CASP14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASP14
Entrez Gene ID	23581
Full Name	caspase 14
Synonyms	ARCI12
General protein information	Preferred Names caspase 14 Names caspase-14 CASP-14 apoptosis-related cysteine protease caspase 14, apoptosis-related cysteine peptidase caspase 14, apoptosis-related cysteine protease
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.12
Summary	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008].
Disorder MIM:	605848
Disorder Html:	Ichthyosis, congenital, autosomal recessive 12, 617320 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011527861.1	XP_011526163.1	caspase-14 isoform X1
NM_012114.3	NP_036246.1	caspase-14 precursor
NM_012114.2	NP_036246.1	caspase-14 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CASP14	XP_001159009.2
Canis lupus familiaris (dog)	CASP14	XP_853064.2
Mus musculus (house mouse)	Casp14	NP_033939.1
Rattus norvegicus (Norway rat)	Casp14	NP_001178705.1
Bos taurus (cattle)	CASP14	NP_001192772.1
Homo sapiens (human)	CASP14	NP_036246.1
	CASP14	XP_001111598.1

Gene Ontology
Bibliography

Related articles in PubMed

Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.
Handa T, Katayama A, Yokobori T, Yamane A, Horiguchi J, Kawabata-Iwakawa R, Rokudai S, Bao P, Gombodorj N, Altan B, Kaira K, Asao T, Kuwano H, Nishiyama M, Oyama T
Journal of surgical oncology116(6)706-715(2017 Nov)

S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.
Li T, Qi Z, Kong F, Li Y, Wang R, Zhang W, Shang Y, Huang L, He D, Xiao X
Experimental dermatology24(5)342-8(2015 May)

Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.
Jung M, Choi J, Lee SA, Kim H, Hwang J, Choi EH
Journal of dermatological science76(3)231-9(2014 Dec)

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T
The Journal of biological chemistry289(29)20026-38(2014 Jul)

Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.
Beasley S, El-Sherbiny M, Megyerdi S, El-Shafey S, Choksi K, Kaddour-Djebbar I, Sheibani N, Hsu S, Al-Shabrawey M
BioMed research international2014417986(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High CASP14 expression is a marker of breast cancer aggressiveness in association with proliferation, TNBC phenotype, and cancer stemness.
Title: Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.

overexpression of S100A7 in A431 skin squamous carcinoma cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3 and caspase-14
Title: S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.

Caspase-14 was decreased in inflammatory lesions compared to non-lesion in atopic dermatitis. The amount of caspase-14 in the lesions correlated with clinical severity as determined by eczema area and severity index score and the skin barrier functions.
Title: Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.

Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
Title: Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.

caspase-14 contributes to retinal pigment epithelium cell barrier disruption under hyperglycemic conditions.
Title: Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.

The following CASP14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASP14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12493	NM_012114.3 Latest version!	Homo sapiens caspase 14 (CASP14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu66337	XM_011527861.1 Latest version!	Homo sapiens caspase 14 (CASP14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu12493	NM_012114.2	Homo sapiens caspase 14 (CASP14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASP14 ( NM_012114.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036246.1 Homo sapiens caspase 14 (CASP14), mRNA.

