KCNE4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNE4
Entrez Gene ID	23704
Full Name	potassium voltage-gated channel subfamily E regulatory subunit 4
Synonyms	MIRP3
General protein information	Preferred Names potassium voltage-gated channel subfamily E regulatory subunit 4 Names potassium voltage-gated channel subfamily E member 4 MINK-related peptide 3 cardiac voltage-gated potassium channel accessory subunit 4 minimum potassium ion channel-related peptide 3 potassium channel subunit beta MiRP3 potassium channel, voltage gated subfamily E regulatory beta subunit 4 potassium voltage-gated channel, Isk-related family, member 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q36.1
Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008].
Disorder MIM:	607775

mRNA and Protein(s)

mRNA	Protein	Name
NM_080671.3	NP_542402.3	potassium voltage-gated channel subfamily E member 4

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	kcne4	NP_001076366.1
Canis lupus familiaris (dog)	KCNE4	XP_005640775.1
Rattus norvegicus (Norway rat)	Kcne4	NP_997691.1
Xenopus tropicalis (tropical clawed frog)	kcne4	XP_002936649.1
Homo sapiens (human)	KCNE4	NP_542402.3
Gallus gallus (chicken)	KCNE4	XP_004937097.1
Bos taurus (cattle)	KCNE4	NP_001075012.1
Mus musculus (house mouse)	Kcne4	NP_067317.1
Pan troglodytes (chimpanzee)	KCNE4	XP_001166586.1
	KCNE4	XP_001108426.2

Gene Ontology
Bibliography

Related articles in PubMed

[Association of KCNE1 and KCNE4 gene polymorphisms with atrial fibrillation among Uygur and Han Chinese populations in Xinjiang].
Miao H, Zhou X, Kabinur K, Zou T, Palida A, Tang B
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(5)743-748(2017 Oct)

Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4.
Abbott GW
Scientific reports638412(2016 Dec)

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.
Sol? L, Roig SR, Vallejo-Gracia A, Serrano-Albarr?s A, Mart?nez-M?rmol R, Tamkun MM, Felipe A
Journal of cell science129(22)4265-4277(2016 11)

Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.
Abbott GW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(8)2959-69(2016 08)

[Effect of additional disease (comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant].
Fre?din MB, Bragina EIu, Saltykova IV, Deeva EV, Ogorodova LM, Puzyrev VP
Genetika49(4)541-4(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction.
Title: The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.

Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respectively.
Title: Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.

the association of the KCNE4 gene variability with allergic rhinitis
Title: [Effect of additional disease (comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant].

KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.
Title: KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.

MiRP3 modulates Kv4.2 current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%.
Title: The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.

The following KCNE4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNE4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11973	NM_080671.3 Latest version!	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 4 (KCNE4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNE4 ( NM_080671.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542402.3 Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 4 (KCNE4), mRNA.

