SARM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SARM1
Entrez Gene ID	23098
Full Name	sterile alpha and TIR motif containing 1
Synonyms	MyD88-5,SAMD2,SARM
General protein information	Preferred Names sterile alpha and TIR motif containing 1 Names sterile alpha and TIR motif-containing protein 1 SAM domain-containing protein 2 sterile alpha and Armadillo repeat protein sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila sterile alpha motif domain-containing protein 2 tir-1 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q11.2
Disorder MIM:	607732

mRNA and Protein(s)

mRNA	Protein	Name
NM_015077.3	NP_055892.2	sterile alpha and TIR motif-containing protein 1 precursor
NM_015077.4	NP_055892.2	sterile alpha and TIR motif-containing protein 1 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	sarm1	NP_001124068.1
Drosophila melanogaster (fruit fly)	Ect4	NP_001246663.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005901	XP_315931.4
Xenopus tropicalis (tropical clawed frog)	sarm1	XP_002937189.2
Pan troglodytes (chimpanzee)	SARM1	XP_003315585.1
Homo sapiens (human)	SARM1	NP_055892.2
	SARM1	XP_001106275.2
Rattus norvegicus (Norway rat)	Sarm1	NP_001099287.1
Caenorhabditis elegans (roundworm)	tir-1	NP_497784.1
Canis lupus familiaris (dog)	SARM1	XP_548285.2
Mus musculus (house mouse)	Sarm1	NP_001161993.1
Gallus gallus (chicken)	SARM1	XP_415814.4

Gene Ontology
Bibliography

Related articles in PubMed

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
Summers DW, Gibson DA, DiAntonio A, Milbrandt J
Proceedings of the National Academy of Sciences of the United States of America113(41)E6271-E6280(2016 10)

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.
Carlsson E, Ding JL, Byrne B
Biochimica et biophysica acta1863(2)244-53(2016 Feb)

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.
Gerdts J, Summers DW, Milbrandt J, DiAntonio A
Neuron89(3)449-60(2016 Feb)

Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
Kwan JS, Hsu YH, Cheung CL, Dupuis J, Saint-Pierre A, Eriksson J, Handelman SK, Aragaki A, Karasik D, Pramstaller PP, Kooperberg C, Lacroix AZ, Larson MG, Lau KS, Lorentzon M, Pichler I, Sham PC, Taliun D, Vandenput L, Kiel DP, Hicks AA, Jackson RD, Ohlsson C, Benjamin EJ, Kung AW
Human molecular genetics23(24)6684-93(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that sterile alpha- and armadillo-motif-containing protein (SARM) modulates MyD88 protein-mediated Toll-like receptors (TLRs) activation through BB-loop dependent interleukin-1 receptor (TIR) TIR-TIR interactions.
Title: SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.

Active nerve degeneration requires SARM1 and MAP kinases, including DLK, while the NAD+ synthetic enzyme NMNAT2 prevents degeneration.
Title: Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.

Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1.
Title: Wallerian degeneration: an emerging axon death pathway linking injury and disease.

Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis.
Title: UXT plays dual opposing roles on SARM-induced apoptosis.

The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.
Title: The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.

The following SARM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SARM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06805	NM_015077.4 Latest version!	Homo sapiens sterile alpha and TIR motif containing 1 (SARM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$369.50-$517.30 $739.00
View Old Accession Versions >>
OHu06805	NM_015077.3	Homo sapiens sterile alpha and TIR motif containing 1 (SARM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$369.50-$517.30 $739.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SARM1 ( NM_015077.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055892.2 Homo sapiens sterile alpha and TIR motif containing 1 (SARM1), mRNA.