Price & Availability↑

CloneID	OHu12493
Clone ID Related Accession (Same CDS sequence)	NM_012114.3 , NM_012114.2
Accession Version	NM_012114.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	caspase-14 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313992.1, AC004699.1 and BM840054.1. On Nov 23, 2018 this sequence version replaced NM_012114.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU502748.1, AK313992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000427043.4/ ENSP00000393417.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAATC CGCGGTCTTT GGAAGAGGAG AAATATGATA TGTCAGGTGC CCGCCTGGCC 
CTAATACTGT GTGTCACCAA AGCCCGGGAA GGTTCCGAAG AAGACCTGGA TGCTCTGGAA 
CACATGTTTC GGCAGCTGAG ATTCGAAAGC ACCATGAAAA GAGACCCCAC TGCCGAGCAA 
TTCCAGGAAG AGCTGGAAAA ATTCCAGCAG GCCATCGATT CCCGGGAAGA TCCCGTCAGT 
TGTGCCTTCG TGGTACTCAT GGCTCACGGG AGGGAAGGCT TCCTCAAGGG AGAAGATGGG 
GAGATGGTCA AGCTGGAGAA TCTCTTCGAG GCCCTGAACA ACAAGAACTG CCAGGCCCTG 
CGAGCTAAGC CCAAGGTGTA CATCATACAG GCCTGTCGAG GAGAACAAAG GGACCCCGGT 
GAAACAGTAG GTGGAGATGA GATTGTGATG GTCATCAAAG ACAGCCCACA AACCATCCCA 
ACATACACAG ATGCCTTGCA CGTTTATTCC ACGGTAGAGG GATACATCGC CTACCGACAT 
GATCAGAAAG GCTCATGCTT TATCCAGACC CTGGTGGATG TGTTCACGAA GAGGAAAGGA 
CATATCTTGG AACTTCTGAC AGAGGTGACC CGGCGGATGG CAGAAGCAGA GCTGGTTCAA 
GAAGGAAAAG CAAGGAAAAC GAACCCTGAA ATCCAAAGCA CCCTCCGGAA ACGGCTGTAT 
CTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036246.1
CDS	213..941
Translation	MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ

Target ORF information:

RefSeq Version	NM_012114.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 14 (CASP14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012114.3

ORF Insert Sequence:

ATGAGCAATC CGCGGTCTTT GGAAGAGGAG AAATATGATA TGTCAGGTGC CCGCCTGGCC 
CTAATACTGT GTGTCACCAA AGCCCGGGAA GGTTCCGAAG AAGACCTGGA TGCTCTGGAA 
CACATGTTTC GGCAGCTGAG ATTCGAAAGC ACCATGAAAA GAGACCCCAC TGCCGAGCAA 
TTCCAGGAAG AGCTGGAAAA ATTCCAGCAG GCCATCGATT CCCGGGAAGA TCCCGTCAGT 
TGTGCCTTCG TGGTACTCAT GGCTCACGGG AGGGAAGGCT TCCTCAAGGG AGAAGATGGG 
GAGATGGTCA AGCTGGAGAA TCTCTTCGAG GCCCTGAACA ACAAGAACTG CCAGGCCCTG 
CGAGCTAAGC CCAAGGTGTA CATCATACAG GCCTGTCGAG GAGAACAAAG GGACCCCGGT 
GAAACAGTAG GTGGAGATGA GATTGTGATG GTCATCAAAG ACAGCCCACA AACCATCCCA 
ACATACACAG ATGCCTTGCA CGTTTATTCC ACGGTAGAGG GATACATCGC CTACCGACAT 
GATCAGAAAG GCTCATGCTT TATCCAGACC CTGGTGGATG TGTTCACGAA GAGGAAAGGA 
CATATCTTGG AACTTCTGAC AGAGGTGACC CGGCGGATGG CAGAAGCAGA GCTGGTTCAA 
GAAGGAAAAG CAAGGAAAAC GAACCCTGAA ATCCAAAGCA CCCTCCGGAA ACGGCTGTAT 
CTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP14 ( NM_012114.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036246.1 Homo sapiens caspase 14 (CASP14), mRNA.

