LSM5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM5
Entrez Gene ID	23658
Full Name	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms	YER146W
General protein information	Preferred Names LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Names U6 snRNA-associated Sm-like protein LSm5 LSM5 U6 small nuclear RNA and mRNA degradation associated LSM5 homolog, U6 small nuclear RNA associated
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.3
Summary	Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Disorder MIM:	607285

mRNA and Protein(s)

mRNA	Protein	Name
NM_001139499.1	NP_001132971.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_001130710.2	NP_001124182.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_001130710.1	NP_001124182.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_012322.3	NP_036454.1	U6 snRNA-associated Sm-like protein LSm5 isoform a
NM_001139499.2	NP_001132971.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_012322.2	NP_036454.1	U6 snRNA-associated Sm-like protein LSm5 isoform a

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lsm5	NP_001100759.1
Caenorhabditis elegans (roundworm)	lsm-5	NP_506870.1
Neurospora crassa	NCU03766	XP_001728350.1
Xenopus tropicalis (tropical clawed frog)	lsm5	NP_001135569.1
	LSM5	XP_001082513.1
Oryza sativa (rice)	Os05g0389300	NP_001055432.1
Canis lupus familiaris (dog)	LSM5	XP_854477.1
Gallus gallus (chicken)	LSM5	XP_418849.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006604	XP_316632.4
Arabidopsis thaliana (thale cress)	SAD1	NP_199698.1
Homo sapiens (human)	LSM5	NP_036454.1
Bos taurus (cattle)	LSM5	NP_001040018.1
Mus musculus (house mouse)	Lsm5	NP_079796.1
Schizosaccharomyces pombe (fission yeast)	lsm5	NP_596373.1
Pan troglodytes (chimpanzee)	LSM5	XP_519030.1
Danio rerio (zebrafish)	zgc:171959	NP_001093908.1
Drosophila melanogaster (fruit fly)	CG6610	NP_001261461.1
Magnaporthe oryzae (rice blast fungus)	MGG_02462	XP_003709256.1

Gene Ontology
Bibliography

Related articles in PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, L?hrmann R, Stark H
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)

Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
Zeng Z, Feingold E, Wang X, Weeks DE, Lee M, Cuenco DT, Broffitt B, Weyant RJ, Crout R, McNeil DW, Levy SM, Marazita ML, Shaffer JR
Caries research48(4)330-8(2014)

Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Wu JH, Lemaitre RN, Manichaikul A, Guan W, Tanaka T, Foy M, Kabagambe EK, Djousse L, Siscovick D, Fretts AM, Johnson C, King IB, Psaty BM, McKnight B, Rich SS, Chen YD, Nettleton JA, Tang W, Bandinelli S, Jacobs DR Jr, Browning BL, Laurie CC, Gu X, Tsai MY, Steffen LM, Ferrucci L, Fornage M, Mozaffarian D
Circulation. Cardiovascular genetics6(2)171-83(2013 Apr)

Dynamic protein-protein interaction wiring of the human spliceosome.
Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, L?hrmann R, Stelzl U
Molecular cell45(4)567-80(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci
Title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.

The following LSM5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14707	NM_012322.3 Latest version!	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14961	NM_001130710.2 Latest version!	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14961	NM_001139499.2 Latest version!	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu14961	NM_001130710.1	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14961	NM_001139499.1	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14707	NM_012322.2	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM5 ( NM_012322.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036454.1 Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14707
Clone ID Related Accession (Same CDS sequence)	NM_012322.3 , NM_012322.2
Accession Version	NM_012322.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm5 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF667238.1, BC040717.1, AF182291.1, AC018641.3, BM786181.1 and CX782029.1. On Nov 22, 2018 this sequence version replaced NM_012322.2. Transcript Variant: This variant encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.221110.1, AK024217.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000450169.7/ ENSP00000410758.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCTA ACGCTACTAC CAACCCGTCG CAGCTGCTGC CCTTAGAGCT TGTGGACAAA 
TGTATAGGAT CAAGAATTCA CATCGTGATG AAGAGTGATA AGGAAATTGT TGGTACTCTT 
CTAGGATTTG ATGACTTTGT CAATATGGTA CTGGAAGATG TCACTGAGTT TGAAATCACA 
CCAGAAGGAA GAAGGATTAC TAAATTAGAT CAGATTTTGC TAAATGGAAA TAATATAACA 
ATGCTGGTTC CTGGAGGAGA AGGACCTGAA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036454.1
CDS	16..291
Translation	MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Target ORF information:

RefSeq Version	NM_012322.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012322.3

ORF Insert Sequence:

