RRP1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RRP1B
Entrez Gene ID	23076
Full Name	ribosomal RNA processing 1B
Synonyms	KIAA0179,NNP1L,Nnp1,PPP1R136,RRP1
General protein information	Preferred Names ribosomal RNA processing 1B Names ribosomal RNA processing protein 1 homolog B RRP1-like protein B protein phosphatase 1, regulatory subunit 136 ribosomal RNA processing 1 homolog B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Disorder MIM:	610654

mRNA and Protein(s)

mRNA	Protein	Name
NM_015056.2	NP_055871.1	ribosomal RNA processing protein 1 homolog B
NM_015056.3	NP_055871.1	ribosomal RNA processing protein 1 homolog B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RRP1B	XP_005639011.1
Bos taurus (cattle)	RRP1B	XP_002685189.1
Gallus gallus (chicken)	RRP1B	NP_001026505.1
Xenopus tropicalis (tropical clawed frog)	rrp1b	NP_001015923.1
Pan troglodytes (chimpanzee)	RRP1B	XP_001144331.1
	RRP1B	XP_001104749.2
Mus musculus (house mouse)	Rrp1b	NP_082520.2
Homo sapiens (human)	RRP1B	NP_055871.1
Danio rerio (zebrafish)	rrp1	XP_003199207.2
Rattus norvegicus (Norway rat)	Rrp1b	XP_228076.4

Gene Ontology
Bibliography

Related articles in PubMed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, G??s H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 Apr)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients.
Ugenskien? R, Myrzaliyeva D, Jankauskait? R, Gedminait? J, Jan?iauskien? R, ?epetauskien? E, Juozaityt? E
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals21(4)363-70(2016)

A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription.
Su WC, Hsu SF, Lee YY, Jeng KS, Lai MM
Journal of virology89(22)11245-55(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis
Title: The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients.

this study characterized the rRNA processing 1 homolog B (RRP1B) protein as an important cellular factor for influenza A virus transcription.
Title: A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription.

Presence of Rrp1b1307TT genotype and T allele confer strong risk for breast cancer development and progression.
Title: Rrp1B gene polymorphism (1307T>C) in metastatic progression of breast cancer.

Data show that RRP1B regulates metastasis associated gene expression by interacting with the transcriptional corepressors TRIM28 and HP1a, which act by recruiting chromatin-modifying enzymes.
Title: Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation.

BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.
Title: BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.

The following RRP1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRP1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28156	NM_015056.3 Latest version!	Homo sapiens ribosomal RNA processing 1B (RRP1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu28156	NM_015056.2	Homo sapiens ribosomal RNA processing 1B (RRP1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RRP1B ( NM_015056.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055871.1 Homo sapiens ribosomal RNA processing 1B (RRP1B), mRNA.

