FOXD4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXD4
Entrez Gene ID	2298
Full Name	forkhead box D4
Synonyms	FKHL9,FOXD4A,FREAC-5,FREAC5
General protein information	Preferred Names forkhead box D4 Names forkhead box protein D4 forkhead, Drosophila, homolog-like 9 forkhead-related activator 5 forkhead-related protein FKHL9 forkhead-related transcription factor 5 myeloid factor-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p24.3
Summary	This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012].
Disorder MIM:	601092

mRNA and Protein(s)

mRNA	Protein	Name
NM_207305.4	NP_997188.2	forkhead box protein D4

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Foxd4	XP_001055972.2
	LOC698459	XP_002800177.1
Bos taurus (cattle)	FOXD4L1	XP_003586437.1
Mus musculus (house mouse)	Foxd4	NP_032048.1
Homo sapiens (human)	FOXD4	NP_997188.2
Pan troglodytes (chimpanzee)	FOXD4L6	XP_003309632.2

Gene Ontology
Bibliography

Related articles in PubMed

Pure distal 9p deletion in a female infant with cerebral palsy.
Chen CP, Lin SP, Su YN, Su JW, Chern SR, Town DD, Wang W
Genetic counseling (Geneva, Switzerland)23(2)215-21(2012)

Maternally inherited partial monosomy 9p (pter???p24.1) and partial trisomy 20p (pter???p12.1) characterized by microarray comparative genomic hybridization.
Freitas ?L, Gribble SM, Simioni M, Vieira TP, Silva-Grecco RL, Balarin MA, Prigmore E, Krepischi-Santos AC, Rosenberg C, Szuhai K, van Haeringen A, Carter NP, Gil-da-Silva-Lopes VL
American journal of medical genetics. Part A155A(11)2754-61(2011 Nov)

Inv dup del(9p): prenatal diagnosis and molecular cytogenetic characterization by fluorescence in situ hybridization and array comparative genomic hybridization.
Chen CP, Su YN, Chern SR, Hsu CY, Tsai FJ, Wu PC, Lee CC, Chen YT, Lee MS, Wang W
Taiwanese journal of obstetrics & gynecology50(1)67-73(2011 Mar)

Update of human and mouse forkhead box (FOX) gene families.
Jackson BC, Carpenter C, Nebert DW, Vasiliou V
Human genomics4(5)345-52(2010 Jun)

A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality.
Minoretti P, Arra M, Emanuele E, Olivieri V, Aldeghi A, Politi P, Martinelli V, Pesenti S, Falcone C
International journal of molecular medicine19(3)369-72(2007 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FOXd4 encodes forkhead box D4 protein.
Title: Pure distal 9p deletion in a female infant with cerebral palsy.

The W148R mutation disrupts an extremely highly conserved tryptophan residue in the forkhead domain of FOXD4, possibly resulting in reduced DNA binding capacity and altered transcriptional activity.
Title: A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality.

The following FOXD4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXD4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20005	NM_207305.4 Latest version!	Homo sapiens forkhead box D4 (FOXD4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXD4 ( NM_207305.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_997188.2 Homo sapiens forkhead box D4 (FOXD4), mRNA.

