| Gene Symbol | ARHGAP26 |
| Entrez Gene ID | 23092 |
| Full Name | Rho GTPase activating protein 26 |
| Synonyms | GRAF,GRAF1,OPHN1L,OPHN1L1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]. |
| Disorder MIM: | |
| Disorder Html: | Leukemia, juvenile myelomonocytic, somatic, 607785 (3) |









































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