Gene Symbol | TARDBP |
Entrez Gene ID | 23435 |
Full Name | TAR DNA binding protein |
Synonyms | ALS10,TDP-43 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Amyotrophic lateral sclerosis 10, with or without FTD, 612069 (3); Frontotemporal lobar degeneration, TARDBP-related, 612069 (3) |