Price & Availability↑

CloneID	OHu12493
Clone ID Related Accession (Same CDS sequence)	NM_012114.3 , NM_012114.2
Accession Version	NM_012114.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	caspase-14 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313992.1, AC004699.1 and BM840054.1. On Nov 24, 2010 this sequence version replaced NM_012114.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU502748.1, AK313992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAATC CGCGGTCTTT GGAAGAGGAG AAATATGATA TGTCAGGTGC CCGCCTGGCC 
CTAATACTGT GTGTCACCAA AGCCCGGGAA GGTTCCGAAG AAGACCTGGA TGCTCTGGAA 
CACATGTTTC GGCAGCTGAG ATTCGAAAGC ACCATGAAAA GAGACCCCAC TGCCGAGCAA 
TTCCAGGAAG AGCTGGAAAA ATTCCAGCAG GCCATCGATT CCCGGGAAGA TCCCGTCAGT 
TGTGCCTTCG TGGTACTCAT GGCTCACGGG AGGGAAGGCT TCCTCAAGGG AGAAGATGGG 
GAGATGGTCA AGCTGGAGAA TCTCTTCGAG GCCCTGAACA ACAAGAACTG CCAGGCCCTG 
CGAGCTAAGC CCAAGGTGTA CATCATACAG GCCTGTCGAG GAGAACAAAG GGACCCCGGT 
GAAACAGTAG GTGGAGATGA GATTGTGATG GTCATCAAAG ACAGCCCACA AACCATCCCA 
ACATACACAG ATGCCTTGCA CGTTTATTCC ACGGTAGAGG GATACATCGC CTACCGACAT 
GATCAGAAAG GCTCATGCTT TATCCAGACC CTGGTGGATG TGTTCACGAA GAGGAAAGGA 
CATATCTTGG AACTTCTGAC AGAGGTGACC CGGCGGATGG CAGAAGCAGA GCTGGTTCAA 
GAAGGAAAAG CAAGGAAAAC GAACCCTGAA ATCCAAAGCA CCCTCCGGAA ACGGCTGTAT 
CTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036246.1
CDS	213..941
Translation	MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ

Target ORF information:

RefSeq Version	NM_012114.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 14 (CASP14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012114.2

ORF Insert Sequence:

ATGAGCAATC CGCGGTCTTT GGAAGAGGAG AAATATGATA TGTCAGGTGC CCGCCTGGCC 
CTAATACTGT GTGTCACCAA AGCCCGGGAA GGTTCCGAAG AAGACCTGGA TGCTCTGGAA 
CACATGTTTC GGCAGCTGAG ATTCGAAAGC ACCATGAAAA GAGACCCCAC TGCCGAGCAA 
TTCCAGGAAG AGCTGGAAAA ATTCCAGCAG GCCATCGATT CCCGGGAAGA TCCCGTCAGT 
TGTGCCTTCG TGGTACTCAT GGCTCACGGG AGGGAAGGCT TCCTCAAGGG AGAAGATGGG 
GAGATGGTCA AGCTGGAGAA TCTCTTCGAG GCCCTGAACA ACAAGAACTG CCAGGCCCTG 
CGAGCTAAGC CCAAGGTGTA CATCATACAG GCCTGTCGAG GAGAACAAAG GGACCCCGGT 
GAAACAGTAG GTGGAGATGA GATTGTGATG GTCATCAAAG ACAGCCCACA AACCATCCCA 
ACATACACAG ATGCCTTGCA CGTTTATTCC ACGGTAGAGG GATACATCGC CTACCGACAT 
GATCAGAAAG GCTCATGCTT TATCCAGACC CTGGTGGATG TGTTCACGAA GAGGAAAGGA 
CATATCTTGG AACTTCTGAC AGAGGTGACC CGGCGGATGG CAGAAGCAGA GCTGGTTCAA 
GAAGGAAAAG CAAGGAAAAC GAACCCTGAA ATCCAAAGCA CCCTCCGGAA ACGGCTGTAT 
CTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP14 ( XM_011527861.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526163.1 Homo sapiens caspase 14 (CASP14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66337
Clone ID Related Accession (Same CDS sequence)	XM_011527861.1
Accession Version	XM_011527861.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	caspase-14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAATC CGCGGTCTTT GGAAGAGGAG AAATATGATA TGTCAGGTGC CCGCCTGGCC 
CTAATACTGT GTGTCACCAA AGCCCGGGAA GGTTCCGAAG AAGACCTGGA TGCTCTGGAA 
CACATGTTTC GGCAGCTGAG ATTCGAAAGC ACCATGAAAA GAGACCCCAC TGCCGAGCAA 
TTCCAGGAAG AGCTGGAAAA ATTCCAGCAG GCCATCGATT CCCGGGAAGA TCCCGTCAGT 
TGTGCCTTCG TGGTACTCAT GGCTCACGGG AGGGAAGGCT TCCTCAAGGG AGAAGATGGG 
GAGATGGTCA AGCTGGAGAA TCTCTTCGAG GCCCTGAACA ACAAGAACTG CCAGGCCCTG 
CGAGCTAAGC CCAAGGTGTA CATCATACAG GCCTGTCGAG GAGAACAAAG GGACCCCGGT 
GAAACAGTAG GTGGAGATGA GATTGTGATG GTCATCAAAG ACAGCCCACA AACCATCCCA 
ACATACACAG ATGCCTTGCA CGTTTATTCC ACGGTAGAGG GACCCACGCC CTTCCAGGAT 
CCCCTCTACC TACCCTCTGA AGCTCCCCCG AACCCACCTC TCTGGAATTC CCAGGATACA 
TCGCCTACCG ACATGATCAG AAAGGCTCAT GCTTTATCCA GACCCTGGTG GATGTGTTCA 
CGAAGAGGAA AGGACATATC TTGGAACTTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526163.1
CDS	213..905
Translation	MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGPTPFQDPLYLPSEAPPNPPLWNSQDTSPTDMIRKAHALSRPWWMCSRRGKDISWNF

