCA GCGCCTGAAC CAGATCTCAC ACGACATCCG CCAGCGCAAC 
AAGTGCCTTC CCATCCCCTA CTACTACCTG GACCCGGTGC TGATTGAGAA CAGCATTTCT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001130.1
CDS	275..2380
Translation	MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI

Target ORF information:

RefSeq Version	NM_001139.3
Organism	Homo sapiens(human)
Definition	Homo sapiens arachidonate 12-lipoxygenase, 12R type (ALOX12B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001139.3

ORF Insert Sequence:

ATGGCCACCT ACAAAGTCAG GGTGGCCACA GGCACCGACC TCTTGTCGGG AACACGGGAC 
TCCATCTCAC TGACCATTGT GGGGACACAA GGAGAGAGCC ATAAGCAGCT GCTGAACCAC 
TTTGGGAGAG ACTTTGCAAC TGGGGCGGTG GGCCAGTACA CCGTGCAGTG CCCTCAGGAC 
CTGGGTGAGC TCATCATCAT CCGCCTGCAC AAAGAGCGGT ACGCCTTCTT CCCCAAGGAC 
CCTTGGTACT GCAACTATGT GCAGATCTGT GCCCCCAACG GCCGTATCTA CCACTTCCCC 
GCCTACCAGT GGATGGATGG CTACGAGACC CTGGCACTCC GGGAGGCCAC AGGAAAGACA 
ACAGCAGATG ACTCGCTCCC CGTCCTCCTG GAGCACAGAA AAGAGGAGAT CAGAGCCAAG 
CAGGACTTCT ACCACTGGCG AGTCTTTCTT CCTGGCCTGC CCAGCTATGT GCACATTCCC 
AGTTACCGCC CTCCGGTGCG GAGGCATCGC AACCCCAACC GGCCTGAGTG GAATGGCTAT 
ATTCCGGGAT TCCCAATTCT CATCAACTTT AAGGCCACCA AGTTCCTGAA CTTAAATCTC 
CGCTACTCCT TCCTCAAGAC GGCCTCCTTC TTCGTCCGCC TGGGGCCCAT GGCACTGGCT 
TTCAAAGTCC GCGGCCTGTT GGACTGCAAA CATTCGTGGA AGAGGCTGAA GGACATTAGG 
AAAATTTTCC CTGGCAAGAA ATCTGTCGTC TCCGAGTACG TGGCCGAGCA CTGGGCAGAG 
GACACCTTCT TTGGGTACCA GTACCTCAAC GGCGTCAACC CCGGCCTGAT CCGCCGCTGC 
ACGCGGATCC CAGACAAGTT CCCCGTCACA GACGACATGG TGGCTCCGTT CCTGGGCGAG 
GGAACGTGCT TGCAAGCGGA GCTGGAGAAG GGGAACATTT ACCTGGCCGA CTACCGCATC 
ATGGAGGGCA TCCCCACCGT GGAGCTCAGC GGCCGGAAGC AGCACCACTG CGCCCCCCTC 
TGCCTGCTGC ACTTTGGACC CGAGGGCAAG ATGATGCCCA TCGCCATCCA GCTCAGCCAG 
ACCCCTGGGC CAGATTGCCC CATCTTCCTG CCCAGTGATT CTGAGTGGGA CTGGCTGCTA 
GCCAAGACGT GGGTACGCTA TGCGGAGTTC TACAGCCACG AGGCCATCGC CCACCTGCTG 
GAGACACACC TCATTGCTGA GGCCTTCTGC CTGGCCTTGC TGAGGAACCT GCCCATGTGC 
CACCCCCTCT ACAAGCTCCT CATCCCCCAT ACCCGATACA CCGTCCAGAT CAACAGCATT 
GGCCGGGCCG TTCTCCTCAA TGAGGGGGGG CTCTCTGCCA AGGGCATGTC CCTGGGCGTG 
GAAGGCTTTG CTGGGGTGAT GGTACGGGCT CTGTCGGAGC TCACCTATGA CAGCCTCTAC 
CTCCCCAATG ACTTTGTGGA GCGTGGGGTC CAGGACCTGC CTGGATATTA CTACCGCGAT 
GACAGCTTGG CGGTGTGGAA TGCACTGGAG AAGTATGTGA CGGAGATCAT CACCTATTAT 
TACCCGAGTG ACGCAGCCGT GGAGGGTGAT CCGGAATTGC AGTCTTGGGT GCAGGAAATA 
TTTAAAGAGT GCCTCCTGGG GCGGGAGAGC TCAGGCTTCC CTAGGTGCTT GCGAACCGTG 
CCTGAGCTGA TCCGATATGT CACTATAGTC ATCTACACCT GCTCTGCCAA GCACGCTGCT 
GTCAACACAG GCCAGATGGA GTTCACCGCC TGGATGCCCA ACTTCCCAGC GTCCATGCGG 
AATCCACCGA TTCAGACTAA GGGGCTGACC ACTCTGGAGA CCTTCATGGA CACGTTGCCG 
GATGTGAAGA CCACGTGCAT CACGCTGCTG GTGCTCTGGA CCCTCAGCCG AGAGCCTGAC 
GACAGGCGGC CCCTGGGACA CTTCCCGGAC ATTCACTTCG TGGAGGAGGC CCCGCGGAGG 
AGCATAGAGG CGTTCCGCCA GCGCCTGAAC CAGATCTCAC ACGACATCCG CCAGCGCAAC 
AAGTGCCTTC CCATCCCCTA CTACTACCTG GACCCGGTGC TGATTGAGAA CAGCATTTCT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALOX12B ( NM_001139.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001130.1 Homo sapiens arachidonate 12-lipoxygenase, 12R type (ALOX12B), mRNA.

