Gene Symbol | WDFY3 |
Entrez Gene ID | 23001 |
Full Name | WD repeat and FYVE domain containing 3 |
Synonyms | ALFY,BCHS,MCPH18,ZFYVE25 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]. |
Disorder MIM: | |
Disorder Html: | ?Microcephaly 18, primary, autosomal dominant, 617520 (3) |