RHOQ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RHOQ
Entrez Gene ID	23433
Full Name	ras homolog family member Q
Synonyms	ARHQ,HEL-S-42,RASL7A,TC10,TC10A
General protein information	Preferred Names ras homolog family member Q Names rho-related GTP-binding protein RhoQ RAS-like, family 7, member A epididymis secretory protein Li 42 ras homolog gene family, member Q ras-like protein TC10 ras-like protein family member 7A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p21
Summary	This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011].
Disorder MIM:	605857

mRNA and Protein(s)

mRNA	Protein	Name
NM_012249.4	NP_036381.2	rho-related GTP-binding protein RhoQ precursor
XM_017003716.1	XP_016859205.1	rho-related GTP-binding protein RhoQ isoform X2
XM_005264229.2	XP_005264286.1	rho-related GTP-binding protein RhoQ isoform X3
XM_011532726.2	XP_011531028.1	rho-related GTP-binding protein RhoQ isoform X1
NM_012249.3	NP_036381.2	rho-related GTP-binding protein RhoQ precursor
XM_011532728.2	XP_011531030.1	rho-related GTP-binding protein RhoQ isoform X4

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rhoq	NP_445974.1
Canis lupus familiaris (dog)	RHOQ	XP_531808.3
Bos taurus (cattle)	RHOQ	NP_001192427.1
Gallus gallus (chicken)	RHOQ	NP_989792.1
Homo sapiens (human)	RHOQ	NP_036381.2
Pan troglodytes (chimpanzee)	RHOQ	XP_001143008.2
Mus musculus (house mouse)	Rhoq	NP_663466.2
Danio rerio (zebrafish)	rhoq	NP_956112.1

Gene Ontology
Bibliography

Related articles in PubMed

RNA editing in RHOQ promotes invasion potential in colorectal cancer.
Han SW, Kim HP, Shin JY, Jeong EG, Lee WC, Kim KY, Park SY, Lee DW, Won JK, Jeong SY, Park KJ, Park JG, Kang GH, Seo JS, Kim JI, Kim TY
The Journal of experimental medicine211(4)613-21(2014 Apr)

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.
Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS, Papadopoulos T
Proceedings of the National Academy of Sciences of the United States of America110(51)20795-800(2013 Dec)

GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.
Fujita A, Koinuma S, Yasuda S, Nagai H, Kamiguchi H, Wada N, Nakamura T
PloS one8(11)e79689(2013)

Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ
BMC genetics1126(2010 Apr)

TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.
Coisy-Quivy M, Touzet O, Bourret A, Hipskind RA, Mercier J, Fort P, Philips A
Journal of cell science122(Pt 7)947-56(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Novel tumor-associated increase of RNA editing in ras homologue family member Q (RHOQ) transcripts, is reported.
Title: RNA editing in RHOQ promotes invasion potential in colorectal cancer.

The enhancement of Cb-induced gephyrin clustering by GTP-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors
Title: Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.

Exocytosis of Rab11- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth
Title: GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Identification of type 2 diabetes-associated combination of SNPs using support vector machine.

These findings reveal a novel signaling pathway in human skeletal muscle that involves obscurin and the Rho GTPase TC10 and implicate this pathway in new sarcomere formation.
Title: TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.

The following RHOQ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RHOQ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09008	NM_012249.4 Latest version!	Homo sapiens ras homolog family member Q (RHOQ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu35338	XM_005264229.2 Latest version!	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu66186	XM_011532726.2 Latest version!	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu66187	XM_017003716.1 Latest version!	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu66188	XM_011532728.2 Latest version!	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu09008	NM_012249.3	Homo sapiens ras homolog family member Q (RHOQ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RHOQ ( NM_012249.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036381.2 Homo sapiens ras homolog family member Q (RHOQ), mRNA.

Price & Availability↑

CloneID	OHu09008
Clone ID Related Accession (Same CDS sequence)	NM_012249.4 , NM_012249.3
Accession Version	NM_012249.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoQ precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018682.4 and BC056154.1. On Nov 23, 2018 this sequence version replaced NM_012249.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU794657.1, SRR1660807.165339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000238738.9/ ENSP00000238738.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGATAGGAGC ATGCTGCTAT 
GTGGAATGTT CAGCTTTAAC CCAGAAGGGA TTGAAGACTG TTTTTGATGA GGCTATCATA 
GCCATTTTAA CTCCAAAGAA ACACACTGTA AAAAAAAGAA TAGGATCAAG ATGTATAAAC 
TGTTGTTTAA TTACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036381.2
CDS	558..1175
Translation	MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT

Target ORF information:

RefSeq Version	NM_012249.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member Q (RHOQ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012249.4

ORF Insert Sequence:

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGATAGGAGC ATGCTGCTAT 
GTGGAATGTT CAGCTTTAAC CCAGAAGGGA TTGAAGACTG TTTTTGATGA GGCTATCATA 
GCCATTTTAA CTCCAAAGAA ACACACTGTA AAAAAAAGAA TAGGATCAAG ATGTATAAAC 
TGTTGTTTAA TTACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOQ ( NM_012249.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036381.2 Homo sapiens ras homolog family member Q (RHOQ), mRNA.

