KCNE5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNE5
Entrez Gene ID	23630
Full Name	potassium voltage-gated channel subfamily E regulatory subunit 5
Synonyms	KCNE1L
General protein information	Preferred Names potassium voltage-gated channel subfamily E regulatory subunit 5 Names potassium voltage-gated channel subfamily E regulatory beta subunit 5 AMME syndrome candidate gene 2 protein AMMECR2 protein KCNE1-like cardiac voltage-gated potassium channel accessory subunit 5 potassium channel subunit beta MiRP4 potassium voltage-gated channel subfamily E member 1-like protein potassium voltage-gated channel, Isk-related family, member 1-like
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq23
Summary	This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016].
Disorder MIM:	300328

mRNA and Protein(s)

mRNA	Protein	Name
NM_012282.4	NP_036414.1	potassium voltage-gated channel subfamily E regulatory beta subunit 5
NM_012282.2	NP_036414.1	potassium voltage-gated channel subfamily E regulatory beta subunit 5
NM_012282.3	NP_036414.1	potassium voltage-gated channel subfamily E regulatory beta subunit 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KCNE1L	NP_001071343.1
Mus musculus (house mouse)	Kcne1l	NP_067462.1
	KCNE1L	XP_001099265.1
Homo sapiens (human)	KCNE1L	NP_036414.1
Pan troglodytes (chimpanzee)	KCNE1L	XP_003317676.1
Canis lupus familiaris (dog)	KCNE1L	XP_853033.1
Rattus norvegicus (Norway rat)	Kcne1l	NP_001094473.1

Gene Ontology
Bibliography

Related articles in PubMed

KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis.
Abbott GW
Gene593(2)249-60(2016 Nov)

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
David JP, Stas JI, Schmitt N, Bocksteins E
Scientific reports512813(2015 Aug)

KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients.
Palmer BR, Frampton CM, Skelton L, Yandle TG, Doughty RN, Whalley GA, Ellis CJ, Troughton RW, Richards AM, Cameron VA
Journal of cardiovascular electrophysiology23(3)319-24(2012 Mar)

Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.
Mistry HD, McCallum LA, Kurlak LO, Greenwood IA, Broughton Pipkin F, Tribe RM
Hypertension (Dallas, Tex. : 1979)58(3)497-504(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

common single nucleotide polymorphism (SNP) from KCNE5, and ECG measurements and survival in postacute acute coronary syndrome patients
Title: KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients.

Data show that KCNQ3 and KCNE5 mRNA expressions were significantly upregulated in preeclampsia.
Title: Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.

KCNE5 modulates I(to), and its novel variants appeared to cause IVF, especially BrS, in male patients through gain-of-function effects on I(to). Screening for KCNE5 variants is relevant for BrS or IVF.
Title: KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation.

A missense mutation in KCNE5 may be associated with nonfamilial or acquired forms of atrial fibrillation.
Title: Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation.

The following KCNE5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNE5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17862	NM_012282.4 Latest version!	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 5 (KCNE5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17862	NM_012282.2	Homo sapiens potassium channel, voltage gated subfamily E regulatory beta subunit 5 (KCNE5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17862	NM_012282.3	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 5 (KCNE5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNE5 ( NM_012282.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036414.1 Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 5 (KCNE5), mRNA.

Price & Availability↑

CloneID	OHu17862
Clone ID Related Accession (Same CDS sequence)	NM_012282.4 , NM_012282.2 , NM_012282.3
Accession Version	NM_012282.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily E regulatory beta subunit 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL118496.22, AK314923.1 and BC035330.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_012282.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR3476690.1123102.1, AK223306.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372101.3/ ENSP00000361173.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACTGCA GCGAGAGCCA GCGGCTGCGA ACCCTTCTGA GCCGCCTGTT GCTCGAGCTG 
CACCACCGGG GTAATGCCAG CGGCTTGGGC GCTGGCCCTC GTCCCAGCAT GGGCATGGGG 
GTCGTGCCTG ACCCTTTCGT GGGCCGCGAG GTGACCAGCG CCAAGGGCGA CGACGCCTAT 
CTCTACATCC TGCTCATCAT GATCTTCTAC GCCTGCTTGG CCGGAGGCCT CATCCTGGCC 
TACACCCGCT CCCGTAAGCT CGTCGAGGCC AAGGACGAGC CGTCCCAGGC TTGCGCCGAG 
CACGAATGGG CCCCGGGAGG CGCCCTGACC GCCGACGCCG AGGCTGCCGC GGGCTCCCAG 
GCCGAGGGCC GCCGCCAGCT TGCCTCCGAG GGGCTGCCTG CCCTCGCCCA GGGCGCTGAG 
CGGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036414.1
CDS	153..581
Translation	MNCSESQRLRTLLSRLLLELHHRGNASGLGAGPRPSMGMGVVPDPFVGREVTSAKGDDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPSQACAEHEWAPGGALTADAEAAAGSQAEGRRQLASEGLPALAQGAERV