Price & Availability↑

CloneID	OHu28156
Clone ID Related Accession (Same CDS sequence)	NM_015056.2 , NM_015056.3
Accession Version	NM_015056.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2277bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ribosomal RNA processing protein 1 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC028386.2, AK056263.1, BX479134.1, AK124620.1, AP001052.1 and BE544027.1. On Nov 3, 2006 this sequence version replaced NM_015056.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.233750.1, SRR1803614.151588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCCG CCATGCAGCC GGCCGAGATC CAATTTGCCC AGCGGCTGGC GTCCAGCGAG 
AAGGGCATCC GGGACCGAGC GGTGAAGAAG CTGCGCCAGT ACATCAGCGT GAAGACGCAG 
AGGGAGACAG GAGGTTTCAG TCAGGAAGAA CTTCTGAAAA TCTGGAAGGG GCTCTTCTAC 
TGCATGTGGG TGCAGGATGA ACCCCTTCTA CAGGAAGAGC TCGCCAACAC CATTGCACAG 
CTAGTCCATG CTGTTAACAA CTCAGCGGCT CAACACCTGT TCATTCAGAC CTTTTGGCAA 
ACCATGAATC GAGAATGGAA AGGAATAGAC AGGCTACGCC TGGACAAATA CTATATGCTG 
ATTCGTCTGG TCCTGAGGCA GTCCTTTGAA GTCTTGAAGC GAAATGGCTG GGAAGAAAGC 
CGAATCAAGG TTTTCTTGGA TGTCCTGATG AAGGAGGTCC TGTGTCCTGA GAGTCAGTCT 
CCTAATGGAG TGAGATTCCA CTTCATTGAT ATTTACCTGG ATGAACTCTC CAAAGTCGGG 
GGGAAGGAGC TTTTAGCAGA TCAGAATCTC AAGTTTATCG ATCCATTCTG CAAAATTGCT 
GCGAAGACGA AGGACCACAC CCTGGTACAG ACCATAGCTC GGGGTGTCTT CGAAGCTATC 
GTAGATCAGT CTCCTTTTGT GCCTGAAGAG ACGATGGAGG AACAGAAGAC AAAAGTGGGT 
GATGGTGACC TCTCTGCTGA GGAGATACCT GAAAATGAGG TATCCTTGAG AAGAGCTGTC 
AGTAAAAAGA AGACAGCACT GGGCAAAAAC CATTCCAGAA AAGATGGACT CAGTGATGAA 
AGAGGAAGAG ATGACTGTGG AACCTTTGAG GACACAGGGC CCCTTCTCCA GTTTGACTAT 
AAGGCTGTTG CTGATCGACT CCTGGAAATG ACCAGCAGGA AGAACACGCC CCACTTCAAC 
AGGAAGCGCC TCTCCAAACT CATCAAGAAA TTCCAAGACC TTTCTGAAGG AAGCAGTATA 
TCTCAACTCA GTTTTGCGGA GGACATTTCT GCTGATGAAG ATGACCAAAT CCTCAGTCAA 
GGAAAGCATA AGAAGAAAGG AAATAAACTT TTAGAGAAAA CTAACTTGGA AAAGGAGAAA 
GGAAGCAGAG TCTTTTGTGT AGAGGAAGAG GACAGTGAAA GCAGTCTTCA AAAGAGAAGA 
AGGAAGAAGA AGAAGAAGCA CCACCTGCAG CCTGAAAATC CAGGCCCAGG GGGTGCAGCC 
