BOP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BOP1
Entrez Gene ID	23246
Full Name	block of proliferation 1
General protein information	Preferred Names block of proliferation 1 Names ribosome biogenesis protein BOP1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.3
Disorder MIM:	610596

mRNA and Protein(s)

mRNA	Protein	Name
NM_015201.5	NP_056016.1	ribosome biogenesis protein BOP1
NM_015201.4	NP_056016.1	ribosome biogenesis protein BOP1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Bop1	NP_001019421.1
Gallus gallus (chicken)	BOP1	XP_004950532.1
Anopheles gambiae (African malaria mosquito)	BOP1_ANOGA	XP_308633.4
Xenopus tropicalis (tropical clawed frog)	bop1	NP_001096309.1
	LOC714024	XP_002805572.1
Danio rerio (zebrafish)	bop1	NP_001071203.1
Caenorhabditis elegans (roundworm)	CELE_Y48B6A.1	NP_496956.1
Kluyveromyces lactis	KLLA0F26653g	XP_456266.1
Eremothecium gossypii	AGOS_ABR101C	NP_983048.2
Neurospora crassa	NCU03321	XP_964498.1
Arabidopsis thaliana (thale cress)	AT2G40360	NP_181567.3
Pan troglodytes (chimpanzee)	BOP1	XP_003312026.2
Canis lupus familiaris (dog)	BOP1	XP_003431868.2
Homo sapiens (human)	BOP1	NP_056016.1
Saccharomyces cerevisiae (baker's yeast)	ERB1	NP_013764.1
Schizosaccharomyces pombe (fission yeast)	SPBC4F6.13c	NP_596113.2
Magnaporthe oryzae (rice blast fungus)	MGG_09313	XP_003709965.1
Oryza sativa (rice)	Os07g0435400	NP_001059502.1
Bos taurus (cattle)	BOP1	XP_002692629.2
Mus musculus (house mouse)	Bop1	NP_038509.1
Drosophila melanogaster (fruit fly)	CG5033	NP_611270.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.
Kellner M, Rohrmoser M, Forn? I, Voss K, Burger K, M?hl B, Gruber-Eber A, Kremmer E, Imhof A, Eick D
Experimental cell research334(1)146-59(2015 May)

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.
Sloan KE, Bohnsack MT, Watkins NJ
Cell reports5(1)237-47(2013 Oct)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition.
Chung KY, Cheng IK, Ching AK, Chu JH, Lai PB, Wong N
Hepatology (Baltimore, Md.)54(1)307-18(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex.
Title: DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.

Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition.
Title: Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition.

Deregulation of the BOP1 pathway contributes to chromosomal instability in colorectal tumorigenesis.
Title: Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis.

The following BOP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BOP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu65794	NM_015201.5 Latest version!	Homo sapiens BOP1 ribosomal biogenesis factor (BOP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu65794	NM_015201.4	Homo sapiens block of proliferation 1 (BOP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BOP1 ( NM_015201.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_056016.1 Homo sapiens BOP1 ribosomal biogenesis factor (BOP1), mRNA.

