SF3B3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SF3B3
Entrez Gene ID	23450
Full Name	splicing factor 3b subunit 3
Synonyms	RSE1,SAP130,SF3b130,STAF130
General protein information	Preferred Names splicing factor 3b subunit 3 Names splicing factor 3B subunit 3 SAP 130 pre-mRNA splicing factor SF3b, 130 kDa subunit spliceosome-associated protein 130
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q22.1
Summary	This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008].
Disorder MIM:	605592

mRNA and Protein(s)

mRNA	Protein	Name
NM_012426.5	NP_036558.3	splicing factor 3B subunit 3
NM_012426.4	NP_036558.3	splicing factor 3B subunit 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SF3B3	XP_536791.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005549	XP_315551.1
Homo sapiens (human)	SF3B3	NP_036558.3
Bos taurus (cattle)	SF3B3	NP_001071319.1
Rattus norvegicus (Norway rat)	Sf3b3	NP_001099657.2
Gallus gallus (chicken)	SF3B3	XP_004944176.1
Danio rerio (zebrafish)	LOC100334114	XP_002667683.2
Magnaporthe oryzae (rice blast fungus)	MGG_06457	XP_003717109.1
Neurospora crassa	NCU00396	XP_957282.2
Xenopus tropicalis (tropical clawed frog)	sf3b3	XP_002931705.1
	SF3B3	XP_002802591.1
Mus musculus (house mouse)	Sf3b3	NP_598714.1
Caenorhabditis elegans (roundworm)	teg-4	NP_491953.1
Arabidopsis thaliana (thale cress)	AT3G55220	NP_567016.1
Pan troglodytes (chimpanzee)	SF3B3	XP_511081.3
Danio rerio (zebrafish)	sf3b3	NP_998668.1
Drosophila melanogaster (fruit fly)	CG13900	NP_728546.1
Schizosaccharomyces pombe (fission yeast)	prp12	NP_594414.1
Arabidopsis thaliana (thale cress)	AT3G55200	NP_567015.1
Oryza sativa (rice)	Os02g0137400	NP_001045829.2

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the human activated spliceosome in three conformational states.
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Cell research(2018 Jan)

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.
Chen K, Xiao H, Zeng J, Yu G, Zhou H, Huang C, Yao W, Xiao W, Hu J, Guan W, Wu L, Huang J, Huang Q, Xu H, Ye Z
Clinical cancer research : an official journal of the American Association for Cancer Research23(13)3428-3441(2017 Jul)

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng T, Tsai JH, Puyang X, Seiler M, Peng S, Prajapati S, Aird D, Buonamici S, Caleb B, Chan B, Corson L, Feala J, Fekkes P, Gerard B, Karr C, Korpal M, Liu X, T Lowe J, Mizui Y, Palacino J, Park E, Smith PG, Subramanian V, Wu ZJ, Zou J, Yu L, Chicas A, Warmuth M, Larsen N, Zhu P
Nature communications815522(2017 May)

Detection of SF3B3 gene mutations in oral cancer by high resolution melting analysis.
Chang CC, Chang YS, Chan WL, Yeh KT, Wei RJ, Chang JG
Clinical laboratory60(12)2023-9(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our findings suggest a role for the elevated expression of SF3B3 in poor prognosis and tamoxifen resistance, leading to recurrence of estrogen receptor-positive breast cancer
Title: Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer.

Report detection of SF3B3 gene mutations in oral cancer using high resolution melting analysis.
Title: Detection of SF3B3 gene mutations in oral cancer by high resolution melting analysis.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following SF3B3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SF3B3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26573	NM_012426.5 Latest version!	Homo sapiens splicing factor 3b subunit 3 (SF3B3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
View Old Accession Versions >>
OHu26573	NM_012426.4	Homo sapiens splicing factor 3b subunit 3 (SF3B3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SF3B3 ( NM_012426.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036558.3 Homo sapiens splicing factor 3b subunit 3 (SF3B3), mRNA.