CCATCCCTGG AACAGAACCG GGGCAGGGAG CCCGAGGCCT CTGGGCTGAA AGCCCTGAAG 
GCACGTGTGG CCGAGCCAGG TGCAGAGGCC ACGTCCAGCA CTGGGGAGGA GAGTGGCTCC 
GAGCATCCTC CAGCCGTCCC CATGCACAAT AAAAGGAAAC GGCCACGGAA GAAGAGCCCG 
AGGGCCCACA GGGAAATGTT GGAATCAGCA GTGTTGCCCC CAGAGGACAT GTCTCAGAGT 
GGCCCGAGTG GCAGTCATCC TCAGGGACCT AGAGGGTCCC CGACAGGTGG AGCCCAACTC 
CTAAAAAGGA AGCGGAAACT TGGAGTTGTG CCCGTCAATG GCAGTGGCCT GTCCACGCCG 
GCCTGGCCTC CATTGCAGCA GGAAGGCCCT CCCACAGGCC CCGCAGAGGG GGCGAACAGC 
CACACCACGC TGCCCCAGCG CAGGAGGCTG CAGAAAAAGA AGGCAGGGCC CGGCAGCCTG 
GAGCTCTGTG GCCTGCCCAG CCAGAAAACA GCAAGTTTGA AAAAGAGGAA GAAAATGAGA 
GTGATGTCAA ACTTGGTGGA GCACAACGGG GTGCTGGAGT CCGAAGCTGG GCAACCCCAG 
GCTCTGGGAA GCAGTGGGAC TTGCAGTTCC CTGAAGAAGC AGAAGCTGAG GGCAGAGAGC 
GACTTTGTGA AGTTTGACAC CCCCTTCTTA CCAAAGCCCC TGTTCTTCAG AAGAGCCAAG 
AGCAGCACTG CCACCCACCC TCCAGGCCCT GCCGTCCAGC TAAACAAGAC ACCATCCAGC 
TCCAAGAAAG TCACCTTTGG GCTGAACAGA AACATGACTG CCGAATTCAA GAAGACAGAC 
AAGAGTATCT TGGTCAGTCC CACGGGCCCT TCTCGAGTGG CCTTCGACCC TGAACAGAAG 
CCCCTCCACG GGGTGCTGAA GACCCCCACC AGCTCACCTG CCAGCTCACC CCTGGTGGCC 
AAGAAGCCCC TGACCACCAC ACCAAGGAGA AGGCCCAGGG CTATGGATTT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055871.1
CDS	115..2391
Translation	MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELLKIWKGLFYCMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYMLIRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVGGKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKVGDGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDYKAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQILSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPGGAAPSLEQNRGREPEASGLKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSPRAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTPAWPPLQQEGPPTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMRVMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAKSSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQKPLHGVLKTPTSSPASSPLVAKKPLTTTPRRRPRAMDFF