Price & Availability↑

CloneID	OHu65794
Clone ID Related Accession (Same CDS sequence)	NM_015201.5 , NM_015201.4
Accession Version	NM_015201.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2241bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ribosome biogenesis protein BOP1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA510177.1, BQ711345.1, BC013787.1, AI937005.1 and AC145291.3. On Nov 23, 2018 this sequence version replaced NM_015201.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.548849.1, BC013980.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000569669.6/ ENSP00000455106.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGTT CGCGGGGTGC GGGGCGCACG GCGGCGCCGA GCGTGCGGCC GGAGAAGCGG 
CGGTCTGAGC CCGAACTGGA GCCTGAGCCC GAGCCGGAGC CCCCCCTCCT CTGCACCTCT 
CCTCTCAGCC ACAGCACCGG CAGCGATTCT GGCGTCTCCG ACAGCGAGGA AAGTGTGTTC 
TCAGGCCTGG AAGATTCCGG CAGTGACAGC AGTGAGGATG ATGACGAAGG CGACGAGGAG 
GGAGAGGACG GAGCCCTTGA TGACGAGGGC CACAGTGGGA TTAAAAAGAC CACTGAGGAG 
CAGGTGCAGG CCAGCACTCC TTGCCCGAGG ACAGAGATGG CGAGCGCCCG GATTGGGGAT 
GAGTATGCGG AGGACAGCTC TGATGAGGAG GACATCCGGA ACACGGTGGG CAACGTGCCC 
TTGGAGTGGT ACGATGACTT CCCCCACGTG GGCTACGACC TGGATGGCAG GCGCATCTAC 
AAGCCCCTGC GGACCCGGGA TGAGCTGGAC CAGTTCCTGG ACAAGATGGA CGATCCTGAC 
TACTGGCGCA CCGTGCAGGA CCCGATGACA GGGCGGGACC TGAGACTGAC GGATGAGCAG 
GTGGCCCTGG TGCGGCGGCT GCAGAGTGGC CAGTTTGGGG ATGTGGGCTT CAACCCCTAT 
GAGCCGGCTG TCGACTTCTT CAGCGGGGAC GTCATGATCC ACCCGGTGAC CAACCGCCCG 
GCCGACAAGC GCAGCTTCAT CCCCTCCCTG GTGGAGAAGG AGAAGGTCTC TCGCATGGTG 
CACGCCATCA AGATGGGCTG GATCCAGCCT CGCCGGCCCC GAGACCCCAC CCCCAGCTTC 
TATGACCTGT GGGCCCAGGA GGACCCCAAC GCCGTGCTCG GGCGCCACAA GATGCACGTA 
CCTGCTCCCA AGCTGGCCCT GCCAGGCCAC GCCGAGTCGT ACAACCCACC CCCTGAATAC 