Price & Availability↑

CloneID	OHu26573
Clone ID Related Accession (Same CDS sequence)	NM_012426.5 , NM_012426.4
Accession Version	NM_012426.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	splicing factor 3B subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI465052.1, BC068974.1, AK291768.1, AC106804.4 and AW449427.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_012426.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.62084.1, SRR1803615.266366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302516.10/ ENSP00000305790.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTTCTGT ACAACTTAAC CTTGCAGAGA GCCACTGGCA TCAGCTTTGC CATTCATGGA 
AACTTTTCTG GAACCAAACA ACAAGAAATT GTTGTTTCCC GTGGGAAGAT CTTGGAGCTG 
CTTCGCCCAG ACCCCAACAC TGGCAAAGTA CATACCCTAC TCACTGTGGA AGTATTCGGT 
GTTATCCGGT CACTCATGGC CTTTAGGCTG ACAGGTGGCA CCAAAGACTA CATTGTAGTT 
GGCAGTGACT CTGGTCGAAT TGTTATTTTG GAATACCAGC CATCTAAGAA TATGTTTGAG 
AAGATTCACC AAGAAACCTT TGGCAAGAGT GGATGCCGTC GCATCGTTCC TGGCCAGTTC 
TTAGCTGTGG ATCCCAAAGG GCGAGCCGTT ATGATTAGTG CCATTGAGAA ACAGAAATTG 
GTGTATATTT TGAACAGAGA TGCTGCAGCC CGACTTACCA TTTCATCTCC CCTGGAAGCC 
CACAAAGCAA ACACTTTAGT GTATCATGTA GTTGGAGTAG ATGTCGGATT TGAAAATCCA 
ATGTTTGCTT GTCTGGAAAT GGATTATGAG GAAGCAGACA ATGATCCAAC AGGGGAAGCA 
GCAGCTAATA CCCAGCAGAC ACTTACTTTC TATGAGCTAG ACCTTGGTTT AAATCATGTG 
GTCCGAAAAT ACAGTGAACC TTTGGAGGAA CACGGCAACT TCCTTATTAC AGTTCCAGGA 
GGGTCAGATG GTCCAAGTGG AGTACTGATC TGCTCTGAAA ACTATATTAC TTACAAGAAC 
TTTGGTGACC AGCCAGATAT CCGCTGTCCA ATTCCCAGGA GGCGGAATGA CCTGGATGAC 
CCTGAAAGAG GAATGATTTT TGTCTGCTCT GCAACCCATA AAACCAAATC GATGTTCTTC 
TTTTTGGCTC AAACTGAGCA GGGAGATATC TTTAAGATCA CTTTGGAGAC AGATGAAGAT 
ATGGTTACTG AGATCCGGCT CAAATATTTT GATACTGTAC CCGTTGCTGC TGCCATGTGT 
GTGCTTAAAA CAGGGTTCCT TTTTGTAGCA TCAGAATTTG GAAACCATTA CTTATATCAA 
ATTGCACATC TTGGAGATGA TGATGAAGAA CCTGAGTTTT CATCAGCCAT GCCTCTGGAA 
GAAGGAGACA CATTCTTTTT TCAGCCAAGA CCACTTAAAA ACCTTGTGCT GGTTGATGAG 
TTGGACAGCC TCTCTCCCAT TCTGTTTTGC CAGATAGCTG ATCTGGCCAA TGAAGATACT 
CCACAGTTGT ATGTGGCCTG TGGTAGGGGA CCCCGATCAT CTCTGAGAGT CCTAAGACAT 
GGACTTGAGG TGTCAGAAAT GGCTGTTTCT GAGCTACCTG GTAACCCCAA CGCTGTCTGG 
ACAGTGCGTC GACACATTGA AGATGAGTTT GATGCCTACA TCATTGTGTC TTTCGTGAAT 
GCCACCCTAG TGTTGTCCAT TGGAGAAACT GTAGAAGAAG TGACTGACTC TGGGTTCCTG 
GGGACCACCC CGACCTTGTC CTGCTCCTTA TTAGGAGATG ATGCCTTGGT GCAGGTCTAT 
CCAGATGGCA TTCGGCACAT ACGAGCAGAC AAGAGAGTCA ATGAGTGGAA GACCCCTGGA 