Target ORF information:

RefSeq Version	NM_015056.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal RNA processing 1B (RRP1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015056.2

ORF Insert Sequence:

ATGGCCCCCG CCATGCAGCC GGCCGAGATC CAATTTGCCC AGCGGCTGGC GTCCAGCGAG 
AAGGGCATCC GGGACCGAGC GGTGAAGAAG CTGCGCCAGT ACATCAGCGT GAAGACGCAG 
AGGGAGACAG GAGGTTTCAG TCAGGAAGAA CTTCTGAAAA TCTGGAAGGG GCTCTTCTAC 
TGCATGTGGG TGCAGGATGA ACCCCTTCTA CAGGAAGAGC TCGCCAACAC CATTGCACAG 
CTAGTCCATG CTGTTAACAA CTCAGCGGCT CAACACCTGT TCATTCAGAC CTTTTGGCAA 
ACCATGAATC GAGAATGGAA AGGAATAGAC AGGCTACGCC TGGACAAATA CTATATGCTG 
ATTCGTCTGG TCCTGAGGCA GTCCTTTGAA GTCTTGAAGC GAAATGGCTG GGAAGAAAGC 
CGAATCAAGG TTTTCTTGGA TGTCCTGATG AAGGAGGTCC TGTGTCCTGA GAGTCAGTCT 
CCTAATGGAG TGAGATTCCA CTTCATTGAT ATTTACCTGG ATGAACTCTC CAAAGTCGGG 
GGGAAGGAGC TTTTAGCAGA TCAGAATCTC AAGTTTATCG ATCCATTCTG CAAAATTGCT 
GCGAAGACGA AGGACCACAC CCTGGTACAG ACCATAGCTC GGGGTGTCTT CGAAGCTATC 
GTAGATCAGT CTCCTTTTGT GCCTGAAGAG ACGATGGAGG AACAGAAGAC AAAAGTGGGT 
GATGGTGACC TCTCTGCTGA GGAGATACCT GAAAATGAGG TATCCTTGAG AAGAGCTGTC 
AGTAAAAAGA AGACAGCACT GGGCAAAAAC CATTCCAGAA AAGATGGACT CAGTGATGAA 
AGAGGAAGAG ATGACTGTGG AACCTTTGAG GACACAGGGC CCCTTCTCCA GTTTGACTAT 
AAGGCTGTTG CTGATCGACT CCTGGAAATG ACCAGCAGGA AGAACACGCC CCACTTCAAC 
AGGAAGCGCC TCTCCAAACT CATCAAGAAA TTCCAAGACC TTTCTGAAGG AAGCAGTATA 
TCTCAACTCA GTTTTGCGGA GGACATTTCT GCTGATGAAG ATGACCAAAT CCTCAGTCAA 
GGAAAGCATA AGAAGAAAGG AAATAAACTT TTAGAGAAAA CTAACTTGGA AAAGGAGAAA 
GGAAGCAGAG TCTTTTGTGT AGAGGAAGAG GACAGTGAAA GCAGTCTTCA AAAGAGAAGA 
AGGAAGAAGA AGAAGAAGCA CCACCTGCAG CCTGAAAATC CAGGCCCAGG GGGTGCAGCC 
CCATCCCTGG AACAGAACCG GGGCAGGGAG CCCGAGGCCT CTGGGCTGAA AGCCCTGAAG 
GCACGTGTGG CCGAGCCAGG TGCAGAGGCC ACGTCCAGCA CTGGGGAGGA GAGTGGCTCC 
GAGCATCCTC CAGCCGTCCC CATGCACAAT AAAAGGAAAC GGCCACGGAA GAAGAGCCCG 
AGGGCCCACA GGGAAATGTT GGAATCAGCA GTGTTGCCCC CAGAGGACAT GTCTCAGAGT 
GGCCCGAGTG GCAGTCATCC TCAGGGACCT AGAGGGTCCC CGACAGGTGG AGCCCAACTC 
CTAAAAAGGA AGCGGAAACT TGGAGTTGTG CCCGTCAATG GCAGTGGCCT GTCCACGCCG 
GCCTGGCCTC CATTGCAGCA GGAAGGCCCT CCCACAGGCC CCGCAGAGGG GGCGAACAGC 
CACACCACGC TGCCCCAGCG CAGGAGGCTG CAGAAAAAGA AGGCAGGGCC CGGCAGCCTG 
GAGCTCTGTG GCCTGCCCAG CCAGAAAACA GCAAGTTTGA AAAAGAGGAA GAAAATGAGA 
GTGATGTCAA ACTTGGTGGA GCACAACGGG GTGCTGGAGT CCGAAGCTGG GCAACCCCAG 
GCTCTGGGAA GCAGTGGGAC TTGCAGTTCC CTGAAGAAGC AGAAGCTGAG GGCAGAGAGC 
GACTTTGTGA AGTTTGACAC CCCCTTCTTA CCAAAGCCCC TGTTCTTCAG AAGAGCCAAG 
AGCAGCACTG CCACCCACCC TCCAGGCCCT GCCGTCCAGC TAAACAAGAC ACCATCCAGC 
TCCAAGAAAG TCACCTTTGG GCTGAACAGA AACATGACTG CCGAATTCAA GAAGACAGAC 
AAGAGTATCT TGGTCAGTCC CACGGGCCCT TCTCGAGTGG CCTTCGACCC TGAACAGAAG 
CCCCTCCACG GGGTGCTGAA GACCCCCACC AGCTCACCTG CCAGCTCACC CCTGGTGGCC 
AAGAAGCCCC TGACCACCAC ACCAAGGAGA AGGCCCAGGG CTATGGATTT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRP1B ( NM_015056.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055871.1 Homo sapiens ribosomal RNA processing 1B (RRP1B), mRNA.

