SHPK cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SHPK
Entrez Gene ID	23729
Full Name	sedoheptulokinase
Synonyms	CARKL,SHK
General protein information	Preferred Names sedoheptulokinase Names sedoheptulokinase carbohydrate kinase-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.2
Summary	The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008].
Disorder MIM:	605060
Disorder Html:	[Sedoheptulokinase deficiency], 617213 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_013276.2	NP_037408.2	sedoheptulokinase
NM_013276.3	NP_037408.2	sedoheptulokinase
NM_013276.4	NP_037408.2	sedoheptulokinase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SHPK	XP_548339.1
Gallus gallus (chicken)	SHPK	XP_415852.4
Xenopus tropicalis (tropical clawed frog)	shpk	NP_001120078.1
Homo sapiens (human)	SHPK	NP_037408.2
Mus musculus (house mouse)	Shpk	NP_083307.1
	LOC721465	XP_001117628.1
Rattus norvegicus (Norway rat)	Shpk	NP_001028854.1
Pan troglodytes (chimpanzee)	SHPK	XP_523551.3
Bos taurus (cattle)	SHPK	NP_001069016.1
Danio rerio (zebrafish)	shpk	XP_001341627.4
Caenorhabditis elegans (roundworm)	CELE_T25C8.1	NP_499810.2

Gene Ontology
Bibliography

Related articles in PubMed

The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.
Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, Knapp B, Haas R, Schmid JA, Jandl C, Amir S, Lubec G, Park J, Esterbauer H, Bilban M, Brizuela L, Pospisilik JA, Otterbein LE, Wagner O
Cell metabolism15(6)813-26(2012 Jun)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray.
Lanktree MB, Hegele RA, Yusuf S, Anand SS
Stroke40(10)3173-9(2009 Oct)

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Analytical chemistry81(11)4493-501(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization
Title: The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Observational study of gene-disease association. (HuGE Navigator)
Title: Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray.

the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP --> sedoheptulose-7-phosphate + ADP, and deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol
Title: Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene.

The following SHPK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SHPK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06316	NM_013276.4 Latest version!	Homo sapiens sedoheptulokinase (SHPK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu06316	NM_013276.2	Homo sapiens sedoheptulokinase (SHPK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu06316	NM_013276.3	Homo sapiens sedoheptulokinase (SHPK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SHPK ( NM_013276.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_037408.2 Homo sapiens sedoheptulokinase (SHPK), mRNA.

