HEBP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HEBP2
Entrez Gene ID	23593
Full Name	heme binding protein 2
Synonyms	C6ORF34B,C6orf34,PP23,SOUL
General protein information	Preferred Names heme binding protein 2 Names heme-binding protein 2 placental protein 23
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q24.1
Summary	The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016].
Disorder MIM:	605825

mRNA and Protein(s)

mRNA	Protein	Name
XM_017010631.1	XP_016866120.1	heme-binding protein 2 isoform X1
NM_001326381.2	NP_001313310.1	heme-binding protein 2 isoform 3
NM_014320.2	NP_055135.1	heme-binding protein 2 isoform 2
NM_014320.3	NP_055135.1	heme-binding protein 2 isoform 2
NM_001326380.1	NP_001313309.1	heme-binding protein 2 isoform 1
NM_001326381.1	NP_001313310.1	heme-binding protein 2 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	HEBP2	NP_055135.1
Bos taurus (cattle)	HEBP2	NP_001179142.1
Danio rerio (zebrafish)	hebp2	NP_956492.1
Arabidopsis thaliana (thale cress)	AT1G78450	NP_565181.1
Mus musculus (house mouse)	Hebp2	NP_062360.1
Rattus norvegicus (Norway rat)	Hebp2	NP_001100985.1
Arabidopsis thaliana (thale cress)	AT1G17100	NP_173153.1
	HEBP2	XP_001097682.2
Canis lupus familiaris (dog)	HEBP2	XP_003638821.1
Gallus gallus (chicken)	HEBP2	XP_422283.4
Oryza sativa (rice)	Os01g0210500	NP_001042368.1
Pan troglodytes (chimpanzee)	HEBP2	XP_001158871.2

Gene Ontology
Bibliography

Related articles in PubMed

Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development.
Qin J, Yang Y, Gao S, Liu Y, Yu F, Zhou Y, Lyu R, Liu M, Liu X, Li D, Zhou J
Journal of cellular physiology232(11)3067-3076(2017 Nov)

Structural and Functional Study of Apoptosis-linked Gene-2?Heme-binding Protein 2 Interactions in HIV-1 Production.
Ma J, Zhang X, Feng Y, Zhang H, Wang X, Zheng Y, Qiao W, Liu X
The Journal of biological chemistry291(52)26670-26685(2016 Dec)

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.
Ambrosi E, Capaldi S, Bovi M, Saccomani G, Perduca M, Monaco HL
The Biochemical journal438(2)291-301(2011 Sep)

Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein.
Szigeti A, Hocsak E, Rapolti E, Racz B, Boronkai A, Pozsgai E, Debreceni B, Bognar Z, Bellyei S, Sumegi B, Gallyas F Jr
The Journal of biological chemistry285(3)2140-51(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The gene copy numbers and mRNA levels for both ALG-2 and HEBP2 are significantly upregulated in breast and lung cancer. Coexpression of ALG-2 and HEBP2 markedly increases the cytoplasmic pool of ALG-2 and alters the subcellular distribution of HEBP2. Abnormalities in the ALG-2/HEBP2 interaction impairs spindle orientation and positioning during mitosis.
Title: Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development.

There are important structural differences in the BH3 domain in the intact SOUL molecule and the same sequence bound to Bcl-xL.
Title: Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.

SOUL can be a novel member of the BH3 domain-only proteins that cannot induce cell death alone but can facilitate both outer and inner mitochondrial membrane permeabilization and predominantly necrotic cell death in oxidative stress.
Title: Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein.

preliminary X ray structure
Title: Preliminary structural characterization of human SOUL, a haem-binding protein.

SOUL promotes necrotic cell death by inducing mitochondrial permeability transition
Title: Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL.

