RCOR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RCOR1
Entrez Gene ID	23186
Full Name	REST corepressor 1
Synonyms	COREST,RCOR
General protein information	Preferred Names REST corepressor 1 Names REST corepressor 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.31-q32.32
Summary	This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011].
Disorder MIM:	607675

mRNA and Protein(s)

mRNA	Protein	Name
NM_015156.3	NP_055971.2	REST corepressor 1
NM_015156.4	NP_055971.2	REST corepressor 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rcor1	NP_001073510.1
Drosophila melanogaster (fruit fly)	CoRest	NP_001188671.1
Bos taurus (cattle)	RCOR1	XP_002696824.2
Mus musculus (house mouse)	Rcor1	NP_932140.1
Gallus gallus (chicken)	RCOR1	XP_004936395.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002488	XP_312450.4
Canis lupus familiaris (dog)	RCOR1	XP_005623886.1
Homo sapiens (human)	RCOR1	NP_055971.2
Pan troglodytes (chimpanzee)	RCOR1	XP_522957.3
Rattus norvegicus (Norway rat)	LOC102554884	XP_006240674.1
	LOC694670	XP_002805264.1
Xenopus tropicalis (tropical clawed frog)	rcor1	NP_001039133.1

Gene Ontology
Bibliography

Related articles in PubMed

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA
Nature communications9(1)53(2018 Jan)

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM
Journal of neurovirology(2017 Dec)

Exploring the Active Center of the LSD1/CoREST Complex by Molecular Dynamics Simulation Utilizing Its Co-crystallized Co-factor Tetrahydrofolate as a Probe.
Zalloum WA, Zalloum HM
Journal of chemical information and modeling57(12)3022-3031(2017 Dec)

Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex.
Dhall A, Weller CE, Chu A, Shelton PMM, Chatterjee C
ACS chemical biology12(9)2275-2280(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study identified histone modification by SUMO as the first post-translational modification that stimulates intranucleosomal demethylation by the developmentally critical LSD1-CoREST complex.
Title: Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex.

results demonstrate that CoREST and LSD1 downregulate the Notch pathway in the developing cerebral cortex
Title: The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development.

ERalpha engages not only LSD1, but its partners of the CoREST corepressor complex and the molecular chaperone Hsp90.
Title: LSD1 engages a corepressor complex for the activation of the estrogen receptor ? by estrogen and cAMP.

Expressions of REST and RCOR1 genes may downregulate SYN1 expression in gliomas.
Title: Expression profiling of RE1-silencing transcription factor (REST), REST corepressor 1 (RCOR1), and Synapsin 1 (SYN1) genes in human gliomas.

Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
Title: The Corepressor Rcor1 Is Essential for Normal Myeloerythroid Lineage Differentiation.

The following RCOR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RCOR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06855	NM_015156.4 Latest version!	Homo sapiens REST corepressor 1 (RCOR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu06855	NM_015156.3	Homo sapiens REST corepressor 1 (RCOR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RCOR1 ( NM_015156.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055971.2 Homo sapiens REST corepressor 1 (RCOR1), mRNA.

