FRAT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FRAT2
Entrez Gene ID	23401
Full Name	FRAT2, WNT signaling pathway regulator
Synonyms	FRAT-2
General protein information	Preferred Names FRAT2, WNT signaling pathway regulator Names GSK-3-binding protein FRAT2 frequently rearranged in advanced T-cell lymphomas 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.1
Summary	The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	605006

mRNA and Protein(s)

mRNA	Protein	Name
NM_012083.3	NP_036215.1	GSK-3-binding protein FRAT2
NM_012083.2	NP_036215.1	GSK-3-binding protein FRAT2

Pathways from BioSystems

Homologies

Homo sapiens (human)	FRAT2	NP_036215.1
Mus musculus (house mouse)	Frat2	NP_808271.1
Rattus norvegicus (Norway rat)	Frat2	XP_006231482.1
Bos taurus (cattle)	FRAT2	XP_005225712.1
Pan troglodytes (chimpanzee)	FRAT2	XP_521572.2
	FRAT2	XP_001102082.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.
Lee DY, Kim H, Ku SY, Kim SH, Choi YM, Kim JG
Menopause (New York, N.Y.)17(5)1064-70(2010 Sep-Oct)

Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
Liu GP, Zhang Y, Yao XQ, Zhang CE, Fang J, Wang Q, Wang JZ
Neurobiology of aging29(9)1348-58(2008 Sep)

FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.
Stoothoff WH, Cho JH, McDonald RP, Johnson GV
The Journal of biological chemistry280(1)270-6(2005 Jan)

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.
Freemantle SJ, Portland HB, Ewings K, Dmitrovsky F, DiPetrillo K, Spinella MJ, Dmitrovsky E
Gene291(1-2)17-27(2002 May)

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD
Structure (London, England : 1993)9(12)1143-52(2001 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.

It suggests that activation of GSK-3 inhibits PP-2A through up-regulation of I(2)(PP-2A) with hnRNP A18-involved mechanism.
Title: Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.

FRAT-2 enhances glycogen synthase kinase 3 beta-mediated phosphorylation of a primed substrate to a greater extent than an unprimed substrate
Title: FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.

The following FRAT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FRAT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01956	NM_012083.3 Latest version!	Homo sapiens FRAT regulator of WNT signaling pathway 2 (FRAT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu01956	NM_012083.2	Homo sapiens FRAT regulator of WNT signaling pathway 2 (FRAT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FRAT2 ( NM_012083.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036215.1 Homo sapiens FRAT regulator of WNT signaling pathway 2 (FRAT2), mRNA.

Price & Availability↑

CloneID	OHu01956
Clone ID Related Accession (Same CDS sequence)	NM_012083.3 , NM_012083.2
Accession Version	NM_012083.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	GSK-3-binding protein FRAT2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355490.24, DR006612.1, AB045118.1 and BU675503.1. On May 17, 2019 this sequence version replaced NM_012083.2. ##Evidence-Data-START## Transcript is intronless :: BC020165.1, AB045118.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371019.4/ ENSP00000360058.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGACGACA GCTTCCTCCT GCTGCAGCAG TCGGTGACGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GGACAGCCCG 
GCCTCGCCGT GCGCGCCCCC GGGGGTGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCCG GCCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCTTCGGCT 
GAGACGGTGG GCCCGGCGCC CTCTGGGGCC CTGCGCTGCG CCCTAGGGGA CCGCGGCCGC 
GTGCGCGGAC GCGCTGCGCC CTACTGCGTG GCGGAGGTCG CCGCAGGCCC CAGCGCGCTG 
CCGGGGCCGT GCCGGCGAGG ATGGCTCAGG GACGCGGTCA CCTCCCGCCG CTTGCAGCAG 
CGCCGATGGA CCCAAGCCGG GGCACGCGCC GGCGACGACG ACCCGCATCG GCTCCTCCAG 
CAGCTCGTGC TCTCGGGAAA CCTCATCAAG GAAGCCGTGC GGAGACTCCA ACGAGCCGTC 
GCCGCGGTTG CAGCCACGGG CCCCGCAAGC GCCCCTGGGC CCGGGGGAGG CCGCAGCGGA 
CCTGACCGCA TTGCCCTGCA GCCCTCAGGC TCCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036215.1
CDS	158..859
Translation	MPCRREEEEEAGEEAEGEEEEDDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQDSPASPCAPPGVPLRAPGPLAAAVPADKARPPAVPLLLPPASAETVGPAPSGALRCALGDRGRVRGRAAPYCVAEVAAGPSALPGPCRRGWLRDAVTSRRLQQRRWTQAGARAGDDDPHRLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASAPGPGGGRSGPDRIALQPSGSLL

Target ORF information:

RefSeq Version	NM_012083.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FRAT regulator of WNT signaling pathway 2 (FRAT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012083.3

ORF Insert Sequence:

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGACGACA GCTTCCTCCT GCTGCAGCAG TCGGTGACGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GGACAGCCCG 
GCCTCGCCGT GCGCGCCCCC GGGGGTGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCCG GCCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCTTCGGCT 
GAGACGGTGG GCCCGGCGCC CTCTGGGGCC CTGCGCTGCG CCCTAGGGGA CCGCGGCCGC 
GTGCGCGGAC GCGCTGCGCC CTACTGCGTG GCGGAGGTCG CCGCAGGCCC CAGCGCGCTG 
CCGGGGCCGT GCCGGCGAGG ATGGCTCAGG GACGCGGTCA CCTCCCGCCG CTTGCAGCAG 
CGCCGATGGA CCCAAGCCGG GGCACGCGCC GGCGACGACG ACCCGCATCG GCTCCTCCAG 
CAGCTCGTGC TCTCGGGAAA CCTCATCAAG GAAGCCGTGC GGAGACTCCA ACGAGCCGTC 
GCCGCGGTTG CAGCCACGGG CCCCGCAAGC GCCCCTGGGC CCGGGGGAGG CCGCAGCGGA 
CCTGACCGCA TTGCCCTGCA GCCCTCAGGC TCCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FRAT2 ( NM_012083.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036215.1 Homo sapiens FRAT regulator of WNT signaling pathway 2 (FRAT2), mRNA.

Price & Availability↑

CloneID	OHu01956
Clone ID Related Accession (Same CDS sequence)	NM_012083.3 , NM_012083.2
Accession Version	NM_012083.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-27
Organism	Homo sapiens(human)
Product	GSK-3-binding protein FRAT2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR006612.1, AB045118.1, AL355490.24 and BU675503.1. On Jun 1, 2003 this sequence version replaced NM_012083.1. COMPLETENESS: complete on the 3' end.

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGACGACA GCTTCCTCCT GCTGCAGCAG TCGGTGACGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GGACAGCCCG 
GCCTCGCCGT GCGCGCCCCC GGGGGTGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCCG GCCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCTTCGGCT 
GAGACGGTGG GCCCGGCGCC CTCTGGGGCC CTGCGCTGCG CCCTAGGGGA CCGCGGCCGC 
GTGCGCGGAC GCGCTGCGCC CTACTGCGTG GCGGAGGTCG CCGCAGGCCC CAGCGCGCTG 
CCGGGGCCGT GCCGGCGAGG ATGGCTCAGG GACGCGGTCA CCTCCCGCCG CTTGCAGCAG 
CGCCGATGGA CCCAAGCCGG GGCACGCGCC GGCGACGACG ACCCGCATCG GCTCCTCCAG 
CAGCTCGTGC TCTCGGGAAA CCTCATCAAG GAAGCCGTGC GGAGACTCCA ACGAGCCGTC 
GCCGCGGTTG CAGCCACGGG CCCCGCAAGC GCCCCTGGGC CCGGGGGAGG CCGCAGCGGA 
CCTGACCGCA TTGCCCTGCA GCCCTCAGGC TCCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036215.1
CDS	130..831
Translation	MPCRREEEEEAGEEAEGEEEEDDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQDSPASPCAPPGVPLRAPGPLAAAVPADKARPPAVPLLLPPASAETVGPAPSGALRCALGDRGRVRGRAAPYCVAEVAAGPSALPGPCRRGWLRDAVTSRRLQQRRWTQAGARAGDDDPHRLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASAPGPGGGRSGPDRIALQPSGSLL

Target ORF information:

RefSeq Version	NM_012083.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FRAT regulator of WNT signaling pathway 2 (FRAT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012083.2

ORF Insert Sequence:

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGACGACA GCTTCCTCCT GCTGCAGCAG TCGGTGACGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GGACAGCCCG 
GCCTCGCCGT GCGCGCCCCC GGGGGTGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCCG GCCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCTTCGGCT 
GAGACGGTGG GCCCGGCGCC CTCTGGGGCC CTGCGCTGCG CCCTAGGGGA CCGCGGCCGC 
GTGCGCGGAC GCGCTGCGCC CTACTGCGTG GCGGAGGTCG CCGCAGGCCC CAGCGCGCTG 
CCGGGGCCGT GCCGGCGAGG ATGGCTCAGG GACGCGGTCA CCTCCCGCCG CTTGCAGCAG 
CGCCGATGGA CCCAAGCCGG GGCACGCGCC GGCGACGACG ACCCGCATCG GCTCCTCCAG 
CAGCTCGTGC TCTCGGGAAA CCTCATCAAG GAAGCCGTGC GGAGACTCCA ACGAGCCGTC 
GCCGCGGTTG CAGCCACGGG CCCCGCAAGC GCCCCTGGGC CCGGGGGAGG CCGCAGCGGA 
CCTGACCGCA TTGCCCTGCA GCCCTCAGGC TCCTTGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.
Menopause (New York, N.Y.)17(5)1064-70(2010 Sep-Oct)
Lee DY,Kim H,Ku SY,Kim SH,Choi YM,Kim JG

Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
Neurobiology of aging29(9)1348-58(2008 Sep)
Liu GP,Zhang Y,Yao XQ,Zhang CE,Fang J,Wang Q,Wang JZ

FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.
The Journal of biological chemistry280(1)270-6(2005 Jan)
Stoothoff WH,Cho JH,McDonald RP,Johnson GV

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.
Gene291(1-2)17-27(2002 May)
Freemantle SJ,Portland HB,Ewings K,Dmitrovsky F,DiPetrillo K,Spinella MJ,Dmitrovsky E

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
Structure (London, England : 1993)9(12)1143-52(2001 Dec)
Bax B,Carter PS,Lewis C,Guy AR,Bridges A,Tanner R,Pettman G,Mannix C,Culbert AA,Brown MJ,Smith DG,Reith AD

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FRAT2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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