MLYCD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MLYCD
Entrez Gene ID	23417
Full Name	malonyl-CoA decarboxylase
Synonyms	MCD
General protein information	Preferred Names malonyl-CoA decarboxylase Names malonyl-CoA decarboxylase, mitochondrial malonyl coenzyme A decarboxylase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q23.3
Summary	The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008].
Disorder MIM:	606761
Disorder Html:	Malonyl-CoA decarboxylase deficiency, 248360 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_012213.3	NP_036345.2	malonyl-CoA decarboxylase, mitochondrial
NM_012213.2	NP_036345.2	malonyl-CoA decarboxylase, mitochondrial

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mlycd	NP_064350.2
Arabidopsis thaliana (thale cress)	AT4G04320	NP_974511.1
Oryza sativa (rice)	Os09g0394100	NP_001063091.1
Xenopus tropicalis (tropical clawed frog)	mlycd	NP_001120413.1
Danio rerio (zebrafish)	LOC100334385	XP_002665369.2
Caenorhabditis elegans (roundworm)	mlcd-1	NP_001022561.1
Homo sapiens (human)	MLYCD	NP_036345.2
Gallus gallus (chicken)	MLYCD	XP_414174.4
Bos taurus (cattle)	MLYCD	NP_001092416.1
Rattus norvegicus (Norway rat)	Mlycd	NP_445929.1
Danio rerio (zebrafish)	mlycd	NP_001082972.1
Pan troglodytes (chimpanzee)	MLYCD	XP_523518.2
	MLYCD	XP_001112117.1
Canis lupus familiaris (dog)	MLYCD	XP_852152.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of the active site of human mitochondrial malonyl-coenzyme a decarboxylase: A combined computational study.
Ling B, Liu Y, Li X, Wang Z, Bi S
Proteins84(6)792-802(2016 06)

A new case of malonyl-CoA decarboxylase deficiency with mild clinical features.
Liu H, Tan D, Han L, Ye J, Qiu W, Gu X, Zhang H
American journal of medical genetics. Part A170A(5)1347-51(2016 May)

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Froese DS, Forouhar F, Tran TH, Vollmar M, Kim YS, Lew S, Neely H, Seetharaman J, Shen Y, Xiao R, Acton TB, Everett JK, Cannone G, Puranik S, Savitsky P, Krojer T, Pilka ES, Kiyani W, Lee WH, Marsden BD, von Delft F, Allerston CK, Spagnolo L, Gileadi O, Montelione GT, Oppermann U, Yue WW, Tong L
Structure (London, England : 1993)21(7)1182-92(2013 Jul)

Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.
Aparicio D, P?rez-Luque R, Carpena X, D?az M, Ferrer JC, Loewen PC, Fita I
The Journal of biological chemistry288(17)11907-19(2013 Apr)

Malonyl coenzyme A decarboxylase deficiency: early dietary restriction and time course of cardiomyopathy.
Prada CE, Jefferies JL, Grenier MA, Huth CM, Page KI, Spicer RL, Towbin JA, Leslie ND
Pediatrics130(2)e456-60(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

To identify the active site of MCD, molecular docking and molecular dynamics simulations were performed to explore the interactions of human mitochondrial MCD (HmMCD) and CoA derivatives. The findings reveal that the active site of HmMCD indeed resides in the prominent groove which resembles that of curacin A.
Title: Identification of the active site of human mitochondrial malonyl-coenzyme a decarboxylase: A combined computational study.

Our result expands the phenotype of malonyl-CoA decarboxylase deficiency and suggests attentions should be paid to the mild form of disorders, for example, malonyl-CoA decarboxylase deficiency, which usually present a severe disease course.
Title: A new case of malonyl-CoA decarboxylase deficiency with mild clinical features.

The MLYCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily.
Title: Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.

Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.
Title: Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.

Our case emphasizes the need for ongoing cardiac disease screening in patients with MCD deficiency and the benefits and limitations of current dietary interventions.
Title: Malonyl coenzyme A decarboxylase deficiency: early dietary restriction and time course of cardiomyopathy.

The following MLYCD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MLYCD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18699	NM_012213.3 Latest version!	Homo sapiens malonyl-CoA decarboxylase (MLYCD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu18699	NM_012213.2	Homo sapiens malonyl-CoA decarboxylase (MLYCD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MLYCD ( NM_012213.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036345.2 Homo sapiens malonyl-CoA decarboxylase (MLYCD), mRNA.