Target ORF information:

RefSeq Version	NM_012282.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 5 (KCNE5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012282.4

ORF Insert Sequence:

ATGAACTGCA GCGAGAGCCA GCGGCTGCGA ACCCTTCTGA GCCGCCTGTT GCTCGAGCTG 
CACCACCGGG GTAATGCCAG CGGCTTGGGC GCTGGCCCTC GTCCCAGCAT GGGCATGGGG 
GTCGTGCCTG ACCCTTTCGT GGGCCGCGAG GTGACCAGCG CCAAGGGCGA CGACGCCTAT 
CTCTACATCC TGCTCATCAT GATCTTCTAC GCCTGCTTGG CCGGAGGCCT CATCCTGGCC 
TACACCCGCT CCCGTAAGCT CGTCGAGGCC AAGGACGAGC CGTCCCAGGC TTGCGCCGAG 
CACGAATGGG CCCCGGGAGG CGCCCTGACC GCCGACGCCG AGGCTGCCGC GGGCTCCCAG 
GCCGAGGGCC GCCGCCAGCT TGCCTCCGAG GGGCTGCCTG CCCTCGCCCA GGGCGCTGAG 
CGGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNE5 ( NM_012282.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036414.1 Homo sapiens potassium channel, voltage gated subfamily E regulatory beta subunit 5 (KCNE5), mRNA.

Price & Availability↑

CloneID	OHu17862
Clone ID Related Accession (Same CDS sequence)	NM_012282.4 , NM_012282.2 , NM_012282.3
Accession Version	NM_012282.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-04-11
Organism	Homo sapiens(Human)
Product	potassium voltage-gated channel subfamily E regulatory beta subunit 5
Comment

ATGAACTGCA GCGAGAGCCA GCGGCTGCGA ACCCTTCTGA GCCGCCTGTT GCTCGAGCTG 
CACCACCGGG GTAATGCCAG CGGCTTGGGC GCTGGCCCTC GTCCCAGCAT GGGCATGGGG 
GTCGTGCCTG ACCCTTTCGT GGGCCGCGAG GTGACCAGCG CCAAGGGCGA CGACGCCTAT 
CTCTACATCC TGCTCATCAT GATCTTCTAC GCCTGCTTGG CCGGAGGCCT CATCCTGGCC 
TACACCCGCT CCCGTAAGCT CGTCGAGGCC AAGGACGAGC CGTCCCAGGC TTGCGCCGAG 
CACGAATGGG CCCCGGGAGG CGCCCTGACC GCCGACGCCG AGGCTGCCGC GGGCTCCCAG 
GCCGAGGGCC GCCGCCAGCT TGCCTCCGAG GGGCTGCCTG CCCTCGCCCA GGGCGCTGAG 
CGGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036414.1
Translation	MNCSESQRLRTLLSRLLLELHHRGNASGLGAGPRPSMGMGVVPDPFVGREVTSAKGDDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPSQACAEHEWAPGGALTADAEAAAGSQAEGRRQLASEGLPALAQGAERV

Target ORF information:

RefSeq Version	NM_012282.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens potassium channel, voltage gated subfamily E regulatory beta subunit 5 (KCNE5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012282.2

ORF Insert Sequence:

ATGAACTGCA GCGAGAGCCA GCGGCTGCGA ACCCTTCTGA GCCGCCTGTT GCTCGAGCTG 
CACCACCGGG GTAATGCCAG CGGCTTGGGC GCTGGCCCTC GTCCCAGCAT GGGCATGGGG 
GTCGTGCCTG ACCCTTTCGT GGGCCGCGAG GTGACCAGCG CCAAGGGCGA CGACGCCTAT 
CTCTACATCC TGCTCATCAT GATCTTCTAC GCCTGCTTGG CCGGAGGCCT CATCCTGGCC 
TACACCCGCT CCCGTAAGCT CGTCGAGGCC AAGGACGAGC CGTCCCAGGC TTGCGCCGAG 
CACGAATGGG CCCCGGGAGG CGCCCTGACC GCCGACGCCG AGGCTGCCGC GGGCTCCCAG 
GCCGAGGGCC GCCGCCAGCT TGCCTCCGAG GGGCTGCCTG CCCTCGCCCA GGGCGCTGAG 
CGGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNE5 ( NM_012282.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036414.1 Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 5 (KCNE5), mRNA.

Price & Availability↑

CloneID	OHu17862
Clone ID Related Accession (Same CDS sequence)	NM_012282.4 , NM_012282.2 , NM_012282.3
Accession Version	NM_012282.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily E regulatory beta subunit 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314923.1, BC035330.1 and AL118496.22. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2016 this sequence version replaced NM_012282.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK223306.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTGCA GCGAGAGCCA GCGGCTGCGA ACCCTTCTGA GCCGCCTGTT GCTCGAGCTG 
CACCACCGGG GTAATGCCAG CGGCTTGGGC GCTGGCCCTC GTCCCAGCAT GGGCATGGGG 
GTCGTGCCTG ACCCTTTCGT GGGCCGCGAG GTGACCAGCG CCAAGGGCGA CGACGCCTAT 
CTCTACATCC TGCTCATCAT GATCTTCTAC GCCTGCTTGG CCGGAGGCCT CATCCTGGCC 
TACACCCGCT CCCGTAAGCT CGTCGAGGCC AAGGACGAGC CGTCCCAGGC TTGCGCCGAG 
CACGAATGGG CCCCGGGAGG CGCCCTGACC GCCGACGCCG AGGCTGCCGC GGGCTCCCAG 
GCCGAGGGCC GCCGCCAGCT TGCCTCCGAG GGGCTGCCTG CCCTCGCCCA GGGCGCTGAG 
CGGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036414.1
CDS	149..577
Translation	MNCSESQRLRTLLSRLLLELHHRGNASGLGAGPRPSMGMGVVPDPFVGREVTSAKGDDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPSQACAEHEWAPGGALTADAEAAAGSQAEGRRQLASEGLPALAQGAERV

Target ORF information:

RefSeq Version	NM_012282.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 5 (KCNE5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012282.3

ORF Insert Sequence:

ATGAACTGCA GCGAGAGCCA GCGGCTGCGA ACCCTTCTGA GCCGCCTGTT GCTCGAGCTG 
CACCACCGGG GTAATGCCAG CGGCTTGGGC GCTGGCCCTC GTCCCAGCAT GGGCATGGGG 
GTCGTGCCTG ACCCTTTCGT GGGCCGCGAG GTGACCAGCG CCAAGGGCGA CGACGCCTAT 
CTCTACATCC TGCTCATCAT GATCTTCTAC GCCTGCTTGG CCGGAGGCCT CATCCTGGCC 
TACACCCGCT CCCGTAAGCT CGTCGAGGCC AAGGACGAGC CGTCCCAGGC TTGCGCCGAG 
CACGAATGGG CCCCGGGAGG CGCCCTGACC GCCGACGCCG AGGCTGCCGC GGGCTCCCAG 
GCCGAGGGCC GCCGCCAGCT TGCCTCCGAG GGGCTGCCTG CCCTCGCCCA GGGCGCTGAG 
CGGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis.
Gene593(2)249-60(2016 Nov)
Abbott GW

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
Scientific reports512813(2015 Aug)
David JP,Stas JI,Schmitt N,Bocksteins E

KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients.
Journal of cardiovascular electrophysiology23(3)319-24(2012 Mar)
Palmer BR,Frampton CM,Skelton L,Yandle TG,Doughty RN,Whalley GA,Ellis CJ,Troughton RW,Richards AM,Cameron VA

Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.
Hypertension (Dallas, Tex. : 1979)58(3)497-504(2011 Sep)
Mistry HD,McCallum LA,Kurlak LO,Greenwood IA,Broughton Pipkin F,Tribe RM

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KCNE5 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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