ORC6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ORC6
Entrez Gene ID	23594
Full Name	origin recognition complex subunit 6
Synonyms	ORC6L
General protein information	Preferred Names origin recognition complex subunit 6 Names origin recognition complex subunit 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q11.2
Summary	The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010].
Disorder MIM:	607213
Disorder Html:	Meier-Gorlin syndrome 3, 613803 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014321.3	NP_055136.1	origin recognition complex subunit 6
NM_014321.4	NP_055136.1	origin recognition complex subunit 6
XM_011522978.3	XP_011521280.1	origin recognition complex subunit 6 isoform X1
XM_011522978.2	XP_011521280.1	origin recognition complex subunit 6 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ORC6	NP_055136.1
Danio rerio (zebrafish)	orc6	NP_997836.1
Arabidopsis thaliana (thale cress)	ORC6	NP_174006.2
Pan troglodytes (chimpanzee)	ORC6	XP_001161833.1
Canis lupus familiaris (dog)	ORC6	XP_539609.2
	ORC6L	XP_001113625.1
Bos taurus (cattle)	ORC6	NP_001039666.1
Mus musculus (house mouse)	Orc6	NP_062690.2
Xenopus tropicalis (tropical clawed frog)	orc6	NP_001017185.1
Rattus norvegicus (Norway rat)	Orc6	NP_001028862.1
Gallus gallus (chicken)	ORC6	NP_001264649.1
Oryza sativa (rice)	Os07g0628600	NP_001060351.1

Gene Ontology
Bibliography

Related articles in PubMed

[A boy with Meier-Gorlin syndrome carrying a novel ORC6 mutation and uniparental disomy of chromosome 16].
Li J, Ding Y, Chang G, Cheng Q, Li X, Wang J, Wang X, Shen Y
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(1)68-72(2017 Feb)

Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3.
Shalev SA, Khayat M, Etty DS, Elpeleg O
American journal of medical genetics. Part A167A(3)607-11(2015 Mar)

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.
Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM
eLife2e00882(2013 Oct)

Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Varma D, Chandrasekaran S, Sundin LJ, Reidy KT, Wan X, Chasse DA, Nevis KR, DeLuca JG, Salmon ED, Cook JG
Nature cell biology14(6)593-603(2012 May)

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.
Liu S, Balasov M, Wang H, Wu L, Chesnokov IN, Liu Y
Proceedings of the National Academy of Sciences of the United States of America108(18)7373-8(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene.
Title: [A boy with Meier-Gorlin syndrome carrying a novel ORC6 mutation and uniparental disomy of chromosome 16].

The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation.
Title: Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3.

our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions
Title: A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.

findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process.
Title: Different roles of the human Orc6 protein in the replication initiation process.

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.
Title: Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.

The following ORC6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORC6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17876	NM_014321.4 Latest version!	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu66343	XM_011522978.3 Latest version!	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu17876	NM_014321.3	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu66343	XM_011522978.2	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ORC6 ( NM_014321.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055136.1 Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17876
Clone ID Related Accession (Same CDS sequence)	NM_014321.3 , NM_014321.4
Accession Version	NM_014321.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	origin recognition complex subunit 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC050725.1 and BC063565.1. This sequence is a reference standard in the RefSeqGene project. On Dec 7, 2010 this sequence version replaced NM_014321.2. Transcript Variant: This variant (1) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF139658.1, AK024019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG ATTCTAAAGC TGAAAGTGGA TAAAAACAAA 
ATGGTAGCCA CATCCGGTGT AAAAAAAGCT ATATTTGATC GACTGTGTAA ACAACTAGAG 
AAGATTGGAC AGCAGGTCGA CAGAGAACCT GGAGATGTAG CTACTCCACC ACGGAAGAGA 
AAGAAGATAG TGGTTGAAGC CCCAGCAAAG GAAATGGAGA AGGTAGAGGA GATGCCACAT 
AAACCACAGA AAGATGAAGA TCTGACACAG GATTATGAAG AATGGAAAAG AAAAATTTTG 
GAAAATGCTG CCAGTGCTCA AAAGGCTACA GCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055136.1
CDS	61..819
Translation	MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE

Target ORF information:

RefSeq Version	NM_014321.3
Organism	Homo sapiens(human)
Definition	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014321.3

ORF Insert Sequence:

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG ATTCTAAAGC TGAAAGTGGA TAAAAACAAA 
ATGGTAGCCA CATCCGGTGT AAAAAAAGCT ATATTTGATC GACTGTGTAA ACAACTAGAG 
AAGATTGGAC AGCAGGTCGA CAGAGAACCT GGAGATGTAG CTACTCCACC ACGGAAGAGA 
AAGAAGATAG TGGTTGAAGC CCCAGCAAAG GAAATGGAGA AGGTAGAGGA GATGCCACAT 
AAACCACAGA AAGATGAAGA TCTGACACAG GATTATGAAG AATGGAAAAG AAAAATTTTG 
GAAAATGCTG CCAGTGCTCA AAAGGCTACA GCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORC6 ( NM_014321.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055136.1 Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17876
Clone ID Related Accession (Same CDS sequence)	NM_014321.3 , NM_014321.4
Accession Version	NM_014321.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	origin recognition complex subunit 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC050725.1 and BC063565.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_014321.3. Transcript Variant: This variant (1) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.196556.1, AK024019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000219097.7/ ENSP00000219097.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG ATTCTAAAGC TGAAAGTGGA TAAAAACAAA 
ATGGTAGCCA CATCCGGTGT AAAAAAAGCT ATATTTGATC GACTGTGTAA ACAACTAGAG 
AAGATTGGAC AGCAGGTCGA CAGAGAACCT GGAGATGTAG CTACTCCACC ACGGAAGAGA 
AAGAAGATAG TGGTTGAAGC CCCAGCAAAG GAAATGGAGA AGGTAGAGGA GATGCCACAT 
AAACCACAGA AAGATGAAGA TCTGACACAG GATTATGAAG AATGGAAAAG AAAAATTTTG 
GAAAATGCTG CCAGTGCTCA AAAGGCTACA GCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055136.1
CDS	48..806
Translation	MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE

Target ORF information:

RefSeq Version	NM_014321.4
Organism	Homo sapiens(human)
Definition	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014321.4

ORF Insert Sequence:

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG ATTCTAAAGC TGAAAGTGGA TAAAAACAAA 
ATGGTAGCCA CATCCGGTGT AAAAAAAGCT ATATTTGATC GACTGTGTAA ACAACTAGAG 
AAGATTGGAC AGCAGGTCGA CAGAGAACCT GGAGATGTAG CTACTCCACC ACGGAAGAGA 
AAGAAGATAG TGGTTGAAGC CCCAGCAAAG GAAATGGAGA AGGTAGAGGA GATGCCACAT 
AAACCACAGA AAGATGAAGA TCTGACACAG GATTATGAAG AATGGAAAAG AAAAATTTTG 
GAAAATGCTG CCAGTGCTCA AAAGGCTACA GCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORC6 ( XM_011522978.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521280.1 Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66343
Clone ID Related Accession (Same CDS sequence)	XM_011522978.3 , XM_011522978.2
Accession Version	XM_011522978.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	origin recognition complex subunit 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011522978.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG TACATACCTA GGAGTATTAA TTGGCATTTA 
TGGAAAACAT CTCTTCAATT CAACAAAAGT ATGTGCATAT ACGGAGGGAG TGCAGCTGAT 
ATTGTAGAAA ACAGTGAGAA TAGTCAACTC TACTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521280.1
CDS	51..629
Translation	MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKYIPRSINWHLWKTSLQFNKSMCIYGGSAADIVENSENSQLYF

