GTPBP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GTPBP4
Entrez Gene ID	23560
Full Name	GTP binding protein 4
Synonyms	CRFG,NGB,NOG1
General protein information	Preferred Names GTP binding protein 4 Names nucleolar GTP-binding protein 1 G protein-binding protein CRFG GTP-binding protein NGB chronic renal failure gene protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p15.3
Summary	GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
XM_024447921.1	XP_024303689.1	nucleolar GTP-binding protein 1 isoform X1
NM_012341.3	NP_036473.2	nucleolar GTP-binding protein 1
NM_012341.2	NP_036473.2	nucleolar GTP-binding protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GTPBP4	XP_535203.3
Bos taurus (cattle)	GTPBP4	NP_001179530.1
Rattus norvegicus (Norway rat)	Gtpbp4	NP_446141.2
Danio rerio (zebrafish)	gtpbp4	NP_956145.1
Drosophila melanogaster (fruit fly)	CG8801	NP_610484.1
Saccharomyces cerevisiae (baker's yeast)	NOG1	NP_015232.1
Arabidopsis thaliana (thale cress)	AT1G10300	NP_172501.1
	GTPBP4	XP_002805585.1
Caenorhabditis elegans (roundworm)	T07A9.9	NP_741288.1
Kluyveromyces lactis	KLLA0E24135g	XP_455039.1
Oryza sativa (rice)	Os06g0195900	NP_001057050.1
Pan troglodytes (chimpanzee)	GTPBP4	XP_003312478.1
Magnaporthe oryzae (rice blast fungus)	MGG_07136	XP_003715331.1
Neurospora crassa	NCU05289	XP_962060.2
Oryza sativa (rice)	Os07g0110200	NP_001058730.2
Xenopus tropicalis (tropical clawed frog)	gtpbp4	XP_002935223.2
Mus musculus (house mouse)	Gtpbp4	NP_081276.2
Gallus gallus (chicken)	GTPBP4	NP_001006354.1
Arabidopsis thaliana (thale cress)	AT1G50920	NP_175505.1
Homo sapiens (human)	GTPBP4	NP_036473.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007050	XP_308713.2
Eremothecium gossypii	AGOS_AGR194W	NP_986860.1
Schizosaccharomyces pombe (fission yeast)	nog1	XP_001713127.1

Gene Ontology
Bibliography

Related articles in PubMed

Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis.
Yu H, Jin S, Zhang N, Xu Q
Biochemical and biophysical research communications480(1)48-54(2016 Nov)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GTPBP4 promotes colorectal cancer metastasis by disrupting actin cytoskeleton, which is mediated by the reduced RhoA activity.Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis.
Title: Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis.

NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation
Title: Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

The following GTPBP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GTPBP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24873	NM_012341.3 Latest version!	Homo sapiens GTP binding protein 4 (GTPBP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OHu106445	XM_024447921.1 Latest version!	Homo sapiens GTP binding protein 4 (GTPBP4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu24873	NM_012341.2	Homo sapiens GTP binding protein 4 (GTPBP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GTPBP4 ( NM_012341.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036473.2 Homo sapiens GTP binding protein 4 (GTPBP4), mRNA.