Price & Availability↑

CloneID	OHu06805
Clone ID Related Accession (Same CDS sequence)	NM_015077.3 , NM_015077.4
Accession Version	NM_015077.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2175bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sterile alpha and TIR motif-containing protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314609.1, BC122860.1, AB011096.1, BC040429.1 and BG820141.1. On Jul 27, 2013 this sequence version replaced NM_015077.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ290445.1, BC040429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGTCCTGA CGCTGCTTCT CTCCGCCTAC AAGCTGTGTC GCTTCTTCGC CATGTCGGGC 
CCACGGCCGG GCGCCGAGCG GCTGGCGGTG CCTGGGCCAG ATGGGGGCGG TGGCACGGGC 
CCATGGTGGG CTGCGGGTGG CCGCGGGCCC CGCGAAGTGT CGCCGGGGGC AGGCACCGAG 
GTGCAGGACG CCCTGGAGCG CGCGCTGCCG GAGCTGCAGC AGGCCTTGTC CGCGCTGAAG 
CAGGCGGGCG GCGCGCGGGC CGTGGGCGCC GGCCTGGCCG AGGTCTTCCA ACTGGTGGAG 
GAGGCCTGGC TGCTGCCGGC CGTGGGCCGC GAGGTAGCCC AGGGTCTGTG CGACGCCATC 
CGCCTCGATG GCGGCCTCGA CCTGCTGTTG CGGCTGCTGC AGGCGCCGGA GTTGGAGACG 
CGTGTGCAGG CCGCGCGCCT GCTGGAGCAG ATCCTGGTGG CTGAGAACCG AGACCGCGTG 
GCGCGCATTG GGCTGGGCGT GATCCTGAAC CTGGCGAAGG AACGCGAACC CGTAGAGCTG 
GCGCGGAGCG TGGCAGGCAT CTTGGAGCAC ATGTTCAAGC ATTCGGAGGA GACATGCCAG 
AGGCTGGTGG CGGCCGGCGG CCTGGACGCG GTGCTGTATT GGTGCCGCCG CACGGACCCC 
GCGCTGCTGC GCCACTGCGC GCTGGCGCTG GGCAACTGCG CGCTGCACGG GGGCCAGGCG 
GTGCAGCGAC GCATGGTAGA GAAGCGCGCA GCCGAGTGGC TCTTCCCGCT CGCCTTCTCC 
AAGGAGGACG AGCTGCTTCG GCTGCACGCC TGCCTCGCAG TAGCGGTGTT GGCGACTAAC 
AAGGAGGTGG AGCGCGAGGT GGAGCGCTCG GGCACGCTGG CGCTCGTGGA GCCGCTTGTG 
GCCTCGCTGG ACCCTGGCCG CTTCGCCCGC TGTCTGGTGG ACGCCAGCGA CACAAGCCAG 
GGCCGCGGGC CCGACGACCT GCAGCGCCTC GTGCCGTTGC TCGACTCTAA CCGCTTGGAG 
GCGCAGTGCA TCGGGGCTTT CTACCTCTGC GCCGAGGCTG CCATCAAGAG CCTGCAAGGC 
AAGACCAAGG TGTTCAGCGA CATCGGCGCC ATCCAGAGCC TGAAACGCCT GGTTTCCTAC 
TCTACCAATG GCACTAAGTC GGCGCTGGCC AAGCGCGCGC TGCGCCTGCT GGGCGAGGAG 
GTGCCACGGC CCATCCTGCC CTCCGTGCCC AGCTGGAAGG AGGCCGAGGT TCAGACGTGG 
CTGCAGCAGA TCGGTTTCTC CAAGTACTGC GAGAGCTTCC GGGAGCAGCA GGTGGATGGC 
GACCTGCTTC TGCGGCTCAC GGAGGAGGAA CTCCAGACCG ACCTGGGCAT GAAATCGGGC 
ATCACCCGCA AGAGGTTCTT TAGGGAGCTC ACGGAGCTCA AGACCTTCGC CAACTATTCT 
ACGTGCGACC GCAGCAACCT GGCGGACTGG CTGGGCAGCC TGGACCCGCG CTTCCGCCAG 
TACACCTACG GCCTGGTCAG CTGCGGCCTG GACCGCTCCC TGCTGCACCG CGTGTCTGAG 
CAGCAGCTGC TGGAAGACTG CGGCATCCAC CTGGGCGTGC ACCGCGCCCG CATCCTCACG 
GCGGCCAGAG AAATGCTACA CTCCCCGCTG CCCTGTACTG GTGGCAAACC CAGTGGGGAC 
ACTCCAGATG TCTTCATCAG CTACCGCCGG AACTCAGGTT CCCAGCTGGC CAGTCTCCTG 
AAGGTGCACC TGCAGCTGCA TGGCTTCAGT GTCTTCATTG ATGTGGAGAA GCTGGAAGCA 
GGCAAGTTCG AGGACAAACT CATCCAGAGT GTCATGGGTG CCCGCAACTT TGTGTTGGTG 
CTATCACCTG GAGCACTGGA CAAGTGCATG CAAGACCATG ACTGCAAGGA TTGGGTGCAT 
AAGGAGATTG TGACTGCTTT AAGCTGCGGC AAGAACATTG TGCCCATCAT TGATGGCTTC 
GAGTGGCCTG AGCCCCAGGT CCTGCCTGAG GACATGCAGG CTGTGCTTAC TTTCAACGGT 
ATCAAGTGGT CCCACGAATA CCAGGAGGCC ACCATTGAGA AGATCATCCG CTTCCTGCAG 
GGCCGCTCCT CCCGGGACTC ATCTGCAGGC TCTGACACCA GTTTGGAGGG TGCTGCACCC 
ATGGGTCCAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055892.2
CDS	372..2546
Translation	MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT

Target ORF information:

RefSeq Version	NM_015077.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sterile alpha and TIR motif containing 1 (SARM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015077.3

ORF Insert Sequence:

ATGGTCCTGA CGCTGCTTCT CTCCGCCTAC AAGCTGTGTC GCTTCTTCGC CATGTCGGGC 
CCACGGCCGG GCGCCGAGCG GCTGGCGGTG CCTGGGCCAG ATGGGGGCGG TGGCACGGGC 
CCATGGTGGG CTGCGGGTGG CCGCGGGCCC CGCGAAGTGT CGCCGGGGGC AGGCACCGAG 
GTGCAGGACG CCCTGGAGCG CGCGCTGCCG GAGCTGCAGC AGGCCTTGTC CGCGCTGAAG 
CAGGCGGGCG GCGCGCGGGC CGTGGGCGCC GGCCTGGCCG AGGTCTTCCA ACTGGTGGAG 
GAGGCCTGGC TGCTGCCGGC CGTGGGCCGC GAGGTAGCCC AGGGTCTGTG CGACGCCATC 
CGCCTCGATG GCGGCCTCGA CCTGCTGTTG CGGCTGCTGC AGGCGCCGGA GTTGGAGACG 
CGTGTGCAGG CCGCGCGCCT GCTGGAGCAG ATCCTGGTGG CTGAGAACCG AGACCGCGTG 
GCGCGCATTG GGCTGGGCGT GATCCTGAAC CTGGCGAAGG AACGCGAACC CGTAGAGCTG 
GCGCGGAGCG TGGCAGGCAT CTTGGAGCAC ATGTTCAAGC ATTCGGAGGA GACATGCCAG 
AGGCTGGTGG CGGCCGGCGG CCTGGACGCG GTGCTGTATT GGTGCCGCCG CACGGACCCC 
GCGCTGCTGC GCCACTGCGC GCTGGCGCTG GGCAACTGCG CGCTGCACGG GGGCCAGGCG 
GTGCAGCGAC GCATGGTAGA GAAGCGCGCA GCCGAGTGGC TCTTCCCGCT CGCCTTCTCC 
AAGGAGGACG AGCTGCTTCG GCTGCACGCC TGCCTCGCAG TAGCGGTGTT GGCGACTAAC 
AAGGAGGTGG AGCGCGAGGT GGAGCGCTCG GGCACGCTGG CGCTCGTGGA GCCGCTTGTG 
GCCTCGCTGG ACCCTGGCCG CTTCGCCCGC TGTCTGGTGG ACGCCAGCGA CACAAGCCAG 
GGCCGCGGGC CCGACGACCT GCAGCGCCTC GTGCCGTTGC TCGACTCTAA CCGCTTGGAG 
GCGCAGTGCA TCGGGGCTTT CTACCTCTGC GCCGAGGCTG CCATCAAGAG CCTGCAAGGC 
AAGACCAAGG TGTTCAGCGA CATCGGCGCC ATCCAGAGCC TGAAACGCCT GGTTTCCTAC 
TCTACCAATG GCACTAAGTC GGCGCTGGCC AAGCGCGCGC TGCGCCTGCT GGGCGAGGAG 
GTGCCACGGC CCATCCTGCC CTCCGTGCCC AGCTGGAAGG AGGCCGAGGT TCAGACGTGG 
CTGCAGCAGA TCGGTTTCTC CAAGTACTGC GAGAGCTTCC GGGAGCAGCA GGTGGATGGC 
GACCTGCTTC TGCGGCTCAC GGAGGAGGAA CTCCAGACCG ACCTGGGCAT GAAATCGGGC 
ATCACCCGCA AGAGGTTCTT TAGGGAGCTC ACGGAGCTCA AGACCTTCGC CAACTATTCT 
ACGTGCGACC GCAGCAACCT GGCGGACTGG CTGGGCAGCC TGGACCCGCG CTTCCGCCAG 
TACACCTACG GCCTGGTCAG CTGCGGCCTG GACCGCTCCC TGCTGCACCG CGTGTCTGAG 
CAGCAGCTGC TGGAAGACTG CGGCATCCAC CTGGGCGTGC ACCGCGCCCG CATCCTCACG 
GCGGCCAGAG AAATGCTACA CTCCCCGCTG CCCTGTACTG GTGGCAAACC CAGTGGGGAC 
ACTCCAGATG TCTTCATCAG CTACCGCCGG AACTCAGGTT CCCAGCTGGC CAGTCTCCTG 
AAGGTGCACC TGCAGCTGCA TGGCTTCAGT GTCTTCATTG ATGTGGAGAA GCTGGAAGCA 
GGCAAGTTCG AGGACAAACT CATCCAGAGT GTCATGGGTG CCCGCAACTT TGTGTTGGTG 
CTATCACCTG GAGCACTGGA CAAGTGCATG CAAGACCATG ACTGCAAGGA TTGGGTGCAT 
AAGGAGATTG TGACTGCTTT AAGCTGCGGC AAGAACATTG TGCCCATCAT TGATGGCTTC 
GAGTGGCCTG AGCCCCAGGT CCTGCCTGAG GACATGCAGG CTGTGCTTAC TTTCAACGGT 
ATCAAGTGGT CCCACGAATA CCAGGAGGCC ACCATTGAGA AGATCATCCG CTTCCTGCAG 
GGCCGCTCCT CCCGGGACTC ATCTGCAGGC TCTGACACCA GTTTGGAGGG TGCTGCACCC 
ATGGGTCCAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SARM1 ( NM_015077.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055892.2 Homo sapiens sterile alpha and TIR motif containing 1 (SARM1), mRNA.