AAGAAAACAA TTGTGAAGTG TGCAGTGAAC CAGCGACAAG TGGTGATTGC CCTGACAGGA 
GGAGAGCTGG TCTATTTCGA GATGGATCCT TCAGGACAGC TGAATGAGTA CACAGAACGG 
AAGGAGATGT CAGCAGATGT GGTGTGCATG AGTCTGGCCA ATGTACCCCC TGGAGAGCAG 
CGGTCTCGCT TCCTGGCTGT GGGGCTTGTG GACAACACTG TCAGAATCAT CTCCCTGGAT 
CCCTCAGACT GTTTGCAACC TCTAAGCATG CAGGCTCTCC CAGCCCAGCC TGAGTCCTTG 
TGTATCGTGG AAATGGGTGG GACTGAGAAG CAGGATGAGC TGGGTGAGAG GGGCTCGATT 
GGCTTCCTAT ACCTGAATAT TGGGCTACAG AACGGTGTGC TGCTGAGGAC TGTCTTGGAC 
CCTGTCACTG GGGATTTGTC TGATACTCGC ACTCGGTACC TGGGGTCCCG TCCTGTGAAG 
CTCTTCCGAG TCCGAATGCA AGGCCAGGAG GCAGTATTGG CCATGTCAAG CCGCTCATGG 
TTGAGCTATT CTTACCAATC TCGCTTCCAT CTCACCCCAC TGTCTTACGA GACACTGGAA 
TTTGCATCGG GTTTTGCCTC GGAACAGTGT CCCGAGGGCA TTGTGGCCAT CTCCACCAAC 
ACCCTACGGA TTTTGGCATT AGAGAAGCTC GGTGCTGTCT TCAATCAAGT AGCCTTCCCA 
CTGCAGTACA CACCCAGGAA ATTTGTCATC CACCCTGAGA GTAACAACCT TATTATCATT 
GAAACGGACC ACAATGCCTA CACTGAGGCC ACGAAAGCTC AGAGAAAGCA GCAGATGGCA 
GAGGAAATGG TGGAAGCAGC AGGGGAGGAT GAGCGGGAGC TGGCCGCAGA GATGGCAGCA 
GCATTCCTCA ATGAAAACCT CCCTGAATCC ATCTTTGGAG CTCCCAAGGC TGGCAATGGG 
CAGTGGGCCT CTGTGATCCG AGTGATGAAT CCCATTCAAG GGAACACACT GGACCTTGTC 
CAGCTGGAAC AGAATGAGGC AGCTTTTAGT GTGGCTGTGT GCAGGTTTTC CAACACTGGT 
GAAGACTGGT ATGTGCTGGT GGGTGTGGCC AAGGACCTGA TACTAAACCC CCGATCTGTG 
GCAGGGGGCT TCGTCTATAC TTACAAGCTT GTGAACAATG GGGAAAAACT GGAGTTTTTG 
CACAAGACTC CTGTGGAAGA GGTCCCTGCT GCTATTGCCC CATTCCAGGG GAGGGTGTTG 
ATTGGTGTGG GGAAGCTGTT GCGTGTCTAT GACCTGGGAA AGAAGAAGTT ACTCCGAAAA 
TGTGAGAATA AGCATATTGC CAATTATATC TCTGGGATCC AGACTATCGG ACATAGGGTA 
ATTGTATCTG ATGTCCAAGA AAGTTTCATC TGGGTTCGCT ACAAGCGTAA TGAAAACCAG 
CTTATCATCT TTGCTGATGA TACCTACCCC CGATGGGTCA CTACAGCCAG CCTCCTGGAC 
TATGACACTG TGGCTGGGGC AGACAAGTTT GGCAACATAT GTGTGGTGAG GCTCCCACCT 
AACACCAATG ATGAAGTAGA TGAGGATCCT ACAGGAAACA AAGCCCTGTG GGACCGTGGC 
TTGCTCAATG GGGCCTCCCA GAAGGCAGAG GTGATCATGA ACTACCATGT CGGGGAGACG 
GTGCTGTCCT TGCAGAAGAC CACGCTGATC CCTGGAGGCT CAGAATCACT TGTCTATACC 
ACCTTGTCTG GAGGAATTGG CATCCTTGTG CCATTCACGT CCCATGAGGA CCATGACTTC 
TTCCAGCATG TGGAAATGCA CCTGCGGTCT GAACATCCCC CTCTCTGTGG GCGGGACCAC 
CTCAGCTTTC GCTCCTACTA CTTCCCTGTG AAGAATGTGA TTGATGGAGA CCTCTGTGAG 
CAGTTCAATT CCATGGAACC CAACAAACAA AAGAACGTCT CTGAAGAACT GGACCGAACC 
CCACCCGAAG TGTCCAAGAA ACTCGAGGAT ATCCGGACCC GCTACGCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036558.3
CDS	184..3837
Translation	MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF

Target ORF information:

RefSeq Version	NM_012426.5
Organism	Homo sapiens(human)
Definition	Homo sapiens splicing factor 3b subunit 3 (SF3B3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012426.5

ORF Insert Sequence:

ATGTTTCTGT ACAACTTAAC CTTGCAGAGA GCCACTGGCA TCAGCTTTGC CATTCATGGA 
AACTTTTCTG GAACCAAACA ACAAGAAATT GTTGTTTCCC GTGGGAAGAT CTTGGAGCTG 
CTTCGCCCAG ACCCCAACAC TGGCAAAGTA CATACCCTAC TCACTGTGGA AGTATTCGGT 
GTTATCCGGT CACTCATGGC CTTTAGGCTG ACAGGTGGCA CCAAAGACTA CATTGTAGTT 
GGCAGTGACT CTGGTCGAAT TGTTATTTTG GAATACCAGC CATCTAAGAA TATGTTTGAG 
AAGATTCACC AAGAAACCTT TGGCAAGAGT GGATGCCGTC GCATCGTTCC TGGCCAGTTC 
TTAGCTGTGG ATCCCAAAGG GCGAGCCGTT ATGATTAGTG CCATTGAGAA ACAGAAATTG 
GTGTATATTT TGAACAGAGA TGCTGCAGCC CGACTTACCA TTTCATCTCC CCTGGAAGCC 
CACAAAGCAA ACACTTTAGT GTATCATGTA GTTGGAGTAG ATGTCGGATT TGAAAATCCA 
ATGTTTGCTT GTCTGGAAAT GGATTATGAG GAAGCAGACA ATGATCCAAC AGGGGAAGCA 
GCAGCTAATA CCCAGCAGAC ACTTACTTTC TATGAGCTAG ACCTTGGTTT AAATCATGTG 
GTCCGAAAAT ACAGTGAACC TTTGGAGGAA CACGGCAACT TCCTTATTAC AGTTCCAGGA 
GGGTCAGATG GTCCAAGTGG AGTACTGATC TGCTCTGAAA ACTATATTAC TTACAAGAAC 
TTTGGTGACC AGCCAGATAT CCGCTGTCCA ATTCCCAGGA GGCGGAATGA CCTGGATGAC 
CCTGAAAGAG GAATGATTTT TGTCTGCTCT GCAACCCATA AAACCAAATC GATGTTCTTC 
TTTTTGGCTC AAACTGAGCA GGGAGATATC TTTAAGATCA CTTTGGAGAC AGATGAAGAT 
ATGGTTACTG AGATCCGGCT CAAATATTTT GATACTGTAC CCGTTGCTGC TGCCATGTGT 
GTGCTTAAAA CAGGGTTCCT TTTTGTAGCA TCAGAATTTG GAAACCATTA CTTATATCAA 
ATTGCACATC TTGGAGATGA TGATGAAGAA CCTGAGTTTT CATCAGCCAT GCCTCTGGAA 
GAAGGAGACA CATTCTTTTT TCAGCCAAGA CCACTTAAAA ACCTTGTGCT GGTTGATGAG 
TTGGACAGCC TCTCTCCCAT TCTGTTTTGC CAGATAGCTG ATCTGGCCAA TGAAGATACT 
CCACAGTTGT ATGTGGCCTG TGGTAGGGGA CCCCGATCAT CTCTGAGAGT CCTAAGACAT 
GGACTTGAGG TGTCAGAAAT GGCTGTTTCT GAGCTACCTG GTAACCCCAA CGCTGTCTGG 
ACAGTGCGTC GACACATTGA AGATGAGTTT GATGCCTACA TCATTGTGTC TTTCGTGAAT 
GCCACCCTAG TGTTGTCCAT TGGAGAAACT GTAGAAGAAG TGACTGACTC TGGGTTCCTG 
GGGACCACCC CGACCTTGTC CTGCTCCTTA TTAGGAGATG ATGCCTTGGT GCAGGTCTAT 
CCAGATGGCA TTCGGCACAT ACGAGCAGAC AAGAGAGTCA ATGAGTGGAA GACCCCTGGA 
AAGAAAACAA TTGTGAAGTG TGCAGTGAAC CAGCGACAAG TGGTGATTGC CCTGACAGGA 
GGAGAGCTGG TCTATTTCGA GATGGATCCT TCAGGACAGC TGAATGAGTA CACAGAACGG 
AAGGAGATGT CAGCAGATGT GGTGTGCATG AGTCTGGCCA ATGTACCCCC TGGAGAGCAG 
CGGTCTCGCT TCCTGGCTGT GGGGCTTGTG GACAACACTG TCAGAATCAT CTCCCTGGAT 
CCCTCAGACT GTTTGCAACC TCTAAGCATG CAGGCTCTCC CAGCCCAGCC TGAGTCCTTG 
TGTATCGTGG AAATGGGTGG GACTGAGAAG CAGGATGAGC TGGGTGAGAG GGGCTCGATT 
GGCTTCCTAT ACCTGAATAT TGGGCTACAG AACGGTGTGC TGCTGAGGAC TGTCTTGGAC 
CCTGTCACTG GGGATTTGTC TGATACTCGC ACTCGGTACC TGGGGTCCCG TCCTGTGAAG 
CTCTTCCGAG TCCGAATGCA AGGCCAGGAG GCAGTATTGG CCATGTCAAG CCGCTCATGG 
TTGAGCTATT CTTACCAATC TCGCTTCCAT CTCACCCCAC TGTCTTACGA GACACTGGAA 
TTTGCATCGG GTTTTGCCTC GGAACAGTGT CCCGAGGGCA TTGTGGCCAT CTCCACCAAC 
ACCCTACGGA TTTTGGCATT AGAGAAGCTC GGTGCTGTCT TCAATCAAGT AGCCTTCCCA 
CTGCAGTACA CACCCAGGAA ATTTGTCATC CACCCTGAGA GTAACAACCT TATTATCATT 
GAAACGGACC ACAATGCCTA CACTGAGGCC ACGAAAGCTC AGAGAAAGCA GCAGATGGCA 
GAGGAAATGG TGGAAGCAGC AGGGGAGGAT GAGCGGGAGC TGGCCGCAGA GATGGCAGCA 
GCATTCCTCA ATGAAAACCT CCCTGAATCC ATCTTTGGAG CTCCCAAGGC TGGCAATGGG 
CAGTGGGCCT CTGTGATCCG AGTGATGAAT CCCATTCAAG GGAACACACT GGACCTTGTC 
CAGCTGGAAC AGAATGAGGC AGCTTTTAGT GTGGCTGTGT GCAGGTTTTC CAACACTGGT 
GAAGACTGGT ATGTGCTGGT GGGTGTGGCC AAGGACCTGA TACTAAACCC CCGATCTGTG 
GCAGGGGGCT TCGTCTATAC TTACAAGCTT GTGAACAATG GGGAAAAACT GGAGTTTTTG 
CACAAGACTC CTGTGGAAGA GGTCCCTGCT GCTATTGCCC CATTCCAGGG GAGGGTGTTG 
ATTGGTGTGG GGAAGCTGTT GCGTGTCTAT GACCTGGGAA AGAAGAAGTT ACTCCGAAAA 
TGTGAGAATA AGCATATTGC CAATTATATC TCTGGGATCC AGACTATCGG ACATAGGGTA 
ATTGTATCTG ATGTCCAAGA AAGTTTCATC TGGGTTCGCT ACAAGCGTAA TGAAAACCAG 
CTTATCATCT TTGCTGATGA TACCTACCCC CGATGGGTCA CTACAGCCAG CCTCCTGGAC 
TATGACACTG TGGCTGGGGC AGACAAGTTT GGCAACATAT GTGTGGTGAG GCTCCCACCT 
AACACCAATG ATGAAGTAGA TGAGGATCCT ACAGGAAACA AAGCCCTGTG GGACCGTGGC 
TTGCTCAATG GGGCCTCCCA GAAGGCAGAG GTGATCATGA ACTACCATGT CGGGGAGACG 
GTGCTGTCCT TGCAGAAGAC CACGCTGATC CCTGGAGGCT CAGAATCACT TGTCTATACC 
ACCTTGTCTG GAGGAATTGG CATCCTTGTG CCATTCACGT CCCATGAGGA CCATGACTTC 
TTCCAGCATG TGGAAATGCA CCTGCGGTCT GAACATCCCC CTCTCTGTGG GCGGGACCAC 
CTCAGCTTTC GCTCCTACTA CTTCCCTGTG AAGAATGTGA TTGATGGAGA CCTCTGTGAG 
CAGTTCAATT CCATGGAACC CAACAAACAA AAGAACGTCT CTGAAGAACT GGACCGAACC 
CCACCCGAAG TGTCCAAGAA ACTCGAGGAT ATCCGGACCC GCTACGCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SF3B3 ( NM_012426.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036558.3 Homo sapiens splicing factor 3b subunit 3 (SF3B3), mRNA.

