FMO2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FMO2
Entrez Gene ID	2327
Full Name	flavin containing monooxygenase 2
Synonyms	FMO1B1
General protein information	Preferred Names flavin containing monooxygenase 2 Names dimethylaniline monooxygenase [N-oxide-forming] 2 FMO, pulmonary dimethylaniline oxidase 2 flavin containing monooxygenase 2 (non-functional) pulmonary flavin-containing monooxygenase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.3
Summary	This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
Disorder MIM:	603955

mRNA and Protein(s)

mRNA	Protein	Name
NM_001301347.1	NP_001288276.1	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform b
NM_001460.4	NP_001451.2	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform a
NM_001365900.1	NP_001352829.1	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform c
NM_001460.5	NP_001451.2	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform a
NM_001301347.2	NP_001288276.1	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform b

Pathways from BioSystems

Homologies

Homo sapiens (human)	FMO2	NP_001451.1
Xenopus tropicalis (tropical clawed frog)	LOC100489408	XP_002934193.2
Rattus norvegicus (Norway rat)	Fmo2	NP_653338.2
Xenopus tropicalis (tropical clawed frog)	MGC89174	NP_001005050.1
Pan troglodytes (chimpanzee)	FMO2	NP_001009008.1
Bos taurus (cattle)	FMO2	NP_001156746.1
Mus musculus (house mouse)	Fmo2	NP_061369.2
Canis lupus familiaris (dog)	FMO2	XP_537197.3

Gene Ontology
Bibliography

Related articles in PubMed

An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1.
Mekonnen E, Bekele E
PloS one12(10)e0184931(2017)

Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide.
Siddens LK, Krueger SK, Henderson MC, Williams DE
Biochemical pharmacology89(1)141-7(2014 May)

Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.
Krueger SK, Henderson MC, Siddens LK, VanDyke JE, Benninghoff AD, Karplus PA, Furnes B, Schlenk D, Williams DE
Drug metabolism and disposition: the biological fate of chemicals37(8)1785-91(2009 Aug)

Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.
Francois AA, Nishida CR, de Montellano PR, Phillips IR, Shephard EA
Drug metabolism and disposition: the biological fate of chemicals37(1)178-86(2009 Jan)

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.
Whetstine JR, Yueh MF, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, Hines RN
Toxicology and applied pharmacology168(3)216-24(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study provides an evidence for the existence of an evolutionary adaptation to an ancient disease based on an ancestral genetic variant acting in a FMO2 haplotypic framework in Ethiopian populations
Title: An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1.

Observational study of gene-disease association. (HuGE Navigator)
Title: Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.

Observational study of genotype prevalence. (HuGE Navigator)
Title: Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.
Title: Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.

The following FMO2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FMO2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu57828	NM_001460.5 Latest version!	Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu57827	NM_001301347.2 Latest version!	Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu106873	NM_001365900.1 Latest version!	Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu57828	NM_001460.4	Homo sapiens flavin containing monooxygenase 2 (FMO2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu57827	NM_001301347.1	Homo sapiens flavin containing monooxygenase 2 (FMO2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FMO2 ( NM_001460.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001451.2 Homo sapiens flavin containing monooxygenase 2 (FMO2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu57828
Clone ID Related Accession (Same CDS sequence)	NM_001460.4 , NM_001460.5
Accession Version	NM_001460.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-02
Organism	Homo sapiens(human)
Product	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI766311.1, DB224311.1, BC005894.1, KF459607.1, AL833218.1, R95468.1, AK098145.1 and AI821378.1. On Aug 9, 2014 this sequence version replaced NM_001460.3. Transcript Variant: This variant (1), which represents the functional FMO2*1 allele, is the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.258376.1, SRR1803612.81140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAAAGA AGGTAGCTGT GATTGGAGCT GGGGTCAGTG GCCTAATTTC TCTGAAGTGC 
TGTGTGGATG AGGGACTTGA GCCCACTTGC TTTGAGAGAA CTGAAGATAT TGGAGGAGTG 
TGGAGGTTCA AAGAGAATGT GGAAGATGGC CGAGCAAGTA TCTATCAATC TGTCGTTACC 
AACACCAGCA AAGAAATGTC CTGTTTCAGT GACTTTCCAA TGCCTGAAGA TTTTCCAAAC 
TTCCTGCATA ATTCTAAACT TCTGGAATAT TTCAGGATTT TTGCTAAAAA ATTTGATCTG 
CTAAAATATA TTCAGTTCCA GACAACTGTC CTTAGTGTGA GAAAATGTCC AGATTTCTCA 
TCCTCTGGCC AATGGAAGGT TGTCACTCAG AGCAACGGCA AGGAGCAGAG TGCTGTCTTT 
GACGCAGTTA TGGTTTGCAG TGGCCACCAC ATTCTACCTC ATATCCCACT GAAGTCATTT 
CCAGGTATGG AGAGGTTCAA AGGCCAATAT TTCCATAGCC GCCAATACAA GCATCCAGAT 
GGATTTGAGG GAAAACGCAT CCTGGTGATT GGAATGGGAA ACTCAGGCTC AGATATTGCT 
GTTGAGCTGA GTAAGAATGC TGCTCAGGTT TTTATCAGCA CCAGGCATGG CACCTGGGTC 
ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001451.2
CDS	159..1766
Translation	MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVTNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