Price & Availability↑

CloneID	OHu06805
Clone ID Related Accession (Same CDS sequence)	NM_015077.3 , NM_015077.4
Accession Version	NM_015077.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2175bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	sterile alpha and TIR motif-containing protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314609.1, BC122860.1, AB011096.1, BC040429.1, BG820141.1 and AC015917.30. On Nov 23, 2018 this sequence version replaced NM_015077.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ290445.1, AB011096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000585482.6/ ENSP00000468032.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTCCTGA CGCTGCTTCT CTCCGCCTAC AAGCTGTGTC GCTTCTTCGC CATGTCGGGC 
CCACGGCCGG GCGCCGAGCG GCTGGCGGTG CCTGGGCCAG ATGGGGGCGG TGGCACGGGC 
CCATGGTGGG CTGCGGGTGG CCGCGGGCCC CGCGAAGTGT CGCCGGGGGC AGGCACCGAG 
GTGCAGGACG CCCTGGAGCG CGCGCTGCCG GAGCTGCAGC AGGCCTTGTC CGCGCTGAAG 
CAGGCGGGCG GCGCGCGGGC CGTGGGCGCC GGCCTGGCCG AGGTCTTCCA ACTGGTGGAG 
GAGGCCTGGC TGCTGCCGGC CGTGGGCCGC GAGGTAGCCC AGGGTCTGTG CGACGCCATC 
CGCCTCGATG GCGGCCTCGA CCTGCTGTTG CGGCTGCTGC AGGCGCCGGA GTTGGAGACG 
CGTGTGCAGG CCGCGCGCCT GCTGGAGCAG ATCCTGGTGG CTGAGAACCG AGACCGCGTG 
GCGCGCATTG GGCTGGGCGT GATCCTGAAC CTGGCGAAGG AACGCGAACC CGTAGAGCTG 
GCGCGGAGCG TGGCAGGCAT CTTGGAGCAC ATGTTCAAGC ATTCGGAGGA GACATGCCAG 
AGGCTGGTGG CGGCCGGCGG CCTGGACGCG GTGCTGTATT GGTGCCGCCG CACGGACCCC 
GCGCTGCTGC GCCACTGCGC GCTGGCGCTG GGCAACTGCG CGCTGCACGG GGGCCAGGCG 
GTGCAGCGAC GCATGGTAGA GAAGCGCGCA GCCGAGTGGC TCTTCCCGCT CGCCTTCTCC 
AAGGAGGACG AGCTGCTTCG GCTGCACGCC TGCCTCGCAG TAGCGGTGTT GGCGACTAAC 