CTGCTCAGCG AGGAGGAGCG CTTGGCGTGG GAACAGCAGG AGCCAGGCGA GAGGAAGCTG 
AGCTTTTTGC CACGCAAGTT CCCGAGCCTG CGGGCCGTGC CTGCCTACGG ACGCTTCATC 
CAGGAACGCT TCGAGCGCTG CCTTGACCTG TACCTGTGCC CACGGCAGCG CAAGATGAGG 
GTGAATGTAG ACCCTGAGGA CCTCATCCCC AAGCTGCCTC GGCCGAGGGA CCTGCAGCCC 
TTCCCCACGT GCCAGGCCCT GGTCTACAGG GGCCACAGTG ACCTTGTCCG GTGCCTCAGT 
GTCTCTCCTG GGGGCCAGTG GCTGGTTTCA GGCTCTGACG ACGGCTCCCT GCGGCTCTGG 
GAGGTGGCCA CTGCCCGCTG TGTGAGGACT GTTCCCGTGG GGGGCGTGGT GAAGAGTGTG 
GCCTGGAACC CCAGCCCCGC TGTCTGCCTG GTGGCTGCAG CCGTGGAGGA CTCGGTGCTG 
CTGCTGAACC CAGCTCTGGG GGACCGGCTG GTGGCGGGCA GCACAGATCA GCTGTTGAGC 
GCCTTCGTCC CGCCTGAGGA GCCCCCCTTG CAGCCGGCCC GCTGGCTGGA GGCCTCAGAG 
GAGGAGCGCC AAGTGGGCCT GCGGCTGCGC ATCTGCCACG GGAAGCCAGT GACGCAGGTG 
ACCTGGCACG GGCGTGGGGA CTACCTGGCC GTGGTGCTGG CCACCCAAGG CCACACCCAG 
GTGCTGATTC ACCAGCTGAG CCGTCGCCGC AGCCAGAGTC CGTTCCGCCG CAGCCACGGA 
CAGGTGCAGC GAGTGGCCTT CCACCCTGCC CGGCCCTTCC TGTTGGTGGC GTCCCAGCGC 
AGCGTCCGCC TCTACCACCT GCTGCGCCAG GAGCTCACCA AGAAGCTGAT GCCCAACTGC 
AAGTGGGTGT CCAGCCTGGC GGTGCACCCT GCAGGTGACA ACGTCATCTG TGGGAGCTAC 
GATAGCAAGC TGGTGTGGTT TGACCTGGAT CTTTCCACCA AGCCATACAG GATGCTGAGA 
CACCACAAGA AGGCTCTGCG GGCTGTGGCC TTCCACCCGC GGTACCCACT CTTTGCGTCA 
GGCTCGGACG ACGGCAGTGT CATCGTCTGC CATGGCATGG TGTACAATGA CCTTCTGCAG 
AACCCCTTGC TGGTGCCCGT CAAGGTGCTG AAGGGACACG TGCTGACCCG AGATCTGGGA 
GTGCTGGACG TCATCTTCCA CCCCACCCAG CCGTGGGTCT TCTCCTCGGG GGCAGACGGG 
ACTGTCCGCC TCTTCACCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056016.1
CDS	69..2309
Translation	MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVFSGLEDSGSDSSEDDDEGDEEGEDGALDDEGHSGIKKTTEEQVQASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT

Target ORF information:

RefSeq Version	NM_015201.5
Organism	Homo sapiens(human)
Definition	Homo sapiens BOP1 ribosomal biogenesis factor (BOP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015201.5

ORF Insert Sequence:

ATGGCGGGTT CGCGGGGTGC GGGGCGCACG GCGGCGCCGA GCGTGCGGCC GGAGAAGCGG 
CGGTCTGAGC CCGAACTGGA GCCTGAGCCC GAGCCGGAGC CCCCCCTCCT CTGCACCTCT 
CCTCTCAGCC ACAGCACCGG CAGCGATTCT GGCGTCTCCG ACAGCGAGGA AAGTGTGTTC 
TCAGGCCTGG AAGATTCCGG CAGTGACAGC AGTGAGGATG ATGACGAAGG CGACGAGGAG 
GGAGAGGACG GAGCCCTTGA TGACGAGGGC CACAGTGGGA TTAAAAAGAC CACTGAGGAG 
CAGGTGCAGG CCAGCACTCC TTGCCCGAGG ACAGAGATGG CGAGCGCCCG GATTGGGGAT 
GAGTATGCGG AGGACAGCTC TGATGAGGAG GACATCCGGA ACACGGTGGG CAACGTGCCC 
TTGGAGTGGT ACGATGACTT CCCCCACGTG GGCTACGACC TGGATGGCAG GCGCATCTAC 
AAGCCCCTGC GGACCCGGGA TGAGCTGGAC CAGTTCCTGG ACAAGATGGA CGATCCTGAC 
TACTGGCGCA CCGTGCAGGA CCCGATGACA GGGCGGGACC TGAGACTGAC GGATGAGCAG 
GTGGCCCTGG TGCGGCGGCT GCAGAGTGGC CAGTTTGGGG ATGTGGGCTT CAACCCCTAT 
GAGCCGGCTG TCGACTTCTT CAGCGGGGAC GTCATGATCC ACCCGGTGAC CAACCGCCCG 
GCCGACAAGC GCAGCTTCAT CCCCTCCCTG GTGGAGAAGG AGAAGGTCTC TCGCATGGTG 
CACGCCATCA AGATGGGCTG GATCCAGCCT CGCCGGCCCC GAGACCCCAC CCCCAGCTTC 
TATGACCTGT GGGCCCAGGA GGACCCCAAC GCCGTGCTCG GGCGCCACAA GATGCACGTA 
CCTGCTCCCA AGCTGGCCCT GCCAGGCCAC GCCGAGTCGT ACAACCCACC CCCTGAATAC 
CTGCTCAGCG AGGAGGAGCG CTTGGCGTGG GAACAGCAGG AGCCAGGCGA GAGGAAGCTG 
AGCTTTTTGC CACGCAAGTT CCCGAGCCTG CGGGCCGTGC CTGCCTACGG ACGCTTCATC 
CAGGAACGCT TCGAGCGCTG CCTTGACCTG TACCTGTGCC CACGGCAGCG CAAGATGAGG 
GTGAATGTAG ACCCTGAGGA CCTCATCCCC AAGCTGCCTC GGCCGAGGGA CCTGCAGCCC 
TTCCCCACGT GCCAGGCCCT GGTCTACAGG GGCCACAGTG ACCTTGTCCG GTGCCTCAGT 
GTCTCTCCTG GGGGCCAGTG GCTGGTTTCA GGCTCTGACG ACGGCTCCCT GCGGCTCTGG 
GAGGTGGCCA CTGCCCGCTG TGTGAGGACT GTTCCCGTGG GGGGCGTGGT GAAGAGTGTG 
GCCTGGAACC CCAGCCCCGC TGTCTGCCTG GTGGCTGCAG CCGTGGAGGA CTCGGTGCTG 
CTGCTGAACC CAGCTCTGGG GGACCGGCTG GTGGCGGGCA GCACAGATCA GCTGTTGAGC 
GCCTTCGTCC CGCCTGAGGA GCCCCCCTTG CAGCCGGCCC GCTGGCTGGA GGCCTCAGAG 
GAGGAGCGCC AAGTGGGCCT GCGGCTGCGC ATCTGCCACG GGAAGCCAGT GACGCAGGTG 
ACCTGGCACG GGCGTGGGGA CTACCTGGCC GTGGTGCTGG CCACCCAAGG CCACACCCAG 
GTGCTGATTC ACCAGCTGAG CCGTCGCCGC AGCCAGAGTC CGTTCCGCCG CAGCCACGGA 
CAGGTGCAGC GAGTGGCCTT CCACCCTGCC CGGCCCTTCC TGTTGGTGGC GTCCCAGCGC 
AGCGTCCGCC TCTACCACCT GCTGCGCCAG GAGCTCACCA AGAAGCTGAT GCCCAACTGC 
AAGTGGGTGT CCAGCCTGGC GGTGCACCCT GCAGGTGACA ACGTCATCTG TGGGAGCTAC 
GATAGCAAGC TGGTGTGGTT TGACCTGGAT CTTTCCACCA AGCCATACAG GATGCTGAGA 
CACCACAAGA AGGCTCTGCG GGCTGTGGCC TTCCACCCGC GGTACCCACT CTTTGCGTCA 
GGCTCGGACG ACGGCAGTGT CATCGTCTGC CATGGCATGG TGTACAATGA CCTTCTGCAG 
AACCCCTTGC TGGTGCCCGT CAAGGTGCTG AAGGGACACG TGCTGACCCG AGATCTGGGA 
GTGCTGGACG TCATCTTCCA CCCCACCCAG CCGTGGGTCT TCTCCTCGGG GGCAGACGGG 
ACTGTCCGCC TCTTCACCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BOP1 ( NM_015201.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056016.1 Homo sapiens block of proliferation 1 (BOP1), mRNA.