Price & Availability↑

CloneID	OHu24873
Clone ID Related Accession (Same CDS sequence)	NM_012341.3 , NM_012341.2
Accession Version	NM_012341.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nucleolar GTP-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL359878.13 and AC022536.13. On Nov 23, 2018 this sequence version replaced NM_012341.2. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.97392.1, SRR1803617.178516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000360803.9/ ENSP00000354040.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCACATT ACAACTTCAA GAAAATTACG GTGGTGCCGT CCGCCAAGGA CTTCATAGAC 
CTCACGTTGT CGAAGACTCA ACGAAAGACT CCAACCGTTA TTCATAAACA TTACCAAATA 
CATCGCATTA GACATTTTTA CATGAGAAAA GTCAAATTTA CTCAACAGAA TTACCATGAT 
AGACTTTCAC AAATTCTAAC AGATTTCCCC AAATTGGATG ATATTCATCC GTTCTATGCT 
GATTTGATGA ATATTCTCTA CGACAAGGAT CATTACAAGT TGGCTCTGGG GCAAATAAAT 
ATTGCCAAAA ATTTAGTGGA CAATGTTGCT AAAGATTATG TGCGACTGAT GAAGTATGGC 
GACTCTCTCT ACCGCTGCAA ACAGCTGAAG CGTGCGGCCC TGGGACGGAT GTGCACAGTG 
ATCAAGAGGC AGAAGCAGAG TTTGGAGTAT TTGGAGCAAG TGCGTCAGCA TTTATCCCGT 
TTGCCAACCA TTGATCCGAA TACCAGGACC CTGCTTTTGT GTGGGTACCC AAATGTTGGG 
AAGTCCAGCT TCATCAACAA GGTGACGAGA GCAGACGTGG ATGTCCAGCC CTATGCGTTC 
ACAACCAAGT CTCTGTTTGT TGGGCACATG GATTATAAGT ATCTACGTTG GCAGGTTGTA 
GACACTCCTG GGATCCTGGA CCACCCTCTG GAGGATAGGA ACACCATCGA GATGCAGGCC 
ATCACTGCCC TGGCCCACCT CCGTGCTGCG GTCCTGTATG TGATGGATTT GTCTGAGCAG 
TGTGGGCATG GGCTGAGGGA GCAGCTAGAA CTCTTCCAGA ACATCAGACC TCTCTTCATC 
AACAAGCCTC TCATAGTTGT AGCCAACAAA TGTGATGTGA AGAGAATAGC TGAACTTTCT 
GAAGATGATC AGAAAATATT TACAGATTTG CAGTCTGAAG GATTCCCTGT AATAGAGACC 
AGCACCCTGA CTGAGGAAGG TGTTATTAAA GTTAAAACAG AGGCTTGCGA TAGGCTTTTG 
GCTCATCGAG TGGAAACCAA AATGAAGGGA AATAAAGTGA ATGAGGTGCT GAATAGACTG 
CACCTGGCTA TCCCAACCAG GAGGGACGAT AAGGAGAGGC CCCCTTTCAT CCCTGAAGGA 
GTGGTGGCTC GCAGGAAGAG GATGGAAACT GAGGAGTCCA GGAAGAAGAG GGAACGAGAT 
CTTGAGCTGG AAATGGGAGA TGATTATATT TTGGATCTTC AGAAGTACTG GGATTTAATG 
AATTTGTCTG AAAAACATGA TAAGATACCA GAAATCTGGG AAGGCCATAA TATAGCTGAT 
TATATTGATC CAGCCATCAT GAAGAAATTG GAAGAATTAG AAAAAGAAGA AGAGCTGAGA 
ACAGCTGCTG GAGAGTATGA CAGTGTATCT GAGAGTGAAG ACGAAGAGAT GCTGGAAATC 
CGACAGCTGG CAAAGCAAAT TCGAGAGAAA AAGAAGTTGA AAATTCTGGA GTCCAAAGAA 
AAGAATACAC AGGGACCCAG GATGCCGCGA ACTGCTAAGA AGGTTCAGAG GACAGTTTTG 
GAGAAGGAGA TGCGTAGTCT TGGTGTTGAC ATGGACGATA AAGACGATGC CCATTACGCA 
GTCCAGGCAA GAAGATCCCG GAGCATCACT AGGAAAAGAA AGCGGGAAGA CTCTGCTCCC 
CCGTCCTCTG TGGCCCGGAG TGGGAGTTGC TCTCGAACTC CACGTGACGT TTCTGGTCTT 
AGGGATGTCA AGATGGTGAA GAAAGCCAAG ACTATGATGA AGAATGCTCA GAAGAAGATG 
AATCGGTTGG GGAAGAAAGG GGAGGCGGAT AGACACGTGT TTGATATGAA GCCCAAGCAC 
TTGCTGTCTG GGAAGAGGAA AGCTGGTAAA AAGGACAGGA GATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036473.2
CDS	47..1951
Translation	MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKVKFTQQNYHDRLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIAKNLVDNVAKDYVRLMKYGDSLYRCKQLKRAALGRMCTVIKRQKQSLEYLEQVRQHLSRLPTIDPNTRTLLLCGYPNVGKSSFINKVTRADVDVQPYAFTTKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQAITALAHLRAAVLYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELSEDDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNRLHLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLMNLSEKHDKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAGEYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQRTVLEKEMRSLGVDMDDKDDAHYAVQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKMNRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR

Target ORF information:

RefSeq Version	NM_012341.3
Organism	Homo sapiens(human)
Definition	Homo sapiens GTP binding protein 4 (GTPBP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012341.3