Target ORF information:

RefSeq Version	XM_011527861.1
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 14 (CASP14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527861.1

ORF Insert Sequence:

ATGAGCAATC CGCGGTCTTT GGAAGAGGAG AAATATGATA TGTCAGGTGC CCGCCTGGCC 
CTAATACTGT GTGTCACCAA AGCCCGGGAA GGTTCCGAAG AAGACCTGGA TGCTCTGGAA 
CACATGTTTC GGCAGCTGAG ATTCGAAAGC ACCATGAAAA GAGACCCCAC TGCCGAGCAA 
TTCCAGGAAG AGCTGGAAAA ATTCCAGCAG GCCATCGATT CCCGGGAAGA TCCCGTCAGT 
TGTGCCTTCG TGGTACTCAT GGCTCACGGG AGGGAAGGCT TCCTCAAGGG AGAAGATGGG 
GAGATGGTCA AGCTGGAGAA TCTCTTCGAG GCCCTGAACA ACAAGAACTG CCAGGCCCTG 
CGAGCTAAGC CCAAGGTGTA CATCATACAG GCCTGTCGAG GAGAACAAAG GGACCCCGGT 
GAAACAGTAG GTGGAGATGA GATTGTGATG GTCATCAAAG ACAGCCCACA AACCATCCCA 
ACATACACAG ATGCCTTGCA CGTTTATTCC ACGGTAGAGG GACCCACGCC CTTCCAGGAT 
CCCCTCTACC TACCCTCTGA AGCTCCCCCG AACCCACCTC TCTGGAATTC CCAGGATACA 
TCGCCTACCG ACATGATCAG AAAGGCTCAT GCTTTATCCA GACCCTGGTG GATGTGTTCA 
CGAAGAGGAA AGGACATATC TTGGAACTTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.
Journal of surgical oncology116(6)706-715(2017 Nov)
Handa T,Katayama A,Yokobori T,Yamane A,Horiguchi J,Kawabata-Iwakawa R,Rokudai S,Bao P,Gombodorj N,Altan B,Kaira K,Asao T,Kuwano H,Nishiyama M,Oyama T

S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.
Experimental dermatology24(5)342-8(2015 May)
Li T,Qi Z,Kong F,Li Y,Wang R,Zhang W,Shang Y,Huang L,He D,Xiao X

Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.
Journal of dermatological science76(3)231-9(2014 Dec)
Jung M,Choi J,Lee SA,Kim H,Hwang J,Choi EH

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
The Journal of biological chemistry289(29)20026-38(2014 Jul)
Yamamoto-Tanaka M,Motoyama A,Miyai M,Matsunaga Y,Matsuda J,Tsuboi R,Hibino T

Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.
BioMed research international2014417986(2014)
Beasley S,El-Sherbiny M,Megyerdi S,El-Shafey S,Choksi K,Kaddour-Djebbar I,Sheibani N,Hsu S,Al-Shabrawey M

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CASP14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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