Price & Availability↑

CloneID	OHu06855
Clone ID Related Accession (Same CDS sequence)	NM_015156.3 , NM_015156.4
Accession Version	NM_015156.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	REST corepressor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB455887.2, AI337324.1, BC051003.1, D31888.1 and AF070627.1. On Aug 27, 2011 this sequence version replaced NM_015156.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D31888.1, SRR1803617.93526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGCCA TGGTGGAGAA GGGCCCCGAG GTCTCAGGGA AGCGGAGAGG GAGGAACAAC 
GCGGCCGCCT CCGCCTCCGC CGCCGCCGCC TCCGCCGCCG CCTCGGCCGC CTGCGCCTCG 
CCAGCCGCCA CTGCCGCCTC GGGCGCCGCC GCCTCCTCAG CCTCGGCCGC CGCCGCCTCA 
GCCGCCGCCG CCCCCAATAA TGGCCAGAAT AAAAGTTTGG CGGCGGCGGC GCCCAATGGC 
AACAGCAGCA GCAACTCCTG GGAGGAAGGC AGCTCGGGCT CGTCCAGCGA CGAGGAGCAC 
GGTGGCGGTG GCATGAGGGT CGGACCCCAG TACCAGGCGG TGGTGCCCGA CTTCGACCCC 
GCCAAACTGG CAAGACGCAG TCAAGAACGG GACAATCTTG GCATGTTGGT CTGGTCACCC 
AATCAAAATC TGTCAGAAGC AAAGTTGGAT GAATACATTG CCATTGCCAA AGAAAAGCAT 
GGGTACAACA TGGAACAGGC TCTTGGGATG CTCTTCTGGC ATAAACATAA TATCGAAAAG 
TCATTGGCTG ATTTGCCCAA CTTTACCCCT TTCCCAGATG AGTGGACTGT GGAAGATAAA 
GTCTTATTTG AGCAAGCCTT TAGTTTTCAT GGGAAAACTT TTCATAGAAT CCAACAAATG 
CTTCCAGATA AATCTATAGC AAGTCTGGTG AAATTTTACT ATTCTTGGAA GAAGACGAGG 
ACTAAAACTA GTGTGATGGA TCGCCATGCC CGGAAACAAA AACGGGAGCG GGAGGAGAGC 
GAGGATGAAC TGGAAGAGGC AAATGGAAAC AATCCCATTG ACATTGAGGT TGATCAAAAC 
AAGGAAAGCA AAAAGGAGGT TCCCCCTACT GAGACAGTTC CTCAGGTCAA AAAAGAAAAA 
CATAGCACAC AAGCTAAAAA TAGAGCAAAA AGGAAACCTC CAAAAGGAAT GTTTCTTTCT 
CAAGAAGATG TGGAGGCTGT TTCTGCCAAT GCCACTGCTG CTACCACGGT GCTGAGACAA 
CTAGACATGG AATTGGTTTC AGTCAAACGA CAGATCCAGA ATATTAAACA GACAAACAGT 
GCTCTCAAAG AAAAACTTGA TGGTGGAATA GAACCATATC GACTTCCAGA GGTCATTCAG 
AAATGTAATG CACGTTGGAC TACAGAAGAG CAGCTTCTCG CCGTACAAGC CATCAGGAAA 
TATGGCCGAG ATTTTCAGGC AATCTCAGAC GTGATTGGGA ACAAATCAGT GGTACAAGTG 
AAAAACTTTT TTGTAAATTA TCGACGCCGC TTCAACATAG ATGAAGTTTT ACAAGAATGG 
GAGGCAGAAC ATGGTAAAGA AGAGACCAAT GGGCCCAGTA ACCAGAAGCC TGTGAAGTCC 
CCAGATAATT CCATTAAGAT GCCCGAAGAG GAAGACGAGG CTCCTGTTCT GGATGTCAGA 
TATGCATCTG CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055971.2
CDS	229..1686
Translation	MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS

Target ORF information:

RefSeq Version	NM_015156.3
Organism	Homo sapiens(human)
Definition	Homo sapiens REST corepressor 1 (RCOR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015156.3

ORF Insert Sequence:

ATGCCGGCCA TGGTGGAGAA GGGCCCCGAG GTCTCAGGGA AGCGGAGAGG GAGGAACAAC 
GCGGCCGCCT CCGCCTCCGC CGCCGCCGCC TCCGCCGCCG CCTCGGCCGC CTGCGCCTCG 
CCAGCCGCCA CTGCCGCCTC GGGCGCCGCC GCCTCCTCAG CCTCGGCCGC CGCCGCCTCA 
GCCGCCGCCG CCCCCAATAA TGGCCAGAAT AAAAGTTTGG CGGCGGCGGC GCCCAATGGC 
AACAGCAGCA GCAACTCCTG GGAGGAAGGC AGCTCGGGCT CGTCCAGCGA CGAGGAGCAC 
GGTGGCGGTG GCATGAGGGT CGGACCCCAG TACCAGGCGG TGGTGCCCGA CTTCGACCCC 
GCCAAACTGG CAAGACGCAG TCAAGAACGG GACAATCTTG GCATGTTGGT CTGGTCACCC 
AATCAAAATC TGTCAGAAGC AAAGTTGGAT GAATACATTG CCATTGCCAA AGAAAAGCAT 
GGGTACAACA TGGAACAGGC TCTTGGGATG CTCTTCTGGC ATAAACATAA TATCGAAAAG 
TCATTGGCTG ATTTGCCCAA CTTTACCCCT TTCCCAGATG AGTGGACTGT GGAAGATAAA 
GTCTTATTTG AGCAAGCCTT TAGTTTTCAT GGGAAAACTT TTCATAGAAT CCAACAAATG 
CTTCCAGATA AATCTATAGC AAGTCTGGTG AAATTTTACT ATTCTTGGAA GAAGACGAGG 
ACTAAAACTA GTGTGATGGA TCGCCATGCC CGGAAACAAA AACGGGAGCG GGAGGAGAGC 
GAGGATGAAC TGGAAGAGGC AAATGGAAAC AATCCCATTG ACATTGAGGT TGATCAAAAC 
AAGGAAAGCA AAAAGGAGGT TCCCCCTACT GAGACAGTTC CTCAGGTCAA AAAAGAAAAA 
CATAGCACAC AAGCTAAAAA TAGAGCAAAA AGGAAACCTC CAAAAGGAAT GTTTCTTTCT 
CAAGAAGATG TGGAGGCTGT TTCTGCCAAT GCCACTGCTG CTACCACGGT GCTGAGACAA 
CTAGACATGG AATTGGTTTC AGTCAAACGA CAGATCCAGA ATATTAAACA GACAAACAGT 
GCTCTCAAAG AAAAACTTGA TGGTGGAATA GAACCATATC GACTTCCAGA GGTCATTCAG 
AAATGTAATG CACGTTGGAC TACAGAAGAG CAGCTTCTCG CCGTACAAGC CATCAGGAAA 
TATGGCCGAG ATTTTCAGGC AATCTCAGAC GTGATTGGGA ACAAATCAGT GGTACAAGTG 
AAAAACTTTT TTGTAAATTA TCGACGCCGC TTCAACATAG ATGAAGTTTT ACAAGAATGG 
GAGGCAGAAC ATGGTAAAGA AGAGACCAAT GGGCCCAGTA ACCAGAAGCC TGTGAAGTCC 
CCAGATAATT CCATTAAGAT GCCCGAAGAG GAAGACGAGG CTCCTGTTCT GGATGTCAGA 
TATGCATCTG CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RCOR1 ( NM_015156.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055971.2 Homo sapiens REST corepressor 1 (RCOR1), mRNA.