ORF Insert Sequence:

ATGGCACATT ACAACTTCAA GAAAATTACG GTGGTGCCGT CCGCCAAGGA CTTCATAGAC 
CTCACGTTGT CGAAGACTCA ACGAAAGACT CCAACCGTTA TTCATAAACA TTACCAAATA 
CATCGCATTA GACATTTTTA CATGAGAAAA GTCAAATTTA CTCAACAGAA TTACCATGAT 
AGACTTTCAC AAATTCTAAC AGATTTCCCC AAATTGGATG ATATTCATCC GTTCTATGCT 
GATTTGATGA ATATTCTCTA CGACAAGGAT CATTACAAGT TGGCTCTGGG GCAAATAAAT 
ATTGCCAAAA ATTTAGTGGA CAATGTTGCT AAAGATTATG TGCGACTGAT GAAGTATGGC 
GACTCTCTCT ACCGCTGCAA ACAGCTGAAG CGTGCGGCCC TGGGACGGAT GTGCACAGTG 
ATCAAGAGGC AGAAGCAGAG TTTGGAGTAT TTGGAGCAAG TGCGTCAGCA TTTATCCCGT 
TTGCCAACCA TTGATCCGAA TACCAGGACC CTGCTTTTGT GTGGGTACCC AAATGTTGGG 
AAGTCCAGCT TCATCAACAA GGTGACGAGA GCAGACGTGG ATGTCCAGCC CTATGCGTTC 
ACAACCAAGT CTCTGTTTGT TGGGCACATG GATTATAAGT ATCTACGTTG GCAGGTTGTA 
GACACTCCTG GGATCCTGGA CCACCCTCTG GAGGATAGGA ACACCATCGA GATGCAGGCC 
ATCACTGCCC TGGCCCACCT CCGTGCTGCG GTCCTGTATG TGATGGATTT GTCTGAGCAG 
TGTGGGCATG GGCTGAGGGA GCAGCTAGAA CTCTTCCAGA ACATCAGACC TCTCTTCATC 
AACAAGCCTC TCATAGTTGT AGCCAACAAA TGTGATGTGA AGAGAATAGC TGAACTTTCT 
GAAGATGATC AGAAAATATT TACAGATTTG CAGTCTGAAG GATTCCCTGT AATAGAGACC 
AGCACCCTGA CTGAGGAAGG TGTTATTAAA GTTAAAACAG AGGCTTGCGA TAGGCTTTTG 
GCTCATCGAG TGGAAACCAA AATGAAGGGA AATAAAGTGA ATGAGGTGCT GAATAGACTG 
CACCTGGCTA TCCCAACCAG GAGGGACGAT AAGGAGAGGC CCCCTTTCAT CCCTGAAGGA 
GTGGTGGCTC GCAGGAAGAG GATGGAAACT GAGGAGTCCA GGAAGAAGAG GGAACGAGAT 
CTTGAGCTGG AAATGGGAGA TGATTATATT TTGGATCTTC AGAAGTACTG GGATTTAATG 
AATTTGTCTG AAAAACATGA TAAGATACCA GAAATCTGGG AAGGCCATAA TATAGCTGAT 
TATATTGATC CAGCCATCAT GAAGAAATTG GAAGAATTAG AAAAAGAAGA AGAGCTGAGA 
ACAGCTGCTG GAGAGTATGA CAGTGTATCT GAGAGTGAAG ACGAAGAGAT GCTGGAAATC 
CGACAGCTGG CAAAGCAAAT TCGAGAGAAA AAGAAGTTGA AAATTCTGGA GTCCAAAGAA 
AAGAATACAC AGGGACCCAG GATGCCGCGA ACTGCTAAGA AGGTTCAGAG GACAGTTTTG 
GAGAAGGAGA TGCGTAGTCT TGGTGTTGAC ATGGACGATA AAGACGATGC CCATTACGCA 
GTCCAGGCAA GAAGATCCCG GAGCATCACT AGGAAAAGAA AGCGGGAAGA CTCTGCTCCC 
CCGTCCTCTG TGGCCCGGAG TGGGAGTTGC TCTCGAACTC CACGTGACGT TTCTGGTCTT 
AGGGATGTCA AGATGGTGAA GAAAGCCAAG ACTATGATGA AGAATGCTCA GAAGAAGATG 
AATCGGTTGG GGAAGAAAGG GGAGGCGGAT AGACACGTGT TTGATATGAA GCCCAAGCAC 
TTGCTGTCTG GGAAGAGGAA AGCTGGTAAA AAGGACAGGA GATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTPBP4 ( NM_012341.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036473.2 Homo sapiens GTP binding protein 4 (GTPBP4), mRNA.

