Gene Symbol | PHLPP1 |
Entrez Gene ID | 23239 |
Full Name | PH domain and leucine rich repeat protein phosphatase 1 |
Synonyms | PHLPP,PLEKHE1,PPM3A,SCOP |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]. |
Disorder MIM: |