Target ORF information:

RefSeq Version	NM_001460.4
Organism	Homo sapiens(human)
Definition	Homo sapiens flavin containing monooxygenase 2 (FMO2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001460.4

ORF Insert Sequence:

ATGGCAAAGA AGGTAGCTGT GATTGGAGCT GGGGTCAGTG GCCTAATTTC TCTGAAGTGC 
TGTGTGGATG AGGGACTTGA GCCCACTTGC TTTGAGAGAA CTGAAGATAT TGGAGGAGTG 
TGGAGGTTCA AAGAGAATGT GGAAGATGGC CGAGCAAGTA TCTATCAATC TGTCGTTACC 
AACACCAGCA AAGAAATGTC CTGTTTCAGT GACTTTCCAA TGCCTGAAGA TTTTCCAAAC 
TTCCTGCATA ATTCTAAACT TCTGGAATAT TTCAGGATTT TTGCTAAAAA ATTTGATCTG 
CTAAAATATA TTCAGTTCCA GACAACTGTC CTTAGTGTGA GAAAATGTCC AGATTTCTCA 
TCCTCTGGCC AATGGAAGGT TGTCACTCAG AGCAACGGCA AGGAGCAGAG TGCTGTCTTT 
GACGCAGTTA TGGTTTGCAG TGGCCACCAC ATTCTACCTC ATATCCCACT GAAGTCATTT 
CCAGGTATGG AGAGGTTCAA AGGCCAATAT TTCCATAGCC GCCAATACAA GCATCCAGAT 
GGATTTGAGG GAAAACGCAT CCTGGTGATT GGAATGGGAA ACTCAGGCTC AGATATTGCT 
GTTGAGCTGA GTAAGAATGC TGCTCAGGTT TTTATCAGCA CCAGGCATGG CACCTGGGTC 
ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FMO2 ( NM_001460.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001451.2 Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu57828
Clone ID Related Accession (Same CDS sequence)	NM_001460.4 , NM_001460.5
Accession Version	NM_001460.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB224311.1, BC005894.1, KF459607.1, AL833218.1, R95468.1, AK098145.1, AI821378.1 and AL021026.1. On Nov 23, 2018 this sequence version replaced NM_001460.4. Transcript Variant: This variant (1), which represents the functional FMO2*1 allele, is the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.258376.1, SRR1803612.81140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000209929.10/ ENSP00000209929.8 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAAAGA AGGTAGCTGT GATTGGAGCT GGGGTCAGTG GCCTAATTTC TCTGAAGTGC 
TGTGTGGATG AGGGACTTGA GCCCACTTGC TTTGAGAGAA CTGAAGATAT TGGAGGAGTG 
TGGAGGTTCA AAGAGAATGT GGAAGATGGC CGAGCAAGTA TCTATCAATC TGTCGTTACC 
AACACCAGCA AAGAAATGTC CTGTTTCAGT GACTTTCCAA TGCCTGAAGA TTTTCCAAAC 
TTCCTGCATA ATTCTAAACT TCTGGAATAT TTCAGGATTT TTGCTAAAAA ATTTGATCTG 
CTAAAATATA TTCAGTTCCA GACAACTGTC CTTAGTGTGA GAAAATGTCC AGATTTCTCA 
TCCTCTGGCC AATGGAAGGT TGTCACTCAG AGCAACGGCA AGGAGCAGAG TGCTGTCTTT 
GACGCAGTTA TGGTTTGCAG TGGCCACCAC ATTCTACCTC ATATCCCACT GAAGTCATTT 
CCAGGTATGG AGAGGTTCAA AGGCCAATAT TTCCATAGCC GCCAATACAA GCATCCAGAT 
GGATTTGAGG GAAAACGCAT CCTGGTGATT GGAATGGGAA ACTCAGGCTC AGATATTGCT 
GTTGAGCTGA GTAAGAATGC TGCTCAGGTT TTTATCAGCA CCAGGCATGG CACCTGGGTC 
ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001451.2
CDS	67..1674
Translation	MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVTNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