Price & Availability↑

CloneID	OHu28156
Clone ID Related Accession (Same CDS sequence)	NM_015056.2 , NM_015056.3
Accession Version	NM_015056.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2277bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	ribosomal RNA processing protein 1 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC028386.2, AK056263.1, BX479134.1, AK124620.1, AP001052.1 and BE544027.1. On Nov 22, 2018 this sequence version replaced NM_015056.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.233750.1, SRR1803614.151588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000340648.6/ ENSP00000339145.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCCCG CCATGCAGCC GGCCGAGATC CAATTTGCCC AGCGGCTGGC GTCCAGCGAG 
AAGGGCATCC GGGACCGAGC GGTGAAGAAG CTGCGCCAGT ACATCAGCGT GAAGACGCAG 
AGGGAGACAG GAGGTTTCAG TCAGGAAGAA CTTCTGAAAA TCTGGAAGGG GCTCTTCTAC 
TGCATGTGGG TGCAGGATGA ACCCCTTCTA CAGGAAGAGC TCGCCAACAC CATTGCACAG 
CTAGTCCATG CTGTTAACAA CTCAGCGGCT CAACACCTGT TCATTCAGAC CTTTTGGCAA 
ACCATGAATC GAGAATGGAA AGGAATAGAC AGGCTACGCC TGGACAAATA CTATATGCTG 
ATTCGTCTGG TCCTGAGGCA GTCCTTTGAA GTCTTGAAGC GAAATGGCTG GGAAGAAAGC 
CGAATCAAGG TTTTCTTGGA TGTCCTGATG AAGGAGGTCC TGTGTCCTGA GAGTCAGTCT 
CCTAATGGAG TGAGATTCCA CTTCATTGAT ATTTACCTGG ATGAACTCTC CAAAGTCGGG 
GGGAAGGAGC TTTTAGCAGA TCAGAATCTC AAGTTTATCG ATCCATTCTG CAAAATTGCT 
GCGAAGACGA AGGACCACAC CCTGGTACAG ACCATAGCTC GGGGTGTCTT CGAAGCTATC 
GTAGATCAGT CTCCTTTTGT GCCTGAAGAG ACGATGGAGG AACAGAAGAC AAAAGTGGGT 
GATGGTGACC TCTCTGCTGA GGAGATACCT GAAAATGAGG TATCCTTGAG AAGAGCTGTC 
AGTAAAAAGA AGACAGCACT GGGCAAAAAC CATTCCAGAA AAGATGGACT CAGTGATGAA 
AGAGGAAGAG ATGACTGTGG AACCTTTGAG GACACAGGGC CCCTTCTCCA GTTTGACTAT 
AAGGCTGTTG CTGATCGACT CCTGGAAATG ACCAGCAGGA AGAACACGCC CCACTTCAAC 
AGGAAGCGCC TCTCCAAACT CATCAAGAAA TTCCAAGACC TTTCTGAAGG AAGCAGTATA 
TCTCAACTCA GTTTTGCGGA GGACATTTCT GCTGATGAAG ATGACCAAAT CCTCAGTCAA 
GGAAAGCATA AGAAGAAAGG AAATAAACTT TTAGAGAAAA CTAACTTGGA AAAGGAGAAA 
GGAAGCAGAG TCTTTTGTGT AGAGGAAGAG GACAGTGAAA GCAGTCTTCA AAAGAGAAGA 