Price & Availability↑

CloneID	OHu17816
Clone ID Related Accession (Same CDS sequence)	NM_001139.3 , NM_001139.2
Accession Version	NM_001139.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2106bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	arachidonate 12-lipoxygenase, 12R-type
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC129492.6, BC041058.1 and AF059250.1. This sequence is a reference standard in the RefSeqGene project. On Dec 27, 2006 this sequence version replaced NM_001139.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF038461.1, BC041058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT ACAAAGTCAG GGTGGCCACA GGCACCGACC TCTTGTCGGG AACACGGGAC 
TCCATCTCAC TGACCATTGT GGGGACACAA GGAGAGAGCC ATAAGCAGCT GCTGAACCAC 
TTTGGGAGAG ACTTTGCAAC TGGGGCGGTG GGCCAGTACA CCGTGCAGTG CCCTCAGGAC 
CTGGGTGAGC TCATCATCAT CCGCCTGCAC AAAGAGCGGT ACGCCTTCTT CCCCAAGGAC 
CCTTGGTACT GCAACTATGT GCAGATCTGT GCCCCCAACG GCCGTATCTA CCACTTCCCC 
GCCTACCAGT GGATGGATGG CTACGAGACC CTGGCACTCC GGGAGGCCAC AGGAAAGACA 
ACAGCAGATG ACTCGCTCCC CGTCCTCCTG GAGCACAGAA AAGAGGAGAT CAGAGCCAAG 
CAGGACTTCT ACCACTGGCG AGTCTTTCTT CCTGGCCTGC CCAGCTATGT GCACATTCCC 
AGTTACCGCC CTCCGGTGCG GAGGCATCGC AACCCCAACC GGCCTGAGTG GAATGGCTAT 
ATTCCGGGAT TCCCAATTCT CATCAACTTT AAGGCCACCA AGTTCCTGAA CTTAAATCTC 
CGCTACTCCT TCCTCAAGAC GGCCTCCTTC TTCGTCCGCC TGGGGCCCAT GGCACTGGCT 
TTCAAAGTCC GCGGCCTGTT GGACTGCAAA CATTCGTGGA AGAGGCTGAA GGACATTAGG 
AAAATTTTCC CTGGCAAGAA ATCTGTCGTC TCCGAGTACG TGGCCGAGCA CTGGGCAGAG 
GACACCTTCT TTGGGTACCA GTACCTCAAC GGCGTCAACC CCGGCCTGAT CCGCCGCTGC 
ACGCGGATCC CAGACAAGTT CCCCGTCACA GACGACATGG TGGCTCCGTT CCTGGGCGAG 
GGAACGTGCT TGCAAGCGGA GCTGGAGAAG GGGAACATTT ACCTGGCCGA CTACCGCATC 
ATGGAGGGCA TCCCCACCGT GGAGCTCAGC GGCCGGAAGC AGCACCACTG CGCCCCCCTC 
TGCCTGCTGC ACTTTGGACC CGAGGGCAAG ATGATGCCCA TCGCCATCCA GCTCAGCCAG 
ACCCCTGGGC CAGATTGCCC CATCTTCCTG CCCAGTGATT CTGAGTGGGA CTGGCTGCTA 
GCCAAGACGT GGGTACGCTA TGCGGAGTTC TACAGCCACG AGGCCATCGC CCACCTGCTG 
GAGACACACC TCATTGCTGA GGCCTTCTGC CTGGCCTTGC TGAGGAACCT GCCCATGTGC 
CACCCCCTCT ACAAGCTCCT CATCCCCCAT ACCCGATACA CCGTCCAGAT CAACAGCATT 
GGCCGGGCCG TTCTCCTCAA TGAGGGGGGG CTCTCTGCCA AGGGCATGTC CCTGGGCGTG 
GAAGGCTTTG CTGGGGTGAT GGTACGGGCT CTGTCGGAGC TCACCTATGA CAGCCTCTAC 
CTCCCCAATG ACTTTGTGGA GCGTGGGGTC CAGGACCTGC CTGGATATTA CTACCGCGAT 
GACAGCTTGG CGGTGTGGAA TGCACTGGAG AAGTATGTGA CGGAGATCAT CACCTATTAT 
TACCCGAGTG ACGCAGCCGT GGAGGGTGAT CCGGAATTGC AGTCTTGGGT GCAGGAAATA 
TTTAAAGAGT GCCTCCTGGG GCGGGAGAGC TCAGGCTTCC CTAGGTGCTT GCGAACCGTG 
CCTGAGCTGA TCCGATATGT CACTATAGTC ATCTACACCT GCTCTGCCAA GCACGCTGCT 
GTCAACACAG GCCAGATGGA GTTCACCGCC TGGATGCCCA ACTTCCCAGC GTCCATGCGG 
AATCCACCGA TTCAGACTAA GGGGCTGACC ACTCTGGAGA CCTTCATGGA CACGTTGCCG 
GATGTGAAGA CCACGTGCAT CACGCTGCTG GTGCTCTGGA CCCTCAGCCG AGAGCCTGAC 
GACAGGCGGC CCCTGGGACA CTTCCCGGAC ATTCACTTCG TGGAGGAGGC CCCGCGGAGG 
AGCATAGAGG CGTTCCGCCA GCGCCTGAAC CAGATCTCAC ACGACATCCG CCAGCGCAAC 
AAGTGCCTTC CCATCCCCTA CTACTACCTG GACCCGGTGC TGATTGAGAA CAGCATTTCT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001130.1
CDS	262..2367
Translation	MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI

Target ORF information:

RefSeq Version	NM_001139.2
Organism	Homo sapiens(human)
Definition	Homo sapiens arachidonate 12-lipoxygenase, 12R type (ALOX12B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001139.2

ORF Insert Sequence:

ATGGCCACCT ACAAAGTCAG GGTGGCCACA GGCACCGACC TCTTGTCGGG AACACGGGAC 
TCCATCTCAC TGACCATTGT GGGGACACAA GGAGAGAGCC ATAAGCAGCT GCTGAACCAC 
TTTGGGAGAG ACTTTGCAAC TGGGGCGGTG GGCCAGTACA CCGTGCAGTG CCCTCAGGAC 
CTGGGTGAGC TCATCATCAT CCGCCTGCAC AAAGAGCGGT ACGCCTTCTT CCCCAAGGAC 
CCTTGGTACT GCAACTATGT GCAGATCTGT GCCCCCAACG GCCGTATCTA CCACTTCCCC 
GCCTACCAGT GGATGGATGG CTACGAGACC CTGGCACTCC GGGAGGCCAC AGGAAAGACA 
ACAGCAGATG ACTCGCTCCC CGTCCTCCTG GAGCACAGAA AAGAGGAGAT CAGAGCCAAG 
CAGGACTTCT ACCACTGGCG AGTCTTTCTT CCTGGCCTGC CCAGCTATGT GCACATTCCC 
AGTTACCGCC CTCCGGTGCG GAGGCATCGC AACCCCAACC GGCCTGAGTG GAATGGCTAT 
ATTCCGGGAT TCCCAATTCT CATCAACTTT AAGGCCACCA AGTTCCTGAA CTTAAATCTC 
CGCTACTCCT TCCTCAAGAC GGCCTCCTTC TTCGTCCGCC TGGGGCCCAT GGCACTGGCT 
TTCAAAGTCC GCGGCCTGTT GGACTGCAAA CATTCGTGGA AGAGGCTGAA GGACATTAGG 
AAAATTTTCC CTGGCAAGAA ATCTGTCGTC TCCGAGTACG TGGCCGAGCA CTGGGCAGAG 
GACACCTTCT TTGGGTACCA GTACCTCAAC GGCGTCAACC CCGGCCTGAT CCGCCGCTGC 
ACGCGGATCC CAGACAAGTT CCCCGTCACA GACGACATGG TGGCTCCGTT CCTGGGCGAG 
GGAACGTGCT TGCAAGCGGA GCTGGAGAAG GGGAACATTT ACCTGGCCGA CTACCGCATC 
ATGGAGGGCA TCCCCACCGT GGAGCTCAGC GGCCGGAAGC AGCACCACTG CGCCCCCCTC 
TGCCTGCTGC ACTTTGGACC CGAGGGCAAG ATGATGCCCA TCGCCATCCA GCTCAGCCAG 
ACCCCTGGGC CAGATTGCCC CATCTTCCTG CCCAGTGATT CTGAGTGGGA CTGGCTGCTA 
GCCAAGACGT GGGTACGCTA TGCGGAGTTC TACAGCCACG AGGCCATCGC CCACCTGCTG 
GAGACACACC TCATTGCTGA GGCCTTCTGC CTGGCCTTGC TGAGGAACCT GCCCATGTGC 
CACCCCCTCT ACAAGCTCCT CATCCCCCAT ACCCGATACA CCGTCCAGAT CAACAGCATT 
GGCCGGGCCG TTCTCCTCAA TGAGGGGGGG CTCTCTGCCA AGGGCATGTC CCTGGGCGTG 
GAAGGCTTTG CTGGGGTGAT GGTACGGGCT CTGTCGGAGC TCACCTATGA CAGCCTCTAC 