AAGGAGGTGG AGCGCGAGGT GGAGCGCTCG GGCACGCTGG CGCTCGTGGA GCCGCTTGTG 
GCCTCGCTGG ACCCTGGCCG CTTCGCCCGC TGTCTGGTGG ACGCCAGCGA CACAAGCCAG 
GGCCGCGGGC CCGACGACCT GCAGCGCCTC GTGCCGTTGC TCGACTCTAA CCGCTTGGAG 
GCGCAGTGCA TCGGGGCTTT CTACCTCTGC GCCGAGGCTG CCATCAAGAG CCTGCAAGGC 
AAGACCAAGG TGTTCAGCGA CATCGGCGCC ATCCAGAGCC TGAAACGCCT GGTTTCCTAC 
TCTACCAATG GCACTAAGTC GGCGCTGGCC AAGCGCGCGC TGCGCCTGCT GGGCGAGGAG 
GTGCCACGGC CCATCCTGCC CTCCGTGCCC AGCTGGAAGG AGGCCGAGGT TCAGACGTGG 
CTGCAGCAGA TCGGTTTCTC CAAGTACTGC GAGAGCTTCC GGGAGCAGCA GGTGGATGGC 
GACCTGCTTC TGCGGCTCAC GGAGGAGGAA CTCCAGACCG ACCTGGGCAT GAAATCGGGC 
ATCACCCGCA AGAGGTTCTT TAGGGAGCTC ACGGAGCTCA AGACCTTCGC CAACTATTCT 
ACGTGCGACC GCAGCAACCT GGCGGACTGG CTGGGCAGCC TGGACCCGCG CTTCCGCCAG 
TACACCTACG GCCTGGTCAG CTGCGGCCTG GACCGCTCCC TGCTGCACCG CGTGTCTGAG 
CAGCAGCTGC TGGAAGACTG CGGCATCCAC CTGGGCGTGC ACCGCGCCCG CATCCTCACG 
GCGGCCAGAG AAATGCTACA CTCCCCGCTG CCCTGTACTG GTGGCAAACC CAGTGGGGAC 
ACTCCAGATG TCTTCATCAG CTACCGCCGG AACTCAGGTT CCCAGCTGGC CAGTCTCCTG 
AAGGTGCACC TGCAGCTGCA TGGCTTCAGT GTCTTCATTG ATGTGGAGAA GCTGGAAGCA 
GGCAAGTTCG AGGACAAACT CATCCAGAGT GTCATGGGTG CCCGCAACTT TGTGTTGGTG 
CTATCACCTG GAGCACTGGA CAAGTGCATG CAAGACCATG ACTGCAAGGA TTGGGTGCAT 
AAGGAGATTG TGACTGCTTT AAGCTGCGGC AAGAACATTG TGCCCATCAT TGATGGCTTC 
GAGTGGCCTG AGCCCCAGGT CCTGCCTGAG GACATGCAGG CTGTGCTTAC TTTCAACGGT 
ATCAAGTGGT CCCACGAATA CCAGGAGGCC ACCATTGAGA AGATCATCCG CTTCCTGCAG 
GGCCGCTCCT CCCGGGACTC ATCTGCAGGC TCTGACACCA GTTTGGAGGG TGCTGCACCC 
ATGGGTCCAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055892.2
CDS	340..2514
Translation	MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT

Target ORF information:

RefSeq Version	NM_015077.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sterile alpha and TIR motif containing 1 (SARM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015077.4

ORF Insert Sequence:

ATGGTCCTGA CGCTGCTTCT CTCCGCCTAC AAGCTGTGTC GCTTCTTCGC CATGTCGGGC 
CCACGGCCGG GCGCCGAGCG GCTGGCGGTG CCTGGGCCAG ATGGGGGCGG TGGCACGGGC 
CCATGGTGGG CTGCGGGTGG CCGCGGGCCC CGCGAAGTGT CGCCGGGGGC AGGCACCGAG 
GTGCAGGACG CCCTGGAGCG CGCGCTGCCG GAGCTGCAGC AGGCCTTGTC CGCGCTGAAG 
CAGGCGGGCG GCGCGCGGGC CGTGGGCGCC GGCCTGGCCG AGGTCTTCCA ACTGGTGGAG 
GAGGCCTGGC TGCTGCCGGC CGTGGGCCGC GAGGTAGCCC AGGGTCTGTG CGACGCCATC 
CGCCTCGATG GCGGCCTCGA CCTGCTGTTG CGGCTGCTGC AGGCGCCGGA GTTGGAGACG 
CGTGTGCAGG CCGCGCGCCT GCTGGAGCAG ATCCTGGTGG CTGAGAACCG AGACCGCGTG 
GCGCGCATTG GGCTGGGCGT GATCCTGAAC CTGGCGAAGG AACGCGAACC CGTAGAGCTG 
GCGCGGAGCG TGGCAGGCAT CTTGGAGCAC ATGTTCAAGC ATTCGGAGGA GACATGCCAG 
AGGCTGGTGG CGGCCGGCGG CCTGGACGCG GTGCTGTATT GGTGCCGCCG CACGGACCCC 
GCGCTGCTGC GCCACTGCGC GCTGGCGCTG GGCAACTGCG CGCTGCACGG GGGCCAGGCG 
GTGCAGCGAC GCATGGTAGA GAAGCGCGCA GCCGAGTGGC TCTTCCCGCT CGCCTTCTCC 
AAGGAGGACG AGCTGCTTCG GCTGCACGCC TGCCTCGCAG TAGCGGTGTT GGCGACTAAC 
AAGGAGGTGG AGCGCGAGGT GGAGCGCTCG GGCACGCTGG CGCTCGTGGA GCCGCTTGTG 
GCCTCGCTGG ACCCTGGCCG CTTCGCCCGC TGTCTGGTGG ACGCCAGCGA CACAAGCCAG 
GGCCGCGGGC CCGACGACCT GCAGCGCCTC GTGCCGTTGC TCGACTCTAA CCGCTTGGAG 
GCGCAGTGCA TCGGGGCTTT CTACCTCTGC GCCGAGGCTG CCATCAAGAG CCTGCAAGGC 
AAGACCAAGG TGTTCAGCGA CATCGGCGCC ATCCAGAGCC TGAAACGCCT GGTTTCCTAC 
TCTACCAATG GCACTAAGTC GGCGCTGGCC AAGCGCGCGC TGCGCCTGCT GGGCGAGGAG 
GTGCCACGGC CCATCCTGCC CTCCGTGCCC AGCTGGAAGG AGGCCGAGGT TCAGACGTGG 
CTGCAGCAGA TCGGTTTCTC CAAGTACTGC GAGAGCTTCC GGGAGCAGCA GGTGGATGGC 
GACCTGCTTC TGCGGCTCAC GGAGGAGGAA CTCCAGACCG ACCTGGGCAT GAAATCGGGC 
ATCACCCGCA AGAGGTTCTT TAGGGAGCTC ACGGAGCTCA AGACCTTCGC CAACTATTCT 