AGGAAGAAGA AGAAGAAGCA CCACCTGCAG CCTGAAAATC CAGGCCCAGG GGGTGCAGCC 
CCATCCCTGG AACAGAACCG GGGCAGGGAG CCCGAGGCCT CTGGGCTGAA AGCCCTGAAG 
GCACGTGTGG CCGAGCCAGG TGCAGAGGCC ACGTCCAGCA CTGGGGAGGA GAGTGGCTCC 
GAGCATCCTC CAGCCGTCCC CATGCACAAT AAAAGGAAAC GGCCACGGAA GAAGAGCCCG 
AGGGCCCACA GGGAAATGTT GGAATCAGCA GTGTTGCCCC CAGAGGACAT GTCTCAGAGT 
GGCCCGAGTG GCAGTCATCC TCAGGGACCT AGAGGGTCCC CGACAGGTGG AGCCCAACTC 
CTAAAAAGGA AGCGGAAACT TGGAGTTGTG CCCGTCAATG GCAGTGGCCT GTCCACGCCG 
GCCTGGCCTC CATTGCAGCA GGAAGGCCCT CCCACAGGCC CCGCAGAGGG GGCGAACAGC 
CACACCACGC TGCCCCAGCG CAGGAGGCTG CAGAAAAAGA AGGCAGGGCC CGGCAGCCTG 
GAGCTCTGTG GCCTGCCCAG CCAGAAAACA GCAAGTTTGA AAAAGAGGAA GAAAATGAGA 
GTGATGTCAA ACTTGGTGGA GCACAACGGG GTGCTGGAGT CCGAAGCTGG GCAACCCCAG 
GCTCTGGGAA GCAGTGGGAC TTGCAGTTCC CTGAAGAAGC AGAAGCTGAG GGCAGAGAGC 
GACTTTGTGA AGTTTGACAC CCCCTTCTTA CCAAAGCCCC TGTTCTTCAG AAGAGCCAAG 
AGCAGCACTG CCACCCACCC TCCAGGCCCT GCCGTCCAGC TAAACAAGAC ACCATCCAGC 
TCCAAGAAAG TCACCTTTGG GCTGAACAGA AACATGACTG CCGAATTCAA GAAGACAGAC 
AAGAGTATCT TGGTCAGTCC CACGGGCCCT TCTCGAGTGG CCTTCGACCC TGAACAGAAG 
CCCCTCCACG GGGTGCTGAA GACCCCCACC AGCTCACCTG CCAGCTCACC CCTGGTGGCC 
AAGAAGCCCC TGACCACCAC ACCAAGGAGA AGGCCCAGGG CTATGGATTT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055871.1
CDS	106..2382
Translation	MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELLKIWKGLFYCMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYMLIRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVGGKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKVGDGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDYKAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQILSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPGGAAPSLEQNRGREPEASGLKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSPRAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTPAWPPLQQEGPPTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMRVMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAKSSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQKPLHGVLKTPTSSPASSPLVAKKPLTTTPRRRPRAMDFF