Target ORF information:

RefSeq Version	NM_001460.5
Organism	Homo sapiens(human)
Definition	Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001460.5

ORF Insert Sequence:

ATGGCAAAGA AGGTAGCTGT GATTGGAGCT GGGGTCAGTG GCCTAATTTC TCTGAAGTGC 
TGTGTGGATG AGGGACTTGA GCCCACTTGC TTTGAGAGAA CTGAAGATAT TGGAGGAGTG 
TGGAGGTTCA AAGAGAATGT GGAAGATGGC CGAGCAAGTA TCTATCAATC TGTCGTTACC 
AACACCAGCA AAGAAATGTC CTGTTTCAGT GACTTTCCAA TGCCTGAAGA TTTTCCAAAC 
TTCCTGCATA ATTCTAAACT TCTGGAATAT TTCAGGATTT TTGCTAAAAA ATTTGATCTG 
CTAAAATATA TTCAGTTCCA GACAACTGTC CTTAGTGTGA GAAAATGTCC AGATTTCTCA 
TCCTCTGGCC AATGGAAGGT TGTCACTCAG AGCAACGGCA AGGAGCAGAG TGCTGTCTTT 
GACGCAGTTA TGGTTTGCAG TGGCCACCAC ATTCTACCTC ATATCCCACT GAAGTCATTT 
CCAGGTATGG AGAGGTTCAA AGGCCAATAT TTCCATAGCC GCCAATACAA GCATCCAGAT 
GGATTTGAGG GAAAACGCAT CCTGGTGATT GGAATGGGAA ACTCAGGCTC AGATATTGCT 
GTTGAGCTGA GTAAGAATGC TGCTCAGGTT TTTATCAGCA CCAGGCATGG CACCTGGGTC 
ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FMO2 ( NM_001301347.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288276.1 Homo sapiens flavin containing monooxygenase 2 (FMO2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu57827
Clone ID Related Accession (Same CDS sequence)	NM_001301347.1 , NM_001301347.2
Accession Version	NM_001301347.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI766311.1, DB224311.1, AK304385.1, KF459607.1, AL833218.1, R95468.1, AK098145.1 and AI821378.1. Transcript Variant: This variant (3) lacks two alternate exons, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288276.1
CDS	538..1485
Translation	MSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

Target ORF information:

RefSeq Version	NM_001301347.1
Organism	Homo sapiens(human)
Definition	Homo sapiens flavin containing monooxygenase 2 (FMO2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301347.1

ORF Insert Sequence:

ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FMO2 ( NM_001301347.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288276.1 Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu57827
Clone ID Related Accession (Same CDS sequence)	NM_001301347.1 , NM_001301347.2
Accession Version	NM_001301347.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK304385.1, KF459607.1, AL833218.1, R95468.1, AK098145.1, AI821378.1 and AL021026.1. On May 31, 2019 this sequence version replaced NM_001301347.1. Transcript Variant: This variant (3) lacks two alternate exons, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304385.1, SRR5189667.67380.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288276.1
CDS	446..1393
Translation	MSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

Target ORF information:

RefSeq Version	NM_001301347.2
Organism	Homo sapiens(human)
Definition	Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301347.2

ORF Insert Sequence:

ATGAGCCGTA TCTCTGAAGA TGGCTATCCT TGGGACTCAG TGTTCCACAC CCGGTTTCGT 
TCTATGCTCC GCAATGTACT GCCACGAACA GCTGTAAAAT GGATGATAGA ACAACAGATG 
AATCGGTGGT TCAACCATGA AAATTATGGC CTTGAGCCTC AAAACAAATA CATTATGAAG 
GAACCTGTAC TAAATGATGA TGTCCCAAGT CGTCTACTCT GTGGAGCCAT CAAGGTGAAA 
TCTACAGTGA AAGAGCTCAC AGAAACTTCT GCCATCTTTG AGGATGGAAC AGTGGAGGAG 
AACATTGATG TCATCATTTT TGCAACAGGA TATAGTTTCT CTTTTCCCTT CCTTGAAGAT 
TCACTCGTTA AAGTAGAGAA TAATATGGTC TCACTGTATA AATACATATT CCCCGCTCAC 
CTGGACAAGT CAACCCTCGC GTGCATTGGT CTCATCCAGC CCCTAGGTTC CATTTTCCCA 
ACTGCTGAAC TTCAAGCTCG TTGGGTGACA AGAGTTTTCA AAGGCTTGTG TAGCCTGCCC 
TCAGAGAGAA CTATGATGAT GGACATTATC AAAAGGAATG AAAAAAGAAT TGACCTGTTT 
GGAGAAAGCC AGAGCCAGAC GTTGCAGACC AATTATGTTG ACTACTTGGA CGAGCTCGCC 
TTAGAGATAG GTGCGAAGCC AGATTTCTGC TCTCTCTTGT TCAAAGATCC TAAACTGGCT 
GTGAGACTCT ATTTCGGACC CTGCAACTCC TATCAGTATC GCCTGGTTGG GCCTGGGCAA 
TGGGAAGGAG CCAGAAATGC CATCTTCACC CAGAAACAAA GAATACTGAA GCCACTCAAG 
ACTCGGGCCC TGAAGGATTC ATCTAATTTC TCAGTTTCTT TTCTGTTGAA AATCCTGGGC 
CTTCTTGCTG TTGTTGTGGC CTTTTTTTGC CAACTTCAAT GGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FMO2 ( NM_001365900.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001352829.1 Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu106873
Clone ID Related Accession (Same CDS sequence)	NM_001365900.1
Accession Version	NM_001365900.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1413bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	dimethylaniline monooxygenase [N-oxide-forming] 2 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL021026.1 and KF459607.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138524.516585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGTCCTGTT TCAGTGACTT TCCAATGCCT GAAGATTTTC CAAACTTCCT GCATAATTCT 
AAACTTCTGG AATATTTCAG GATTTTTGCT AAAAAATTTG ATCTGCTAAA ATATATTCAG 
TTCCAGACAA CTGTCCTTAG TGTGAGAAAA TGTCCAGATT TCTCATCCTC TGGCCAATGG 
AAGGTTGTCA CTCAGAGCAA CGGCAAGGAG CAGAGTGCTG TCTTTGACGC AGTTATGGTT 
TGCAGTGGCC ACCACATTCT ACCTCATATC CCACTGAAGT CATTTCCAGG TATGGAGAGG 
TTCAAAGGCC AATATTTCCA TAGCCGCCAA TACAAGCATC CAGATGGATT TGAGGGAAAA 
CGCATCCTGG TGATTGGAAT GGGAAACTCA GGCTCAGATA TTGCTGTTGA GCTGAGTAAG 
AATGCTGCTC AGGTTTTTAT CAGCACCAGG CATGGCACCT GGGTCATGAG CCGTATCTCT 
GAAGATGGCT ATCCTTGGGA CTCAGTGTTC CACACCCGGT TTCGTTCTAT GCTCCGCAAT 
GTACTGCCAC GAACAGCTGT AAAATGGATG ATAGAACAAC AGATGAATCG GTGGTTCAAC 
CATGAAAATT ATGGCCTTGA GCCTCAAAAC AAATACATTA TGAAGGAACC TGTACTAAAT 
GATGATGTCC CAAGTCGTCT ACTCTGTGGA GCCATCAAGG TGAAATCTAC AGTGAAAGAG 
CTCACAGAAA CTTCTGCCAT CTTTGAGGAT GGAACAGTGG AGGAGAACAT TGATGTCATC 
ATTTTTGCAA CAGGATATAG TTTCTCTTTT CCCTTCCTTG AAGATTCACT CGTTAAAGTA 
GAGAATAATA TGGTCTCACT GTATAAATAC ATATTCCCCG CTCACCTGGA CAAGTCAACC 
CTCGCGTGCA TTGGTCTCAT CCAGCCCCTA GGTTCCATTT TCCCAACTGC TGAACTTCAA 
GCTCGTTGGG TGACAAGAGT TTTCAAAGGC TTGTGTAGCC TGCCCTCAGA GAGAACTATG 
ATGATGGACA TTATCAAAAG GAATGAAAAA AGAATTGACC TGTTTGGAGA AAGCCAGAGC 
CAGACGTTGC AGACCAATTA TGTTGACTAC TTGGACGAGC TCGCCTTAGA GATAGGTGCG 
AAGCCAGATT TCTGCTCTCT CTTGTTCAAA GATCCTAAAC TGGCTGTGAG ACTCTATTTC 
GGACCCTGCA ACTCCTATCA GTATCGCCTG GTTGGGCCTG GGCAATGGGA AGGAGCCAGA 
AATGCCATCT TCACCCAGAA ACAAAGAATA CTGAAGCCAC TCAAGACTCG GGCCCTGAAG 
GATTCATCTA ATTTCTCAGT TTCTTTTCTG TTGAAAATCC TGGGCCTTCT TGCTGTTGTT 
GTGGCCTTTT TTTGCCAACT TCAATGGTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001352829.1
CDS	216..1628
Translation	MSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