Price & Availability↑

CloneID	OHu26573
Clone ID Related Accession (Same CDS sequence)	NM_012426.5 , NM_012426.4
Accession Version	NM_012426.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-30
Organism	Homo sapiens(human)
Product	splicing factor 3B subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI465052.1, BC068974.1, AK291768.1, AC106804.4 and AW449427.1. This sequence is a reference standard in the RefSeqGene project. On Mar 24, 2009 this sequence version replaced NM_012426.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.4234.1, SRR1803615.266366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTCTGT ACAACTTAAC CTTGCAGAGA GCCACTGGCA TCAGCTTTGC CATTCATGGA 
AACTTTTCTG GAACCAAACA ACAAGAAATT GTTGTTTCCC GTGGGAAGAT CTTGGAGCTG 
CTTCGCCCAG ACCCCAACAC TGGCAAAGTA CATACCCTAC TCACTGTGGA AGTATTCGGT 
GTTATCCGGT CACTCATGGC CTTTAGGCTG ACAGGTGGCA CCAAAGACTA CATTGTAGTT 
GGCAGTGACT CTGGTCGAAT TGTTATTTTG GAATACCAGC CATCTAAGAA TATGTTTGAG 
AAGATTCACC AAGAAACCTT TGGCAAGAGT GGATGCCGTC GCATCGTTCC TGGCCAGTTC 
TTAGCTGTGG ATCCCAAAGG GCGAGCCGTT ATGATTAGTG CCATTGAGAA ACAGAAATTG 
GTGTATATTT TGAACAGAGA TGCTGCAGCC CGACTTACCA TTTCATCTCC CCTGGAAGCC 
CACAAAGCAA ACACTTTAGT GTATCATGTA GTTGGAGTAG ATGTCGGATT TGAAAATCCA 
ATGTTTGCTT GTCTGGAAAT GGATTATGAG GAAGCAGACA ATGATCCAAC AGGGGAAGCA 
GCAGCTAATA CCCAGCAGAC ACTTACTTTC TATGAGCTAG ACCTTGGTTT AAATCATGTG 
GTCCGAAAAT ACAGTGAACC TTTGGAGGAA CACGGCAACT TCCTTATTAC AGTTCCAGGA 
GGGTCAGATG GTCCAAGTGG AGTACTGATC TGCTCTGAAA ACTATATTAC TTACAAGAAC 
TTTGGTGACC AGCCAGATAT CCGCTGTCCA ATTCCCAGGA GGCGGAATGA CCTGGATGAC 
CCTGAAAGAG GAATGATTTT TGTCTGCTCT GCAACCCATA AAACCAAATC GATGTTCTTC 
TTTTTGGCTC AAACTGAGCA GGGAGATATC TTTAAGATCA CTTTGGAGAC AGATGAAGAT 
ATGGTTACTG AGATCCGGCT CAAATATTTT GATACTGTAC CCGTTGCTGC TGCCATGTGT 
GTGCTTAAAA CAGGGTTCCT TTTTGTAGCA TCAGAATTTG GAAACCATTA CTTATATCAA 
ATTGCACATC TTGGAGATGA TGATGAAGAA CCTGAGTTTT CATCAGCCAT GCCTCTGGAA 
GAAGGAGACA CATTCTTTTT TCAGCCAAGA CCACTTAAAA ACCTTGTGCT GGTTGATGAG 
TTGGACAGCC TCTCTCCCAT TCTGTTTTGC CAGATAGCTG ATCTGGCCAA TGAAGATACT 
CCACAGTTGT ATGTGGCCTG TGGTAGGGGA CCCCGATCAT CTCTGAGAGT CCTAAGACAT 
GGACTTGAGG TGTCAGAAAT GGCTGTTTCT GAGCTACCTG GTAACCCCAA CGCTGTCTGG 
ACAGTGCGTC GACACATTGA AGATGAGTTT GATGCCTACA TCATTGTGTC TTTCGTGAAT 
GCCACCCTAG TGTTGTCCAT TGGAGAAACT GTAGAAGAAG TGACTGACTC TGGGTTCCTG 
GGGACCACCC CGACCTTGTC CTGCTCCTTA TTAGGAGATG ATGCCTTGGT GCAGGTCTAT 
CCAGATGGCA TTCGGCACAT ACGAGCAGAC AAGAGAGTCA ATGAGTGGAA GACCCCTGGA 