Price & Availability↑

CloneID	OHu65794
Clone ID Related Accession (Same CDS sequence)	NM_015201.5 , NM_015201.4
Accession Version	NM_015201.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2241bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	ribosome biogenesis protein BOP1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA510177.1, BQ711345.1, BC013787.1 and AI937005.1. On Dec 17, 2014 this sequence version replaced NM_015201.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013980.2, SRR1163657.263681.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGTT CGCGGGGTGC GGGGCGCACG GCGGCGCCGA GCGTGCGGCC GGAGAAGCGG 
CGGTCTGAGC CCGAACTGGA GCCTGAGCCC GAGCCGGAGC CCCCCCTCCT CTGCACCTCT 
CCTCTCAGCC ACAGCACCGG CAGCGATTCT GGCGTCTCCG ACAGCGAGGA AAGTGTGTTC 
TCAGGCCTGG AAGATTCCGG CAGTGACAGC AGTGAGGATG ATGACGAAGG CGACGAGGAG 
GGAGAGGACG GAGCCCTTGA TGACGAGGGC CACAGTGGGA TTAAAAAGAC CACTGAGGAG 
CAGGTGCAGG CCAGCACTCC TTGCCCGAGG ACAGAGATGG CGAGCGCCCG GATTGGGGAT 
GAGTATGCGG AGGACAGCTC TGATGAGGAG GACATCCGGA ACACGGTGGG CAACGTGCCC 
TTGGAGTGGT ACGATGACTT CCCCCACGTG GGCTACGACC TGGATGGCAG GCGCATCTAC 
AAGCCCCTGC GGACCCGGGA TGAGCTGGAC CAGTTCCTGG ACAAGATGGA CGATCCTGAC 
TACTGGCGCA CCGTGCAGGA CCCGATGACA GGGCGGGACC TGAGACTGAC GGATGAGCAG 
GTGGCCCTGG TGCGGCGGCT GCAGAGTGGC CAGTTTGGGG ATGTGGGCTT CAACCCCTAT 
GAGCCGGCTG TCGACTTCTT CAGCGGGGAC GTCATGATCC ACCCGGTGAC CAACCGCCCG 
GCCGACAAGC GCAGCTTCAT CCCCTCCCTG GTGGAGAAGG AGAAGGTCTC TCGCATGGTG 
CACGCCATCA AGATGGGCTG GATCCAGCCT CGCCGGCCCC GAGACCCCAC CCCCAGCTTC 
TATGACCTGT GGGCCCAGGA GGACCCCAAC GCCGTGCTCG GGCGCCACAA GATGCACGTA 
CCTGCTCCCA AGCTGGCCCT GCCAGGCCAC GCCGAGTCGT ACAACCCACC CCCTGAATAC 
CTGCTCAGCG AGGAGGAGCG CTTGGCGTGG GAACAGCAGG AGCCAGGCGA GAGGAAGCTG 
AGCTTTTTGC CACGCAAGTT CCCGAGCCTG CGGGCCGTGC CTGCCTACGG ACGCTTCATC 
CAGGAACGCT TCGAGCGCTG CCTTGACCTG TACCTGTGCC CACGGCAGCG CAAGATGAGG 
GTGAATGTAG ACCCTGAGGA CCTCATCCCC AAGCTGCCTC GGCCGAGGGA CCTGCAGCCC 
TTCCCCACGT GCCAGGCCCT GGTCTACAGG GGCCACAGTG ACCTTGTCCG GTGCCTCAGT 
GTCTCTCCTG GGGGCCAGTG GCTGGTTTCA GGCTCTGACG ACGGCTCCCT GCGGCTCTGG 
GAGGTGGCCA CTGCCCGCTG TGTGAGGACT GTTCCCGTGG GGGGCGTGGT GAAGAGTGTG 
GCCTGGAACC CCAGCCCCGC TGTCTGCCTG GTGGCTGCAG CCGTGGAGGA CTCGGTGCTG 
CTGCTGAACC CAGCTCTGGG GGACCGGCTG GTGGCGGGCA GCACAGATCA GCTGTTGAGC 
GCCTTCGTCC CGCCTGAGGA GCCCCCCTTG CAGCCGGCCC GCTGGCTGGA GGCCTCAGAG 
GAGGAGCGCC AAGTGGGCCT GCGGCTGCGC ATCTGCCACG GGAAGCCAGT GACGCAGGTG 
ACCTGGCACG GGCGTGGGGA CTACCTGGCC GTGGTGCTGG CCACCCAAGG CCACACCCAG 
GTGCTGATTC ACCAGCTGAG CCGTCGCCGC AGCCAGAGTC CGTTCCGCCG CAGCCACGGA 
CAGGTGCAGC GAGTGGCCTT CCACCCTGCC CGGCCCTTCC TGTTGGTGGC GTCCCAGCGC 
AGCGTCCGCC TCTACCACCT GCTGCGCCAG GAGCTCACCA AGAAGCTGAT GCCCAACTGC 
AAGTGGGTGT CCAGCCTGGC GGTGCACCCT GCAGGTGACA ACGTCATCTG TGGGAGCTAC 
GATAGCAAGC TGGTGTGGTT TGACCTGGAT CTTTCCACCA AGCCATACAG GATGCTGAGA 
CACCACAAGA AGGCTCTGCG GGCTGTGGCC TTCCACCCGC GGTACCCACT CTTTGCGTCA 
GGCTCGGACG ACGGCAGTGT CATCGTCTGC CATGGCATGG TGTACAATGA CCTTCTGCAG 
AACCCCTTGC TGGTGCCCGT CAAGGTGCTG AAGGGACACG TGCTGACCCG AGATCTGGGA 
GTGCTGGACG TCATCTTCCA CCCCACCCAG CCGTGGGTCT TCTCCTCGGG GGCAGACGGG 
ACTGTCCGCC TCTTCACCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056016.1
CDS	69..2309
Translation	MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVFSGLEDSGSDSSEDDDEGDEEGEDGALDDEGHSGIKKTTEEQVQASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT

Target ORF information:

RefSeq Version	NM_015201.4
Organism	Homo sapiens(human)
Definition	Homo sapiens block of proliferation 1 (BOP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015201.4

ORF Insert Sequence:

ATGGCGGGTT CGCGGGGTGC GGGGCGCACG GCGGCGCCGA GCGTGCGGCC GGAGAAGCGG 
CGGTCTGAGC CCGAACTGGA GCCTGAGCCC GAGCCGGAGC CCCCCCTCCT CTGCACCTCT 
CCTCTCAGCC ACAGCACCGG CAGCGATTCT GGCGTCTCCG ACAGCGAGGA AAGTGTGTTC 
TCAGGCCTGG AAGATTCCGG CAGTGACAGC AGTGAGGATG ATGACGAAGG CGACGAGGAG 
GGAGAGGACG GAGCCCTTGA TGACGAGGGC CACAGTGGGA TTAAAAAGAC CACTGAGGAG 
CAGGTGCAGG CCAGCACTCC TTGCCCGAGG ACAGAGATGG CGAGCGCCCG GATTGGGGAT 
GAGTATGCGG AGGACAGCTC TGATGAGGAG GACATCCGGA ACACGGTGGG CAACGTGCCC 
TTGGAGTGGT ACGATGACTT CCCCCACGTG GGCTACGACC TGGATGGCAG GCGCATCTAC 
AAGCCCCTGC GGACCCGGGA TGAGCTGGAC CAGTTCCTGG ACAAGATGGA CGATCCTGAC 
TACTGGCGCA CCGTGCAGGA CCCGATGACA GGGCGGGACC TGAGACTGAC GGATGAGCAG 
GTGGCCCTGG TGCGGCGGCT GCAGAGTGGC CAGTTTGGGG ATGTGGGCTT CAACCCCTAT 
GAGCCGGCTG TCGACTTCTT CAGCGGGGAC GTCATGATCC ACCCGGTGAC CAACCGCCCG 
GCCGACAAGC GCAGCTTCAT CCCCTCCCTG GTGGAGAAGG AGAAGGTCTC TCGCATGGTG 
CACGCCATCA AGATGGGCTG GATCCAGCCT CGCCGGCCCC GAGACCCCAC CCCCAGCTTC 
TATGACCTGT GGGCCCAGGA GGACCCCAAC GCCGTGCTCG GGCGCCACAA GATGCACGTA 
CCTGCTCCCA AGCTGGCCCT GCCAGGCCAC GCCGAGTCGT ACAACCCACC CCCTGAATAC 
CTGCTCAGCG AGGAGGAGCG CTTGGCGTGG GAACAGCAGG AGCCAGGCGA GAGGAAGCTG 
AGCTTTTTGC CACGCAAGTT CCCGAGCCTG CGGGCCGTGC CTGCCTACGG ACGCTTCATC 
CAGGAACGCT TCGAGCGCTG CCTTGACCTG TACCTGTGCC CACGGCAGCG CAAGATGAGG 
GTGAATGTAG ACCCTGAGGA CCTCATCCCC AAGCTGCCTC GGCCGAGGGA CCTGCAGCCC 
TTCCCCACGT GCCAGGCCCT GGTCTACAGG GGCCACAGTG ACCTTGTCCG GTGCCTCAGT 
GTCTCTCCTG GGGGCCAGTG GCTGGTTTCA GGCTCTGACG ACGGCTCCCT GCGGCTCTGG 
