MMD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMD
Entrez Gene ID	23531
Full Name	monocyte to macrophage differentiation associated
Synonyms	MMA,MMD1,PAQR11
General protein information	Preferred Names monocyte to macrophage differentiation associated Names monocyte to macrophage differentiation factor macrophage maturation-associated monocyte to macrophage differentiation protein progestin and adipoQ receptor family member 11 progestin and adipoQ receptor family member XI
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q22
Summary	This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008].
Disorder MIM:	604467

mRNA and Protein(s)

mRNA	Protein	Name
XM_006721795.2	XP_006721858.1	monocyte to macrophage differentiation factor isoform X1
XM_006721795.3	XP_006721858.1	monocyte to macrophage differentiation factor isoform X1
NM_012329.2	NP_036461.2	monocyte to macrophage differentiation factor
NM_012329.3	NP_036461.2	monocyte to macrophage differentiation factor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MMD	NP_001069069.1
Canis lupus familiaris (dog)	MMD	XP_537684.1
Mus musculus (house mouse)	Mmd	NP_080454.1
Drosophila melanogaster (fruit fly)	CG4615	NP_572382.1
Pan troglodytes (chimpanzee)	MMD	XP_511895.1
	MMD	XP_001103680.1
Rattus norvegicus (Norway rat)	Mmd	NP_001007674.1
Gallus gallus (chicken)	MMD	NP_001025875.1
Danio rerio (zebrafish)	mmd	NP_001032496.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006136	XP_316199.4
Homo sapiens (human)	MMD	NP_036461.2
Xenopus tropicalis (tropical clawed frog)	mmd	XP_002937857.1

Gene Ontology
Bibliography

Related articles in PubMed

Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11.
Tan X, Banerjee P, Guo HF, Ireland S, Pankova D, Ahn YH, Nikolaidis IM, Liu X, Zhao Y, Xue Y, Burns AR, Roybal J, Gibbons DL, Zal T, Creighton CJ, Ungar D, Wang Y, Kurie JM
The Journal of clinical investigation127(1)117-131(2017 Jan)

Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer.
Li W, He F
Biochemical and biophysical research communications450(1)844-50(2014 Jul)

PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.
Jin T, Ding Q, Huang H, Xu D, Jiang Y, Zhou B, Li Z, Jiang X, He J, Liu W, Zhang Y, Pan Y, Wang Z, Thomas WG, Chen Y
Cell research22(4)661-76(2012 Apr)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes and immunity11(3)232-8(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

high PAQR11 levels were correlated with epithelial-to-mesenchymal transition (EMT) and shorter survival in human cancers, and PAQR11 was found to be essential for tumor cell migration and metastasis in EMT-driven lung adenocarcinoma models.
Title: Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11.

Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.
Title: Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer.

this study uncovers a new paradigm of spatial regulation of Ras signaling in the Golgi apparatus by PAQR10 and PAQR11.
Title: PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

The following MMD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06184	NM_012329.3 Latest version!	Homo sapiens monocyte to macrophage differentiation associated (MMD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu50248	XM_006721795.3 Latest version!	Homo sapiens monocyte to macrophage differentiation associated (MMD), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu50248	XM_006721795.2	Homo sapiens monocyte to macrophage differentiation associated (MMD), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu06184	NM_012329.2	Homo sapiens monocyte to macrophage differentiation associated (MMD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMD ( NM_012329.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036461.2 Homo sapiens monocyte to macrophage differentiation associated (MMD), mRNA.

Price & Availability↑

CloneID	OHu06184
Clone ID Related Accession (Same CDS sequence)	NM_012329.2 , NM_012329.3
Accession Version	NM_012329.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	monocyte to macrophage differentiation factor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI546449.1, AY424289.1, X85750.1, N40480.1 and BC026324.1. On Sep 24, 2004 this sequence version replaced NM_012329.1. ##Evidence-Data-START## Transcript exon combination :: AY424289.1, BC026324.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTAAA TCTTCGTGAA 
CTTGGACCCC TGGCATCTCA TATGCGTTGG TTTATCTGGC TCATGGCAGC TGGAGGAACC 
ATTTATGTAT TTCTCTACCA TGAAAAATAT AAGGTGGTTG AACTCTTTTT CTATCTCACA 
ATGGGATTCT CTCCAGCCTT GGTGGTGACA TCAATGAACA ACACCGATGG ACTTCAGGAA 
CTTGCCTGTG GGGGCTTAAT TTATTGCTTG GGAGTTGTGT TCTTCAAGAG TGATGGCATC 
ATTCCATTTG CCCACGCCAT CTGGCACCTG TTTGTGGCCA CGGCAGCTGC AGTGCATTAC 
TACGCCATTT GGAAATACCT TTACCGAAGT CCTACGGACT TTATGCGGCA TTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036461.2
CDS	286..1002
Translation	MRFKNRFQRFMNHRAPANGRYKPTCYEHAANCYTHAFLIVPAIVGSALLHRLSDDCWEKITAWIYGMGLCALFIVSTVFHIVSWKKSHLRTVEHCFHMCDRMVIYFFIAASYAPWLNLRELGPLASHMRWFIWLMAAGGTIYVFLYHEKYKVVELFFYLTMGFSPALVVTSMNNTDGLQELACGGLIYCLGVVFFKSDGIIPFAHAIWHLFVATAAAVHYYAIWKYLYRSPTDFMRHL