AAGAAAACAA TTGTGAAGTG TGCAGTGAAC CAGCGACAAG TGGTGATTGC CCTGACAGGA 
GGAGAGCTGG TCTATTTCGA GATGGATCCT TCAGGACAGC TGAATGAGTA CACAGAACGG 
AAGGAGATGT CAGCAGATGT GGTGTGCATG AGTCTGGCCA ATGTACCCCC TGGAGAGCAG 
CGGTCTCGCT TCCTGGCTGT GGGGCTTGTG GACAACACTG TCAGAATCAT CTCCCTGGAT 
CCCTCAGACT GTTTGCAACC TCTAAGCATG CAGGCTCTCC CAGCCCAGCC TGAGTCCTTG 
TGTATCGTGG AAATGGGTGG GACTGAGAAG CAGGATGAGC TGGGTGAGAG GGGCTCGATT 
GGCTTCCTAT ACCTGAATAT TGGGCTACAG AACGGTGTGC TGCTGAGGAC TGTCTTGGAC 
CCTGTCACTG GGGATTTGTC TGATACTCGC ACTCGGTACC TGGGGTCCCG TCCTGTGAAG 
CTCTTCCGAG TCCGAATGCA AGGCCAGGAG GCAGTATTGG CCATGTCAAG CCGCTCATGG 
TTGAGCTATT CTTACCAATC TCGCTTCCAT CTCACCCCAC TGTCTTACGA GACACTGGAA 
TTTGCATCGG GTTTTGCCTC GGAACAGTGT CCCGAGGGCA TTGTGGCCAT CTCCACCAAC 
ACCCTACGGA TTTTGGCATT AGAGAAGCTC GGTGCTGTCT TCAATCAAGT AGCCTTCCCA 
CTGCAGTACA CACCCAGGAA ATTTGTCATC CACCCTGAGA GTAACAACCT TATTATCATT 
GAAACGGACC ACAATGCCTA CACTGAGGCC ACGAAAGCTC AGAGAAAGCA GCAGATGGCA 
GAGGAAATGG TGGAAGCAGC AGGGGAGGAT GAGCGGGAGC TGGCCGCAGA GATGGCAGCA 
GCATTCCTCA ATGAAAACCT CCCTGAATCC ATCTTTGGAG CTCCCAAGGC TGGCAATGGG 
CAGTGGGCCT CTGTGATCCG AGTGATGAAT CCCATTCAAG GGAACACACT GGACCTTGTC 
CAGCTGGAAC AGAATGAGGC AGCTTTTAGT GTGGCTGTGT GCAGGTTTTC CAACACTGGT 
GAAGACTGGT ATGTGCTGGT GGGTGTGGCC AAGGACCTGA TACTAAACCC CCGATCTGTG 
GCAGGGGGCT TCGTCTATAC TTACAAGCTT GTGAACAATG GGGAAAAACT GGAGTTTTTG 
CACAAGACTC CTGTGGAAGA GGTCCCTGCT GCTATTGCCC CATTCCAGGG GAGGGTGTTG 
ATTGGTGTGG GGAAGCTGTT GCGTGTCTAT GACCTGGGAA AGAAGAAGTT ACTCCGAAAA 
TGTGAGAATA AGCATATTGC CAATTATATC TCTGGGATCC AGACTATCGG ACATAGGGTA 
ATTGTATCTG ATGTCCAAGA AAGTTTCATC TGGGTTCGCT ACAAGCGTAA TGAAAACCAG 
CTTATCATCT TTGCTGATGA TACCTACCCC CGATGGGTCA CTACAGCCAG CCTCCTGGAC 
TATGACACTG TGGCTGGGGC AGACAAGTTT GGCAACATAT GTGTGGTGAG GCTCCCACCT 
AACACCAATG ATGAAGTAGA TGAGGATCCT ACAGGAAACA AAGCCCTGTG GGACCGTGGC 
TTGCTCAATG GGGCCTCCCA GAAGGCAGAG GTGATCATGA ACTACCATGT CGGGGAGACG 
GTGCTGTCCT TGCAGAAGAC CACGCTGATC CCTGGAGGCT CAGAATCACT TGTCTATACC 
ACCTTGTCTG GAGGAATTGG CATCCTTGTG CCATTCACGT CCCATGAGGA CCATGACTTC 
TTCCAGCATG TGGAAATGCA CCTGCGGTCT GAACATCCCC CTCTCTGTGG GCGGGACCAC 
CTCAGCTTTC GCTCCTACTA CTTCCCTGTG AAGAATGTGA TTGATGGAGA CCTCTGTGAG 
CAGTTCAATT CCATGGAACC CAACAAACAA AAGAACGTCT CTGAAGAACT GGACCGAACC 
CCACCCGAAG TGTCCAAGAA ACTCGAGGAT ATCCGGACCC GCTACGCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036558.3
CDS	212..3865
Translation	MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF

Target ORF information:

RefSeq Version	NM_012426.4
Organism	Homo sapiens(human)
Definition	Homo sapiens splicing factor 3b subunit 3 (SF3B3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012426.4

ORF Insert Sequence:

ATGTTTCTGT ACAACTTAAC CTTGCAGAGA GCCACTGGCA TCAGCTTTGC CATTCATGGA 
AACTTTTCTG GAACCAAACA ACAAGAAATT GTTGTTTCCC GTGGGAAGAT CTTGGAGCTG 
CTTCGCCCAG ACCCCAACAC TGGCAAAGTA CATACCCTAC TCACTGTGGA AGTATTCGGT 
GTTATCCGGT CACTCATGGC CTTTAGGCTG ACAGGTGGCA CCAAAGACTA CATTGTAGTT 
GGCAGTGACT CTGGTCGAAT TGTTATTTTG GAATACCAGC CATCTAAGAA TATGTTTGAG 
AAGATTCACC AAGAAACCTT TGGCAAGAGT GGATGCCGTC GCATCGTTCC TGGCCAGTTC 
TTAGCTGTGG ATCCCAAAGG GCGAGCCGTT ATGATTAGTG CCATTGAGAA ACAGAAATTG 
GTGTATATTT TGAACAGAGA TGCTGCAGCC CGACTTACCA TTTCATCTCC CCTGGAAGCC 
CACAAAGCAA ACACTTTAGT GTATCATGTA GTTGGAGTAG ATGTCGGATT TGAAAATCCA 
ATGTTTGCTT GTCTGGAAAT GGATTATGAG GAAGCAGACA ATGATCCAAC AGGGGAAGCA 
GCAGCTAATA CCCAGCAGAC ACTTACTTTC TATGAGCTAG ACCTTGGTTT AAATCATGTG 
GTCCGAAAAT ACAGTGAACC TTTGGAGGAA CACGGCAACT TCCTTATTAC AGTTCCAGGA 
GGGTCAGATG GTCCAAGTGG AGTACTGATC TGCTCTGAAA ACTATATTAC TTACAAGAAC 
TTTGGTGACC AGCCAGATAT CCGCTGTCCA ATTCCCAGGA GGCGGAATGA CCTGGATGAC 
CCTGAAAGAG GAATGATTTT TGTCTGCTCT GCAACCCATA AAACCAAATC GATGTTCTTC 
TTTTTGGCTC AAACTGAGCA GGGAGATATC TTTAAGATCA CTTTGGAGAC AGATGAAGAT 
ATGGTTACTG AGATCCGGCT CAAATATTTT GATACTGTAC CCGTTGCTGC TGCCATGTGT 
GTGCTTAAAA CAGGGTTCCT TTTTGTAGCA TCAGAATTTG GAAACCATTA CTTATATCAA 
ATTGCACATC TTGGAGATGA TGATGAAGAA CCTGAGTTTT CATCAGCCAT GCCTCTGGAA 
GAAGGAGACA CATTCTTTTT TCAGCCAAGA CCACTTAAAA ACCTTGTGCT GGTTGATGAG 
TTGGACAGCC TCTCTCCCAT TCTGTTTTGC CAGATAGCTG ATCTGGCCAA TGAAGATACT 
CCACAGTTGT ATGTGGCCTG TGGTAGGGGA CCCCGATCAT CTCTGAGAGT CCTAAGACAT 
GGACTTGAGG TGTCAGAAAT GGCTGTTTCT GAGCTACCTG GTAACCCCAA CGCTGTCTGG 
ACAGTGCGTC GACACATTGA AGATGAGTTT GATGCCTACA TCATTGTGTC TTTCGTGAAT 
GCCACCCTAG TGTTGTCCAT TGGAGAAACT GTAGAAGAAG TGACTGACTC TGGGTTCCTG 
GGGACCACCC CGACCTTGTC CTGCTCCTTA TTAGGAGATG ATGCCTTGGT GCAGGTCTAT 
CCAGATGGCA TTCGGCACAT ACGAGCAGAC AAGAGAGTCA ATGAGTGGAA GACCCCTGGA 
AAGAAAACAA TTGTGAAGTG TGCAGTGAAC CAGCGACAAG TGGTGATTGC CCTGACAGGA 
GGAGAGCTGG TCTATTTCGA GATGGATCCT TCAGGACAGC TGAATGAGTA CACAGAACGG 
AAGGAGATGT CAGCAGATGT GGTGTGCATG AGTCTGGCCA ATGTACCCCC TGGAGAGCAG 
CGGTCTCGCT TCCTGGCTGT GGGGCTTGTG GACAACACTG TCAGAATCAT CTCCCTGGAT 
CCCTCAGACT GTTTGCAACC TCTAAGCATG CAGGCTCTCC CAGCCCAGCC TGAGTCCTTG 
TGTATCGTGG AAATGGGTGG GACTGAGAAG CAGGATGAGC TGGGTGAGAG GGGCTCGATT 
GGCTTCCTAT ACCTGAATAT TGGGCTACAG AACGGTGTGC TGCTGAGGAC TGTCTTGGAC 
CCTGTCACTG GGGATTTGTC TGATACTCGC ACTCGGTACC TGGGGTCCCG TCCTGTGAAG 