Price & Availability↑

CloneID	OHu06855
Clone ID Related Accession (Same CDS sequence)	NM_015156.3 , NM_015156.4
Accession Version	NM_015156.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	REST corepressor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136293.5, DB455887.2, AI337324.1, BC051003.1, D31888.1 and AF070627.1. On Nov 22, 2018 this sequence version replaced NM_015156.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D31888.1, SRR1803617.93526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262241.7/ ENSP00000262241.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGCCA TGGTGGAGAA GGGCCCCGAG GTCTCAGGGA AGCGGAGAGG GAGGAACAAC 
GCGGCCGCCT CCGCCTCCGC CGCCGCCGCC TCCGCCGCCG CCTCGGCCGC CTGCGCCTCG 
CCAGCCGCCA CTGCCGCCTC GGGCGCCGCC GCCTCCTCAG CCTCGGCCGC CGCCGCCTCA 
GCCGCCGCCG CCCCCAATAA TGGCCAGAAT AAAAGTTTGG CGGCGGCGGC GCCCAATGGC 
AACAGCAGCA GCAACTCCTG GGAGGAAGGC AGCTCGGGCT CGTCCAGCGA CGAGGAGCAC 
GGTGGCGGTG GCATGAGGGT CGGACCCCAG TACCAGGCGG TGGTGCCCGA CTTCGACCCC 
GCCAAACTGG CAAGACGCAG TCAAGAACGG GACAATCTTG GCATGTTGGT CTGGTCACCC 
AATCAAAATC TGTCAGAAGC AAAGTTGGAT GAATACATTG CCATTGCCAA AGAAAAGCAT 
GGGTACAACA TGGAACAGGC TCTTGGGATG CTCTTCTGGC ATAAACATAA TATCGAAAAG 
TCATTGGCTG ATTTGCCCAA CTTTACCCCT TTCCCAGATG AGTGGACTGT GGAAGATAAA 
GTCTTATTTG AGCAAGCCTT TAGTTTTCAT GGGAAAACTT TTCATAGAAT CCAACAAATG 
CTTCCAGATA AATCTATAGC AAGTCTGGTG AAATTTTACT ATTCTTGGAA GAAGACGAGG 
ACTAAAACTA GTGTGATGGA TCGCCATGCC CGGAAACAAA AACGGGAGCG GGAGGAGAGC 
GAGGATGAAC TGGAAGAGGC AAATGGAAAC AATCCCATTG ACATTGAGGT TGATCAAAAC 
AAGGAAAGCA AAAAGGAGGT TCCCCCTACT GAGACAGTTC CTCAGGTCAA AAAAGAAAAA 
CATAGCACAC AAGCTAAAAA TAGAGCAAAA AGGAAACCTC CAAAAGGAAT GTTTCTTTCT 
CAAGAAGATG TGGAGGCTGT TTCTGCCAAT GCCACTGCTG CTACCACGGT GCTGAGACAA 
CTAGACATGG AATTGGTTTC AGTCAAACGA CAGATCCAGA ATATTAAACA GACAAACAGT 
GCTCTCAAAG AAAAACTTGA TGGTGGAATA GAACCATATC GACTTCCAGA GGTCATTCAG 
AAATGTAATG CACGTTGGAC TACAGAAGAG CAGCTTCTCG CCGTACAAGC CATCAGGAAA 
TATGGCCGAG ATTTTCAGGC AATCTCAGAC GTGATTGGGA ACAAATCAGT GGTACAAGTG 
AAAAACTTTT TTGTAAATTA TCGACGCCGC TTCAACATAG ATGAAGTTTT ACAAGAATGG 
GAGGCAGAAC ATGGTAAAGA AGAGACCAAT GGGCCCAGTA ACCAGAAGCC TGTGAAGTCC 
CCAGATAATT CCATTAAGAT GCCCGAAGAG GAAGACGAGG CTCCTGTTCT GGATGTCAGA 
TATGCATCTG CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055971.2
CDS	239..1696
Translation	MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS

Target ORF information:

RefSeq Version	NM_015156.4
Organism	Homo sapiens(human)
Definition	Homo sapiens REST corepressor 1 (RCOR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015156.4

ORF Insert Sequence:

ATGCCGGCCA TGGTGGAGAA GGGCCCCGAG GTCTCAGGGA AGCGGAGAGG GAGGAACAAC 
GCGGCCGCCT CCGCCTCCGC CGCCGCCGCC TCCGCCGCCG CCTCGGCCGC CTGCGCCTCG 
CCAGCCGCCA CTGCCGCCTC GGGCGCCGCC GCCTCCTCAG CCTCGGCCGC CGCCGCCTCA 
GCCGCCGCCG CCCCCAATAA TGGCCAGAAT AAAAGTTTGG CGGCGGCGGC GCCCAATGGC 
AACAGCAGCA GCAACTCCTG GGAGGAAGGC AGCTCGGGCT CGTCCAGCGA CGAGGAGCAC 
GGTGGCGGTG GCATGAGGGT CGGACCCCAG TACCAGGCGG TGGTGCCCGA CTTCGACCCC 
GCCAAACTGG CAAGACGCAG TCAAGAACGG GACAATCTTG GCATGTTGGT CTGGTCACCC 
AATCAAAATC TGTCAGAAGC AAAGTTGGAT GAATACATTG CCATTGCCAA AGAAAAGCAT 
GGGTACAACA TGGAACAGGC TCTTGGGATG CTCTTCTGGC ATAAACATAA TATCGAAAAG 
TCATTGGCTG ATTTGCCCAA CTTTACCCCT TTCCCAGATG AGTGGACTGT GGAAGATAAA 
GTCTTATTTG AGCAAGCCTT TAGTTTTCAT GGGAAAACTT TTCATAGAAT CCAACAAATG 
CTTCCAGATA AATCTATAGC AAGTCTGGTG AAATTTTACT ATTCTTGGAA GAAGACGAGG 
ACTAAAACTA GTGTGATGGA TCGCCATGCC CGGAAACAAA AACGGGAGCG GGAGGAGAGC 
GAGGATGAAC TGGAAGAGGC AAATGGAAAC AATCCCATTG ACATTGAGGT TGATCAAAAC 
AAGGAAAGCA AAAAGGAGGT TCCCCCTACT GAGACAGTTC CTCAGGTCAA AAAAGAAAAA 
CATAGCACAC AAGCTAAAAA TAGAGCAAAA AGGAAACCTC CAAAAGGAAT GTTTCTTTCT 
CAAGAAGATG TGGAGGCTGT TTCTGCCAAT GCCACTGCTG CTACCACGGT GCTGAGACAA 
CTAGACATGG AATTGGTTTC AGTCAAACGA CAGATCCAGA ATATTAAACA GACAAACAGT 
GCTCTCAAAG AAAAACTTGA TGGTGGAATA GAACCATATC GACTTCCAGA GGTCATTCAG 
AAATGTAATG CACGTTGGAC TACAGAAGAG CAGCTTCTCG CCGTACAAGC CATCAGGAAA 
TATGGCCGAG ATTTTCAGGC AATCTCAGAC GTGATTGGGA ACAAATCAGT GGTACAAGTG 
AAAAACTTTT TTGTAAATTA TCGACGCCGC TTCAACATAG ATGAAGTTTT ACAAGAATGG 
GAGGCAGAAC ATGGTAAAGA AGAGACCAAT GGGCCCAGTA ACCAGAAGCC TGTGAAGTCC 
CCAGATAATT CCATTAAGAT GCCCGAAGAG GAAGACGAGG CTCCTGTTCT GGATGTCAGA 
TATGCATCTG CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Nature communications9(1)53(2018 Jan)
Kalin JH,Wu M,Gomez AV,Song Y,Das J,Hayward D,Adejola N,Wu M,Panova I,Chung HJ,Kim E,Roberts HJ,Roberts JM,Prusevich P,Jeliazkov JR,Roy Burman SS,Fairall L,Milano C,Eroglu A,Proby CM,Dinkova-Kostova AT,Hancock WW,Gray JJ,Bradner JE,Valente S,Mai A,Anders NM,Rudek MA,Hu Y,Ryu B,Schwabe JWR,Mattevi A,Alani RM,Cole PA

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Journal of neurovirology(2017 Dec)
Llewellyn GN,Alvarez-Carbonell D,Chateau M,Karn J,Cannon PM

Exploring the Active Center of the LSD1/CoREST Complex by Molecular Dynamics Simulation Utilizing Its Co-crystallized Co-factor Tetrahydrofolate as a Probe.
Journal of chemical information and modeling57(12)3022-3031(2017 Dec)
Zalloum WA,Zalloum HM

Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex.
ACS chemical biology12(9)2275-2280(2017 Sep)
Dhall A,Weller CE,Chu A,Shelton PMM,Chatterjee C

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RCOR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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