Target ORF information:

RefSeq Version	NM_012329.2
Organism	Homo sapiens(human)
Definition	Homo sapiens monocyte to macrophage differentiation associated (MMD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012329.2

ORF Insert Sequence:

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTAAA TCTTCGTGAA 
CTTGGACCCC TGGCATCTCA TATGCGTTGG TTTATCTGGC TCATGGCAGC TGGAGGAACC 
ATTTATGTAT TTCTCTACCA TGAAAAATAT AAGGTGGTTG AACTCTTTTT CTATCTCACA 
ATGGGATTCT CTCCAGCCTT GGTGGTGACA TCAATGAACA ACACCGATGG ACTTCAGGAA 
CTTGCCTGTG GGGGCTTAAT TTATTGCTTG GGAGTTGTGT TCTTCAAGAG TGATGGCATC 
ATTCCATTTG CCCACGCCAT CTGGCACCTG TTTGTGGCCA CGGCAGCTGC AGTGCATTAC 
TACGCCATTT GGAAATACCT TTACCGAAGT CCTACGGACT TTATGCGGCA TTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MMD ( NM_012329.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036461.2 Homo sapiens monocyte to macrophage differentiation associated (MMD), mRNA.

Price & Availability↑

CloneID	OHu06184
Clone ID Related Accession (Same CDS sequence)	NM_012329.2 , NM_012329.3
Accession Version	NM_012329.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	monocyte to macrophage differentiation factor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY424289.1, X85750.1, N40480.1 and BC026324.1. On Nov 23, 2018 this sequence version replaced NM_012329.2. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.32382.1, AY424289.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262065.8/ ENSP00000262065.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTAAA TCTTCGTGAA 
CTTGGACCCC TGGCATCTCA TATGCGTTGG TTTATCTGGC TCATGGCAGC TGGAGGAACC 
ATTTATGTAT TTCTCTACCA TGAAAAATAT AAGGTGGTTG AACTCTTTTT CTATCTCACA 
ATGGGATTCT CTCCAGCCTT GGTGGTGACA TCAATGAACA ACACCGATGG ACTTCAGGAA 
CTTGCCTGTG GGGGCTTAAT TTATTGCTTG GGAGTTGTGT TCTTCAAGAG TGATGGCATC 
ATTCCATTTG CCCACGCCAT CTGGCACCTG TTTGTGGCCA CGGCAGCTGC AGTGCATTAC 
TACGCCATTT GGAAATACCT TTACCGAAGT CCTACGGACT TTATGCGGCA TTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036461.2
CDS	141..857
Translation	MRFKNRFQRFMNHRAPANGRYKPTCYEHAANCYTHAFLIVPAIVGSALLHRLSDDCWEKITAWIYGMGLCALFIVSTVFHIVSWKKSHLRTVEHCFHMCDRMVIYFFIAASYAPWLNLRELGPLASHMRWFIWLMAAGGTIYVFLYHEKYKVVELFFYLTMGFSPALVVTSMNNTDGLQELACGGLIYCLGVVFFKSDGIIPFAHAIWHLFVATAAAVHYYAIWKYLYRSPTDFMRHL

Target ORF information:

RefSeq Version	NM_012329.3
Organism	Homo sapiens(human)
Definition	Homo sapiens monocyte to macrophage differentiation associated (MMD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012329.3

ORF Insert Sequence:

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTAAA TCTTCGTGAA 
CTTGGACCCC TGGCATCTCA TATGCGTTGG TTTATCTGGC TCATGGCAGC TGGAGGAACC 
ATTTATGTAT TTCTCTACCA TGAAAAATAT AAGGTGGTTG AACTCTTTTT CTATCTCACA 
ATGGGATTCT CTCCAGCCTT GGTGGTGACA TCAATGAACA ACACCGATGG ACTTCAGGAA 
CTTGCCTGTG GGGGCTTAAT TTATTGCTTG GGAGTTGTGT TCTTCAAGAG TGATGGCATC 
ATTCCATTTG CCCACGCCAT CTGGCACCTG TTTGTGGCCA CGGCAGCTGC AGTGCATTAC 
TACGCCATTT GGAAATACCT TTACCGAAGT CCTACGGACT TTATGCGGCA TTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MMD ( XM_006721795.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006721858.1 Homo sapiens monocyte to macrophage differentiation associated (MMD), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu50248
Clone ID Related Accession (Same CDS sequence)	XM_006721795.2 , XM_006721795.3
Accession Version	XM_006721795.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	monocyte to macrophage differentiation factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006721795.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTCTT CTCATTAAGG 
TTTGTAAGTA ATCTGCTCCC AAATACATGG TCAGAAATTA AAGGGCAAGC AGTTTTGACC 
TCATTCTGCC TAATAGGGTT AAATCTTCGT GAACTTGGAC CCCTGGCATC TCATATGCGT 
TGGTTTATCT GGCTCATGGC AGCTGGAGGA ACCATTTATG TATTTCTCTA CCATGAAAAA 
TATAAGGTGG TTGAACTCTT TTTCTATCTC ACAATGGGAT TCTCTCCAGC CTTGGTGGTG 
ACATCAATGA ACAACACCGA TGGACTTCAG GAACTTGCCT GTGGGGGCTT AATTTATTGC 
TTGGGAGTTG TGTTCTTCAA GAGTGATGGC ATCATTCCAT TTGCCCACGC CATCTGGCAC 
CTGTTTGTGG CCACGGCAGC TGCAGTGCAT TACTACGCCA TTTGGAAATA CCTTTACCGA 
AGTCCTACGG ACTTTATGCG GCATTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006721858.1
CDS	299..1108
Translation	MRFKNRFQRFMNHRAPANGRYKPTCYEHAANCYTHAFLIVPAIVGSALLHRLSDDCWEKITAWIYGMGLCALFIVSTVFHIVSWKKSHLRTVEHCFHMCDRMVIYFFIAASYAPWFFSLRFVSNLLPNTWSEIKGQAVLTSFCLIGLNLRELGPLASHMRWFIWLMAAGGTIYVFLYHEKYKVVELFFYLTMGFSPALVVTSMNNTDGLQELACGGLIYCLGVVFFKSDGIIPFAHAIWHLFVATAAAVHYYAIWKYLYRSPTDFMRHL

Target ORF information:

RefSeq Version	XM_006721795.2
Organism	Homo sapiens(human)
Definition	Homo sapiens monocyte to macrophage differentiation associated (MMD), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006721795.2

ORF Insert Sequence:

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTCTT CTCATTAAGG 
TTTGTAAGTA ATCTGCTCCC AAATACATGG TCAGAAATTA AAGGGCAAGC AGTTTTGACC 
TCATTCTGCC TAATAGGGTT AAATCTTCGT GAACTTGGAC CCCTGGCATC TCATATGCGT 
TGGTTTATCT GGCTCATGGC AGCTGGAGGA ACCATTTATG TATTTCTCTA CCATGAAAAA 
TATAAGGTGG TTGAACTCTT TTTCTATCTC ACAATGGGAT TCTCTCCAGC CTTGGTGGTG 
ACATCAATGA ACAACACCGA TGGACTTCAG GAACTTGCCT GTGGGGGCTT AATTTATTGC 
TTGGGAGTTG TGTTCTTCAA GAGTGATGGC ATCATTCCAT TTGCCCACGC CATCTGGCAC 
CTGTTTGTGG CCACGGCAGC TGCAGTGCAT TACTACGCCA TTTGGAAATA CCTTTACCGA 
AGTCCTACGG ACTTTATGCG GCATTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MMD ( XM_006721795.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006721858.1 Homo sapiens monocyte to macrophage differentiation associated (MMD), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu50248
Clone ID Related Accession (Same CDS sequence)	XM_006721795.2 , XM_006721795.3
Accession Version	XM_006721795.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	monocyte to macrophage differentiation factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006721795.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTCTT CTCATTAAGG 
TTTGTAAGTA ATCTGCTCCC AAATACATGG TCAGAAATTA AAGGGCAAGC AGTTTTGACC 
TCATTCTGCC TAATAGGGTT AAATCTTCGT GAACTTGGAC CCCTGGCATC TCATATGCGT 
TGGTTTATCT GGCTCATGGC AGCTGGAGGA ACCATTTATG TATTTCTCTA CCATGAAAAA 
TATAAGGTGG TTGAACTCTT TTTCTATCTC ACAATGGGAT TCTCTCCAGC CTTGGTGGTG 
ACATCAATGA ACAACACCGA TGGACTTCAG GAACTTGCCT GTGGGGGCTT AATTTATTGC 
TTGGGAGTTG TGTTCTTCAA GAGTGATGGC ATCATTCCAT TTGCCCACGC CATCTGGCAC 
CTGTTTGTGG CCACGGCAGC TGCAGTGCAT TACTACGCCA TTTGGAAATA CCTTTACCGA 
AGTCCTACGG ACTTTATGCG GCATTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006721858.1
CDS	181..990
Translation	MRFKNRFQRFMNHRAPANGRYKPTCYEHAANCYTHAFLIVPAIVGSALLHRLSDDCWEKITAWIYGMGLCALFIVSTVFHIVSWKKSHLRTVEHCFHMCDRMVIYFFIAASYAPWFFSLRFVSNLLPNTWSEIKGQAVLTSFCLIGLNLRELGPLASHMRWFIWLMAAGGTIYVFLYHEKYKVVELFFYLTMGFSPALVVTSMNNTDGLQELACGGLIYCLGVVFFKSDGIIPFAHAIWHLFVATAAAVHYYAIWKYLYRSPTDFMRHL