Price & Availability↑

CloneID	OHu20005
Clone ID Related Accession (Same CDS sequence)	NM_207305.4
Accession Version	NM_207305.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	forkhead box protein D4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC089432.1, CF139066.1 and CA313252.1. This sequence is a reference standard in the RefSeqGene project. On Mar 17, 2012 this sequence version replaced NM_207305.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC089432.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACTTGC CAAGAGCTGA GCGCCTTCGC TCCACACCGC AGCGCAGCCT CCGGGACTCC 
GATGGGGAAG ACGGTAAAAT CGATGTCCTG GGAGAGGAGG AAGATGAAGA CGAGGAGGAG 
GCGGCGAGCC AGCAGTTCCT AGAGCAGTCG CTCCAGCCGG GGCTGCAGGT GGCCCGGTGG 
GGCGGGGTTG CGCTTCCCCG AGAGCACATC GAGGGCGGCG GCGGCCCGAG CGACCCCTCA 
GAGTTTGGCA CCGAGTTCAG GGCACCGCCA AGGTCTGCGG CGGCCTCTGA AGATGCCCGG 
CAGCCGGCAA AGCCCCCCTC CTCGTACATC GCGCTCATCA CCATGGCCAT CCTGCAAAGC 
CCGCACAAGC GCCTCACGCT CAGCGGCATC TGCGCCTTCA TTAGTGACCG CTTCCCCTAC 
TACCGCCGCA AGTTCCCCGC CTGGCAGAAC AGCATCCGCC ACAACCTCTC GCTGAACGAC 
TGCTTCGTCA AGATCCCCCG CGAGCCGGGC CGCCCAGGCA AGGGCAACTA CTGGAGCCTG 
GACCCCGCCT CCCAGGACAT GTTCGACAAT GGCAGCTTTC TCCGGCGTAG GAAGCGTTTC 
CAGCGCCACC AACCGACCCC GGGAGCCCAC CTGCCCCACC CCTTCCCTCT ACCTGCTGCA 
CACGCCGCCC TGCACAACCC CCGCCCAGGC CCTCTGCTTG GGGCCCCTGC CCCGCCGCAG 
CCAGTCCCGG GGGCCTACCC CAACACCGGC CCCGGGAGAC GCCCTTACGC TCTGCTGCAC 
CCGCATCCTC CTCGCTACCT ACTGCTCTCG GCCCCCGCCT ATGCCGGGGC ACCGAAGAAA 
GCAGAAGGCG CGGACCTGGC GACCCCGGCA CCCTTCCCGT GCTGCAGCCC TCACTTGGTC 
CTCAGCCTTG GGAGGAGGGC AAGGGTCTGG CGTCGCCACC GGGAGGCGGA TGCATCTCTT 
TCAGCATTGA GAGTATCATG CAAGGGGTCA GGGGAGCGGG TACAGGGGCT GCGCAGAGTT 
TGTCCCCGAC CGCGTGGAGC TACTGCCCCC TGCTCCAGCG ACCGTCAAGC CTGTCGGACA 
ATTTTGCAGC AACAGCAGCG GCATCAGGAG GAGGACTGCG CCAACGGCTG CGCTCCCACC 
AAGGGCGCGG TGCTGGGCGG GCACCTGTCG GCCGCGTCGG CGCTGCTGCG GTATCAGGCG 
GTGGCAGAGG GCTCTGGGCT GACATCGCTG GCCGCCCCTT TGGGCGGAGA GGGGACCTCA 
CCAGTTTTTT TAGTATCGCC CACGCCCAGT TCCCTGGCCG AGTCCGCAGG GCCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997188.2
CDS	299..1618
Translation	MNLPRAERLRSTPQRSLRDSDGEDGKIDVLGEEEDEDEEEAASQQFLEQSLQPGLQVARWGGVALPREHIEGGGGPSDPSEFGTEFRAPPRSAAASEDARQPAKPPSSYIALITMAILQSPHKRLTLSGICAFISDRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPGRPGKGNYWSLDPASQDMFDNGSFLRRRKRFQRHQPTPGAHLPHPFPLPAAHAALHNPRPGPLLGAPAPPQPVPGAYPNTGPGRRPYALLHPHPPRYLLLSAPAYAGAPKKAEGADLATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVSCKGSGERVQGLRRVCPRPRGATAPCSSDRQACRTILQQQQRHQEEDCANGCAPTKGAVLGGHLSAASALLRYQAVAEGSGLTSLAAPLGGEGTSPVFLVSPTPSSLAESAGPS

Target ORF information:

RefSeq Version	NM_207305.4
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box D4 (FOXD4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207305.4

ORF Insert Sequence:

ATGAACTTGC CAAGAGCTGA GCGCCTTCGC TCCACACCGC AGCGCAGCCT CCGGGACTCC 
GATGGGGAAG ACGGTAAAAT CGATGTCCTG GGAGAGGAGG AAGATGAAGA CGAGGAGGAG 
GCGGCGAGCC AGCAGTTCCT AGAGCAGTCG CTCCAGCCGG GGCTGCAGGT GGCCCGGTGG 
GGCGGGGTTG CGCTTCCCCG AGAGCACATC GAGGGCGGCG GCGGCCCGAG CGACCCCTCA 
GAGTTTGGCA CCGAGTTCAG GGCACCGCCA AGGTCTGCGG CGGCCTCTGA AGATGCCCGG 
CAGCCGGCAA AGCCCCCCTC CTCGTACATC GCGCTCATCA CCATGGCCAT CCTGCAAAGC 
CCGCACAAGC GCCTCACGCT CAGCGGCATC TGCGCCTTCA TTAGTGACCG CTTCCCCTAC 
TACCGCCGCA AGTTCCCCGC CTGGCAGAAC AGCATCCGCC ACAACCTCTC GCTGAACGAC 
TGCTTCGTCA AGATCCCCCG CGAGCCGGGC CGCCCAGGCA AGGGCAACTA CTGGAGCCTG 
GACCCCGCCT CCCAGGACAT GTTCGACAAT GGCAGCTTTC TCCGGCGTAG GAAGCGTTTC 
CAGCGCCACC AACCGACCCC GGGAGCCCAC CTGCCCCACC CCTTCCCTCT ACCTGCTGCA 
CACGCCGCCC TGCACAACCC CCGCCCAGGC CCTCTGCTTG GGGCCCCTGC CCCGCCGCAG 
CCAGTCCCGG GGGCCTACCC CAACACCGGC CCCGGGAGAC GCCCTTACGC TCTGCTGCAC 
CCGCATCCTC CTCGCTACCT ACTGCTCTCG GCCCCCGCCT ATGCCGGGGC ACCGAAGAAA 
GCAGAAGGCG CGGACCTGGC GACCCCGGCA CCCTTCCCGT GCTGCAGCCC TCACTTGGTC 
CTCAGCCTTG GGAGGAGGGC AAGGGTCTGG CGTCGCCACC GGGAGGCGGA TGCATCTCTT 
TCAGCATTGA GAGTATCATG CAAGGGGTCA GGGGAGCGGG TACAGGGGCT GCGCAGAGTT 
TGTCCCCGAC CGCGTGGAGC TACTGCCCCC TGCTCCAGCG ACCGTCAAGC CTGTCGGACA 
ATTTTGCAGC AACAGCAGCG GCATCAGGAG GAGGACTGCG CCAACGGCTG CGCTCCCACC 
AAGGGCGCGG TGCTGGGCGG GCACCTGTCG GCCGCGTCGG CGCTGCTGCG GTATCAGGCG 
GTGGCAGAGG GCTCTGGGCT GACATCGCTG GCCGCCCCTT TGGGCGGAGA GGGGACCTCA 
CCAGTTTTTT TAGTATCGCC CACGCCCAGT TCCCTGGCCG AGTCCGCAGG GCCCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pure distal 9p deletion in a female infant with cerebral palsy.
Genetic counseling (Geneva, Switzerland)23(2)215-21(2012)
Chen CP,Lin SP,Su YN,Su JW,Chern SR,Town DD,Wang W

Maternally inherited partial monosomy 9p (pter???p24.1) and partial trisomy 20p (pter???p12.1) characterized by microarray comparative genomic hybridization.
American journal of medical genetics. Part A155A(11)2754-61(2011 Nov)
Freitas ?L,Gribble SM,Simioni M,Vieira TP,Silva-Grecco RL,Balarin MA,Prigmore E,Krepischi-Santos AC,Rosenberg C,Szuhai K,van Haeringen A,Carter NP,Gil-da-Silva-Lopes VL

Inv dup del(9p): prenatal diagnosis and molecular cytogenetic characterization by fluorescence in situ hybridization and array comparative genomic hybridization.
Taiwanese journal of obstetrics & gynecology50(1)67-73(2011 Mar)
Chen CP,Su YN,Chern SR,Hsu CY,Tsai FJ,Wu PC,Lee CC,Chen YT,Lee MS,Wang W

Update of human and mouse forkhead box (FOX) gene families.
Human genomics4(5)345-52(2010 Jun)
Jackson BC,Carpenter C,Nebert DW,Vasiliou V

A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality.
International journal of molecular medicine19(3)369-72(2007 Mar)
Minoretti P,Arra M,Emanuele E,Olivieri V,Aldeghi A,Politi P,Martinelli V,Pesenti S,Falcone C

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FOXD4 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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