The following HEBP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEBP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu101492	NM_001326380.1 Latest version!	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu13211	NM_014320.3 Latest version!	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu96489	NM_001326381.2 Latest version!	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu96489	XM_017010631.1 Latest version!	Homo sapiens heme binding protein 2 (HEBP2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu13211	NM_014320.2	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu96489	NM_001326381.1	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HEBP2 ( NM_001326380.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001313309.1 Homo sapiens heme binding protein 2 (HEBP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu101492
Clone ID Related Accession (Same CDS sequence)	NM_001326380.1
Accession Version	NM_001326380.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	heme-binding protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031003.1 and AL391669.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX398463.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188, SAMN03267783 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGTCC TCTGGGGGGC GCCGGAGCCG TGCCGGGTCC CCGCCGCAGG GGACAGTAAC 
GCGGAGTCGG CCTGGCCGGC GGAAAGGGGG TGCTGGGGAA CAGAGCCGCA CCCCACTCGG 
CTCGGGAAAG CCCTGCCCGG AAGTTATGAG ATCCGACACT ATGGACCAGC CAAGTGGGTC 
AGCACGTCCG TGGAGTCTAT GGACTGGGAT TCAGCCATCC AGACGGGCTT TACGAAACTG 
AACAGCTACA TTCAAGGCAA AAACGAGAAA GAGATGAAAA TAAAGATGAC AGCTCCAGTG 
ACAAGCTACG TGGAGCCTGG TTCAGGTCCT TTTAGTGAGT CTACCATTAC CATTTCCCTG 
TATATTCCCT CTGAACAGCA ATTTGATCCA CCCAGGCCTT TAGAGTCAGA TGTCTTCATT 
GAAGATAGAG CCGAAATGAC TGTGTTTGTA CGGTCTTTCG ATGGATTTTC TAGTGCCCAA 
AAGAATCAAG AACAACTTTT GACATTAGCA AGCATTTTAA GGGAAGATGG AAAAGTTTTC 
GATGAGAAGG TTTACTACAC TGCAGGCTAC AACAGTCCTG TCAAATTGCT TAATAGAAAT 
AATGAAGTGT GGTTGATTCA AAAAAATGAA CCCACCAAAG AAAACGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001313309.1
CDS	34..684
Translation	MGVLWGAPEPCRVPAAGDSNAESAWPAERGCWGTEPHPTRLGKALPGSYEIRHYGPAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSESTITISLYIPSEQQFDPPRPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLASILREDGKVFDEKVYYTAGYNSPVKLLNRNNEVWLIQKNEPTKENE

Target ORF information:

RefSeq Version	NM_001326380.1
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001326380.1

ORF Insert Sequence:

ATGGGAGTCC TCTGGGGGGC GCCGGAGCCG TGCCGGGTCC CCGCCGCAGG GGACAGTAAC 
GCGGAGTCGG CCTGGCCGGC GGAAAGGGGG TGCTGGGGAA CAGAGCCGCA CCCCACTCGG 
CTCGGGAAAG CCCTGCCCGG AAGTTATGAG ATCCGACACT ATGGACCAGC CAAGTGGGTC 
AGCACGTCCG TGGAGTCTAT GGACTGGGAT TCAGCCATCC AGACGGGCTT TACGAAACTG 
AACAGCTACA TTCAAGGCAA AAACGAGAAA GAGATGAAAA TAAAGATGAC AGCTCCAGTG 
ACAAGCTACG TGGAGCCTGG TTCAGGTCCT TTTAGTGAGT CTACCATTAC CATTTCCCTG 
TATATTCCCT CTGAACAGCA ATTTGATCCA CCCAGGCCTT TAGAGTCAGA TGTCTTCATT 
GAAGATAGAG CCGAAATGAC TGTGTTTGTA CGGTCTTTCG ATGGATTTTC TAGTGCCCAA 
AAGAATCAAG AACAACTTTT GACATTAGCA AGCATTTTAA GGGAAGATGG AAAAGTTTTC 
GATGAGAAGG TTTACTACAC TGCAGGCTAC AACAGTCCTG TCAAATTGCT TAATAGAAAT 
AATGAAGTGT GGTTGATTCA AAAAAATGAA CCCACCAAAG AAAACGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEBP2 ( NM_014320.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055135.1 Homo sapiens heme binding protein 2 (HEBP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13211
Clone ID Related Accession (Same CDS sequence)	NM_014320.2 , NM_014320.3
Accession Version	NM_014320.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-24
Organism	Homo sapiens(human)
Product	heme-binding protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF974311.1, AF117616.1 and AK057928.1. This sequence is a reference standard in the RefSeqGene project. On Jan 30, 2004 this sequence version replaced NM_014320.1. ##Evidence-Data-START## Transcript exon combination :: AK057928.1, AF117616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTGAGTCTA CCATTACCAT TTCCCTGTAT ATTCCCTCTG AACAGCAATT TGATCCACCC 
AGGCCTTTAG AGTCAGATGT CTTCATTGAA GATAGAGCCG AAATGACTGT GTTTGTACGG 
TCTTTCGATG GATTTTCTAG TGCCCAAAAG AATCAAGAAC AACTTTTGAC ATTAGCAAGC 
ATTTTAAGGG AAGATGGAAA AGTTTTCGAT GAGAAGGTTT ACTACACTGC AGGCTACAAC 
AGTCCTGTCA AATTGCTTAA TAGAAATAAT GAAGTGTGGT TGATTCAAAA AAATGAACCC 
ACCAAAGAAA ACGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055135.1
CDS	298..915
Translation	MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSESTITISLYIPSEQQFDPPRPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLASILREDGKVFDEKVYYTAGYNSPVKLLNRNNEVWLIQKNEPTKENE