Price & Availability↑

CloneID	OHu24873
Clone ID Related Accession (Same CDS sequence)	NM_012341.3 , NM_012341.2
Accession Version	NM_012341.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	nucleolar GTP-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK001552.1, AF120334.1 and AI740474.1. On Nov 22, 2004 this sequence version replaced NM_012341.1. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.145932.1, SRR1660807.238407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCACATT ACAACTTCAA GAAAATTACG GTGGTGCCGT CCGCCAAGGA CTTCATAGAC 
CTCACGTTGT CGAAGACTCA ACGAAAGACT CCAACCGTTA TTCATAAACA TTACCAAATA 
CATCGCATTA GACATTTTTA CATGAGAAAA GTCAAATTTA CTCAACAGAA TTACCATGAT 
AGACTTTCAC AAATTCTAAC AGATTTCCCC AAATTGGATG ATATTCATCC GTTCTATGCT 
GATTTGATGA ATATTCTCTA CGACAAGGAT CATTACAAGT TGGCTCTGGG GCAAATAAAT 
ATTGCCAAAA ATTTAGTGGA CAATGTTGCT AAAGATTATG TGCGACTGAT GAAGTATGGC 
GACTCTCTCT ACCGCTGCAA ACAGCTGAAG CGTGCGGCCC TGGGACGGAT GTGCACAGTG 
ATCAAGAGGC AGAAGCAGAG TTTGGAGTAT TTGGAGCAAG TGCGTCAGCA TTTATCCCGT 
TTGCCAACCA TTGATCCGAA TACCAGGACC CTGCTTTTGT GTGGGTACCC AAATGTTGGG 
AAGTCCAGCT TCATCAACAA GGTGACGAGA GCAGACGTGG ATGTCCAGCC CTATGCGTTC 
ACAACCAAGT CTCTGTTTGT TGGGCACATG GATTATAAGT ATCTACGTTG GCAGGTTGTA 
GACACTCCTG GGATCCTGGA CCACCCTCTG GAGGATAGGA ACACCATCGA GATGCAGGCC 
ATCACTGCCC TGGCCCACCT CCGTGCTGCG GTCCTGTATG TGATGGATTT GTCTGAGCAG 
TGTGGGCATG GGCTGAGGGA GCAGCTAGAA CTCTTCCAGA ACATCAGACC TCTCTTCATC 
AACAAGCCTC TCATAGTTGT AGCCAACAAA TGTGATGTGA AGAGAATAGC TGAACTTTCT 
GAAGATGATC AGAAAATATT TACAGATTTG CAGTCTGAAG GATTCCCTGT AATAGAGACC 
AGCACCCTGA CTGAGGAAGG TGTTATTAAA GTTAAAACAG AGGCTTGCGA TAGGCTTTTG 
GCTCATCGAG TGGAAACCAA AATGAAGGGA AATAAAGTGA ATGAGGTGCT GAATAGACTG 
CACCTGGCTA TCCCAACCAG GAGGGACGAT AAGGAGAGGC CCCCTTTCAT CCCTGAAGGA 
GTGGTGGCTC GCAGGAAGAG GATGGAAACT GAGGAGTCCA GGAAGAAGAG GGAACGAGAT 
CTTGAGCTGG AAATGGGAGA TGATTATATT TTGGATCTTC AGAAGTACTG GGATTTAATG 
AATTTGTCTG AAAAACATGA TAAGATACCA GAAATCTGGG AAGGCCATAA TATAGCTGAT 
TATATTGATC CAGCCATCAT GAAGAAATTG GAAGAATTAG AAAAAGAAGA AGAGCTGAGA 
ACAGCTGCTG GAGAGTATGA CAGTGTATCT GAGAGTGAAG ACGAAGAGAT GCTGGAAATC 
CGACAGCTGG CAAAGCAAAT TCGAGAGAAA AAGAAGTTGA AAATTCTGGA GTCCAAAGAA 
AAGAATACAC AGGGACCCAG GATGCCGCGA ACTGCTAAGA AGGTTCAGAG GACAGTTTTG 
GAGAAGGAGA TGCGTAGTCT TGGTGTTGAC ATGGACGATA AAGACGATGC CCATTACGCA 
GTCCAGGCAA GAAGATCCCG GAGCATCACT AGGAAAAGAA AGCGGGAAGA CTCTGCTCCC 
CCGTCCTCTG TGGCCCGGAG TGGGAGTTGC TCTCGAACTC CACGTGACGT TTCTGGTCTT 
AGGGATGTCA AGATGGTGAA GAAAGCCAAG ACTATGATGA AGAATGCTCA GAAGAAGATG 
AATCGGTTGG GGAAGAAAGG GGAGGCGGAT AGACACGTGT TTGATATGAA GCCCAAGCAC 
TTGCTGTCTG GGAAGAGGAA AGCTGGTAAA AAGGACAGGA GATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036473.2
CDS	72..1976
Translation	MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKVKFTQQNYHDRLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIAKNLVDNVAKDYVRLMKYGDSLYRCKQLKRAALGRMCTVIKRQKQSLEYLEQVRQHLSRLPTIDPNTRTLLLCGYPNVGKSSFINKVTRADVDVQPYAFTTKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQAITALAHLRAAVLYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELSEDDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNRLHLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLMNLSEKHDKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAGEYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQRTVLEKEMRSLGVDMDDKDDAHYAVQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKMNRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR

Target ORF information:

RefSeq Version	NM_012341.2
Organism	Homo sapiens(human)
Definition	Homo sapiens GTP binding protein 4 (GTPBP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012341.2

ORF Insert Sequence:

ATGGCACATT ACAACTTCAA GAAAATTACG GTGGTGCCGT CCGCCAAGGA CTTCATAGAC 
CTCACGTTGT CGAAGACTCA ACGAAAGACT CCAACCGTTA TTCATAAACA TTACCAAATA 
CATCGCATTA GACATTTTTA CATGAGAAAA GTCAAATTTA CTCAACAGAA TTACCATGAT 
AGACTTTCAC AAATTCTAAC AGATTTCCCC AAATTGGATG ATATTCATCC GTTCTATGCT 
GATTTGATGA ATATTCTCTA CGACAAGGAT CATTACAAGT TGGCTCTGGG GCAAATAAAT 
ATTGCCAAAA ATTTAGTGGA CAATGTTGCT AAAGATTATG TGCGACTGAT GAAGTATGGC 
GACTCTCTCT ACCGCTGCAA ACAGCTGAAG CGTGCGGCCC TGGGACGGAT GTGCACAGTG 
ATCAAGAGGC AGAAGCAGAG TTTGGAGTAT TTGGAGCAAG TGCGTCAGCA TTTATCCCGT 
TTGCCAACCA TTGATCCGAA TACCAGGACC CTGCTTTTGT GTGGGTACCC AAATGTTGGG 
AAGTCCAGCT TCATCAACAA GGTGACGAGA GCAGACGTGG ATGTCCAGCC CTATGCGTTC 
ACAACCAAGT CTCTGTTTGT TGGGCACATG GATTATAAGT ATCTACGTTG GCAGGTTGTA 
GACACTCCTG GGATCCTGGA CCACCCTCTG GAGGATAGGA ACACCATCGA GATGCAGGCC 
ATCACTGCCC TGGCCCACCT CCGTGCTGCG GTCCTGTATG TGATGGATTT GTCTGAGCAG 
TGTGGGCATG GGCTGAGGGA GCAGCTAGAA CTCTTCCAGA ACATCAGACC TCTCTTCATC 
AACAAGCCTC TCATAGTTGT AGCCAACAAA TGTGATGTGA AGAGAATAGC TGAACTTTCT 
GAAGATGATC AGAAAATATT TACAGATTTG CAGTCTGAAG GATTCCCTGT AATAGAGACC 
AGCACCCTGA CTGAGGAAGG TGTTATTAAA GTTAAAACAG AGGCTTGCGA TAGGCTTTTG 
GCTCATCGAG TGGAAACCAA AATGAAGGGA AATAAAGTGA ATGAGGTGCT GAATAGACTG 
CACCTGGCTA TCCCAACCAG GAGGGACGAT AAGGAGAGGC CCCCTTTCAT CCCTGAAGGA 
GTGGTGGCTC GCAGGAAGAG GATGGAAACT GAGGAGTCCA GGAAGAAGAG GGAACGAGAT 
CTTGAGCTGG AAATGGGAGA TGATTATATT TTGGATCTTC AGAAGTACTG GGATTTAATG 
AATTTGTCTG AAAAACATGA TAAGATACCA GAAATCTGGG AAGGCCATAA TATAGCTGAT 
TATATTGATC CAGCCATCAT GAAGAAATTG GAAGAATTAG AAAAAGAAGA AGAGCTGAGA 
ACAGCTGCTG GAGAGTATGA CAGTGTATCT GAGAGTGAAG ACGAAGAGAT GCTGGAAATC 
CGACAGCTGG CAAAGCAAAT TCGAGAGAAA AAGAAGTTGA AAATTCTGGA GTCCAAAGAA 
AAGAATACAC AGGGACCCAG GATGCCGCGA ACTGCTAAGA AGGTTCAGAG GACAGTTTTG 
GAGAAGGAGA TGCGTAGTCT TGGTGTTGAC ATGGACGATA AAGACGATGC CCATTACGCA 
GTCCAGGCAA GAAGATCCCG GAGCATCACT AGGAAAAGAA AGCGGGAAGA CTCTGCTCCC 
CCGTCCTCTG TGGCCCGGAG TGGGAGTTGC TCTCGAACTC CACGTGACGT TTCTGGTCTT 
AGGGATGTCA AGATGGTGAA GAAAGCCAAG ACTATGATGA AGAATGCTCA GAAGAAGATG 
AATCGGTTGG GGAAGAAAGG GGAGGCGGAT AGACACGTGT TTGATATGAA GCCCAAGCAC 