CTCTTCCGAG TCCGAATGCA AGGCCAGGAG GCAGTATTGG CCATGTCAAG CCGCTCATGG 
TTGAGCTATT CTTACCAATC TCGCTTCCAT CTCACCCCAC TGTCTTACGA GACACTGGAA 
TTTGCATCGG GTTTTGCCTC GGAACAGTGT CCCGAGGGCA TTGTGGCCAT CTCCACCAAC 
ACCCTACGGA TTTTGGCATT AGAGAAGCTC GGTGCTGTCT TCAATCAAGT AGCCTTCCCA 
CTGCAGTACA CACCCAGGAA ATTTGTCATC CACCCTGAGA GTAACAACCT TATTATCATT 
GAAACGGACC ACAATGCCTA CACTGAGGCC ACGAAAGCTC AGAGAAAGCA GCAGATGGCA 
GAGGAAATGG TGGAAGCAGC AGGGGAGGAT GAGCGGGAGC TGGCCGCAGA GATGGCAGCA 
GCATTCCTCA ATGAAAACCT CCCTGAATCC ATCTTTGGAG CTCCCAAGGC TGGCAATGGG 
CAGTGGGCCT CTGTGATCCG AGTGATGAAT CCCATTCAAG GGAACACACT GGACCTTGTC 
CAGCTGGAAC AGAATGAGGC AGCTTTTAGT GTGGCTGTGT GCAGGTTTTC CAACACTGGT 
GAAGACTGGT ATGTGCTGGT GGGTGTGGCC AAGGACCTGA TACTAAACCC CCGATCTGTG 
GCAGGGGGCT TCGTCTATAC TTACAAGCTT GTGAACAATG GGGAAAAACT GGAGTTTTTG 
CACAAGACTC CTGTGGAAGA GGTCCCTGCT GCTATTGCCC CATTCCAGGG GAGGGTGTTG 
ATTGGTGTGG GGAAGCTGTT GCGTGTCTAT GACCTGGGAA AGAAGAAGTT ACTCCGAAAA 
TGTGAGAATA AGCATATTGC CAATTATATC TCTGGGATCC AGACTATCGG ACATAGGGTA 
ATTGTATCTG ATGTCCAAGA AAGTTTCATC TGGGTTCGCT ACAAGCGTAA TGAAAACCAG 
CTTATCATCT TTGCTGATGA TACCTACCCC CGATGGGTCA CTACAGCCAG CCTCCTGGAC 
TATGACACTG TGGCTGGGGC AGACAAGTTT GGCAACATAT GTGTGGTGAG GCTCCCACCT 
AACACCAATG ATGAAGTAGA TGAGGATCCT ACAGGAAACA AAGCCCTGTG GGACCGTGGC 
TTGCTCAATG GGGCCTCCCA GAAGGCAGAG GTGATCATGA ACTACCATGT CGGGGAGACG 
GTGCTGTCCT TGCAGAAGAC CACGCTGATC CCTGGAGGCT CAGAATCACT TGTCTATACC 
ACCTTGTCTG GAGGAATTGG CATCCTTGTG CCATTCACGT CCCATGAGGA CCATGACTTC 
TTCCAGCATG TGGAAATGCA CCTGCGGTCT GAACATCCCC CTCTCTGTGG GCGGGACCAC 
CTCAGCTTTC GCTCCTACTA CTTCCCTGTG AAGAATGTGA TTGATGGAGA CCTCTGTGAG 
CAGTTCAATT CCATGGAACC CAACAAACAA AAGAACGTCT CTGAAGAACT GGACCGAACC 
CCACCCGAAG TGTCCAAGAA ACTCGAGGAT ATCCGGACCC GCTACGCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the human activated spliceosome in three conformational states.
Cell research(2018 Jan)
Zhang X,Yan C,Zhan X,Li L,Lei J,Shi Y

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research23(13)3428-3441(2017 Jul)
Chen K,Xiao H,Zeng J,Yu G,Zhou H,Huang C,Yao W,Xiao W,Hu J,Guan W,Wu L,Huang J,Huang Q,Xu H,Ye Z

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nature communications815522(2017 May)
Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ,Zou J,Yu L,Chicas A,Warmuth M,Larsen N,Zhu P

Detection of SF3B3 gene mutations in oral cancer by high resolution melting analysis.
Clinical laboratory60(12)2023-9(2014)
Chang CC,Chang YS,Chan WL,Yeh KT,Wei RJ,Chang JG

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SF3B3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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