Target ORF information:

RefSeq Version	NM_014320.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014320.2

ORF Insert Sequence:

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTGAGTCTA CCATTACCAT TTCCCTGTAT ATTCCCTCTG AACAGCAATT TGATCCACCC 
AGGCCTTTAG AGTCAGATGT CTTCATTGAA GATAGAGCCG AAATGACTGT GTTTGTACGG 
TCTTTCGATG GATTTTCTAG TGCCCAAAAG AATCAAGAAC AACTTTTGAC ATTAGCAAGC 
ATTTTAAGGG AAGATGGAAA AGTTTTCGAT GAGAAGGTTT ACTACACTGC AGGCTACAAC 
AGTCCTGTCA AATTGCTTAA TAGAAATAAT GAAGTGTGGT TGATTCAAAA AAATGAACCC 
ACCAAAGAAA ACGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEBP2 ( NM_014320.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055135.1 Homo sapiens heme binding protein 2 (HEBP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13211
Clone ID Related Accession (Same CDS sequence)	NM_014320.2 , NM_014320.3
Accession Version	NM_014320.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	heme-binding protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF974311.1, AF117616.1, AK057928.1 and AL391669.11. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_014320.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK057928.1, AF117616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000607197.6/ ENSP00000475750.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTGAGTCTA CCATTACCAT TTCCCTGTAT ATTCCCTCTG AACAGCAATT TGATCCACCC 
AGGCCTTTAG AGTCAGATGT CTTCATTGAA GATAGAGCCG AAATGACTGT GTTTGTACGG 
TCTTTCGATG GATTTTCTAG TGCCCAAAAG AATCAAGAAC AACTTTTGAC ATTAGCAAGC 
ATTTTAAGGG AAGATGGAAA AGTTTTCGAT GAGAAGGTTT ACTACACTGC AGGCTACAAC 
AGTCCTGTCA AATTGCTTAA TAGAAATAAT GAAGTGTGGT TGATTCAAAA AAATGAACCC 
ACCAAAGAAA ACGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055135.1
CDS	274..891
Translation	MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSESTITISLYIPSEQQFDPPRPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLASILREDGKVFDEKVYYTAGYNSPVKLLNRNNEVWLIQKNEPTKENE

Target ORF information:

RefSeq Version	NM_014320.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014320.3

ORF Insert Sequence:

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTGAGTCTA CCATTACCAT TTCCCTGTAT ATTCCCTCTG AACAGCAATT TGATCCACCC 
AGGCCTTTAG AGTCAGATGT CTTCATTGAA GATAGAGCCG AAATGACTGT GTTTGTACGG 
TCTTTCGATG GATTTTCTAG TGCCCAAAAG AATCAAGAAC AACTTTTGAC ATTAGCAAGC 
ATTTTAAGGG AAGATGGAAA AGTTTTCGAT GAGAAGGTTT ACTACACTGC AGGCTACAAC 
AGTCCTGTCA AATTGCTTAA TAGAAATAAT GAAGTGTGGT TGATTCAAAA AAATGAACCC 
ACCAAAGAAA ACGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEBP2 ( NM_001326381.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001313310.1 Homo sapiens heme binding protein 2 (HEBP2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu96489
Clone ID Related Accession (Same CDS sequence)	XM_017010631.1 , NM_001326381.2 , NM_001326381.1
Accession Version	NM_001326381.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	heme-binding protein 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031003.1 and AL391669.11. On May 31, 2019 this sequence version replaced NM_001326381.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.353284.1, BF974311.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTCTTTCGA TGGATTTTCT AGTGCCCAAA AGAATCAAGA ACAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001313310.1
CDS	274..624
Translation	MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSLSMDFLVPKRIKNNF

Target ORF information:

RefSeq Version	NM_001326381.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001326381.2

ORF Insert Sequence:

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTCTTTCGA TGGATTTTCT AGTGCCCAAA AGAATCAAGA ACAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEBP2 ( NM_001326381.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001313310.1 Homo sapiens heme binding protein 2 (HEBP2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu96489
Clone ID Related Accession (Same CDS sequence)	XM_017010631.1 , NM_001326381.2 , NM_001326381.1
Accession Version	NM_001326381.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-14
Organism	Homo sapiens(human)
Product	heme-binding protein 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031003.1 and AL391669.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BF974311.1, BG614439.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTCTTTCGA TGGATTTTCT AGTGCCCAAA AGAATCAAGA ACAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001313310.1
CDS	298..648
Translation	MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSLSMDFLVPKRIKNNF

Target ORF information:

RefSeq Version	NM_001326381.1
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 2 (HEBP2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001326381.1

ORF Insert Sequence:

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTCTTTCGA TGGATTTTCT AGTGCCCAAA AGAATCAAGA ACAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEBP2 ( XM_017010631.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866120.1 Homo sapiens heme binding protein 2 (HEBP2), transcript variant X2, mRNA.

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CloneID	OHu96489
Clone ID Related Accession (Same CDS sequence)	XM_017010631.1 , NM_001326381.2 , NM_001326381.1
Accession Version	XM_017010631.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	heme-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTCTTTCGA TGGATTTTCT AGTGCCCAAA AGAATCAAGA ACAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866120.1
CDS	271..621
Translation	MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSLSMDFLVPKRIKNNF

Target ORF information:

RefSeq Version	XM_017010631.1
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 2 (HEBP2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017010631.1

ORF Insert Sequence:

ATGGCCGAGC CGCTCCAGCC AGACCCCGGG GCGGCCGAGG ACGCGGCGGC CCAAGCTGTG 
GAGACGCCGG GCTGGAAGGC CCCGGAGGAC GCCGGCCCCC AGCCCGGAAG TTATGAGATC 
CGACACTATG GACCAGCCAA GTGGGTCAGC ACGTCCGTGG AGTCTATGGA CTGGGATTCA 
GCCATCCAGA CGGGCTTTAC GAAACTGAAC AGCTACATTC AAGGCAAAAA CGAGAAAGAG 
ATGAAAATAA AGATGACAGC TCCAGTGACA AGCTACGTGG AGCCTGGTTC AGGTCCTTTT 
AGTCTTTCGA TGGATTTTCT AGTGCCCAAA AGAATCAAGA ACAACTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development.
Journal of cellular physiology232(11)3067-3076(2017 Nov)
Qin J,Yang Y,Gao S,Liu Y,Yu F,Zhou Y,Lyu R,Liu M,Liu X,Li D,Zhou J

Structural and Functional Study of Apoptosis-linked Gene-2?Heme-binding Protein 2 Interactions in HIV-1 Production.
The Journal of biological chemistry291(52)26670-26685(2016 Dec)
Ma J,Zhang X,Feng Y,Zhang H,Wang X,Zheng Y,Qiao W,Liu X

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.
The Biochemical journal438(2)291-301(2011 Sep)
Ambrosi E,Capaldi S,Bovi M,Saccomani G,Perduca M,Monaco HL

Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein.
The Journal of biological chemistry285(3)2140-51(2010 Jan)
Szigeti A,Hocsak E,Rapolti E,Racz B,Boronkai A,Pozsgai E,Debreceni B,Bognar Z,Bellyei S,Sumegi B,Gallyas F Jr

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HEBP2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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