GAGGTGGCCA CTGCCCGCTG TGTGAGGACT GTTCCCGTGG GGGGCGTGGT GAAGAGTGTG 
GCCTGGAACC CCAGCCCCGC TGTCTGCCTG GTGGCTGCAG CCGTGGAGGA CTCGGTGCTG 
CTGCTGAACC CAGCTCTGGG GGACCGGCTG GTGGCGGGCA GCACAGATCA GCTGTTGAGC 
GCCTTCGTCC CGCCTGAGGA GCCCCCCTTG CAGCCGGCCC GCTGGCTGGA GGCCTCAGAG 
GAGGAGCGCC AAGTGGGCCT GCGGCTGCGC ATCTGCCACG GGAAGCCAGT GACGCAGGTG 
ACCTGGCACG GGCGTGGGGA CTACCTGGCC GTGGTGCTGG CCACCCAAGG CCACACCCAG 
GTGCTGATTC ACCAGCTGAG CCGTCGCCGC AGCCAGAGTC CGTTCCGCCG CAGCCACGGA 
CAGGTGCAGC GAGTGGCCTT CCACCCTGCC CGGCCCTTCC TGTTGGTGGC GTCCCAGCGC 
AGCGTCCGCC TCTACCACCT GCTGCGCCAG GAGCTCACCA AGAAGCTGAT GCCCAACTGC 
AAGTGGGTGT CCAGCCTGGC GGTGCACCCT GCAGGTGACA ACGTCATCTG TGGGAGCTAC 
GATAGCAAGC TGGTGTGGTT TGACCTGGAT CTTTCCACCA AGCCATACAG GATGCTGAGA 
CACCACAAGA AGGCTCTGCG GGCTGTGGCC TTCCACCCGC GGTACCCACT CTTTGCGTCA 
GGCTCGGACG ACGGCAGTGT CATCGTCTGC CATGGCATGG TGTACAATGA CCTTCTGCAG 
AACCCCTTGC TGGTGCCCGT CAAGGTGCTG AAGGGACACG TGCTGACCCG AGATCTGGGA 
GTGCTGGACG TCATCTTCCA CCCCACCCAG CCGTGGGTCT TCTCCTCGGG GGCAGACGGG 
ACTGTCCGCC TCTTCACCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.
Experimental cell research334(1)146-59(2015 May)
Kellner M,Rohrmoser M,Forn? I,Voss K,Burger K,M?hl B,Gruber-Eber A,Kremmer E,Imhof A,Eick D

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.
Cell reports5(1)237-47(2013 Oct)
Sloan KE,Bohnsack MT,Watkins NJ

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition.
Hepatology (Baltimore, Md.)54(1)307-18(2011 Jul)
Chung KY,Cheng IK,Ching AK,Chu JH,Lai PB,Wong N

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BOP1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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