Price & Availability↑

CloneID	OHu06316
Clone ID Related Accession (Same CDS sequence)	NM_013276.2 , NM_013276.3 , NM_013276.4
Accession Version	NM_013276.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	sedoheptulokinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF163573.1 and BC020543.1. This sequence is a reference standard in the RefSeqGene project. On Sep 9, 2005 this sequence version replaced NM_013276.1. ##Evidence-Data-START## Transcript exon combination :: AF163573.1, SRR1660807.3106.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC GGCCGATCAC CCTCGGCATT GACCTGGGCA CCACATCTGT GAAGGCAGCT 
CTGCTGAGGG CCGCGCCCGA CGACCCATCC GGGTTCGCAG TGCTGGCGAG CTGTGCCCGT 
GCTGCGCGGG CAGAGGCGGC GGTCGAGAGC GCGGTGGCCG GGCCCCAGGG GCGGGAGCAG 
GATGTGAGTA GAATCCTCCA AGCCCTACAC GAGTGCCTTG CTGCCCTTCC CCGACCCCAG 
CTCCGGAGCG TCGTGGGCAT CGGGGTGTCG GGCCAGATGC ATGGAGTCGT GTTTTGGAAA 
ACAGGCCAAG GCTGTGAATG GACAGAGGGA GGGATTACCC CGGTGTTCGA GCCCCGAGCT 
GTTAGCCACC TGGTCACGTG GCAGGATGGC CGATGTAGCA GCGAATTCCT GGCCTCTCTG 
CCCCAGCCGA AGTCTCATCT CAGTGTGGCC ACGGGCTTCG GCTGTGCAAC CATCTTCTGG 
CTTTTGAAAT ATCGCCCAGA GTTCCTGAAG TCCTACGACG CAGCCGGTAC CATCCACGAC 
TATGTGGTTG CCATGCTGTG TGGCTTGCCA AGACCTCTGA TGTCCGACCA GAATGCTGCC 
AGCTGGGGCT ATTTCAACAC GCAGAGCCAA AGCTGGAACG TAGAGACACT GAGGAGCTCG 
GGTTTTCCTG TCCACCTGCT CCCAGACATC GCCGAGCCTG GCAGTGTGGC GGGCAGAACT 
TCCCACATGT GGTTTGAAAT CCCAAAGGGG ACGCAGGTGG GAGTGGCCTT GGGTGATTTA 
CAGGCCTCTG TCTATTCCTG CATGGCCCAG AGGACAGATG CAGTTCTCAA CATCAGCACC 
TCGGTTCAGC TGGCAGCCTC CATGCCTTCA GGATTCCAGC CTGCACAGAC TCCAGACCCT 
ACGGCCCCAG TCGCCTACTT CCCATACTTC AACAGGACCT ACCTGGGGGT GGCCGCGTCA 
CTCAACGGGG GCAATGTGCT GGCCACGTTC GTCCACATGC TGGTTCAGTG GATGGCAGAT 
CTAGGCCTGG AGGTTGAAGA ATCCACTGTG TATTCACGCA TGATTCAGGC AGCTGTGCAG 
CAGAGAGATA CCCACCTGAC CATCACCCCG ACAGTGCTGG GGGAGAGGCA CCTGCCGGAC 
CAGCTGGCCT CAGTGACCAG AATCTCCTCC TCCGACCTCT CCCTGGGGCA CGTGACCCGG 
GCTCTGTGCC GAGGCATTGT TCAGAACCTG CACTCCATGC TTCCGATTCA GCAGCTCCAG 
GAGTGGGGCG TGGAGAGGGT GATGGGCAGT GGGAGTGCGC TGTCCAGGAA TGACGTGCTG 
AAGCAGGAGG TGCAGAGGGC TTTCCCTTTG CCCATGTCCT TTGGGCAGGA TGTGGATGCA 
GCTGTCGGGG CAGCTCTGGT CATGCTCCGG AGACACCTCA ACCAGAAGGA ATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037408.2
CDS	104..1540
Translation	MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQDVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCATIFWLLKYRPEFLKSYDAAGTIHDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRTSHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQEWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES

Target ORF information:

RefSeq Version	NM_013276.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sedoheptulokinase (SHPK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013276.2

ORF Insert Sequence:

ATGGCTGCGC GGCCGATCAC CCTCGGCATT GACCTGGGCA CCACATCTGT GAAGGCAGCT 
CTGCTGAGGG CCGCGCCCGA CGACCCATCC GGGTTCGCAG TGCTGGCGAG CTGTGCCCGT 
GCTGCGCGGG CAGAGGCGGC GGTCGAGAGC GCGGTGGCCG GGCCCCAGGG GCGGGAGCAG 
GATGTGAGTA GAATCCTCCA AGCCCTACAC GAGTGCCTTG CTGCCCTTCC CCGACCCCAG 
CTCCGGAGCG TCGTGGGCAT CGGGGTGTCG GGCCAGATGC ATGGAGTCGT GTTTTGGAAA 
ACAGGCCAAG GCTGTGAATG GACAGAGGGA GGGATTACCC CGGTGTTCGA GCCCCGAGCT 
GTTAGCCACC TGGTCACGTG GCAGGATGGC CGATGTAGCA GCGAATTCCT GGCCTCTCTG 
CCCCAGCCGA AGTCTCATCT CAGTGTGGCC ACGGGCTTCG GCTGTGCAAC CATCTTCTGG 
CTTTTGAAAT ATCGCCCAGA GTTCCTGAAG TCCTACGACG CAGCCGGTAC CATCCACGAC 
TATGTGGTTG CCATGCTGTG TGGCTTGCCA AGACCTCTGA TGTCCGACCA GAATGCTGCC 
AGCTGGGGCT ATTTCAACAC GCAGAGCCAA AGCTGGAACG TAGAGACACT GAGGAGCTCG 
GGTTTTCCTG TCCACCTGCT CCCAGACATC GCCGAGCCTG GCAGTGTGGC GGGCAGAACT 
TCCCACATGT GGTTTGAAAT CCCAAAGGGG ACGCAGGTGG GAGTGGCCTT GGGTGATTTA 
CAGGCCTCTG TCTATTCCTG CATGGCCCAG AGGACAGATG CAGTTCTCAA CATCAGCACC 
TCGGTTCAGC TGGCAGCCTC CATGCCTTCA GGATTCCAGC CTGCACAGAC TCCAGACCCT 
ACGGCCCCAG TCGCCTACTT CCCATACTTC AACAGGACCT ACCTGGGGGT GGCCGCGTCA 
CTCAACGGGG GCAATGTGCT GGCCACGTTC GTCCACATGC TGGTTCAGTG GATGGCAGAT 
CTAGGCCTGG AGGTTGAAGA ATCCACTGTG TATTCACGCA TGATTCAGGC AGCTGTGCAG 
CAGAGAGATA CCCACCTGAC CATCACCCCG ACAGTGCTGG GGGAGAGGCA CCTGCCGGAC 
CAGCTGGCCT CAGTGACCAG AATCTCCTCC TCCGACCTCT CCCTGGGGCA CGTGACCCGG 
GCTCTGTGCC GAGGCATTGT TCAGAACCTG CACTCCATGC TTCCGATTCA GCAGCTCCAG 
GAGTGGGGCG TGGAGAGGGT GATGGGCAGT GGGAGTGCGC TGTCCAGGAA TGACGTGCTG 
AAGCAGGAGG TGCAGAGGGC TTTCCCTTTG CCCATGTCCT TTGGGCAGGA TGTGGATGCA 
GCTGTCGGGG CAGCTCTGGT CATGCTCCGG AGACACCTCA ACCAGAAGGA ATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SHPK ( NM_013276.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037408.2 Homo sapiens sedoheptulokinase (SHPK), mRNA.