Price & Availability↑

CloneID	OHu09008
Clone ID Related Accession (Same CDS sequence)	NM_012249.4 , NM_012249.3
Accession Version	NM_012249.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoQ precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018682.4 and BC056154.1. On Aug 16, 2006 this sequence version replaced NM_012249.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU794657.1, SRR1660807.165339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGATAGGAGC ATGCTGCTAT 
GTGGAATGTT CAGCTTTAAC CCAGAAGGGA TTGAAGACTG TTTTTGATGA GGCTATCATA 
GCCATTTTAA CTCCAAAGAA ACACACTGTA AAAAAAAGAA TAGGATCAAG ATGTATAAAC 
TGTTGTTTAA TTACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036381.2
CDS	320..937
Translation	MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT

Target ORF information:

RefSeq Version	NM_012249.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member Q (RHOQ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012249.3

ORF Insert Sequence:

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGATAGGAGC ATGCTGCTAT 
GTGGAATGTT CAGCTTTAAC CCAGAAGGGA TTGAAGACTG TTTTTGATGA GGCTATCATA 
GCCATTTTAA CTCCAAAGAA ACACACTGTA AAAAAAAGAA TAGGATCAAG ATGTATAAAC 
TGTTGTTTAA TTACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOQ ( XM_005264229.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264286.1 Homo sapiens ras homolog family member Q (RHOQ), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu35338
Clone ID Related Accession (Same CDS sequence)	XM_005264229.2
Accession Version	XM_005264229.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoQ isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005264229.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GATAGGAGCA TGCTGCTATG TGGAATGTTC AGCTTTAACC 
CAGAAGGGAT TGAAGACTGT TTTTGATGAG GCTATCATAG CCATTTTAAC TCCAAAGAAA 
CACACTGTAA AAAAAAGAAT AGGATCAAGA TGTATAAACT GTTGTTTAAT TACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264286.1
CDS	283..639
Translation	MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT

Target ORF information:

RefSeq Version	XM_005264229.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264229.2

ORF Insert Sequence:

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GATAGGAGCA TGCTGCTATG TGGAATGTTC AGCTTTAACC 
CAGAAGGGAT TGAAGACTGT TTTTGATGAG GCTATCATAG CCATTTTAAC TCCAAAGAAA 
CACACTGTAA AAAAAAGAAT AGGATCAAGA TGTATAAACT GTTGTTTAAT TACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOQ ( XM_011532726.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011531028.1 Homo sapiens ras homolog family member Q (RHOQ), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66186
Clone ID Related Accession (Same CDS sequence)	XM_011532726.2
Accession Version	XM_011532726.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoQ isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532726.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGATGTCAGC ACATGTGGAC 
GCCACACAGC AGGGACTCTG CTCTTTCGTT CAGTTCACTG ACATATCCCC AGGACCTAAA 
CAGTGCTTGA CATATAGTAG ATACCCAGTA AATATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011531028.1
CDS	497..1075
Translation	MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEMSAHVDATQQGLCSFVQFTDISPGPKQCLTYSRYPVNM

Target ORF information:

RefSeq Version	XM_011532726.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532726.2

ORF Insert Sequence:

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGATGTCAGC ACATGTGGAC 
GCCACACAGC AGGGACTCTG CTCTTTCGTT CAGTTCACTG ACATATCCCC AGGACCTAAA 
CAGTGCTTGA CATATAGTAG ATACCCAGTA AATATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOQ ( XM_017003716.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016859205.1 Homo sapiens ras homolog family member Q (RHOQ), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu66187
Clone ID Related Accession (Same CDS sequence)	XM_017003716.1
Accession Version	XM_017003716.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoQ isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGGTGGAGTG CTTTACATGC 
ATTATCTCAT TTAATCCTTG CATGAACTCA GTGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016859205.1
CDS	639..1157
Translation	MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEVECFTCIISFNPCMNSVR

Target ORF information:

RefSeq Version	XM_017003716.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017003716.1

ORF Insert Sequence:

ATGGCTCACG GGCCCGGCGC GCTGATGCTC AAGTGCGTGG TGGTCGGCGA CGGGGCGGTG 
GGCAAGACGT GCCTACTCAT GAGCTATGCC AACGACGCCT TCCCGGAGGA GTACGTGCCC 
ACCGTCTTCG ACCACTACGC AGTCAGCGTC ACCGTGGGGG GCAAGCAGTA CCTCCTAGGA 
CTCTATGACA CGGCCGGACA GGAAGACTAT GACCGTCTGA GGCCTTTATC TTACCCAATG 
ACCGATGTCT TCCTTATATG CTTCTCGGTG GTAAATCCAG CCTCATTTCA AAATGTGAAA 
GAGGAGTGGG TACCGGAACT TAAGGAATAC GCACCAAATG TACCCTTTTT ATTAATAGGA 
ACTCAGATTG ATCTCCGAGA TGACCCCAAA ACTTTAGCAA GACTGAATGA TATGAAAGAA 
AAACCTATAT GTGTGGAACA AGGACAGAAA CTAGCAAAAG AGGTGGAGTG CTTTACATGC 
ATTATCTCAT TTAATCCTTG CATGAACTCA GTGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOQ ( XM_011532728.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011531030.1 Homo sapiens ras homolog family member Q (RHOQ), transcript variant X4, mRNA.

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CloneID	OHu66188
Clone ID Related Accession (Same CDS sequence)	XM_011532728.2
Accession Version	XM_011532728.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoQ isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532728.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAACGA CGCCTTCCCG GAGGAGTACG TGCCCACCGT CTTCGACCAC TACGCAGGAA 
GACTATGACC GTCTGAGGCC TTTATCTTAC CCAATGACCG ATGTCTTCCT TATATGCTTC 
TCGGTGGTAA ATCCAGCCTC ATTTCAAAAT GTGAAAGAGG AGTGGGTACC GGAACTTAAG 
GAATACGCAC CAAATGTACC CTTTTTATTA ATAGGAACTC AGATTGATCT CCGAGATGAC 
CCCAAAACTT TAGCAAGACT GAATGATATG AAAGAAAAAC CTATATGTGT GGAACAAGGA 
CAGAAACTAG CAAAAGAGAT AGGAGCATGC TGCTATGTGG AATGTTCAGC TTTAACCCAG 
AAGGGATTGA AGACTGTTTT TGATGAGGCT ATCATAGCCA TTTTAACTCC AAAGAAACAC 
ACTGTAAAAA AAAGAATAGG ATCAAGATGT ATAAACTGTT GTTTAATTAC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011531030.1
CDS	30..503
Translation	MPTTPSRRSTCPPSSTTTQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT

Target ORF information:

RefSeq Version	XM_011532728.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member Q (RHOQ), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532728.2

ORF Insert Sequence:

ATGCCAACGA CGCCTTCCCG GAGGAGTACG TGCCCACCGT CTTCGACCAC TACGCAGGAA 
GACTATGACC GTCTGAGGCC TTTATCTTAC CCAATGACCG ATGTCTTCCT TATATGCTTC 
TCGGTGGTAA ATCCAGCCTC ATTTCAAAAT GTGAAAGAGG AGTGGGTACC GGAACTTAAG 
GAATACGCAC CAAATGTACC CTTTTTATTA ATAGGAACTC AGATTGATCT CCGAGATGAC 
CCCAAAACTT TAGCAAGACT GAATGATATG AAAGAAAAAC CTATATGTGT GGAACAAGGA 
CAGAAACTAG CAAAAGAGAT AGGAGCATGC TGCTATGTGG AATGTTCAGC TTTAACCCAG 
AAGGGATTGA AGACTGTTTT TGATGAGGCT ATCATAGCCA TTTTAACTCC AAAGAAACAC 
ACTGTAAAAA AAAGAATAGG ATCAAGATGT ATAAACTGTT GTTTAATTAC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNA editing in RHOQ promotes invasion potential in colorectal cancer.
The Journal of experimental medicine211(4)613-21(2014 Apr)
Han SW,Kim HP,Shin JY,Jeong EG,Lee WC,Kim KY,Park SY,Lee DW,Won JK,Jeong SY,Park KJ,Park JG,Kang GH,Seo JS,Kim JI,Kim TY

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.
Proceedings of the National Academy of Sciences of the United States of America110(51)20795-800(2013 Dec)
Mayer S,Kumar R,Jaiswal M,Soykan T,Ahmadian MR,Brose N,Betz H,Rhee JS,Papadopoulos T

GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.
PloS one8(11)e79689(2013)
Fujita A,Koinuma S,Yasuda S,Nagai H,Kamiguchi H,Wada N,Nakamura T

Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
BMC genetics1126(2010 Apr)
Ban HJ,Heo JY,Oh KS,Park KJ

TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.
Journal of cell science122(Pt 7)947-56(2009 Apr)
Coisy-Quivy M,Touzet O,Bourret A,Hipskind RA,Mercier J,Fort P,Philips A

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RHOQ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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