CTCCCCAATG ACTTTGTGGA GCGTGGGGTC CAGGACCTGC CTGGATATTA CTACCGCGAT 
GACAGCTTGG CGGTGTGGAA TGCACTGGAG AAGTATGTGA CGGAGATCAT CACCTATTAT 
TACCCGAGTG ACGCAGCCGT GGAGGGTGAT CCGGAATTGC AGTCTTGGGT GCAGGAAATA 
TTTAAAGAGT GCCTCCTGGG GCGGGAGAGC TCAGGCTTCC CTAGGTGCTT GCGAACCGTG 
CCTGAGCTGA TCCGATATGT CACTATAGTC ATCTACACCT GCTCTGCCAA GCACGCTGCT 
GTCAACACAG GCCAGATGGA GTTCACCGCC TGGATGCCCA ACTTCCCAGC GTCCATGCGG 
AATCCACCGA TTCAGACTAA GGGGCTGACC ACTCTGGAGA CCTTCATGGA CACGTTGCCG 
GATGTGAAGA CCACGTGCAT CACGCTGCTG GTGCTCTGGA CCCTCAGCCG AGAGCCTGAC 
GACAGGCGGC CCCTGGGACA CTTCCCGGAC ATTCACTTCG TGGAGGAGGC CCCGCGGAGG 
AGCATAGAGG CGTTCCGCCA GCGCCTGAAC CAGATCTCAC ACGACATCCG CCAGCGCAAC 
AAGTGCCTTC CCATCCCCTA CTACTACCTG GACCCGGTGC TGATTGAGAA CAGCATTTCT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates.
International journal of dermatology56(5)514-523(2017 May)
Bastaki F,Mohamed M,Nair P,Saif F,Mustafa EM,Bizzari S,Al-Ali MT,Hamzeh AR

A novel deletion mutation in the ALOX12B gene in a Kurdish family with autosomal recessive congenital ichthyosis.
Journal of the European Academy of Dermatology and Venereology : JEADV30(11)e144-e145(2016 Nov)
Lolas IB,Sommerlund M,Okkels H,Ramsing M,Petersen MB

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.
Biochimica et biophysica acta1841(3)401-8(2014 Mar)
Mu?oz-Garcia A,Thomas CP,Keeney DS,Zheng Y,Brash AR

The role of lipoxygenases in epidermis.
Biochimica et biophysica acta1841(3)390-400(2014 Mar)
Krieg P,F?rstenberger G

Non-syndromic autosomal recessive congenital ichthyosis in the Israeli population.
Clinical and experimental dermatology38(8)911-6(2013 Dec)
Israeli S,Goldberg I,Fuchs-Telem D,Bergman R,Indelman M,Bitterman-Deutsch O,Harel A,Mashiach Y,Sarig O,Sprecher E

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ALOX12B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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