Price & Availability↑

CloneID	OHu06316
Clone ID Related Accession (Same CDS sequence)	NM_013276.2 , NM_013276.3 , NM_013276.4
Accession Version	NM_013276.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-16
Organism	Homo sapiens(human)
Product	sedoheptulokinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF163573.1, BC020543.1 and AC027796.9. On May 17, 2019 this sequence version replaced NM_013276.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.180036.1, SRR1660809.48451.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC GGCCGATCAC CCTCGGCATT GACCTGGGCA CCACATCTGT GAAGGCAGCT 
CTGCTGAGGG CCGCGCCCGA CGACCCATCC GGGTTCGCAG TGCTGGCGAG CTGTGCCCGT 
GCTGCGCGGG CAGAGGCGGC GGTCGAGAGC GCGGTGGCCG GGCCCCAGGG GCGGGAGCAG 
GATGTGAGTA GAATCCTCCA AGCCCTACAC GAGTGCCTTG CTGCCCTTCC CCGACCCCAG 
CTCCGGAGCG TCGTGGGCAT CGGGGTGTCG GGCCAGATGC ATGGAGTCGT GTTTTGGAAA 
ACAGGCCAAG GCTGTGAATG GACAGAGGGA GGGATTACCC CGGTGTTCGA GCCCCGAGCT 
GTTAGCCACC TGGTCACGTG GCAGGATGGC CGATGTAGCA GCGAATTCCT GGCCTCTCTG 
CCCCAGCCGA AGTCTCATCT CAGTGTGGCC ACGGGCTTCG GCTGTGCAAC CATCTTCTGG 
CTTTTGAAAT ATCGCCCAGA GTTCCTGAAG TCCTACGACG CAGCCGGTAC CATCCACGAC 
TATGTGGTTG CCATGCTGTG TGGCTTGCCA AGACCTCTGA TGTCCGACCA GAATGCTGCC 
AGCTGGGGCT ATTTCAACAC GCAGAGCCAA AGCTGGAACG TAGAGACACT GAGGAGCTCG 
GGTTTTCCTG TCCACCTGCT CCCAGACATC GCCGAGCCTG GCAGTGTGGC GGGCAGAACT 
TCCCACATGT GGTTTGAAAT CCCAAAGGGG ACGCAGGTGG GAGTGGCCTT GGGTGATTTA 
CAGGCCTCTG TCTATTCCTG CATGGCCCAG AGGACAGATG CAGTTCTCAA CATCAGCACC 
TCGGTTCAGC TGGCAGCCTC CATGCCTTCA GGATTCCAGC CTGCACAGAC TCCAGACCCT 
ACGGCCCCAG TCGCCTACTT CCCATACTTC AACAGGACCT ACCTGGGGGT GGCCGCGTCA 
CTCAACGGGG GCAATGTGCT GGCCACGTTC GTCCACATGC TGGTTCAGTG GATGGCAGAT 
CTAGGCCTGG AGGTTGAAGA ATCCACTGTG TATTCACGCA TGATTCAGGC AGCTGTGCAG 
CAGAGAGATA CCCACCTGAC CATCACCCCG ACAGTGCTGG GGGAGAGGCA CCTGCCGGAC 
CAGCTGGCCT CAGTGACCAG AATCTCCTCC TCCGACCTCT CCCTGGGGCA CGTGACCCGG 
GCTCTGTGCC GAGGCATTGT TCAGAACCTG CACTCCATGC TTCCGATTCA GCAGCTCCAG 
GAGTGGGGCG TGGAGAGGGT GATGGGCAGT GGGAGTGCGC TGTCCAGGAA TGACGTGCTG 
AAGCAGGAGG TGCAGAGGGC TTTCCCTTTG CCCATGTCCT TTGGGCAGGA TGTGGATGCA 
GCTGTCGGGG CAGCTCTGGT CATGCTCCGG AGACACCTCA ACCAGAAGGA ATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037408.2
CDS	32..1468
Translation	MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQDVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCATIFWLLKYRPEFLKSYDAAGTIHDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRTSHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQEWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES

Target ORF information:

RefSeq Version	NM_013276.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sedoheptulokinase (SHPK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013276.3

ORF Insert Sequence:

ATGGCTGCGC GGCCGATCAC CCTCGGCATT GACCTGGGCA CCACATCTGT GAAGGCAGCT 
CTGCTGAGGG CCGCGCCCGA CGACCCATCC GGGTTCGCAG TGCTGGCGAG CTGTGCCCGT 
GCTGCGCGGG CAGAGGCGGC GGTCGAGAGC GCGGTGGCCG GGCCCCAGGG GCGGGAGCAG 
GATGTGAGTA GAATCCTCCA AGCCCTACAC GAGTGCCTTG CTGCCCTTCC CCGACCCCAG 
CTCCGGAGCG TCGTGGGCAT CGGGGTGTCG GGCCAGATGC ATGGAGTCGT GTTTTGGAAA 
ACAGGCCAAG GCTGTGAATG GACAGAGGGA GGGATTACCC CGGTGTTCGA GCCCCGAGCT 
GTTAGCCACC TGGTCACGTG GCAGGATGGC CGATGTAGCA GCGAATTCCT GGCCTCTCTG 
CCCCAGCCGA AGTCTCATCT CAGTGTGGCC ACGGGCTTCG GCTGTGCAAC CATCTTCTGG 
CTTTTGAAAT ATCGCCCAGA GTTCCTGAAG TCCTACGACG CAGCCGGTAC CATCCACGAC 
TATGTGGTTG CCATGCTGTG TGGCTTGCCA AGACCTCTGA TGTCCGACCA GAATGCTGCC 
AGCTGGGGCT ATTTCAACAC GCAGAGCCAA AGCTGGAACG TAGAGACACT GAGGAGCTCG 
GGTTTTCCTG TCCACCTGCT CCCAGACATC GCCGAGCCTG GCAGTGTGGC GGGCAGAACT 
TCCCACATGT GGTTTGAAAT CCCAAAGGGG ACGCAGGTGG GAGTGGCCTT GGGTGATTTA 
CAGGCCTCTG TCTATTCCTG CATGGCCCAG AGGACAGATG CAGTTCTCAA CATCAGCACC 
TCGGTTCAGC TGGCAGCCTC CATGCCTTCA GGATTCCAGC CTGCACAGAC TCCAGACCCT 
ACGGCCCCAG TCGCCTACTT CCCATACTTC AACAGGACCT ACCTGGGGGT GGCCGCGTCA 
CTCAACGGGG GCAATGTGCT GGCCACGTTC GTCCACATGC TGGTTCAGTG GATGGCAGAT 
CTAGGCCTGG AGGTTGAAGA ATCCACTGTG TATTCACGCA TGATTCAGGC AGCTGTGCAG 
CAGAGAGATA CCCACCTGAC CATCACCCCG ACAGTGCTGG GGGAGAGGCA CCTGCCGGAC 
CAGCTGGCCT CAGTGACCAG AATCTCCTCC TCCGACCTCT CCCTGGGGCA CGTGACCCGG 
GCTCTGTGCC GAGGCATTGT TCAGAACCTG CACTCCATGC TTCCGATTCA GCAGCTCCAG 
GAGTGGGGCG TGGAGAGGGT GATGGGCAGT GGGAGTGCGC TGTCCAGGAA TGACGTGCTG 
AAGCAGGAGG TGCAGAGGGC TTTCCCTTTG CCCATGTCCT TTGGGCAGGA TGTGGATGCA 
GCTGTCGGGG CAGCTCTGGT CATGCTCCGG AGACACCTCA ACCAGAAGGA ATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SHPK ( NM_013276.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037408.2 Homo sapiens sedoheptulokinase (SHPK), mRNA.