ATGGCGGCTA ACGCTACTAC CAACCCGTCG CAGCTGCTGC CCTTAGAGCT TGTGGACAAA 
TGTATAGGAT CAAGAATTCA CATCGTGATG AAGAGTGATA AGGAAATTGT TGGTACTCTT 
CTAGGATTTG ATGACTTTGT CAATATGGTA CTGGAAGATG TCACTGAGTT TGAAATCACA 
CCAGAAGGAA GAAGGATTAC TAAATTAGAT CAGATTTTGC TAAATGGAAA TAATATAACA 
ATGCTGGTTC CTGGAGGAGA AGGACCTGAA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM5 ( NM_012322.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036454.1 Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14707
Clone ID Related Accession (Same CDS sequence)	NM_012322.3 , NM_012322.2
Accession Version	NM_012322.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm5 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF667238.1, BC040717.1, AF182291.1, AC018641.3, BM786181.1 and CX782029.1. On Aug 2, 2008 this sequence version replaced NM_012322.1. Transcript Variant: This variant encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK024217.1, SRR1803613.239747.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTA ACGCTACTAC CAACCCGTCG CAGCTGCTGC CCTTAGAGCT TGTGGACAAA 
TGTATAGGAT CAAGAATTCA CATCGTGATG AAGAGTGATA AGGAAATTGT TGGTACTCTT 
CTAGGATTTG ATGACTTTGT CAATATGGTA CTGGAAGATG TCACTGAGTT TGAAATCACA 
CCAGAAGGAA GAAGGATTAC TAAATTAGAT CAGATTTTGC TAAATGGAAA TAATATAACA 
ATGCTGGTTC CTGGAGGAGA AGGACCTGAA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036454.1
CDS	47..322
Translation	MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Target ORF information:

RefSeq Version	NM_012322.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012322.2

ORF Insert Sequence:

ATGGCGGCTA ACGCTACTAC CAACCCGTCG CAGCTGCTGC CCTTAGAGCT TGTGGACAAA 
TGTATAGGAT CAAGAATTCA CATCGTGATG AAGAGTGATA AGGAAATTGT TGGTACTCTT 
CTAGGATTTG ATGACTTTGT CAATATGGTA CTGGAAGATG TCACTGAGTT TGAAATCACA 
CCAGAAGGAA GAAGGATTAC TAAATTAGAT CAGATTTTGC TAAATGGAAA TAATATAACA 
ATGCTGGTTC CTGGAGGAGA AGGACCTGAA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM5 ( NM_001139499.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001132971.1 Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14961
Clone ID Related Accession (Same CDS sequence)	NM_001139499.1 , NM_001130710.2 , NM_001130710.1 , NM_001139499.2
Accession Version	NM_001139499.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm5 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF700164.1, DA736378.1, AC018641.3 and CX782029.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a segment of the 5' coding region, and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA736378.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001132971.1
CDS	310..498
Translation	MKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Target ORF information:

RefSeq Version	NM_001139499.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001139499.1

ORF Insert Sequence:

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM5 ( NM_001130710.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124182.1 Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14961
Clone ID Related Accession (Same CDS sequence)	NM_001139499.1 , NM_001130710.2 , NM_001130710.1 , NM_001139499.2
Accession Version	NM_001130710.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm5 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018641.3, BF700164.1, AF182291.1, BM786181.1 and CX782029.1. On Jun 1, 2019 this sequence version replaced NM_001130710.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a segment of the 5' coding region, and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.188137.1, SRR1803614.166975.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267756, SAMN03267764 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124182.1
CDS	96..284
Translation	MKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Target ORF information:

RefSeq Version	NM_001130710.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130710.2

ORF Insert Sequence:

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM5 ( NM_001130710.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124182.1 Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14961
Clone ID Related Accession (Same CDS sequence)	NM_001139499.1 , NM_001130710.2 , NM_001130710.1 , NM_001139499.2
Accession Version	NM_001130710.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm5 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF700164.1, AF182291.1, AC018641.3, BM786181.1 and CX782029.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a segment of the 5' coding region, and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF701546.1, SRR1803614.166975.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267756, SAMN03267764 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124182.1
CDS	71..259
Translation	MKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Target ORF information:

RefSeq Version	NM_001130710.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130710.1

ORF Insert Sequence:

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM5 ( NM_001139499.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001132971.1 Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14961
Clone ID Related Accession (Same CDS sequence)	NM_001139499.1 , NM_001130710.2 , NM_001130710.1 , NM_001139499.2
Accession Version	NM_001139499.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm5 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018641.3, BF700164.1, DA736378.1 and CX782029.1. On May 31, 2019 this sequence version replaced NM_001139499.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a segment of the 5' coding region, and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA736378.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001132971.1
CDS	335..523
Translation	MKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Target ORF information:

RefSeq Version	NM_001139499.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001139499.2

ORF Insert Sequence:

ATGAAGAGTG ATAAGGAAAT TGTTGGTACT CTTCTAGGAT TTGATGACTT TGTCAATATG 
GTACTGGAAG ATGTCACTGA GTTTGAAATC ACACCAGAAG GAAGAAGGAT TACTAAATTA 
GATCAGATTT TGCTAAATGG AAATAATATA ACAATGCTGG TTCCTGGAGG AGAAGGACCT 
GAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,L?hrmann R,Stark H

Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
Caries research48(4)330-8(2014)
Zeng Z,Feingold E,Wang X,Weeks DE,Lee M,Cuenco DT,Broffitt B,Weyant RJ,Crout R,McNeil DW,Levy SM,Marazita ML,Shaffer JR

Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Circulation. Cardiovascular genetics6(2)171-83(2013 Apr)
Wu JH,Lemaitre RN,Manichaikul A,Guan W,Tanaka T,Foy M,Kabagambe EK,Djousse L,Siscovick D,Fretts AM,Johnson C,King IB,Psaty BM,McKnight B,Rich SS,Chen YD,Nettleton JA,Tang W,Bandinelli S,Jacobs DR Jr,Browning BL,Laurie CC,Gu X,Tsai MY,Steffen LM,Ferrucci L,Fornage M,Mozaffarian D

Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,L?hrmann R,Stelzl U

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LSM5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

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Target ORF information:

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ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

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