Target ORF information:

RefSeq Version	NM_015056.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal RNA processing 1B (RRP1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015056.3

ORF Insert Sequence:

ATGGCCCCCG CCATGCAGCC GGCCGAGATC CAATTTGCCC AGCGGCTGGC GTCCAGCGAG 
AAGGGCATCC GGGACCGAGC GGTGAAGAAG CTGCGCCAGT ACATCAGCGT GAAGACGCAG 
AGGGAGACAG GAGGTTTCAG TCAGGAAGAA CTTCTGAAAA TCTGGAAGGG GCTCTTCTAC 
TGCATGTGGG TGCAGGATGA ACCCCTTCTA CAGGAAGAGC TCGCCAACAC CATTGCACAG 
CTAGTCCATG CTGTTAACAA CTCAGCGGCT CAACACCTGT TCATTCAGAC CTTTTGGCAA 
ACCATGAATC GAGAATGGAA AGGAATAGAC AGGCTACGCC TGGACAAATA CTATATGCTG 
ATTCGTCTGG TCCTGAGGCA GTCCTTTGAA GTCTTGAAGC GAAATGGCTG GGAAGAAAGC 
CGAATCAAGG TTTTCTTGGA TGTCCTGATG AAGGAGGTCC TGTGTCCTGA GAGTCAGTCT 
CCTAATGGAG TGAGATTCCA CTTCATTGAT ATTTACCTGG ATGAACTCTC CAAAGTCGGG 
GGGAAGGAGC TTTTAGCAGA TCAGAATCTC AAGTTTATCG ATCCATTCTG CAAAATTGCT 
GCGAAGACGA AGGACCACAC CCTGGTACAG ACCATAGCTC GGGGTGTCTT CGAAGCTATC 
GTAGATCAGT CTCCTTTTGT GCCTGAAGAG ACGATGGAGG AACAGAAGAC AAAAGTGGGT 
GATGGTGACC TCTCTGCTGA GGAGATACCT GAAAATGAGG TATCCTTGAG AAGAGCTGTC 
AGTAAAAAGA AGACAGCACT GGGCAAAAAC CATTCCAGAA AAGATGGACT CAGTGATGAA 
AGAGGAAGAG ATGACTGTGG AACCTTTGAG GACACAGGGC CCCTTCTCCA GTTTGACTAT 
AAGGCTGTTG CTGATCGACT CCTGGAAATG ACCAGCAGGA AGAACACGCC CCACTTCAAC 
AGGAAGCGCC TCTCCAAACT CATCAAGAAA TTCCAAGACC TTTCTGAAGG AAGCAGTATA 
TCTCAACTCA GTTTTGCGGA GGACATTTCT GCTGATGAAG ATGACCAAAT CCTCAGTCAA 
GGAAAGCATA AGAAGAAAGG AAATAAACTT TTAGAGAAAA CTAACTTGGA AAAGGAGAAA 
GGAAGCAGAG TCTTTTGTGT AGAGGAAGAG GACAGTGAAA GCAGTCTTCA AAAGAGAAGA 
AGGAAGAAGA AGAAGAAGCA CCACCTGCAG CCTGAAAATC CAGGCCCAGG GGGTGCAGCC 
CCATCCCTGG AACAGAACCG GGGCAGGGAG CCCGAGGCCT CTGGGCTGAA AGCCCTGAAG 
GCACGTGTGG CCGAGCCAGG TGCAGAGGCC ACGTCCAGCA CTGGGGAGGA GAGTGGCTCC 
GAGCATCCTC CAGCCGTCCC CATGCACAAT AAAAGGAAAC GGCCACGGAA GAAGAGCCCG 
AGGGCCCACA GGGAAATGTT GGAATCAGCA GTGTTGCCCC CAGAGGACAT GTCTCAGAGT 
GGCCCGAGTG GCAGTCATCC TCAGGGACCT AGAGGGTCCC CGACAGGTGG AGCCCAACTC 
CTAAAAAGGA AGCGGAAACT TGGAGTTGTG CCCGTCAATG GCAGTGGCCT GTCCACGCCG 
GCCTGGCCTC CATTGCAGCA GGAAGGCCCT CCCACAGGCC CCGCAGAGGG GGCGAACAGC 
CACACCACGC TGCCCCAGCG CAGGAGGCTG CAGAAAAAGA AGGCAGGGCC CGGCAGCCTG 
GAGCTCTGTG GCCTGCCCAG CCAGAAAACA GCAAGTTTGA AAAAGAGGAA GAAAATGAGA 
GTGATGTCAA ACTTGGTGGA GCACAACGGG GTGCTGGAGT CCGAAGCTGG GCAACCCCAG 
GCTCTGGGAA GCAGTGGGAC TTGCAGTTCC CTGAAGAAGC AGAAGCTGAG GGCAGAGAGC 
GACTTTGTGA AGTTTGACAC CCCCTTCTTA CCAAAGCCCC TGTTCTTCAG AAGAGCCAAG 
AGCAGCACTG CCACCCACCC TCCAGGCCCT GCCGTCCAGC TAAACAAGAC ACCATCCAGC 
TCCAAGAAAG TCACCTTTGG GCTGAACAGA AACATGACTG CCGAATTCAA GAAGACAGAC 
AAGAGTATCT TGGTCAGTCC CACGGGCCCT TCTCGAGTGG CCTTCGACCC TGAACAGAAG 
CCCCTCCACG GGGTGCTGAA GACCCCCACC AGCTCACCTG CCAGCTCACC CCTGGTGGCC 
AAGAAGCCCC TGACCACCAC ACCAAGGAGA AGGCCCAGGG CTATGGATTT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Cell systems4(4)430-444.e5(2017 Apr)
Yadav L,Tamene F,G??s H,van Drogen A,Katainen R,Aebersold R,Gstaiger M,Varjosalo M

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals21(4)363-70(2016)
Ugenskien? R,Myrzaliyeva D,Jankauskait? R,Gedminait? J,Jan?iauskien? R,?epetauskien? E,Juozaityt? E

A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription.
Journal of virology89(22)11245-55(2015 Nov)
Su WC,Hsu SF,Lee YY,Jeng KS,Lai MM

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RRP1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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