TTGCTGTCTG GGAAGAGGAA AGCTGGTAAA AAGGACAGGA GATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTPBP4 ( XM_024447921.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303689.1 Homo sapiens GTP binding protein 4 (GTPBP4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu106445
Clone ID Related Accession (Same CDS sequence)	XM_024447921.1
Accession Version	XM_024447921.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nucleolar GTP-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTATA AGTATCTACG TTGGCAGGTT GTAGACACTC CTGGGATCCT GGACCACCCT 
CTGGAGGATA GGAACACCAT CGAGATGCAG GCCATCACTG CCCTGGCCCA CCTCCGTGCT 
GCGGTCCTGT ATGTGATGGA TTTGTCTGAG CAGTGTGGGC ATGGGCTGAG GGAGCAGCTA 
GAACTCTTCC AGAACATCAG ACCTCTCTTC ATCAACAAGC CTCTCATAGT TGTAGCCAAC 
AAATGTGATG TGAAGAGAAT AGCTGAACTT TCTGAAGATG ATCAGAAAAT ATTTACAGAT 
TTGCAGTCTG AAGGATTCCC TGTAATAGAG ACCAGCACCC TGACTGAGGA AGGTGTTATT 
AAAGTTAAAA CAGAGGCTTG CGATAGGCTT TTGGCTCATC GAGTGGAAAC CAAAATGAAG 
GGAAATAAAG TGAATGAGGT GCTGAATAGA CTGCACCTGG CTATCCCAAC CAGGAGGGAC 
GATAAGGAGA GGCCCCCTTT CATCCCTGAA GGAGTGGTGG CTCGCAGGAA GAGGATGGAA 
ACTGAGGAGT CCAGGAAGAA GAGGGAACGA GATCTTGAGC TGGAAATGGG AGATGATTAT 
ATTTTGGATC TTCAGAAGTA CTGGGATTTA ATGAATTTGT CTGAAAAACA TGATAAGATA 
CCAGAAATCT GGGAAGGCCA TAATATAGCT GATTATATTG ATCCAGCCAT CATGAAGAAA 
TTGGAAGAAT TAGAAAAAGA AGAAGAGCTG AGAACAGCTG CTGGAGAGTA TGACAGTGTA 
TCTGAGAGTG AAGACGAAGA GATGCTGGAA ATCCGACAGC TGGCAAAGCA AATTCGAGAG 
AAAAAGAAGT TGAAAATTCT GGAGTCCAAA GAAAAGAATA CACAGGGACC CAGGATGCCG 
CGAACTGCTA AGAAGGTTCA GAGGACAGTT TTGGAGAAGG AGATGCGTAG TCTTGGTGTT 
GACATGGACG ATAAAGACGA TGCCCATTAC GCAGTCCAGG CAAGAAGATC CCGGAGCATC 
ACTAGGAAAA GAAAGCGGGA AGACTCTGCT CCCCCGTCCT CTGTGGCCCG GAGTGGGAGT 
TGCTCTCGAA CTCCACGTGA CGTTTCTGGT CTTAGGGATG TCAAGATGGT GAAGAAAGCC 
AAGACTATGA TGAAGAATGC TCAGAAGAAG ATGAATCGGT TGGGGAAGAA AGGGGAGGCG 
GATAGACACG TGTTTGATAT GAAGCCCAAG CACTTGCTGT CTGGGAAGAG GAAAGCTGGT 
AAAAAGGACA GGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303689.1
CDS	548..1825
Translation	MDYKYLRWQVVDTPGILDHPLEDRNTIEMQAITALAHLRAAVLYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELSEDDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNRLHLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLMNLSEKHDKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAGEYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQRTVLEKEMRSLGVDMDDKDDAHYAVQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKMNRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR

Target ORF information:

RefSeq Version	XM_024447921.1
Organism	Homo sapiens(human)
Definition	Homo sapiens GTP binding protein 4 (GTPBP4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447921.1

ORF Insert Sequence:

ATGGATTATA AGTATCTACG TTGGCAGGTT GTAGACACTC CTGGGATCCT GGACCACCCT 
CTGGAGGATA GGAACACCAT CGAGATGCAG GCCATCACTG CCCTGGCCCA CCTCCGTGCT 
GCGGTCCTGT ATGTGATGGA TTTGTCTGAG CAGTGTGGGC ATGGGCTGAG GGAGCAGCTA 
GAACTCTTCC AGAACATCAG ACCTCTCTTC ATCAACAAGC CTCTCATAGT TGTAGCCAAC 
AAATGTGATG TGAAGAGAAT AGCTGAACTT TCTGAAGATG ATCAGAAAAT ATTTACAGAT 
TTGCAGTCTG AAGGATTCCC TGTAATAGAG ACCAGCACCC TGACTGAGGA AGGTGTTATT 
AAAGTTAAAA CAGAGGCTTG CGATAGGCTT TTGGCTCATC GAGTGGAAAC CAAAATGAAG 
GGAAATAAAG TGAATGAGGT GCTGAATAGA CTGCACCTGG CTATCCCAAC CAGGAGGGAC 
GATAAGGAGA GGCCCCCTTT CATCCCTGAA GGAGTGGTGG CTCGCAGGAA GAGGATGGAA 
ACTGAGGAGT CCAGGAAGAA GAGGGAACGA GATCTTGAGC TGGAAATGGG AGATGATTAT 
ATTTTGGATC TTCAGAAGTA CTGGGATTTA ATGAATTTGT CTGAAAAACA TGATAAGATA 
CCAGAAATCT GGGAAGGCCA TAATATAGCT GATTATATTG ATCCAGCCAT CATGAAGAAA 
TTGGAAGAAT TAGAAAAAGA AGAAGAGCTG AGAACAGCTG CTGGAGAGTA TGACAGTGTA 
TCTGAGAGTG AAGACGAAGA GATGCTGGAA ATCCGACAGC TGGCAAAGCA AATTCGAGAG 
AAAAAGAAGT TGAAAATTCT GGAGTCCAAA GAAAAGAATA CACAGGGACC CAGGATGCCG 
CGAACTGCTA AGAAGGTTCA GAGGACAGTT TTGGAGAAGG AGATGCGTAG TCTTGGTGTT 
GACATGGACG ATAAAGACGA TGCCCATTAC GCAGTCCAGG CAAGAAGATC CCGGAGCATC 
ACTAGGAAAA GAAAGCGGGA AGACTCTGCT CCCCCGTCCT CTGTGGCCCG GAGTGGGAGT 
TGCTCTCGAA CTCCACGTGA CGTTTCTGGT CTTAGGGATG TCAAGATGGT GAAGAAAGCC 
AAGACTATGA TGAAGAATGC TCAGAAGAAG ATGAATCGGT TGGGGAAGAA AGGGGAGGCG 
GATAGACACG TGTTTGATAT GAAGCCCAAG CACTTGCTGT CTGGGAAGAG GAAAGCTGGT 
AAAAAGGACA GGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis.
Biochemical and biophysical research communications480(1)48-54(2016 Nov)
Yu H,Jin S,Zhang N,Xu Q

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

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GTPBP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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