Target ORF information:

RefSeq Version	XM_006721795.3
Organism	Homo sapiens(human)
Definition	Homo sapiens monocyte to macrophage differentiation associated (MMD), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006721795.3

ORF Insert Sequence:

ATGCGGTTCA AGAATCGATT CCAGCGGTTC ATGAACCATC GAGCTCCAGC CAATGGCCGC 
TACAAGCCAA CTTGCTATGA ACATGCTGCT AACTGTTACA CACACGCATT CCTCATTGTT 
CCGGCCATCG TGGGCAGTGC CCTCCTCCAT CGGCTGTCTG ATGACTGCTG GGAAAAGATA 
ACAGCATGGA TTTATGGAAT GGGACTCTGT GCCCTCTTCA TCGTTTCTAC AGTATTTCAC 
ATTGTATCAT GGAAAAAGAG CCACTTAAGG ACAGTGGAGC ATTGTTTTCA CATGTGTGAT 
AGAATGGTTA TCTATTTCTT CATTGCTGCT TCTTATGCTC CATGGTTCTT CTCATTAAGG 
TTTGTAAGTA ATCTGCTCCC AAATACATGG TCAGAAATTA AAGGGCAAGC AGTTTTGACC 
TCATTCTGCC TAATAGGGTT AAATCTTCGT GAACTTGGAC CCCTGGCATC TCATATGCGT 
TGGTTTATCT GGCTCATGGC AGCTGGAGGA ACCATTTATG TATTTCTCTA CCATGAAAAA 
TATAAGGTGG TTGAACTCTT TTTCTATCTC ACAATGGGAT TCTCTCCAGC CTTGGTGGTG 
ACATCAATGA ACAACACCGA TGGACTTCAG GAACTTGCCT GTGGGGGCTT AATTTATTGC 
TTGGGAGTTG TGTTCTTCAA GAGTGATGGC ATCATTCCAT TTGCCCACGC CATCTGGCAC 
CTGTTTGTGG CCACGGCAGC TGCAGTGCAT TACTACGCCA TTTGGAAATA CCTTTACCGA 
AGTCCTACGG ACTTTATGCG GCATTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11.
The Journal of clinical investigation127(1)117-131(2017 Jan)
Tan X,Banerjee P,Guo HF,Ireland S,Pankova D,Ahn YH,Nikolaidis IM,Liu X,Zhao Y,Xue Y,Burns AR,Roybal J,Gibbons DL,Zal T,Creighton CJ,Ungar D,Wang Y,Kurie JM

Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer.
Biochemical and biophysical research communications450(1)844-50(2014 Jul)
Li W,He F

PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.
Cell research22(4)661-76(2012 Apr)
Jin T,Ding Q,Huang H,Xu D,Jiang Y,Zhou B,Li Z,Jiang X,He J,Liu W,Zhang Y,Pan Y,Wang Z,Thomas WG,Chen Y

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

New genetic associations detected in a host response study to hepatitis B vaccine.
Genes and immunity11(3)232-8(2010 Apr)
Davila S,Froeling FE,Tan A,Bonnard C,Boland GJ,Snippe H,Hibberd ML,Seielstad M

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MMD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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