Price & Availability↑

CloneID	OHu11973
Clone ID Related Accession (Same CDS sequence)	NM_080671.3
Accession Version	NM_080671.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily E member 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK294423.1, AC017014.4, AK313203.1 and BM662449.1. On Nov 15, 2012 this sequence version replaced NM_080671.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.244530.1, SRR1660805.86008.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACTTCT TGACTATATA TCCCAACTGC AGCAGCGGAG TTGTCAGAGC GCAGAGCCGG 
ACAGAGCAGA AGAACCCTCT TGGACTGGAC GATTTGGGAA TTCAAAACTT GGGACAAACT 
GTCAGCCTTG CCCCTGCTGT GGAGGCAGCC TCAATGCTGA AAATGGAGCC TCTGAACAGC 
ACGCACCCCG GCACCGCCGC CTCCAGCAGC CCCCTGGAGT CCCGTGCGGC CGGCGGCGGC 
AGCGGCAATG GCAACGAGTA CTTCTACATT CTGGTTGTCA TGTCCTTCTA CGGCATTTTC 
TTGATCGGAA TCATGCTGGG CTACATGAAA TCCAAGAGGC GGGAGAAGAA GTCCAGCCTC 
CTGCTGCTGT ACAAAGACGA GGAGCGGCTC TGGGGGGAGG CCATGAAGCC GCTGCCTGTG 
GTGTCGGGCC TGAGGTCGGT GCAGGTGCCC CTGATGCTGA ACATGCTGCA GGAGAGCGTG 
GCGCCCGCGC TGTCCTGCAC CCTCTGTTCC ATGGAAGGGG ACAGCGTGAG CTCCGAGTCC 
TCCTCCCCGG ACGTGCACCT CACCATTCAG GAGGAGGGGG CAGACGATGA GCTGGAGGAG 
ACCTCGGAGA CGCCCCTCAA CGAGAGCAGC GAAGGGTCCT CGGAGAACAT CCATCAGAAT 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542402.3
CDS	216..881
Translation	MHFLTIYPNCSSGVVRAQSRTEQKNPLGLDDLGIQNLGQTVSLAPAVEAASMLKMEPLNSTHPGTAASSSPLESRAAGGGSGNGNEYFYILVVMSFYGIFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPVVSGLRSVQVPLMLNMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGADDELEETSETPLNESSEGSSENIHQNS

Target ORF information:

RefSeq Version	NM_080671.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 4 (KCNE4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080671.3

ORF Insert Sequence:

ATGCACTTCT TGACTATATA TCCCAACTGC AGCAGCGGAG TTGTCAGAGC GCAGAGCCGG 
ACAGAGCAGA AGAACCCTCT TGGACTGGAC GATTTGGGAA TTCAAAACTT GGGACAAACT 
GTCAGCCTTG CCCCTGCTGT GGAGGCAGCC TCAATGCTGA AAATGGAGCC TCTGAACAGC 
ACGCACCCCG GCACCGCCGC CTCCAGCAGC CCCCTGGAGT CCCGTGCGGC CGGCGGCGGC 
AGCGGCAATG GCAACGAGTA CTTCTACATT CTGGTTGTCA TGTCCTTCTA CGGCATTTTC 
TTGATCGGAA TCATGCTGGG CTACATGAAA TCCAAGAGGC GGGAGAAGAA GTCCAGCCTC 
CTGCTGCTGT ACAAAGACGA GGAGCGGCTC TGGGGGGAGG CCATGAAGCC GCTGCCTGTG 
GTGTCGGGCC TGAGGTCGGT GCAGGTGCCC CTGATGCTGA ACATGCTGCA GGAGAGCGTG 
GCGCCCGCGC TGTCCTGCAC CCTCTGTTCC ATGGAAGGGG ACAGCGTGAG CTCCGAGTCC 
TCCTCCCCGG ACGTGCACCT CACCATTCAG GAGGAGGGGG CAGACGATGA GCTGGAGGAG 
ACCTCGGAGA CGCCCCTCAA CGAGAGCAGC GAAGGGTCCT CGGAGAACAT CCATCAGAAT 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Association of KCNE1 and KCNE4 gene polymorphisms with atrial fibrillation among Uygur and Han Chinese populations in Xinjiang].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(5)743-748(2017 Oct)
Miao H,Zhou X,Kabinur K,Zou T,Palida A,Tang B

Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4.
Scientific reports638412(2016 Dec)
Abbott GW

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.
Journal of cell science129(22)4265-4277(2016 11)
Sol? L,Roig SR,Vallejo-Gracia A,Serrano-Albarr?s A,Mart?nez-M?rmol R,Tamkun MM,Felipe A

Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(8)2959-69(2016 08)
Abbott GW

[Effect of additional disease (comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant].
Genetika49(4)541-4(2013 Apr)
Fre?din MB,Bragina EIu,Saltykova IV,Deeva EV,Ogorodova LM,Puzyrev VP

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

KCNE4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報