Target ORF information:

RefSeq Version	NM_001365900.1
Organism	Homo sapiens(human)
Definition	Homo sapiens flavin containing dimethylaniline monoxygenase 2 (FMO2), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001365900.1

ORF Insert Sequence:

ATGTCCTGTT TCAGTGACTT TCCAATGCCT GAAGATTTTC CAAACTTCCT GCATAATTCT 
AAACTTCTGG AATATTTCAG GATTTTTGCT AAAAAATTTG ATCTGCTAAA ATATATTCAG 
TTCCAGACAA CTGTCCTTAG TGTGAGAAAA TGTCCAGATT TCTCATCCTC TGGCCAATGG 
AAGGTTGTCA CTCAGAGCAA CGGCAAGGAG CAGAGTGCTG TCTTTGACGC AGTTATGGTT 
TGCAGTGGCC ACCACATTCT ACCTCATATC CCACTGAAGT CATTTCCAGG TATGGAGAGG 
TTCAAAGGCC AATATTTCCA TAGCCGCCAA TACAAGCATC CAGATGGATT TGAGGGAAAA 
CGCATCCTGG TGATTGGAAT GGGAAACTCA GGCTCAGATA TTGCTGTTGA GCTGAGTAAG 
AATGCTGCTC AGGTTTTTAT CAGCACCAGG CATGGCACCT GGGTCATGAG CCGTATCTCT 
GAAGATGGCT ATCCTTGGGA CTCAGTGTTC CACACCCGGT TTCGTTCTAT GCTCCGCAAT 
GTACTGCCAC GAACAGCTGT AAAATGGATG ATAGAACAAC AGATGAATCG GTGGTTCAAC 
CATGAAAATT ATGGCCTTGA GCCTCAAAAC AAATACATTA TGAAGGAACC TGTACTAAAT 
GATGATGTCC CAAGTCGTCT ACTCTGTGGA GCCATCAAGG TGAAATCTAC AGTGAAAGAG 
CTCACAGAAA CTTCTGCCAT CTTTGAGGAT GGAACAGTGG AGGAGAACAT TGATGTCATC 
ATTTTTGCAA CAGGATATAG TTTCTCTTTT CCCTTCCTTG AAGATTCACT CGTTAAAGTA 
GAGAATAATA TGGTCTCACT GTATAAATAC ATATTCCCCG CTCACCTGGA CAAGTCAACC 
CTCGCGTGCA TTGGTCTCAT CCAGCCCCTA GGTTCCATTT TCCCAACTGC TGAACTTCAA 
GCTCGTTGGG TGACAAGAGT TTTCAAAGGC TTGTGTAGCC TGCCCTCAGA GAGAACTATG 
ATGATGGACA TTATCAAAAG GAATGAAAAA AGAATTGACC TGTTTGGAGA AAGCCAGAGC 
CAGACGTTGC AGACCAATTA TGTTGACTAC TTGGACGAGC TCGCCTTAGA GATAGGTGCG 
AAGCCAGATT TCTGCTCTCT CTTGTTCAAA GATCCTAAAC TGGCTGTGAG ACTCTATTTC 
GGACCCTGCA ACTCCTATCA GTATCGCCTG GTTGGGCCTG GGCAATGGGA AGGAGCCAGA 
AATGCCATCT TCACCCAGAA ACAAAGAATA CTGAAGCCAC TCAAGACTCG GGCCCTGAAG 
GATTCATCTA ATTTCTCAGT TTCTTTTCTG TTGAAAATCC TGGGCCTTCT TGCTGTTGTT 
GTGGCCTTTT TTTGCCAACT TCAATGGTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1.
PloS one12(10)e0184931(2017)
Mekonnen E,Bekele E

Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide.
Biochemical pharmacology89(1)141-7(2014 May)
Siddens LK,Krueger SK,Henderson MC,Williams DE

Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.
Drug metabolism and disposition: the biological fate of chemicals37(8)1785-91(2009 Aug)
Krueger SK,Henderson MC,Siddens LK,VanDyke JE,Benninghoff AD,Karplus PA,Furnes B,Schlenk D,Williams DE

Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.
Drug metabolism and disposition: the biological fate of chemicals37(1)178-86(2009 Jan)
Francois AA,Nishida CR,de Montellano PR,Phillips IR,Shephard EA

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.
Toxicology and applied pharmacology168(3)216-24(2000 Nov)
Whetstine JR,Yueh MF,McCarver DG,Williams DE,Park CS,Kang JH,Cha YN,Dolphin CT,Shephard EA,Phillips IR,Hines RN

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FMO2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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