Price & Availability↑

CloneID	OHu06316
Clone ID Related Accession (Same CDS sequence)	NM_013276.2 , NM_013276.3 , NM_013276.4
Accession Version	NM_013276.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	sedoheptulokinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF163573.1, BC020543.1 and AC027796.9. On Aug 31, 2019 this sequence version replaced NM_013276.3. ##Evidence-Data-START## Transcript exon combination :: AF163573.1, BC020543.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC GGCCGATCAC CCTCGGCATT GACCTGGGCA CCACATCTGT GAAGGCAGCT 
CTGCTGAGGG CCGCGCCCGA CGACCCATCC GGGTTCGCAG TGCTGGCGAG CTGTGCCCGT 
GCTGCGCGGG CAGAGGCGGC GGTCGAGAGC GCGGTGGCCG GGCCCCAGGG GCGGGAGCAG 
GATGTGAGTA GAATCCTCCA AGCCCTACAC GAGTGCCTTG CTGCCCTTCC CCGACCCCAG 
CTCCGGAGCG TCGTGGGCAT CGGGGTGTCG GGCCAGATGC ATGGAGTCGT GTTTTGGAAA 
ACAGGCCAAG GCTGTGAATG GACAGAGGGA GGGATTACCC CGGTGTTCGA GCCCCGAGCT 
GTTAGCCACC TGGTCACGTG GCAGGATGGC CGATGTAGCA GCGAATTCCT GGCCTCTCTG 
CCCCAGCCGA AGTCTCATCT CAGTGTGGCC ACGGGCTTCG GCTGTGCAAC CATCTTCTGG 
CTTTTGAAAT ATCGCCCAGA GTTCCTGAAG TCCTACGACG CAGCCGGTAC CATCCACGAC 
TATGTGGTTG CCATGCTGTG TGGCTTGCCA AGACCTCTGA TGTCCGACCA GAATGCTGCC 
AGCTGGGGCT ATTTCAACAC GCAGAGCCAA AGCTGGAACG TAGAGACACT GAGGAGCTCG 
GGTTTTCCTG TCCACCTGCT CCCAGACATC GCCGAGCCTG GCAGTGTGGC GGGCAGAACT 
TCCCACATGT GGTTTGAAAT CCCAAAGGGG ACGCAGGTGG GAGTGGCCTT GGGTGATTTA 
CAGGCCTCTG TCTATTCCTG CATGGCCCAG AGGACAGATG CAGTTCTCAA CATCAGCACC 
TCGGTTCAGC TGGCAGCCTC CATGCCTTCA GGATTCCAGC CTGCACAGAC TCCAGACCCT 
ACGGCCCCAG TCGCCTACTT CCCATACTTC AACAGGACCT ACCTGGGGGT GGCCGCGTCA 
CTCAACGGGG GCAATGTGCT GGCCACGTTC GTCCACATGC TGGTTCAGTG GATGGCAGAT 
CTAGGCCTGG AGGTTGAAGA ATCCACTGTG TATTCACGCA TGATTCAGGC AGCTGTGCAG 
CAGAGAGATA CCCACCTGAC CATCACCCCG ACAGTGCTGG GGGAGAGGCA CCTGCCGGAC 
CAGCTGGCCT CAGTGACCAG AATCTCCTCC TCCGACCTCT CCCTGGGGCA CGTGACCCGG 
GCTCTGTGCC GAGGCATTGT TCAGAACCTG CACTCCATGC TTCCGATTCA GCAGCTCCAG 
GAGTGGGGCG TGGAGAGGGT GATGGGCAGT GGGAGTGCGC TGTCCAGGAA TGACGTGCTG 
AAGCAGGAGG TGCAGAGGGC TTTCCCTTTG CCCATGTCCT TTGGGCAGGA TGTGGATGCA 
GCTGTCGGGG CAGCTCTGGT CATGCTCCGG AGACACCTCA ACCAGAAGGA ATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037408.2
CDS	32..1468
Translation	MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQDVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCATIFWLLKYRPEFLKSYDAAGTIHDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRTSHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQEWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES

Target ORF information:

RefSeq Version	NM_013276.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sedoheptulokinase (SHPK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013276.4

ORF Insert Sequence:

ATGGCTGCGC GGCCGATCAC CCTCGGCATT GACCTGGGCA CCACATCTGT GAAGGCAGCT 
CTGCTGAGGG CCGCGCCCGA CGACCCATCC GGGTTCGCAG TGCTGGCGAG CTGTGCCCGT 
GCTGCGCGGG CAGAGGCGGC GGTCGAGAGC GCGGTGGCCG GGCCCCAGGG GCGGGAGCAG 
GATGTGAGTA GAATCCTCCA AGCCCTACAC GAGTGCCTTG CTGCCCTTCC CCGACCCCAG 
CTCCGGAGCG TCGTGGGCAT CGGGGTGTCG GGCCAGATGC ATGGAGTCGT GTTTTGGAAA 
ACAGGCCAAG GCTGTGAATG GACAGAGGGA GGGATTACCC CGGTGTTCGA GCCCCGAGCT 
GTTAGCCACC TGGTCACGTG GCAGGATGGC CGATGTAGCA GCGAATTCCT GGCCTCTCTG 
CCCCAGCCGA AGTCTCATCT CAGTGTGGCC ACGGGCTTCG GCTGTGCAAC CATCTTCTGG 
CTTTTGAAAT ATCGCCCAGA GTTCCTGAAG TCCTACGACG CAGCCGGTAC CATCCACGAC 
TATGTGGTTG CCATGCTGTG TGGCTTGCCA AGACCTCTGA TGTCCGACCA GAATGCTGCC 
AGCTGGGGCT ATTTCAACAC GCAGAGCCAA AGCTGGAACG TAGAGACACT GAGGAGCTCG 
GGTTTTCCTG TCCACCTGCT CCCAGACATC GCCGAGCCTG GCAGTGTGGC GGGCAGAACT 
TCCCACATGT GGTTTGAAAT CCCAAAGGGG ACGCAGGTGG GAGTGGCCTT GGGTGATTTA 
CAGGCCTCTG TCTATTCCTG CATGGCCCAG AGGACAGATG CAGTTCTCAA CATCAGCACC 
TCGGTTCAGC TGGCAGCCTC CATGCCTTCA GGATTCCAGC CTGCACAGAC TCCAGACCCT 
ACGGCCCCAG TCGCCTACTT CCCATACTTC AACAGGACCT ACCTGGGGGT GGCCGCGTCA 
CTCAACGGGG GCAATGTGCT GGCCACGTTC GTCCACATGC TGGTTCAGTG GATGGCAGAT 
CTAGGCCTGG AGGTTGAAGA ATCCACTGTG TATTCACGCA TGATTCAGGC AGCTGTGCAG 
CAGAGAGATA CCCACCTGAC CATCACCCCG ACAGTGCTGG GGGAGAGGCA CCTGCCGGAC 
CAGCTGGCCT CAGTGACCAG AATCTCCTCC TCCGACCTCT CCCTGGGGCA CGTGACCCGG 
GCTCTGTGCC GAGGCATTGT TCAGAACCTG CACTCCATGC TTCCGATTCA GCAGCTCCAG 
GAGTGGGGCG TGGAGAGGGT GATGGGCAGT GGGAGTGCGC TGTCCAGGAA TGACGTGCTG 
AAGCAGGAGG TGCAGAGGGC TTTCCCTTTG CCCATGTCCT TTGGGCAGGA TGTGGATGCA 
GCTGTCGGGG CAGCTCTGGT CATGCTCCGG AGACACCTCA ACCAGAAGGA ATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.
Cell metabolism15(6)813-26(2012 Jun)
Haschemi A,Kosma P,Gille L,Evans CR,Burant CF,Starkl P,Knapp B,Haas R,Schmid JA,Jandl C,Amir S,Lubec G,Park J,Esterbauer H,Bilban M,Brizuela L,Pospisilik JA,Otterbein LE,Wagner O

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray.
Stroke40(10)3173-9(2009 Oct)
Lanktree MB,Hegele RA,Yusuf S,Anand SS

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Analytical chemistry81(11)4493-501(2009 Jun)
Gauci S,Helbig AO,Slijper M,Krijgsveld J,Heck AJ,Mohammed S

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SHPK cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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