Price & Availability↑

CloneID	OHu18699
Clone ID Related Accession (Same CDS sequence)	NM_012213.3 , NM_012213.2
Accession Version	NM_012213.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	malonyl-CoA decarboxylase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009119.10 and BC052592.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_012213.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052592.1, SRR1163657.461974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000262430.6/ ENSP00000262430.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGAGGCT TCGGGCCAGG CTTGACGGCC AGGCGTCTCC TCCCGCTGCG GTTGCCCCCG 
CGGCCGCCCG GGCCCCGGCT GGCGAGCGGG CAGGCGGCCG GCGCCCTGGA GCGGGCCATG 
GACGAGCTGC TGCGCCGCGC GGTGCCGCCG ACGCCGGCCT ACGAGCTGCG CGAGAAGACA 
CCGGCGCCCG CCGAGGGTCA GTGCGCGGAC TTCGTGAGCT TCTACGGTGG GCTGGCCGAG 
ACGGCCCAGC GGGCCGAACT GCTGGGCCGC CTGGCGCGGG GCTTCGGCGT GGACCACGGC 
CAGGTGGCGG AGCAGAGCGC CGGCGTGCTC CATCTGCGCC AGCAGCAGCG GGAGGCGGCG 
GTGCTGCTGC AGGCCGAGGA CCGGCTGCGC TACGCGCTGG TGCCGCGCTA TCGCGGCCTC 
TTCCACCACA TCAGCAAGCT GGACGGCGGC GTGCGCTTCC TGGTGCAGCT GCGGGCCGAC 
CTGCTGGAGG CGCAGGCCCT CAAGCTGGTG GAGGGGCCGG ACGTCCGGGA AATGAATGGG 
GTGCTGAAAG GAATGCTCTC AGAATGGTTT TCCTCCGGGT TCCTGAACCT AGAACGGGTT 
ACCTGGCATT CACCGTGTGA AGTGCTTCAG AAAATCAGTG AGGCTGAGGC TGTGCATCCT 
GTAAAAAACT GGATGGACAT GAAGCGCCGC GTTGGGCCCT ACAGAAGGTG TTACTTCTTT 
TCTCACTGTT CGACCCCTGG GGAGCCCCTG GTCGTTTTGC ACGTGGCACT GACTGGTGAC 
ATCTCCAGCA ACATCCAGGC AATCGTGAAG GAACATCCTC CATCAGAAAC AGAAGAGAAG 
AACAAAATCA CTGCTGCGAT CTTTTATTCC ATCAGCTTGA CCCAGCAGGG ACTCCAAGGG 
GTGGAGCTGG GAACATTCCT CATAAAGCGA GTCGTCAAGG AGTTGCAGAG AGAGTTTCCT 
CACCTTGGGG TGTTTTCAAG TCTGTCACCT ATACCTGGTT TCACCAAATG GCTTCTGGGG 
CTTCTGAACT CGCAAACGAA GGAGCATGGG AGGAATGAAC TCTTTACAGA TTCGGAATGT 
AAGGAAATCT CGGAGATCAC AGGTGGCCCC ATTAACGAGA CCCTCAAGCT CCTCCTCAGC 
AGCAGCGAGT GGGTGCAGTC GGAGAAGCTG GTGCGGGCGC TGCAGACTCC GCTGATGAGG 
CTGTGCGCCT GGTACCTGTA TGGAGAGAAG CACCGCGGCT ACGCGCTGAA CCCCGTGGCC 
AACTTCCACC TGCAGAACGG GGCGGTGCTG TGGCGCATCA ACTGGATGGC GGATGTGAGC 
CTCAGAGGCA TCACCGGCTC CTGCGGCCTG ATGGCCAACT ACCGCTACTT CCTGGAGGAG 
ACGGGCCCCA ACAGCACCTC CTACCTCGGC TCCAAGATCA TCAAAGCCTC TGAGCAGGTC 
CTCAGCCTAG TGGCCCAGTT TCAAAAGAAC AGCAAGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036345.2
CDS	31..1512
Translation	MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL

Target ORF information:

RefSeq Version	NM_012213.3
Organism	Homo sapiens(human)
Definition	Homo sapiens malonyl-CoA decarboxylase (MLYCD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012213.3

ORF Insert Sequence:

ATGCGAGGCT TCGGGCCAGG CTTGACGGCC AGGCGTCTCC TCCCGCTGCG GTTGCCCCCG 
CGGCCGCCCG GGCCCCGGCT GGCGAGCGGG CAGGCGGCCG GCGCCCTGGA GCGGGCCATG 
GACGAGCTGC TGCGCCGCGC GGTGCCGCCG ACGCCGGCCT ACGAGCTGCG CGAGAAGACA 
CCGGCGCCCG CCGAGGGTCA GTGCGCGGAC TTCGTGAGCT TCTACGGTGG GCTGGCCGAG 
ACGGCCCAGC GGGCCGAACT GCTGGGCCGC CTGGCGCGGG GCTTCGGCGT GGACCACGGC 
CAGGTGGCGG AGCAGAGCGC CGGCGTGCTC CATCTGCGCC AGCAGCAGCG GGAGGCGGCG 
GTGCTGCTGC AGGCCGAGGA CCGGCTGCGC TACGCGCTGG TGCCGCGCTA TCGCGGCCTC 
TTCCACCACA TCAGCAAGCT GGACGGCGGC GTGCGCTTCC TGGTGCAGCT GCGGGCCGAC 
CTGCTGGAGG CGCAGGCCCT CAAGCTGGTG GAGGGGCCGG ACGTCCGGGA AATGAATGGG 
GTGCTGAAAG GAATGCTCTC AGAATGGTTT TCCTCCGGGT TCCTGAACCT AGAACGGGTT 
ACCTGGCATT CACCGTGTGA AGTGCTTCAG AAAATCAGTG AGGCTGAGGC TGTGCATCCT 
GTAAAAAACT GGATGGACAT GAAGCGCCGC GTTGGGCCCT ACAGAAGGTG TTACTTCTTT 
TCTCACTGTT CGACCCCTGG GGAGCCCCTG GTCGTTTTGC ACGTGGCACT GACTGGTGAC 
ATCTCCAGCA ACATCCAGGC AATCGTGAAG GAACATCCTC CATCAGAAAC AGAAGAGAAG 
AACAAAATCA CTGCTGCGAT CTTTTATTCC ATCAGCTTGA CCCAGCAGGG ACTCCAAGGG 
GTGGAGCTGG GAACATTCCT CATAAAGCGA GTCGTCAAGG AGTTGCAGAG AGAGTTTCCT 
CACCTTGGGG TGTTTTCAAG TCTGTCACCT ATACCTGGTT TCACCAAATG GCTTCTGGGG 
CTTCTGAACT CGCAAACGAA GGAGCATGGG AGGAATGAAC TCTTTACAGA TTCGGAATGT 
AAGGAAATCT CGGAGATCAC AGGTGGCCCC ATTAACGAGA CCCTCAAGCT CCTCCTCAGC 
AGCAGCGAGT GGGTGCAGTC GGAGAAGCTG GTGCGGGCGC TGCAGACTCC GCTGATGAGG 
CTGTGCGCCT GGTACCTGTA TGGAGAGAAG CACCGCGGCT ACGCGCTGAA CCCCGTGGCC 
AACTTCCACC TGCAGAACGG GGCGGTGCTG TGGCGCATCA ACTGGATGGC GGATGTGAGC 
CTCAGAGGCA TCACCGGCTC CTGCGGCCTG ATGGCCAACT ACCGCTACTT CCTGGAGGAG 
ACGGGCCCCA ACAGCACCTC CTACCTCGGC TCCAAGATCA TCAAAGCCTC TGAGCAGGTC 
CTCAGCCTAG TGGCCCAGTT TCAAAAGAAC AGCAAGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLYCD ( NM_012213.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036345.2 Homo sapiens malonyl-CoA decarboxylase (MLYCD), mRNA.