ACGTGCGACC GCAGCAACCT GGCGGACTGG CTGGGCAGCC TGGACCCGCG CTTCCGCCAG 
TACACCTACG GCCTGGTCAG CTGCGGCCTG GACCGCTCCC TGCTGCACCG CGTGTCTGAG 
CAGCAGCTGC TGGAAGACTG CGGCATCCAC CTGGGCGTGC ACCGCGCCCG CATCCTCACG 
GCGGCCAGAG AAATGCTACA CTCCCCGCTG CCCTGTACTG GTGGCAAACC CAGTGGGGAC 
ACTCCAGATG TCTTCATCAG CTACCGCCGG AACTCAGGTT CCCAGCTGGC CAGTCTCCTG 
AAGGTGCACC TGCAGCTGCA TGGCTTCAGT GTCTTCATTG ATGTGGAGAA GCTGGAAGCA 
GGCAAGTTCG AGGACAAACT CATCCAGAGT GTCATGGGTG CCCGCAACTT TGTGTTGGTG 
CTATCACCTG GAGCACTGGA CAAGTGCATG CAAGACCATG ACTGCAAGGA TTGGGTGCAT 
AAGGAGATTG TGACTGCTTT AAGCTGCGGC AAGAACATTG TGCCCATCAT TGATGGCTTC 
GAGTGGCCTG AGCCCCAGGT CCTGCCTGAG GACATGCAGG CTGTGCTTAC TTTCAACGGT 
ATCAAGTGGT CCCACGAATA CCAGGAGGCC ACCATTGAGA AGATCATCCG CTTCCTGCAG 
GGCCGCTCCT CCCGGGACTC ATCTGCAGGC TCTGACACCA GTTTGGAGGG TGCTGCACCC 
ATGGGTCCAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
Proceedings of the National Academy of Sciences of the United States of America113(41)E6271-E6280(2016 10)
Summers DW,Gibson DA,DiAntonio A,Milbrandt J

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.
Biochimica et biophysica acta1863(2)244-53(2016 Feb)
Carlsson E,Ding JL,Byrne B

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.
Neuron89(3)449-60(2016 Feb)
Gerdts J,Summers DW,Milbrandt J,DiAntonio A

Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
Human molecular genetics23(24)6684-93(2014 Dec)
Kwan JS,Hsu YH,Cheung CL,Dupuis J,Saint-Pierre A,Eriksson J,Handelman SK,Aragaki A,Karasik D,Pramstaller PP,Kooperberg C,Lacroix AZ,Larson MG,Lau KS,Lorentzon M,Pichler I,Sham PC,Taliun D,Vandenput L,Kiel DP,Hicks AA,Jackson RD,Ohlsson C,Benjamin EJ,Kung AW

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SARM1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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