Target ORF information:

RefSeq Version	XM_011522978.3
Organism	Homo sapiens(human)
Definition	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522978.3

ORF Insert Sequence:

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG TACATACCTA GGAGTATTAA TTGGCATTTA 
TGGAAAACAT CTCTTCAATT CAACAAAAGT ATGTGCATAT ACGGAGGGAG TGCAGCTGAT 
ATTGTAGAAA ACAGTGAGAA TAGTCAACTC TACTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORC6 ( XM_011522978.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521280.1 Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66343
Clone ID Related Accession (Same CDS sequence)	XM_011522978.3 , XM_011522978.2
Accession Version	XM_011522978.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	origin recognition complex subunit 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011522978.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG TACATACCTA GGAGTATTAA TTGGCATTTA 
TGGAAAACAT CTCTTCAATT CAACAAAAGT ATGTGCATAT ACGGAGGGAG TGCAGCTGAT 
ATTGTAGAAA ACAGTGAGAA TAGTCAACTC TACTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521280.1
CDS	51..629
Translation	MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKYIPRSINWHLWKTSLQFNKSMCIYGGSAADIVENSENSQLYF

Target ORF information:

RefSeq Version	XM_011522978.2
Organism	Homo sapiens(human)
Definition	Homo sapiens origin recognition complex subunit 6 (ORC6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522978.2

ORF Insert Sequence:

ATGGGGTCGG AGCTGATCGG GCGCCTAGCC CCGCGCCTGG GCCTCGCCGA GCCCGACATG 
CTGAGGAAAG CAGAGGAGTA CTTGCGCCTG TCCCGGGTGA AGTGTGTCGG CCTCTCCGCA 
CGCACCACGG AGACCAGCAG TGCAGTCATG TGCCTGGACC TTGCAGCTTC CTGGATGAAG 
TGCCCCTTGG ACAGGGCTTA TTTAATTAAA CTTTCTGGTT TGAACAAGGA GACATATCAG 
AGCTGTCTTA AATCTTTTGA GTGTTTACTG GGCCTGAATT CAAATATTGG AATAAGAGAC 
CTAGCTGTAC AGTTTAGCTG TATAGAAGCA GTGAACATGG CTTCAAAGAT ACTAAAAAGC 
TATGAGTCCA GTCTTCCCCA GACACAGCAA GTGGATCTTG ACTTATCCAG GCCACTTTTC 
ACTTCTGCTG CACTGCTTTC AGCATGCAAG TACATACCTA GGAGTATTAA TTGGCATTTA 
TGGAAAACAT CTCTTCAATT CAACAAAAGT ATGTGCATAT ACGGAGGGAG TGCAGCTGAT 
ATTGTAGAAA ACAGTGAGAA TAGTCAACTC TACTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[A boy with Meier-Gorlin syndrome carrying a novel ORC6 mutation and uniparental disomy of chromosome 16].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(1)68-72(2017 Feb)
Li J,Ding Y,Chang G,Cheng Q,Li X,Wang J,Wang X,Shen Y

Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3.
American journal of medical genetics. Part A167A(3)607-11(2015 Mar)
Shalev SA,Khayat M,Etty DS,Elpeleg O

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.
eLife2e00882(2013 Oct)
Bleichert F,Balasov M,Chesnokov I,Nogales E,Botchan MR,Berger JM

Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Nature cell biology14(6)593-603(2012 May)
Varma D,Chandrasekaran S,Sundin LJ,Reidy KT,Wan X,Chasse DA,Nevis KR,DeLuca JG,Salmon ED,Cook JG

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.
Proceedings of the National Academy of Sciences of the United States of America108(18)7373-8(2011 May)
Liu S,Balasov M,Wang H,Wu L,Chesnokov IN,Liu Y

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ORC6 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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ORF Insert Sequence:

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ORF Insert Sequence:

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ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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