Price & Availability↑

CloneID	OHu18699
Clone ID Related Accession (Same CDS sequence)	NM_012213.3 , NM_012213.2
Accession Version	NM_012213.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	malonyl-CoA decarboxylase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052592.1. This sequence is a reference standard in the RefSeqGene project. On Jul 14, 2006 this sequence version replaced NM_012213.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052592.1, BC000286.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGAGGCT TCGGGCCAGG CTTGACGGCC AGGCGTCTCC TCCCGCTGCG GTTGCCCCCG 
CGGCCGCCCG GGCCCCGGCT GGCGAGCGGG CAGGCGGCCG GCGCCCTGGA GCGGGCCATG 
GACGAGCTGC TGCGCCGCGC GGTGCCGCCG ACGCCGGCCT ACGAGCTGCG CGAGAAGACA 
CCGGCGCCCG CCGAGGGTCA GTGCGCGGAC TTCGTGAGCT TCTACGGTGG GCTGGCCGAG 
ACGGCCCAGC GGGCCGAACT GCTGGGCCGC CTGGCGCGGG GCTTCGGCGT GGACCACGGC 
CAGGTGGCGG AGCAGAGCGC CGGCGTGCTC CATCTGCGCC AGCAGCAGCG GGAGGCGGCG 
GTGCTGCTGC AGGCCGAGGA CCGGCTGCGC TACGCGCTGG TGCCGCGCTA TCGCGGCCTC 
TTCCACCACA TCAGCAAGCT GGACGGCGGC GTGCGCTTCC TGGTGCAGCT GCGGGCCGAC 
CTGCTGGAGG CGCAGGCCCT CAAGCTGGTG GAGGGGCCGG ACGTCCGGGA AATGAATGGG 
GTGCTGAAAG GAATGCTCTC AGAATGGTTT TCCTCCGGGT TCCTGAACCT AGAACGGGTT 
ACCTGGCATT CACCGTGTGA AGTGCTTCAG AAAATCAGTG AGGCTGAGGC TGTGCATCCT 
GTAAAAAACT GGATGGACAT GAAGCGCCGC GTTGGGCCCT ACAGAAGGTG TTACTTCTTT 
TCTCACTGTT CGACCCCTGG GGAGCCCCTG GTCGTTTTGC ACGTGGCACT GACTGGTGAC 
ATCTCCAGCA ACATCCAGGC AATCGTGAAG GAACATCCTC CATCAGAAAC AGAAGAGAAG 
AACAAAATCA CTGCTGCGAT CTTTTATTCC ATCAGCTTGA CCCAGCAGGG ACTCCAAGGG 
GTGGAGCTGG GAACATTCCT CATAAAGCGA GTCGTCAAGG AGTTGCAGAG AGAGTTTCCT 
CACCTTGGGG TGTTTTCAAG TCTGTCACCT ATACCTGGTT TCACCAAATG GCTTCTGGGG 
CTTCTGAACT CGCAAACGAA GGAGCATGGG AGGAATGAAC TCTTTACAGA TTCGGAATGT 
AAGGAAATCT CGGAGATCAC AGGTGGCCCC ATTAACGAGA CCCTCAAGCT CCTCCTCAGC 
AGCAGCGAGT GGGTGCAGTC GGAGAAGCTG GTGCGGGCGC TGCAGACTCC GCTGATGAGG 
CTGTGCGCCT GGTACCTGTA TGGAGAGAAG CACCGCGGCT ACGCGCTGAA CCCCGTGGCC 
AACTTCCACC TGCAGAACGG GGCGGTGCTG TGGCGCATCA ACTGGATGGC GGATGTGAGC 
CTCAGAGGCA TCACCGGCTC CTGCGGCCTG ATGGCCAACT ACCGCTACTT CCTGGAGGAG 
ACGGGCCCCA ACAGCACCTC CTACCTCGGC TCCAAGATCA TCAAAGCCTC TGAGCAGGTC 
CTCAGCCTAG TGGCCCAGTT TCAAAAGAAC AGCAAGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036345.2
CDS	21..1502
Translation	MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL

Target ORF information:

RefSeq Version	NM_012213.2
Organism	Homo sapiens(human)
Definition	Homo sapiens malonyl-CoA decarboxylase (MLYCD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012213.2

ORF Insert Sequence:

ATGCGAGGCT TCGGGCCAGG CTTGACGGCC AGGCGTCTCC TCCCGCTGCG GTTGCCCCCG 
CGGCCGCCCG GGCCCCGGCT GGCGAGCGGG CAGGCGGCCG GCGCCCTGGA GCGGGCCATG 
GACGAGCTGC TGCGCCGCGC GGTGCCGCCG ACGCCGGCCT ACGAGCTGCG CGAGAAGACA 
CCGGCGCCCG CCGAGGGTCA GTGCGCGGAC TTCGTGAGCT TCTACGGTGG GCTGGCCGAG 
ACGGCCCAGC GGGCCGAACT GCTGGGCCGC CTGGCGCGGG GCTTCGGCGT GGACCACGGC 
CAGGTGGCGG AGCAGAGCGC CGGCGTGCTC CATCTGCGCC AGCAGCAGCG GGAGGCGGCG 
GTGCTGCTGC AGGCCGAGGA CCGGCTGCGC TACGCGCTGG TGCCGCGCTA TCGCGGCCTC 
TTCCACCACA TCAGCAAGCT GGACGGCGGC GTGCGCTTCC TGGTGCAGCT GCGGGCCGAC 
CTGCTGGAGG CGCAGGCCCT CAAGCTGGTG GAGGGGCCGG ACGTCCGGGA AATGAATGGG 
GTGCTGAAAG GAATGCTCTC AGAATGGTTT TCCTCCGGGT TCCTGAACCT AGAACGGGTT 
ACCTGGCATT CACCGTGTGA AGTGCTTCAG AAAATCAGTG AGGCTGAGGC TGTGCATCCT 
GTAAAAAACT GGATGGACAT GAAGCGCCGC GTTGGGCCCT ACAGAAGGTG TTACTTCTTT 
TCTCACTGTT CGACCCCTGG GGAGCCCCTG GTCGTTTTGC ACGTGGCACT GACTGGTGAC 
ATCTCCAGCA ACATCCAGGC AATCGTGAAG GAACATCCTC CATCAGAAAC AGAAGAGAAG 
AACAAAATCA CTGCTGCGAT CTTTTATTCC ATCAGCTTGA CCCAGCAGGG ACTCCAAGGG 
GTGGAGCTGG GAACATTCCT CATAAAGCGA GTCGTCAAGG AGTTGCAGAG AGAGTTTCCT 
CACCTTGGGG TGTTTTCAAG TCTGTCACCT ATACCTGGTT TCACCAAATG GCTTCTGGGG 
CTTCTGAACT CGCAAACGAA GGAGCATGGG AGGAATGAAC TCTTTACAGA TTCGGAATGT 
AAGGAAATCT CGGAGATCAC AGGTGGCCCC ATTAACGAGA CCCTCAAGCT CCTCCTCAGC 
AGCAGCGAGT GGGTGCAGTC GGAGAAGCTG GTGCGGGCGC TGCAGACTCC GCTGATGAGG 
CTGTGCGCCT GGTACCTGTA TGGAGAGAAG CACCGCGGCT ACGCGCTGAA CCCCGTGGCC 
AACTTCCACC TGCAGAACGG GGCGGTGCTG TGGCGCATCA ACTGGATGGC GGATGTGAGC 
CTCAGAGGCA TCACCGGCTC CTGCGGCCTG ATGGCCAACT ACCGCTACTT CCTGGAGGAG 
ACGGGCCCCA ACAGCACCTC CTACCTCGGC TCCAAGATCA TCAAAGCCTC TGAGCAGGTC 
CTCAGCCTAG TGGCCCAGTT TCAAAAGAAC AGCAAGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of the active site of human mitochondrial malonyl-coenzyme a decarboxylase: A combined computational study.
Proteins84(6)792-802(2016 06)
Ling B,Liu Y,Li X,Wang Z,Bi S

A new case of malonyl-CoA decarboxylase deficiency with mild clinical features.
American journal of medical genetics. Part A170A(5)1347-51(2016 May)
Liu H,Tan D,Han L,Ye J,Qiu W,Gu X,Zhang H

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure (London, England : 1993)21(7)1182-92(2013 Jul)
Froese DS,Forouhar F,Tran TH,Vollmar M,Kim YS,Lew S,Neely H,Seetharaman J,Shen Y,Xiao R,Acton TB,Everett JK,Cannone G,Puranik S,Savitsky P,Krojer T,Pilka ES,Kiyani W,Lee WH,Marsden BD,von Delft F,Allerston CK,Spagnolo L,Gileadi O,Montelione GT,Oppermann U,Yue WW,Tong L

Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.
The Journal of biological chemistry288(17)11907-19(2013 Apr)
Aparicio D,P?rez-Luque R,Carpena X,D?az M,Ferrer JC,Loewen PC,Fita I

Malonyl coenzyme A decarboxylase deficiency: early dietary restriction and time course of cardiomyopathy.
Pediatrics130(2)e456-60(2012 Aug)
Prada CE,Jefferies JL,Grenier MA,Huth CM,Page KI,Spicer RL,Towbin JA,Leslie ND

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MLYCD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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